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Sir I am having a breast lump, outer quadrant n painless. Oval shaped encapsulated hypoechoic lesion of size -17.8 *12 mm noted at 10 O'clock position of right breast - fibroadenoma. Glucose (random) 81.0 .biological reference intervals <200 mg/dl. Thyroid hormone assay - TSH (3rd generation) 2.29.biological reference intervals 0.39-5.55μIU/ml. Doctor wat does ths suggest. please reply.
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss about any specific problem, you can consult a Sexologist.
Hello doctor, I am having a burning or may be acidity from my stomach to my throat and sometimes in my chest, sometimes when I breath deep I feel someone is stretching my veins in my chest, and I feel some kind of lumps is there in my throat, I am having this for 4 days. I use to smoke a little, but was a heavy smoker for 3 years like 10 cigarettes on an average in past but now 1 or 2 on a daily basis, should I be worried of cancer or something, am nervous and can't sleep please help me out doctor. Thanks a lot in advance.
Eating Starchy and Sugary food that have a high glycemic index can increase the risk of lung cancer especially among nonsmokers
In a Study of 1905 participants with lung cancer and 2413 healthy controls, those with the highest consumption of high GI food had a 49 percent greater risk for lung cancer.Nonsmokers were more than twice as likely to develop lung cancer if they ate a high glycemic index diet
What is the symptoms of cancer how I know because I am having pain on my solder from last 2/3 months pls help.
Regular medical checkups and tests can be very helpful in prevention of cancer and growth of malignant cells or tumours. With the increase in the rates of cervical cancer, gynaecological checkups are of utmost need. For effective cervical cancer prevention, Pap smear bears the maximum number of success rates.
Pap smear is a medical procedure that helps to detect cancer or signs of other cervical infections. The Pap smear test however cannot detect ovarian cell cancer or uterine cancer. It is known to detect changes only in the vaginal cells and cervical dysplasia. Cervical dysplasia refers to the growth of pre-cancerous cells.
How this test is conducted?
1. Pap smear is conducted when the woman is not menstruating.
2. An instrument called speculum is inserted into one’s vagina to be able to access the cervix more easily.
3. Pap smear involves the collection of sample cells from the outer cervix area.
4. Cervical brush is inserted into the speculum and the sample cells are collected.
5. Then, the samples are put on a glass slide for further evaluation.
6. The Pap smear procedure takes only a few minutes bu can prevent serious medical problems in the long run.
7. The Pap smear is not a painful procedure, though it may be slightly uncomfortable for a few minutes only.
Who can undergo Pap smear?
1. Women can undergo Pap smear procedures once they are of 21 years of age and are generally sexually active
2. Women can go for pap smears up to the age of 70
3. Pap smears should be conducted preferably every two or three years
4. Women aged 65 and above and who have had no abnormalities in the last three consecutive tests, may stop taking pap smears
5. Before undergoing the test, it is important to stop douching and using vaginal creams for at least 2 days.
6. If there has been a case of multiple and frequent change of sexual partners, then you must go for Pap smear frequently
7. Women with weak immune system and who bear the risk of HIV Aids
8. Women who are heavy smokers