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Trihexyphenidyl

Prescription vs.OTC: Prescription by Doctor required
Last Updated: March 03, 2021

Trihexyphenidyl is known to be an anticholinergic, thus it effectively relaxes some muscles of the body by stalling nerve impulses. The drug is used in the treatment of Parkinson’s disease and other conditions with similar symptoms and also for the treatment of drug-induced extrapyramidal effects.

Doctor’s generally do not recommend this medicine to patients who may be allergic to components present in it or patients who have problems like angle closure glaucoma, bowel and stomach issues, heart issues, an esophagus that has narrowed or blockage of the urinary tract.

Certain medical conditions can reduce the effectiveness of the drug or create complications with the treatment. Thus before you start taking Trihexyphenidyl provide your doctor a detailed medical history, and ensure that it includes the health issues you currently have and related medicines you are taking.

Pregnant women or women who are planning to have a baby should also inform their doctor before taking this drug. The same applies for breast feeding women. It is best that you tell your medical practitioner about any kidney or liver problems you suffer from as well.

Trihexyphenidyl should be taken orally, either before a meal or after. If you mouth becomes extremely dry after you take the tablet, it is recommended that you take your dose before food. Although patients who suffer from nausea are generally advised to take the drug after food.

Like all medicines, even Trihexyphenidyl results in some side effects. You may suffer from some minor side effects like constipation, blurry vision, dryness of the mouth, feeling sleepy, increased sensitivity to light and headache.

Although major side effects are very rare, immediate medical aid should be sought if they do occur. For instance get in touch with your doctor if you experience chest pain, problems with swallowing food, problems while urinating or develop fever accompanied with chills.

Take exactly as directed; with meals if GI upset occurs, before meals if dry mouth occurs, after eating if drooling or if nausea occurs. Take at the same time each day. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake); void before taking medication.

Do not use alcohol and all prescription or OTC sedatives or CNS depressants without consulting prescriber. You may experience drowsiness, confusion, or vision changes (use caution when driving, climbing stairs, or engaging in tasks requiring alertness until response to drug is known).

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

The primary use of this medication is as follows:

This medicine causes side effects such as:

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 6 to 12 hours.
  • What is the onset of action?

    The effect of this medicine can be observed in 1 hour.
  • Are there any pregnancy warnings?

    This medicine is not recommended for pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Is it habit forming?

    No habit forming tendency has been reported
  • Are there any breast-feeding warnings?

    This medicine is not recommended in breastfeeding women.
  • Is It safe with alcohol?

    Consumption of alcohol must be avoided while taking this medicine.
  • Is it safe to drive while on this medicine?

    Driving must be avoided while taking this medicine as this drug might affect the patients consciousness.
  • Does this affect kidney function?

    Limited information is available regarding its use in patients with kidney disease. Kindly consult your doctor before taking it.
  • Does this affect liver function?

    Limited information is available regarding its use in patients with liver disease. Kindly consult your doctor before taking it.
  • Missed Dose instructions

    If you miss a dose of Trihexyphenidyl, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Trihexyphenidyl as ingredient

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This medication works by blocking cholinergic activity in the central nervous system and reduces the body secretions, increases the heart rate, dilates the pupils and reduces spasm of smooth muscle. It also increases dopamine which is used for smooth muscle movement.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine

    • Decreased effect: May increase gastric degradation of levodopa and decrease the amount of levodopa absorbed by delaying gastric emptying; the opposite may be true for digoxin.
    • Therapeutic effects of cholinergic agents (tacrine, donepezil) and neuroleptics may be antagonized.
    • Increased toxicity: Central and/or peripheral anticholinergic syndrome can occur when administered with amantadine, rimantadine, narcotic analgesics, phenothiazines and other antipsychotics (especially with high anticholinergic activity), tricyclic antidepressants, quinidine and some other antiarrhythmics, and antihistamines.
  • Interaction with Food

    Information not available.
  • Interaction with Disease

    Elderly patients require strict dosage regulation. Use with caution in patients with tachycardia, cardiac arrhythmias, hypertension, hypotension, prostatic hypertrophy or any tendency toward urinary retention, liver or kidney disorders, and obstructive disease of the GI or GU tract. May exacerbate mental symptoms when used to treat extrapyramidal reactions. When given in large doses or to susceptible patients, may cause weakness. Does not improve symptoms of tardive dyskinesias.

Ques: Is Trihexyphenidyl a narcotic? Can I get high after taking Trihexyphenidyl?

Ans: No, Trihexyphenidyl is not a narcotic. However, its hallucinogenic and euphoriant properties may make the people abuse its use.

Ques: Does Trihexyphenidyl make you drowsy?

Ans: Yes, Trihexyphenidyl may cause drowsiness in some cases. Some people may even experience difficulty in falling asleep. Do not drive or operate heavy machinery when you experience drowsiness or if it causes blurring of vision, dizziness, mild nausea and mental confusion.

Ques: Does Trihexyphenidyl cause weight gain?

Ans: Yes, Trihexyphenidyl may cause weight gain. If you are concerned about your weight gain, consult a dietitian for a diet plan, exercise regularly, and eat a healthy and nutritious diet.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Trihexyphenidyl
What are the uses of Trihexyphenidyl
What are the contraindications of Trihexyphenidyl ?
What are the side effects of Trihexyphenidyl ?
Key highlights of Trihexyphenidyl
What are the dosage instructions?
Where is the Trihexyphenidyl approved?
Medicines containing Trihexyphenidyl
How does this medication work?
What are the interactions of Trihexyphenidyl ?
FAQs about Trihexyphenidyl