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Dr. Vijay Rao K R

MBBS, MRCP Rheumatology (London)

Rheumatologist, Bangalore

15 Years Experience  ·  700 at clinic
Dr. Vijay Rao K R MBBS, MRCP Rheumatology (London) Rheumatologist, Bangalore
15 Years Experience  ·  700 at clinic
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Personal Statement

My favorite part of being a doctor is the opportunity to directly improve the health and wellbeing of my patients and to develop professional and personal relationships with them....more
My favorite part of being a doctor is the opportunity to directly improve the health and wellbeing of my patients and to develop professional and personal relationships with them.
More about Dr. Vijay Rao K R
Dr. Vijay Rao K R is one of the best Rheumatologists in Malleshwaram, Bangalore. He has helped numerous patients in his 15 years of experience as a Rheumatologist. He has completed MBBS, MRCP Rheumatology (London) . He is currently practising at Northside Manipal Hospital in Malleshwaram, Bangalore. Don’t wait in a queue, book an instant appointment online with Dr. Vijay Rao K R on Lybrate.com.

Lybrate.com has a number of highly qualified Rheumatologists in India. You will find Rheumatologists with more than 33 years of experience on Lybrate.com. You can find Rheumatologists online in Bangalore and from across India. View the profile of medical specialists and their reviews from other patients to make an informed decision.

Info

Education
MBBS - - 2002
MRCP Rheumatology (London) - - 2009
Languages spoken
English
Professional Memberships
Indian Medical Association (IMA)
British Society of Rheumatology
Medical Defence Union
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Membership of Royal Colleges of Physicians (MRCP)

Location

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8th Main, 13th Cross, Malleswaram. Landmark: Opp. to Canara UnionBangalore Get Directions
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98, HAL Airport RoadBangalore Get Directions
700 at clinic
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Hello I am 27 years old I am suffering from lack of sleep. My sleep time is 12 am to 9 am but I am not able to get proper sleep. Feel insomnia. I am shifting my side whole night and even not feeling comfortable and sleepy. This is second time happening. First time I wasn't able to sept for more than 20 nights and days as well. My heart rates also increase some times at night. No pain nothing but m feeling my heart is having pressure or something like that. I do 2 hours of gym workout. please help.

Diploma in Obstetrics & Gynaecology, MBBS
General Physician, Delhi
Hello I am 27 years old I am suffering from lack of sleep. My sleep time is 12 am to 9 am but I am not able to get pr...
If you do 2 hours of Gymn, you require a good diet along with Rest, an Overtired Body is always restless and sleep deprived. Please do not take any sleeping tablets. Try taking a warm glass of milk+honey at bedtime + listen to some soothing music ,Avoid aggressive TV programmes and do read some motivational books like autobiographies. Give us a positive feed back after 2 weeks trial.
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Dear sir, I am 43 years old men. Suffering from Knee pain (both legs) past 13 years. I take medicine several times. But no result. Doctor advised it is deficiency of cartilege. Please advise me for clear my knee pain.

BPTh/BPT
Physiotherapist, Delhi
1.Take Physiotherapy sessions and learn exercise for Knee joint. 2. Wear knee cap open patella. 3.Take calcium(morning) and methylcobalamine(after dinner) supplement with Glucosamine(after lunch) and omega3(lunch). Don't sit on floors.
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3 days back I fell down from steps, leg got twisted due to that one nerve in the leg became swell, I went to doctor given pain killer injection and tab for 4 days but pain in there & left leg is solen due to nerver got solen. Please guide. Daily taking pain killer & band age putting in morning time & massage doing from iodex & one oil massage.

MPT - Orthopedic Physiotherapy, BPTh/BPT
Physiotherapist, Coimbatore
Apply ice and crepe bandage take rest don't massage don't put your legs down always keep it up if it does not resolve in a week consult me privately.
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My mother is patient of arthritis along from past 13 years. And I am not able to find a good doctor for my mother so please suggest me a doctor because my mother is suffering from major pain.

MBBS, MS - Orthopaedics
Orthopedist, Delhi
Kindly show me a photograph & digital x rays of affected part. Rule out diabetes & vit. D deficiency or any other metabolic disorder. Sleep on a hard bed with soft bedding on it. Spring beds, folding beds or thick matress are harmful use no pillow under the head. Do hot fomantation. Ibuprofen 200mg od & sos x 5days. Bio d3 max 1tab od x10. Do neck, back & general exercises. It may have to be further investigated. You will need other supportive medicines also. Make sure you are not allergic to any of the medicines you are going to take. Do reply back for detailed treatment plan. Do not ignore. It could be beginning of a serious problem.
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Common Causes and Prevention of Osteoporosis

Fellowship in spinal tumor surgery, Fellowship in Cervical spine surgery, FNB Spine Surgery, Fellowship in spinal deformity, fellowship in MInimalli invasive(Keyhole) surgery, CPC paliative care, MS-Orthopaedics, MBBS
Orthopedist, Delhi
Common Causes and Prevention of Osteoporosis

What is osteoporosis?

Osteoporosis is a disease concerning the bones. Decreased strength of the bones poses a risk for them to break. Osteoporosis is very common among older people, whose bones become brittle with age. The most common bones affected by this disease include the backbone, forearm bones and the hip bone. There are no such symptoms until a broken bone occurs. The bones weaken to such an extent that a break may happen in case of very minor stress. Usually, a broken bone is followed by chronic pain and the disability to perform daily activities. Surveys show that 15% of white people in their 50s and 70% of white people in their 80s are affected by osteoporosis.

What are the common causes and symptoms of osteoporosis?

  1. May occur due to the lowering of the 'peak bone mass index'.
  2. In women, bone loss increases after menopause stage due to lowering down of estrogen level.
  3. Also occurs because of another disease or previous treatments. This includes alcoholism, surgical ovary removal, hyperthyroidism, anorexia or any form of kidney disorder.
  4. Anti-seizure medicines, chemotherapy, selective serotonin reuptake inhibitors and taking of performance-enhancing drugs like steroid increase the bone loss rate.
  5. Lack of regular exercise may lead to osteoporosis.
  6. Osteoporosis is defined as a 'bone density of 2.5 standard deviations below than that of a young adult'.
  7. Osteoporosis is hereditary in nature. People having a family history of osteoporosis are at a high risk of getting the disease.
  8. More than thirty genes are linked with osteoporosis development.
  9. If you have had a fracture before, you are at a risk of a repeat.
  10. Early menopause in women is also responsible for osteoporosis.
  11. People with a small structure and body build are at a risk of getting osteoporosis.
  12. Protein and vitamin deficiency makes your bones weak and makes you vulnerable to osteoporosis.
  13. Phosphoric acid present in soft drinks is another threat, which may cause the disease.
  14. People suffering from malnutrition are likely to get osteoporosis.
  15. Over replacement of L-Thyroxine may lead to osteoporosis.
  16. Use of heparin and warfarin for a long time decreases the bone density.

How can Osteoporosis be prevented?
The best way to avoid getting osteoporosis in the future is to maintain a preventive lifestyle.

  1. Exercise regularly
  2. Indulge in natural calcium sources
  3. Maintain intake of vitamin D and K
  4. Do not smoke and consume alcohol
  5. Don't undertake stressful physical activities
  6. Go for regular health checkups
  7. Stay fit and stay away from obesity

Osteoporosis is a disease you must stay away from. It leaves you physically incapable and unfit.

2452 people found this helpful

Sir i am trying to sleep from last 4 days but cannot sleep fr a second. I have my usual time for sleeping is 2 am. But last 4 days I am trying to sleep but not single things working.

MPTh/MPT
Physiotherapist,
Kindly do yoga and meditation regularly by early morning. Try to sleep by 10 pm and get up 5 or 6 am in morning and do meditation and yoga regularly. This will be help full
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I am having problems in my knees. And it matters all the time for me while playing cricket and it is impossible for me to stand properly after playing it.

MPTh/MPT
Physiotherapist, Indore
I am having problems in my knees.
And it matters all the time for me while playing cricket and it is impossible for m...
Hello lybrate-user, I would suggest you to go for a mri. To rule out any meniscus or ligaments tear to avoid early arthritis. If you can share history of injury, than it would be better to understand the nature of cause of pain. Regards.
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What should I do to get rid of knee and thigh pain? I am a bit fatty and this is the reason why I'm facing such pains but I want I solution for it.

BPTh/BPT, MPTh/MPT
Physiotherapist, Noida
What should I do to get rid of knee and thigh pain? I am a bit fatty and this is the reason why I'm facing such pains...
Avoid Squatting- Quadriceps Exercises- Lie straight, make a towel role and put it under the knee, press the keen against the role, hold it for 20 secs. Repeat 20 times twice a day. This will help relieve some pain. Core Strengthening Exercise- Straight Leg Raised With Toes Turned Outward, repeat 10 times, twice a day.
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I am Having Leg gout pain. Every day same time right leg same time left leg and same back and shoulder. So how I will reduce my body pain?

BPTh/BPT
Physiotherapist, Delhi
I am Having Leg gout pain. Every day same time right leg same time left leg and same back and shoulder. So how I will...
1. Start with Physiotherapy treatment 2. Learn exercise. 3. Do hot fermentation twice a day. 4. Apply volini cream before sleeping. 5. Don't lift heavy things. 6. Do do forward bending. 7. Take calcium, vitamin D 3 and Methylcobalmine supplement for one month minimum.
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My mother is suffering from arthritis and have leg pain and back pain while sleeping.

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Bundi
My mother is suffering from arthritis and have leg pain and back pain while sleeping.
If you could tell me status of uric acid, ESR, RA Blood reports and X-ray of LS spine repirt, it would be easier to comment correctly. If leg pain is radiating from back, it proves intervertebral disc involvement. You cannot depend on pain killers for life. Physio, Yoga and herbal approach is must for safe management. Pl inform for proper advise or consult any Ayurveda doctor near you. Till then pl arrange for Nycanthes leaves and boil these daily sip warm by adding pure turmeric. For other medicines pl consult me or any Ayurveda doctor for medicine part.
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I am 22 years old I am suffering from arthritis for last 8 MONTHS. SIR What to do to get cure?

BAMS
Ayurveda, Ambala
Arthritis is swelling of joints with pain , stiffness . There are some methods you can apply : • Do exercise such as walking that strength your muscles and move your joint .From movement of joint you got relief from pain and stiffness. •Gentle massage your joints with lukewarm oil. You can use medicated oil.you can apply ice packs and heat with warm water bottle on your painful area. • If you are obese then lose some weight . Heavy weight make strain on your joint and causes pain. • Take healthy diet avoid junk foods.Take diet rich in calcium such as milk, cheese.Do not take stress . • you can take physiotherapy advice . • Stretch your body lightly in the morning when get out from the bed. • Eat healthy diet green leafy vegetables and fruits. * Take one teaspoon of haldi with milk it will reduce your swelling .
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My age is 40. i have been getting pain in my knee while climbing steps. request advise

Fellowship in Shoulder and Knee Surgeries, DNB (Orthopedics), Diploma In Orthopaedics (D. Ortho), MBBS
Orthopedist, Nagpur
It may be meniscus tear or Chondromalacia patellae. Is the pain inside knee joint or in front portion? Visit knee specialist. Dr Prashant Parate. Shoulder and Knee specialist.
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I am 63 year old male no sugar BP normal with medicine. My problem is 20 year back operate on my right leg hip joint with nailing. 3 year back remove nails. My right leg short about half inch. I walk limb. And due to that full body load come on left side leg. Now days my left side leg pain in knee. For that pl. Suggest medicine or treatment.

BPTh/BPT
Physiotherapist, Kota
I am 63 year old male no sugar BP normal with medicine. My problem is 20 year back operate on my right leg hip joint ...
Leg & Hip pain k liye ap exercise kijiye I hope you feel well. Hip Strengthening – Basic Exercises To begin with, the following basic hip strengthening exercises should be performed approximately 10 times, 3 times daily. As your hip strength improves, the exercises can be progressed by gradually increasing the repetitions and strength of contraction provided they do not cause or increase pain. Bridging Begin this exercise lying on your back in the position demonstrated (figure 1). Slowly lift your bottom pushing through your feet, until your knee, hip and shoulder are in a straight line. Tighten your bottom muscles (gluteals) as you do this. Hold for 2 seconds and repeat 10 times. Hip Extension in Lying Begin this exercise lying on your stomach in the position demonstrated (figure 2). Keeping your knee straight, slowly lift your leg tightening your bottom muscles (gluteals). Hold for 2 seconds and repeat 10 times. Adductor Squeeze Begin this exercise lying in the position demonstrated with a rolled towel or ball between your knees (figure 3). Slowly squeeze the ball between your knees tightening your inner thigh muscles (adductors). Hold for 5 seconds and repeat 10 times as hard as possible pain free. Figure 3 – Adductor Squeeze Hip Abduction Sidelying Begin this exercise lying on your side in the position demonstrated (figure 4). Keeping your back and knee straight and foot facing forwards, slowly take your leg to the side tightening the muscles at the side of your thigh / hip (abductors). Hold for 2 seconds and repeat 10 times as far as possible pain free. Hip Abduction Standing Begin this exercise standing at a bench or table for balance (figure 5). Keeping your back and knee straight and foot facing forwards, slowly take your leg to the side tightening the muscles at the side of your thigh / hip (abductors). Hold for 2 seconds and repeat 10 times as far as possible pain free. Straight Leg Raise Begin this exercise lying on your back with one leg straight and one leg bent (figure 6). Slowly lift your straight leg to approximately 45 degrees keeping your knee and toes facing the ceiling. Hold for 2 seconds and repeat 10 times provided it is pain free. Hip Flexion Begin this exercise standing at a bench or table for balance (figure 7). Slowly lift your knee up as high as you can while keeping your back straight and tightening the muscles at the front of your hip (hip flexors). Hold for 2 seconds and repeat 10 times as far as possible pain free.
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I got lateral minucus tear in july 2011 while playing football. I underwent arthroscopic surgery in my left knee in September 2013. Before surgery, mri report said lateral miniscus tear with cyst in my left knee. After surgery in manipal hospital Bangalore, my life became hell and I faced knee pain, stiffness, bike riding knee pain, could not stand for 30 min continously, could not use indian toilet, prolong sitting impossible on chair etc etc. None of these problems I had before surgery. Before surgery Dr. Claimed that I can play football within 6 months. After 6 months of surgery that is on apr 2014 I did mri which said no fresh tear with cmp condromalecia patella level 1 and ra blood test negative with vitamin d correction needed. I lost all hope with my surgeon and believed that only for money he did surgery to me and ruined my life. I had tendocare medicine from september 14 till apr 15 and simultaneously homeopathy. Now my condition is better as compared to aug 14 case. I believe it's cos of homeopathy medicine. Past one month I m doing isometric knee strengthen exercise including vmo at home. These physiotherapy I did post surgery for 3_4 months but as pain was still there so I stopped these strengthen exercise but I re started them last month as my injured knee thickness is half of my correct right leg. My condition is better now say 5/10 but prolong sitting in office or rainy season cold increases pain n stiffness. I feel burning sensation, stiffness, not able to bend knee fully, pain around knee cap, can't walk for say 30 mins without pain, uneasiness and pain at the bottom of knee cap. Now my only remedy is to apply knee pain killer oil and exercise and take homeopathy medicine. I wonder if I can be equally fit as I was before surgery. I doubt if surgery was needed for me at first place but that was already done 1 yr 8 months back. I request a orthopaedic doctor to advise me as in what is my knee problem and how I can get rid of it Thank you.

Dip. SICOT (Belgium), MNAMS, DNB (Orthopedics), MBBS
Orthopedist, Delhi
Hi thanks for your query and welcome to lybrate. I am Dr. Akshay from fortis hospital, new delhi. As you had lateral meniscus tear with a cyst, if you had symptoms correlating with your mri findings, then there is a valid reason for arthroscopic knee surgery which was done in your case to excise the cyst and balance the meniscus. Also fresh mri revealed no tears in your knee structures, so I think the surgery was well done and your mensicus was balanced well. So there is no need to crib about it at all. I think what you lacked was a scientific approach to post operative rehabilitation which is poorly understood in our country. Anyway now you have improved and your symptoms are due to chondromalacia of knee, atleast that is what you have written. Again for this physical therapy is mainstay of treatment with strengthening of quadriceps, stretching of other group muscles - adequate calcium and vitamin d intake - daily brisk walks for 2-3 km per day in morning - you should actually avoid indian toilet, sitting cross legged till the time you have pain. - you can use a gentle anti inflammatory medication like tab etoshine or one which suits you on a sos basis for some time. Let me know in 2-3 weeks time how you are feeling, so that we can discuss and take your case forwards. Do not hesitate to contact me if you need any further assistance.
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Sir, can you name the fruits & vegetables only which a Rheumatoid patients can have. My elder sister is suffering from this disease. Having pain in all over her body. Thanking you.

MD - General Medicine, DM - Rheumatology
Rheumatologist, Delhi
Sir, can you name the fruits & vegetables only which a Rheumatoid patients can have. My elder sister is suffering fro...
There are not diet restrictions for a patient of Rheumatoid arthritis. She can eat anything and everything. Concept of diet restriction in RA is a myth.
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I have little pain in my left knee due to which I am not able to run n have to walk slowly. I haven't got any injury in last 10 years.

BPTh/BPT, MPTh/MPT
Physiotherapist, Noida
I have little pain in my left knee due to which I am not able to run n have to walk slowly. I haven't got any injury ...
Advice. Avoid sitting cross legged. Avoid squatting- quadriceps exercises- lie straight, make a towel role and put it under the knee, press the keen against the role, hold it for 20 secs. Repeat 20 times twice a day. This will help relieve some pain. Core strengthening exercise- straight leg raised with toes turned outward, repeat 10 times, twice a day. Hams stretching- lie straight, take the leg up, pull the feet towards yourself, with a elastic tube or normal belt. Repeat 10 times, twice a day. Sports taping- stretch the tape from both ends and apply on the affected area contrast fomentation (hot and cold).
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Hi I am suffering from left knee pain from so many months took medication took x ray was fine. But still it didn't go away and since few days it's paining a lot. please help. Unable to sleep. When I walk I can hear a pop sounds.

MS - Orthopaedics
Orthopedist, Delhi
Hi I am suffering from left knee pain from so many months took medication took x ray was fine. But still it didn't go...
Hello lybrate-user, If your knee pain is persistent for the past few months and is not going despite medications and rest, you need to consider getting an MRI of knee joint done. Pop sounds from the knee can be due to Loose bodies/meniscal tear/ligamentous injury etc and needs to be clinically examined. Regards.
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Dengue Vaxia

M.B.B.S,C.C.A,D.C.A,AASECT,FPA,AAD,M.I.M.S
General Physician,
Dengue Vaxia

Dengvaxia - first vaccine against dengue

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Read more:

Dengue symptoms and what to do if you think you have denguedengue fever - remedies using papaya leaf juice

Full prescribing info - dengvaxia

Contents

Dengue tetravalent vaccine (live, attenuated).

Indications / uses

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Dosage / direction for use

The patient will receive 3 injections of 0.5 ml each at 6-month intervals.

The first injection will occur at the chosen or scheduled date; the second injection, 6 months after the first injection; and the third injection, 6 months after the second injection. Dengvaxia should be used according to the local vaccination schedule.

If the patient forgot an injection of dengvaxia: if the patient missed a scheduled injection, the physician will decide when to give the missed injection.

It is important that the patient follows the instructions of the physician, pharmacist or nurse regarding return visits for the follow-up injection. If the patient forgets or is not able to go back to the physician, pharmacist or nurse at the scheduled time, ask the physician, pharmacist or nurse for advice.

Administration: dengvaxia is given by the physician or nurse as an injection underneath the skin (subcutaneous route) in the upper arm.

Contraindications

Do not use dengvaxia if the patient is allergic (hypertensive) to the active substances or any of the other ingredients of dengvaxia listed in description (see description); has developed an allergic reaction after prior administration of dengvaxia. Signs of an allergic reaction may include an itchy rash, shortness of breath and swelling of the face and tongue; is suffering from a disease with mild to high fever or acute disease. In this case, the physician will postpone the administration of dengvaxia until the patient has recovered; has a weakened immune system, for example due to a genetic defect, hiv infection or therapies that affect the immune system (for example, high-dose corticosteroids or chemotherapy); is pregnant; is breastfeeding.

Use in pregnancy lactation: dengvaxia must not be given to pregnant or breastfeeding women.

If the patient is of child-bearing stage, the patient should take the necessary precautions to avoid pregnancy for 1 month following administration of dengvaxia; is pregnant or breastfeeding, the patient thinks may be pregnant or is planning to have a baby, ask the physician, pharmacist or nurse for advice before receiving dengvaxia.

Special precautions

Inform the physician, pharmacist or nurse before receiving dengvaxia if the patient is taking an immunosuppressive treatment (prednisone or equivalent to 20 mg or 2 mg/kg for 2 weeks or more). The physician will postpone administration of dengvaxia until 4 weeks after the treatment is discontinued; has experienced any health problems after prior administration of any vaccines. The physician will carefully consider the risks and benefits of vaccination.

As with all vaccines, dengvaxia may not protect 100% of persons who have been vaccinated. Vaccination with dengvaxia is not a substitute for protection against mosquito bites. The patient should take appropriate precautions to prevent mosquito bites, including the use of repellents, adequate clothing, and mosquito nets.

Fainting, sometimes accompanied by falling, can occur (mostly in adolescents) following, or even before, any injection with a needle. Therefore inform the physician, pharmacist or nurse if the patient fainted with a prior injection.

Adults above 45 years of age: adults above 45 years of age should not receive the vaccine.

Driving and using machines: no data are available on the effects of dengvaxia on the ability to drive or use machines.

Use in children: children less than 9 years of age should not receive the vaccine.

Side effects

Like all medicines, dengvaxia can cause side effects, although not all patients get them.

Serious allergic reactions: if any of these symptoms occur after leaving the place where the patient received an injection, consult a physician immediately: difficulty in breathing, blueness of the tongue or lips, a rash, swelling of the face or throat, low blood pressure causing dizziness or collapse.

When these signs and symptoms occur they usually develop quickly after the injection is given and while the patient is still in clinic or physician's surgery.

Serious allergic reactions are very rare (may affect up to 1 in 10, 000 people), after receiving any vaccine.

Other side effects: the following side effects were reported during clinical studies in children, adolescents and adults (from 9 to and including 60 years of age). Most of the reported side effects occurred within 3 days after the injection of the vaccine: very common (may affect more than 1 user in 10): headache, muscle pain (myalgia), generally feeling unwell (malaise), feeling of weakness (asthenia), injection site pain, fever.

Common (may affect up to 1 user in 10): injection site reactions: redness (erythema), bruising (hematoma), swelling, and itching (pruritus).

Uncommon (may affect up to 1 user in 100): infections of the upper respiratory tract, dizziness, sore throat (oropharyngeal pain), cough, runny nose (rhinorrhea), nausea, skin eruption (rash), neck pain, hardening of skin at the injection site (injection site induration).

Additional side effects in adults (from 18 to and including 60 years of age): uncommon (may affect up to 1 user in 100): swollen glands (lymphadenopathy), migraine, joint pain (arthralgia), flu-like symptoms (influenza-like illness).

Additional side effects in children and adolescents (from 9 to and including 17 years of age: uncommon (may affect up to 1 user in 100): itchy rash (urticaria).

Reporting of side effects or any suspected adverse event: if the patient experiences any side effects after vaccination, advised to seek immediate medical attention.

By reporting side effects, it can help provide more information on the safety of the vaccine.

Click to view adr monitoring form

Interactions

Using other medicines and dengvaxia: dengvaxia may not have an optimal effect if it used at the same time as medicines that suppress the immune system such as corticosteroids or chemotherapy.

Inform the physician, pharmacist or nurse if the patient is taking or has recently taken any other vaccines or any other medicines, including medicines obtained without a prescription.

Caution for usage

Before administering any biological, the person responsible for administration must take all precautions to prevent allergic or other reactions. As with all injectable vaccines, appropriate medical treatment and supervision must always be readily available in the event of an anaphylactic reaction following the administration of dengvaxia.

Epinephrine (1: 1000) and other appropriate agents used to control immediate allergic reactions must be available to treat unexpected events such as anaphylaxis.

Dengvaxia must not be mixed with other medicinal products in the same syringe.

Dengvaxia must not be administered by intravascular injection under any circumstances.

Syncope (fainting) can occur following, or even before, any vaccination as a psychogenic response to injection with a needle. Procedures should be in place to prevent injury from falling and to manage syncopal reactions.

Separate syringes and needles, separate injection sites and preferably separate limbs must be used if any other vaccine (s) or medicinal product (s) is/are concomitantly administered.

Dengvaxia is reconstituted by transferring all the solvent (0.4% sodium chloride solution) provided in the blue-labeled pre-filled syringe into the vial of freeze dried powder with a yellowish green flip off cap. The pre-filled syringe is fitted with a sterile needle for this transfer. The vial is then gently swirled. After complete dissolution, a 0.5 ml dose of reconstituted suspension is withdrawn into the same syringe. For injection, the syringe should be fitted with the new sterile needle.

The suspension should be visually inspected prior to administration. After reconstitution, dengvaxia is clear, colorless liquid with the possible presence of white to translucent particles (of endogenous nature).

After reconstitution with the solvent provided, dengvaxia must be used immediately.

Any unused dengvaxia or waste material should be disposed of, preferably by heat inactivation or incineration, in accordance with local regulations.

Do not throw away any medicines via wastewater or household waste. Ask a pharmacist on how to throw away medicines that no longer use. These measures will help to protect the environment.

Storage

Store in a refrigerator. Do not freeze. Keep the vaccine in the outer carton in order to protect it from light.

Description

After reconstitution, one dose (0.5 ml) contains 4.5-6.0 log10 ccid50* of each serotype of the cyd dengue virus** (1, 2, 3 and 4).

* ccid50: 50% cell culture infectious dose.

** produced in serum-free vero cells by recombinant dna technology.

The powder is a white, homogenous, freeze-dried powder with possible retraction at the base, and may form a ring-shaped cake.

The solvent (0.4% sodium chloride solution) is a clear, colorless liquid.

After reconstitution with the solvent provided, dengvaxia is a clear, colorless liquid with the possible presence of white to translucent particles.

Excipients/inactive ingredients: essential amino acids including l-phenylalanine, non-essential amino acids, l-arginine hydrochloride, sucrose, d-trehalose dihydrate, d-sorbitol, trometamol, urea, sodium chloride, water for injections.

Mechanism of action

Dengvaxia contains dengue virus serotypes 1, 2, 3 and 4 that have been weakened. Dengvaxia works by stimulating the body's natural defenses (immune system), which produces its own protection (antibodies) against the viruses that cause dengue disease.

Dengue is a viral infection transmitted to humans through the bite of an infected aedes mosquito. Dengue is not transmitted directly from person-to-person. Nevertheless the virus which replicates in an infected individual can be transmitted to other humans through mosquito bites for 4-5 days (maximum 12 days) after the first symptoms appear.

Dengue disease results in a wide range of symptoms including fever, headache, pain behind the eyes, muscle and joint pain, nausea, vomiting, swollen glands or skin rash. Symptoms usually last for 2-7 days. Dengue disease can also be asymptomatic.

However, occasionally dengue can be severe and potentially lead to hospitalization and in rare cases to death. Severe dengue is characterized by high fever and any of the following symptoms: severe abdominal pain, persistent vomiting, rapid breathing, severe bleeding, bleeding in stomach, bleeding gums, fatigue, restlessness, coma, seizure and organ failure.

Source:- http://www.mims.com/philippines/drug/info/dengvaxia

More information about dengvaxia - first vaccine against dengue

Sanofi awaits govt approval to launch dengue vaccine in india

Sanofi pasteur - dengue vaccine frequently asked questions

13 people found this helpful

I am facing knee pain since 2 years. The pain is more morning hours and night hours. So please advise me how can I avoid this.

BPTh/BPT, MPTh/MPT
Physiotherapist, Noida
I am facing knee pain since 2 years. The pain is more morning hours and night hours. So please advise me how can I av...
Quadriceps exercises- lie straight, make a towel role and put it under the knee, press the keen against the role, hold it for 20 secs. Repeat 20 times twice a day. This will help relieve some pain. Core strengthening exercise- straight leg raised with toes turned outward, repeat 10 times, twice a day. Hams stretching- lie straight, take the leg up, pull the feet towards yourself, with a elastic tube or normal belt. Repeat 10 times, twice a day.
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I am 21 year old and having pain in left knee. Pain started with an injury two years ago please suggest what I should do.

Fellowship in Shoulder and Knee Surgeries, DNB (Orthopedics), Diploma In Orthopaedics (D. Ortho), MBBS
Orthopedist, Nagpur
I am 21 year old and having pain in left knee. Pain started with an injury two years ago please suggest what I should...
Post injury knee pain is mostly because of meniscus tear or ligament injury. Get MRI of knee at best centre with 3 tesla machine. That will be helpful to have diagnosis Then treatment can be advised
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