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Molecules Roles They Play In Sleep!

Dr.Aravinda Jawali 91% (1523ratings)
Psychiatrist, Bangalore
Molecules Roles They Play In Sleep!

Benzodiazepines are a family of molecules, some of which are used as sleep-inducing medications, while others are used as tranquilizers. 
Benzodiazepines bind to a specific site on a neuron’s receptor for GABA, a neurotransmitter that counteracts the brain’s wakefulness mechanisms. Thus benzodiazepines promote sleep by augmenting this natural process.

The same gabaergic receptor also has binding sites that can be used both by barbiturates (a class of drugs once commonly used as sleep aids but now almost never used for that purpose) and by anesthetics, whose purpose is to put surgical patients to sleep.

Molecules that build up and make you sleep

As each day draws to a close, you feel the need to lie down and go to sleep. The onset of sleep, which seems like such a simple phenomenon from a behavioral perspective, is actually quite complex from a molecular one.
In the early 20th century, French psychologist Henri piéron hypothesized that prolonged wakefulness causes the build-up of a “sleep toxin" that is subsequently broken down during sleep. To test his hypothesis, piéron walked dogs through Paris at night to prevent them from sleeping. He then injected their cerebrospinal fluid into the brains of other dogs. He found that these other dogs then slept longer and more deeply than usual.

We now know that the “hypnogenic” (sleep-inducing) substances that piéron hypothesized do in fact exist. Some of them are small protein molecules that are produced by brain structures such as the hypothalamus and that inhibit the neurons of the wakefulness system.

But these proteins are not the only hypnogenic molecules. The build-up of serotonin in certain parts of the brain during periods of wakefulness also contributes to the onset of sleep. The serotonin level in certain areas of the brain also affects mood. That is why some problems such as depression and anxiety often lead to sleep disorders. People with low serotonin levels also tend to spend less time in restorative non-rem sleep over the course of the night.

Serotonin also plays an important role in sleep because the body uses it to synthesize melatonin. Melatonin is produced at night and plays a fundamental role in regulating the body’s biological clock. In fact, melatonin governs the entire sleep/wake cycle, whereas serotonin is involved more specifically in wakefulness, in triggering sleep, and in rem sleep.

Diagram of a melatonin molecule-
 (atoms: pale blue = carbon, dark blue = nitrogen, red = oxygen,
White = hydrogen)
Thus sleep is triggered by two inter-related processes: the production and build-up of hypnogenic substances in the body while we are awake, and cyclical fluctuations in substances such as melatonin that are associated with our body’s biological clock. 

Among the hypnogenic substances that build up while we are awake, adenosine has been the subject of much discussion since the mid-1990s. 

1 person found this helpful

Dominant, Submissive and Other Roles involved in BDSM

Dr.Vijay Abbot 92% (760ratings)
Graduate in Ayurvedic Medicine and Surgery ( GAMS )
Sexologist, Delhi
Dominant, Submissive and Other Roles involved in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  1. Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  2. Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  1. Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  2. Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  3. Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM. If you wish to discuss about any specific problem, you can consult a sexologist.

In case you have a concern or query regarding sexual health ask a doctor online, you can consult the best sexologist doctor online, & get the answers to your questions.

 

9267 people found this helpful

Dominants and Submissives Relationships: Different Roles in BDSM

Gautam Clinic Pvt Ltd 93% (8242ratings)
Sexologist Clinic
Sexologist, Faridabad
Dominants and Submissives Relationships: Different Roles in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  • Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  • Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress  can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  • Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  • Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  • Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM.

6684 people found this helpful

Understanding The Role Of Hormones In Infertility!

Dr.Abhay Ahluwalia 87% (100ratings)
MBBS, MD - General Medicine, DNB, DM - Endocrinology
Endocrinologist, Gurgaon
Understanding The Role Of Hormones In Infertility!

Ever wondered how your body releases an egg each month or how the uterus wall thins and thickens at different times of the month? It is the job of your body’s chemical messengers – hormones, which manage the various processes involved in preparing your body for fertilization.

Hormones and Fertility
A subtle balance of different hormones, involved in managing the reproductive organs, enables and maintains fertility. These hormones regulation changes like the discharge of an egg from the ovary and thickening of the uterine wall lining (endometrium). Infertility results if this balance is disrupted.

Roles of hormones in making a woman infertile

Knowing the role of a hormone in making a woman infertile will be easier if you know its role in making the same woman fertile. Here is the role of the five most important hormones that encourage fertility in women-

  1. FSH or Follicle-stimulating hormone - The pituitary gland in the brain releases the Follicle-stimulating hormone. The major role of this hormone is to allow a woman to have better control over her menstrual cycle and production of an egg in her ovary. The levels of this hormone designate the proper functioning of the ovary as well as the quality of the produced egg. When there is an imbalance in this hormone, the ovary of the woman will not function properly to produce eggs, thus creating infertility in women.
  2. LH or Luteinizing hormone - The pituitary gland releases this hormone. It plays a vital role in stimulating the ovary of a woman to discharge eggs. It instigates the manufacturing of progesterone to prepare the uterus of a woman to accept a fertilized egg. When the level of this hormone is disturbed, it will not stimulate the ovary to release eggs.
  3. Estradiol Hormone - This is a vital form of the oestrogen hormone. When the levels of this hormone become irregular, it will reduce the chances of making a woman conceive.
  4. Thyroid hormones - This hormone assists greatly in making the ovulation as well as the ovary of a woman to function normally by interacting with the progesterone and oestrogen hormones.
  5. Progesterone hormone - This hormone plays an important role in making a fertilized egg to continue as well as to develop in the uterus of a woman. Any imbalance in the level of this hormone will not allow the egg in the uterus to grow.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2006 people found this helpful

Hormones & Infertility - Is There A Link?

Dr.Rajesh Jain 91% (220ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery, MD Preventive Medicine, PG Diploma Diabetes
Endocrinologist, Kanpur
Hormones & Infertility - Is There A Link?

Ever wondered how your body releases an egg each month or how the uterus wall thins and thickens at different times of the month? It is the job of your body’s chemical messengers – hormones, which manage the various processes involved in preparing your body for fertilization.

Hormones and Fertility
A subtle balance of different hormones, involved in managing the reproductive organs, enables and maintains fertility. These hormones regulation changes like the discharge of an egg from the ovary and thickening of the uterine wall lining (endometrium). Infertility results if this balance is disrupted.

Roles of hormones in making a woman infertile

Knowing the role of a hormone in making a woman infertile will be easier if you know its role in making the same woman fertile. Here is the role of the five most important hormones that encourage fertility in women-

  1. FSH or Follicle-stimulating hormone - The pituitary gland in the brain releases the Follicle-stimulating hormone. The major role of this hormone is to allow a woman to have better control over her menstrual cycle and production of an egg in her ovary. The levels of this hormone designate the proper functioning of the ovary as well as the quality of the produced egg. When there is an imbalance in this hormone, the ovary of the woman will not function properly to produce eggs, thus creating infertility in women.
  2. LH or Luteinizing hormone - The pituitary gland releases this hormone. It plays a vital role in stimulating the ovary of a woman to discharge eggs. It instigates the manufacturing of progesterone to prepare the uterus of a woman to accept a fertilized egg. When the level of this hormone is disturbed, it will not stimulate the ovary to release eggs.
  3. Estradiol Hormone - This is a vital form of the oestrogen hormone. When the levels of this hormone become irregular, it will reduce the chances of making a woman conceive.
  4. Thyroid hormones - This hormone assists greatly in making the ovulation as well as the ovary of a woman to function normally by interacting with the progesterone and oestrogen hormones.
  5. Progesterone hormone - This hormone plays an important role in making a fertilized egg to continue as well as to develop in the uterus of a woman. Any imbalance in the level of this hormone will not allow the egg in the uterus to grow.
1485 people found this helpful

Dr.Masroor Ahmad Wani 90% (5195ratings)
MD, sexologist, Fellowship
Sexologist, Srinagar
Good morning friends

Partners’ Responses to Entry Dyspareunia

A new study in the Journal of Sexual Medicine has examined the relationship between a male partner’s cognitions and a woman’s experiences with entry dyspareunia.

Specifically, the study focused on male catastrophizing and views of his partner’s self-efficacy. Researchers explored how these two factors influenced his female partner’s pain intensity, sexual function, and sexual satisfaction.

Dyspareunia refers to painful intercourse. Entry dyspareunia occurs when vaginal penetration causes the pain. It is estimated that 21% of women have problems with entry dyspareunia, which can greatly affect quality of life.

The study authors defined catastrophizing as “an exaggerated and negative set of cognitions during real or anticipated painful experiences.” Self-efficacy was defined as “the confidence an individual has in his or her ability to perform a specific task.”

One hundred seventy-nine couples participated in the study. The mean age for the women was 31 years. For the men, it was 33 years. The mean relationship duration was six years. Women reported having pain for a mean of six years.

To assess the couples, the following measures were used:
• Pain Numeric Visual Analog Scale (women’s pain intensity)
• Female Sexual Functioning Index (women’s sexual functioning)
• Global Measure of Sexual Satisfaction (women’s sexual satisfaction)
• Pain Catastrophizing Scale (women’s and partners’ catastrophizing)
• Painful Intercourse Self-Efficacy Scale (women’s and partners’ self-efficacy)

After controlling for the women’s catastrophizing and self-efficacy, the researchers found that the women’s pain was less intense when their partners had higher levels of partner-perceived self-efficacy and lower levels of catastrophizing.

This authors suggest that in the case of couples dealing with entry dyspareunia, a man’s catastrophizing may make a woman more aware of her pain, thus increasing its intensity.

However, partner-perceived self-efficacy and partner catastrophizing did not appear to affect the women’s sexual function or satisfaction.

Many women continue to have sex despite their pain out of concern for their partners, so intercourse could be happening no matter what levels of partner catastrophizing or partner-perceived self-efficacy were present.

The authors also noted that women’s own perceptions of their sexual situation may carry more weight than their partner’s views.

“[Women’s] cognitions about pain (for example their own self-efficacy with regards to pain management and degree of pain catastrophizing) may serve to better explain variation in their sexual experience,” they wrote.

The study results point to the importance of considering the couple’s relationship when treating women with entry dyspareunia.

“Explaining to the couple how they both have a role to play in the experience of entry dyspareunia pain may serve to increase partner implication in treatment, diminish the identified patient’s feelings of guilt, and help in motivation toward change,” they wrote.

Resources
The Journal of Sexual Medicine
Lemieux, Ashley J., MA, et al.
“Do Romantic Partners' Responses to Entry Dyspareunia Affect Women's Experience of Pain? The Roles of Catastrophizing and Self-Efficacy”
(Full-text. First published online: June 27, 2013)
http://onlinelibrary.wiley.com/doi/10.1111/jsm.12252/abstract
- See more at: http://www.issm.info/news/sex-health-headlines/partners-responses-to-entry-dyspareunia#sthash.UKc8jmw6.dpuf

What Causes Acid Reflux? 8 Tips to Deal With it

Dr.Pranjal Deka 93% (1388ratings)
MCh HPB Surgery, Fellow European Board of Surgery, MS - General Surgery, MBBS
Gastroenterologist, Guwahati
What Causes Acid Reflux? 8 Tips to Deal With it

The LES valve in the stomach is designed in such a way that as soon as food passes through it, it closes. If however, LES remains partially or fully open, acid produced by the stomach can move up to the esophagus resulting in a burning sensation called acid reflux or heartburn. This condition is commonly known as the hital hernia.

Some of the common symptoms of acid reflux:
1. Consumption of large meals at one go.
2. Lying down immediately after having a meal.
3. Obesity or being overweight.
4. Consumption of snacks just before bedtime .
5. Consumption of certain food items such as chocolate, garlic, onion and citrus-related food.
6. Consumption of caffeine related products such as coffee, liquor and cigarettes.
7. Certain medicines such as aspirin is also known to be a trigger for acid reflux.
8. Pregnant women or patients with blood pressure are known to be suffering from acid reflux.

Tips to deal with acid reflux
There is a wide range of treatment options available for acid reflux. If you are suffering from occasional heartburn, there are some wonderful home remedies that can be tried. However, if the acid reflux recurs more than once in a week, it is best to consult a doctor. Home remedies to deal with acid reflux:
1. Sleeping on the left side is known to reduce acid reflux.
2. Reducing weight greatly helps in tackling acid burn. Patients with obesity are more vulnerable to acid burn.

3. It is best to avoid food that triggers acid burn.
4. Chewing gum greatly helps in countering acid burn. It helps in producing saliva which soothe the esophagus.
5. Intake of One spoon of baking soda every day proves to be extremely effective. Baking soda contains sodium bicarbonate which has a pH of more than 7 and can effectively neutralize the acid from stomach.
6. Intake of aloe vera, apple, banana or ginger is known to have very positive effects on acid burn.
7. Intake of 1 table-spoon of mustard can give instant relief from acid burn. Mustard’s alkaline properties can make the acid neutral in the system.
8. Regular intake (one after every meal) of almond helps to fight acid burn

Medication:
1. If you are buying over the counter, Histamine 2 blockers is a great medicine that instantly gives relief from an acid burn. Typically Doctors suggest this medicine with a higher dosage. This medicine can be consumed half an hour before the consumption of a meal. However, It is best to consult a doctor before consuming any medication.
2. Doctors often suggest medicine from the PPI family. It effectively blocks acid production in the esophagus for a longer duration. Some common medicine from this group includes Lansoprazole, Pantoprazole and Rabeprazole

In case you have a concern or query you can always consult an expert & get answers to your questions!

2214 people found this helpful

GERD - Complications Associated With It!

MS, MBBS, Clinical Fellow Pancreatic Surgery, FMBS
General Surgeon, Delhi
GERD - Complications Associated With It!

GERD or acid reflux is caused by the regurgitation of acidic liquid stomach contents back up into the esophagus. It is a long-term condition where stomach contents come back upwards from the gastro-intestinal tract resulting in either symptoms or complications. It is a commonly occurring digestion condition. A burning sensation in the chest is usually caused by acid reflux which radiates up from the stomach to the mid-chest or throat. This condition is also known as the heartburn. A sour taste in the back of the mouth is a common experience amongst the patients. Long term reflux of gastric contents causes the condition to become chronic which can lead to difficulty in swallowing. In some cases the erosion of the tract lining can also cause breathing problems.

Symptoms:

  1. Heartburn is a burning sensation felt in the retrosternal area. Most commonly it occurs post-prandial or nocturnally. Consumption of fatty foods, spicy foods, acidic foods aggravates the condition. Burning sensation is relieved with antacids, water or milk.
  2. Perception of gastric content reflux in the mouth or hypopharynx is termed as acid regurgitation. It is also known as water brash. A bitter or acidic taste is felt in the mouth.
  3. Other symptoms include dysphagia, odynophagia, nausea, chest pain, dyspepsia, epigastric fullness, bloating, frequent belching
  4. Extra-esophageal symptoms like chronic cough, hoarseness, laryngitis, dysfunction of the vocal cords, bronchospasm can also be observed.

Complications:

  1. Peptic stricture
  2. Ulcers of the esophagus
  3. Metaplastic disease (Barrett’s esophagus)
  4. Dysplastic disease (Adenocarcinoma)
  5. Laryngitis or bronchitis
  6. Pulmonary disease
  7. Fluid in the sinuses and the middle ear

Diagnosis:

The diagnosis of GERD is made by its most commonly presenting symptom- heartburn. To confirm the diagnosis of GERD, the physicians treat patients with medications for suppression of the production of acid by stomach. If heartburn diminishes to a large extent by the medications, diagnosis of GERD is considered confirmed.

 

Conditions like an ulcer caused by bacterial infection, mimic the symptoms of GERD. To get a clearer diagnosis, an endoscopy is then performed. The common diagnostic modality for GERD is Upper intestinal gastro-endoscopy. A tube containing an optical system for visualization is swallowed, the tube progresses down the gastrointestinal tract, and then the lining of the esophagus, stomach, and duodenum can be examined. A normal esophagus is observed in most patients with symptoms of reflux.

However, sometimes the lining of the esophagus appears inflamed. If erosions (superficial breaks in the esophageal lining) or ulcers (deeper breaks in the lining) are seen, a diagnosis of GERD can be made definitely. Other complications of GERD like ulcers, strictures, and Barrett's esophagus are also identified. Biopsies also may be obtained. Other common problems that may be causing GERD like symptoms can be diagnosed (for example ulcers, inflammation, or cancers of the stomach or duodenum) with EGD. Previously, barium meal x-ray was undertaken to diagnose GERD. It is now discontinued.

Other tests that are carried out are esophageal acid testing, esophageal motility testing, gastric emptying studies and acid perfusion test.

Treatment:

  1. Lifestyle modifications – Avoiding acidic foods, quitting smoking, weight loss, abstaining from alcohol consumption improves symptoms in people with GERD.
  2. Medications – Proton pump inhibitors (Pantoprazole, Omeprazole, Rabeprazole), H2 receptor blockers (Ranitidine, Cimetidine) and antacids.
  3. Surgery – In cases where the proton pump inhibitors are unsuccessful in relieving symptoms of GERD, a surgical procedure called Nissen fundo-plication is done.

In case you have a concern or query you can always consult an expert & get answers to your questions!






 

2010 people found this helpful

Avoid The Ban Medicines To Be Safe

Dr.Sumit Gupta 87% (17ratings)
BHMS
Homeopathy Doctor, Singrauli
Avoid The Ban Medicines To Be Safe

Govt bans 344 drugs, including phensedyl, corex
Sr. No. Product name (irrational fdc) 
1 aceclofenac + paracetamol + rabeprazole
2 nimesulide + diclofenac
3 nimesulide + cetirizine + caffeine
4 nimesulide + tizanidine
5 paracetamol + cetirizine + caffeine
6 diclofenac + tramadol + chlorzoxazone
7 dicyclomine + paracetamol + domperidone
8 nimesulide + paracetamol
9 paracetamol + phenylephrine + caffeine
10 diclofenac+ tramadol + paracetamol
11 diclofenac + paracetamol + chlorzoxazone + famotidine
12 naproxen + paracetamol
13 nimesulide + serratiopeptidase
14 paracetamol + diclofenac + famotidine
15 nimesulide + pifofenone + fenpiverinium + benzyl alcohol
16 omeprazole + paracetamol + diclofenac
17 nimesulide + paracetamol injection
18 tamsulosin + diclofenac
19 paracetamol + phenylephrine + chlorpheniramine + dextromethorphan + caffeine
20 diclofenac + zinc carnosine
21 diclofenac + paracetamol + chlorpheniramine maleate + magnesium trisillicate
22 paracetamol + pseudoephedrine + cetrizine
23 phenylbutazone + sodium salicylate
24 lornoxicam + paracetamol + trypsin
25 paracetamol + mefenamic acid + ranitidine + dicylomine
26 nimesulide + dicyclomine
27 heparin + diclofenac
28 glucosamine + methyl sulfonyl methane + vitamini d3 + maganese + boron + copper + zinc
29 paracetamol + tapentadol
30 tranexamic acid + proanthocyanidin
31 benzoxonium chloride + lidocaine
32 lornoxicam + paracetamol + tramadol
33 lornoxicam + paracetamol + serratiopeptidase
34 diclofenac + paracetamol + magnesium trisilicate
35 paracetamol + domperidone + caffeine
36 ammonium chloride + sodium citrate + chlorpheniramine maleate + menthol
37 paracetamol + prochlorperazine maleate
38 serratiopeptidase (enteric coated 20000 units) + diclofenac potassium & 2 tablets of doxycycline
39 nimesulide + paracetamol suspension
40 aceclofenac + paracetamol + famotidine
41 aceclofenac + zinc carnosine
42 paracetamol + disodium hydrogen citrate + caffeine
43 paracetamol + dl methionine
44 disodium hydrogen citrate + paracetamol
45 paracetamol + caffeine + codeine
46 aceclofenac (sr) + paracetamol
47 diclofenac + paracetamol injection
48 azithromycin + cefixime
49 amoxicillin + dicloxacillin
50 amoxicillin 250 mg + potassium clavulanate diluted 62.5 mg
51 azithromycin + levofloxacin
52 cefixime + linezolid
53 amoxicillin + cefixime + potassium clavulanic acid
54 ofloxacin + nitazoxanide
55 cefpodoxime proxetil + levofloxacin
56 azithromycin, secnidazole and fluconazole kit
57 levofloxacin + ornidazole + alpha tocopherol acetate
58 nimorazole + ofloxacin
59 azithromycin + ofloxacin
60 amoxycillin + tinidazole
61 doxycycline + serratiopeptidase
62 cefixime + levofloxacin
63 ofloxacin + metronidazole + zinc acetate
64 diphenoxylate + atropine + furazolidonee
65 fluconazole tablet, azithromycin tablet and ornidazole tablets
66 ciprofloxacin + phenazopyridine
67 amoxycillin + dicloxacillin + serratiopeptidase
68 azithromycin + cefpodoxime
69 lignocaine + clotrimazole + ofloxacin + beclomethasone
70 cefuroxime + linezolid
71 ofloxacin + ornidazole + zinc bisglycinate
72 metronidazole + norfloxacin
73 amoxicillin + bromhexine
74 ciprofloxacin + fluticasone + clotrimazole + neomycin is
75 metronidazole + tetracycline
76 cephalexin + neomycin + prednisolone
77 azithromycin + ambroxol
78 cilnidipine + metoprolol succinate + metoprolol tartrate
79 l-arginine + sildenafil
80 atorvastatin + vitamin d3 + folic acid + vitamin b12 + pyridoxine
81 metformin + atorvastatin
82 clindamycin + telmisartan
83 olmesartan + hydrochlorothiazide + chlorthalidone
84 l-5-methyltetrahydrofolate calcium + escitalopram
85 pholcodine + promethazine
86 paracetamol + promethazine
87 betahistine + ginkgo biloba extract + vinpocetine + piracetam
88 cetirizine + diethyl carbamazine
89 doxylamine + pyridoxine + mefenamic acid + paracetamol
90 drotaverine + clidinium + chlordiazepoxide
91 imipramine + diazepam
92 flupentixol + escitalopram
93 paracetamol + prochloperazine
94 gabapentin + mecobalamin + pyridoxine + thiamine
95 imipramine + chlordiazepoxide + trifluoperazine + trihexyphenidyl
96 chlorpromazine + trihexyphenidyl
97 ursodeoxycholic acid + silymarin
98 metformin 1000/1000/500/500mg + pioglitazone 7.5/7.5/7.5/7.5mg + glimepiride
99 gliclazide 80 mg + metformin 325 mg
100 voglibose+ metformin + chromium picolinate
101 pioglitazone 7.5/7.5mg + metformin 500/1000mg
102 glimepiride 1mg/2mg/3mg + pioglitazone 15mg/15mg/15mg + metformin 1000mg/1000mg/1000mg
103 glimepiride 1mg/2mg+ pioglitazone 15mg/15mg + metformin 850mg/850mg
104 metformin 850mg + pioglitazone 7.5 mg + glimepiride 2mg
105 metformin 850mg + pioglitazone 7.5 mg + glimepiride 1mg
106 metformin 500mg/500mg+gliclazide sr 30mg/60mg + pioglitazone 7.5mg/7.5mg
107 voglibose + pioglitazone + metformin
108 metformin + bromocriptine
109 metformin + glimepiride + methylcobalamin
110 pioglitazone 30 mg + metformin 500 mg
111 glimepiride + pioglitazone + metformin
112 glipizide 2.5mg + metformin 400 mg
113 pioglitazone 15mg + metformin 850 mg
114 metformin er + gliclazide Mr. + voglibose
115 chromium polynicotinate + metformin
116 metformin + gliclazide + piogllitazone + chromium polynicotinate
117 metformin + gliclazide + chromium polynicotinate
118 glibenclamide + metformin (sr)+ pioglitazone
119 metformin (sustainded release) 500mg + pioglitazone 15 mg + glimepiride 3mg
120 metformin (sr) 500mg + pioglitazone 5mg
121 chloramphenicol + beclomethasone + clomitrimazole + lignocaine
122 of clotrimazole + ofloxaxin + lignocaine + glycerine and propylene glycol
123 chloramphennicol + lignocaine + betamethasone + clotrimazole + ofloxacin + antipyrine
124 ofloxacin + clotrimazole + betamethasone + lignocaine
125 gentamicin sulphate + clotrimazole + betamethasone + lignocaine
126 clotrimazole + beclomethasone + ofloxacin + lignocaine
127 becloemthasone + clotrimazole + chloramphenicol + gentamycin + lignocaine ear
128 flunarizine + paracetamole + domperidone
129 rabeprazole + zinc carnosine
130 magaldrate + famotidine + simethicone
131 cyproheptadine + thiamine
132 magaldrate + ranitidine + pancreatin + domperidone
133 ranitidine + magaldrate + simethicone
134 magaldrate + papain + fungul diastase + simethicone
135 rabeprazole + zinc + domperidone
136 famotidine + oxytacaine + magaldrate
137 ranitidine + domperidone + simethicone
138 alginic acid + sodium bicarbonate + dried aluminium hydroxide + magnesium hydroxide
139 clidinium + paracetamol + dicyclomine + activated dimethicone
140 furazolidone + metronidazole + loperamide
141 rabeprazole + diclofenac + paracetamol
142 ranitidine + magaldrate
143 norfloxacin+ metronidazole + zinc acetate
144 zinc carnosine + oxetacaine
145 oxetacaine + magaldrate + famotidine
146 pantoprazole (as enteric coated tablet) + zinc carnosine (as film coated tablets)
147 zinc carnosine + magnesium hydroxide + dried aluminium hydroxide + simethicone
148 zinc carnosine + sucralfate
149 mebeverine & inner hpmc capsule (streptococcus faecalis + clostridium butyricum + bacillus
Mesentricus + lactic acid bacillus)
150 clindamycin + clotrimazole + lactic acid bacillus

151 sildenafil + estradiol valerate
152 clomifene citrate + ubidecarenone + zinc + folic acid + methylcobalamin + pyridoxine + lycopene
+ selenium + levocarnitine tartrate + l-arginine
153 thyroxine + pyridoxine + folic acid
154 gentamycin + dexamethasone + chloramphenicol + tobramycin + ofloxacin
155 dextromethorphan + levocetirizine + phenylephrine + zinc
156 nimesulide + loratadine + phenylephrine + ambroxol
157 bromhexine + phenylephrine + chlorepheniramine maleate
158 dextromethorphan + bromhexine + guaiphenesin
159 paracetamol + loratadine + phenylephrine + dextromethorphan + caffeine
160 nimesulide + phenylephrine + caffeine + levocetirizine
161 azithromycin + acebrophylline
162 diphenhydramine + terpine + ammonium chloride + sodium chloride + menthol
163 nimesulide + paracetamol + cetirizine + phenylephrine
164 paracetamol + loratadine + dextromethophan + pseudoepheridine + caffeine
165 chlorpheniramine maleate + dextromethorphan + dextromethophan + guaiphenesin + ammonium
Chloride + menthol
166 chlorpheniramine maleate + ammonium chloride + sodium citrate
167 cetirizine + phenylephrine + paracetamol + zinc gluconate
168 ambroxol
+ guaiphenesin + ammonium chloride + phenylephrine + chlorpheniramine maleate + menthol
169 dextromethorphen + bromhexine + chlorpheniramine maleate + guaiphenesin
170 levocetirizine + ambroxol + phenylephrine + guaiphenesin
171 dextromethorphan + chlorpheniramine + chlorpheniramine maleate 
172 cetirizine + ambroxol + guaiphenesin + ammonium chloride + phenylephrine +
Menthol
173 hlorpheniramine + phenylephrine + caffeine
174 dextromethorphan + triprolidine + phenylephrine
175 dextromethorphan + phenylephrine + zinc gluconate + menthol
176 chlorpheniramine + codeine + sodium citrate + menthol syrup
177 enrofloxacin + bromhexin
178 bromhexine + dextromethorphan + phenylephrine + menthol
179 levofloxacin + bromhexine
180 levocetirizine + phenylephrine + ambroxol + guaiphenesin + paracetamol
181 cetirizine + dextromethorphan + phenylephrine + zinc gluconate + paracetamol + menthol
182 paracetamol + pseudoephedrine + dextromethorphan+cetirizine
183 diphenhydramine + guaiphenesin + ammonium chloride + bromhexine
184 chlorpheniramine + dextromethorphan + phenylephrine + paracetamol
185 dextromethorphen + promethazine
186 diethylcabamazine citrate + cetirizine + guaiphenesin
187 chlorpheniramine + phenylephrine + dextromethophan + menthol
188 ambroxol + terbutaline + dextromethorphan
189 dextromethorphan + chlorpheniramine + guaiphenesin
190 terbutaline + bromhexine + guaiphenesin + dextromethorphan
191 dextromethorphan + tripolidine + phenylephirine
192 paracetamol + dextromethorphan + chlorpheniramine
193 codeine + levocetirizine + menthol
194 dextromethorphan + ambroxol + guaifenesin + phenylephrine + chlorpheniramine
195 cetirizine + phenylephrine + dextromethorphan + menthol
196 roxithromycin + serratiopeptidase
197 paracetamol + phenylephrine + triprolidine
198 cetirizine + acetaminophen + dextromethorphan + phenyephrine + zinc gluconate 
199 diphenhydramine + guaifenesin + bromhexine + ammonium chloride + menthol
200 chlopheniramine maleate + codeine syrup
201 cetirizine + dextromethorphan + zinc gluconate + menthol
202 paracetamol + phenylephrine + desloratadine + zinc gluconate + ambroxol
203 levocetirizine + montelukast + acebrophylline
204 dextromethorphan + phenylephrine + ammonium chloride + menthol
205 acrivastine + paracetamol + caffeine + phenylephrine
206 naphazoline + carboxy methyl cellulose + menthol + camphor + phenylephrine
207 dextromethorphan + cetirizine
208 nimesulide + paracetamol + levocetirizine + phenylephrine + caffeine
209 terbutaline + ambroxol + guaiphenesin + zinc + menthol
210 dextromethorphan + phenylephrine + guaifenesin + triprolidine
211 ammomium chloride + bromhexine + dextromethorphan 
212 diethylcarbamazine + cetirizine + ambroxol
213 ethylmorphine + noscapine + chlorpheniramine
214 cetirizine + dextromethorphan + ambroxol
215 ambroxol + guaifenesin + phenylephrine + chlorpheniramine
216 paracetamol + phenylephrine + chlorpheniramine + zinc gluconate
217 dextromethorphan + phenylephrine + cetirizine + paracetamol + caffeine
218 dextromethophan + chlorpheniramine + guaifenesin + ammonium chloride
219 levocetirizine + dextromethorphan + zinc
220 paracetamol + phenylephrine + levocetirizine + caffeine
221 chlorphaniramine + ammonium chloride + sodium chloride
222 paracetamol + dextromethorphan + bromhexine + phenylephrine + diphenhydramine
223 salbutamol + bromhexine + guaiphenesin + menthol
224 cetirizine + dextromethorphan + bromhexine + guaifenesin
225 diethyl carbamazine + chlorpheniramine + guaifenesin
226 ketotifen + cetirizine
227 terbutaline + bromhexine + etofylline
228 ketotifen + theophylline
229 ambroxol + salbutamol + theophylline
230 cetririzine + nimesulide + phenylephrine
231 chlorpheniramine + phenylephrine + paracetamol + zink gluconate
232 acetaminophen + guaifenesin + dextromethorphan + chlorpheniramine
233 cetirizine + dextromethorphan + phenylephrine + tulsi
234 cetirizine + phenylephrine + paracetamol + ambroxol + caffeine
235 guaifenesin + dextromethorphan
236 levocetirizine + paracetamol + phenylephirine + caffeine
237 caffeine + paracetamol + phenylephrine + chlorpheniramine
238 levocetirizine + paracetamol + phenylephirine + caffeine
239 caffeine + paracetamol + phenylephrine + chlorpheniramine
240 ketotifen + levocetrizine
241 paracetamol + levocetirizine + phenylephirine + zink gluconate
242 paracetamol + phenylephrine + triprolidine + caffeine
243 caffeine + paracetamol + phenylephrine + cetirizine
244 caffeine + paracetamol + chlorpheniramine
245 ammonium chloride + dextromethorphan + cetirizine + menthol
246 dextromethorphan + paracetamol + cetirizine + phenylephrine
247 chlorpheniramine + terpin + antimony potassium tartrate + ammonium chloride + sodium
Citrate + menthol
248 terbutaline + etofylline + ambroxol
249 paracetamol + codeine + chlorpheniramine
250 paracetamol+pseudoephedrine+certirizine+caffeine
251 chlorpheniramine+ammonium chloride + menthol
252 n-acetyl cysteine + ambroxol + phenylephrine + levocertirizine
253 dextromethorphan + phenylephrine + tripolidine + menthol
254 salbutamol + certirizine + ambroxol
255 dextromethorphan + phenylephrine + bromhexine + guaifenesin + chlorpheniramine
256 nimesulide + certirizine + phenylephrine
257 naphazoline + chlorpheniramine + zinc sulphate + boric acid + sodium chloride + chlorobutol
258 paracetamol + bromhexine + phenylephrine + chlorpheniramine + guaifenesin
259 salbutamol + bromhexine
260 dextromethorphan + phenylephrine + guaifenesin + certirizine + acetaminophen
261 guaifenesin + bromhexine + chlorpheniramine + paracetamo
262 chlorpheniramine + ammonium chloride + chloroform + menthol
263 salbutamol + choline theophylinate + ambroxol
264 chlorpheniramine + codeine phosphate + menthol syrup
265 pseudoephedrine + bromhexine
266 certirizine + phenylephrine + paracetamol + caffeine + nimesulide
267 dextromethorphan + cetirizine + guaifenesin + ammonium chloride
268 dextromethorphan + cetirizine + guaifenesin + ammonium chloride
269 ambroxol + salbutamol + choline theophyllinate + menthol
270 paracetamol + chlorpheniramine + ambroxol + guaifenesin + phenylephrine
271 chlorpheniramine + vasaka + tolubalsm + ammonium chloride + sodium citrate + menthol
272 bromhexine + cetrizine + phenylephrine ip+guaifenesin + menthol
273 dextromethorphan + ambroxol + ammonium chloride + chlorpheniramine + menthol
274 dextromethorphan + phenylephrine + cetirizine + zinc + menthol
275 terbutaline + n-acetyl l-cysteine + guaifenesin
276 calcium gluconate + levocetirizine
277 paracetamol + levocetirizine + pseudoephedrine
278 salbutamol + choline theophylinate + carbocisteine
279 chlorpheniramine + vitamin c
280 calcium gluconate + chlorpheniramine + vitamin c
281 chlorpheniramine + paracetamol + pseudoephedrine + caffeine
282 guaifenesin + bromhexine + chlorpheniramine + phenylephrine + paracetamol + serratiopeptidase
(as enteric coated granules) 10000 sp units
283 paracetamol + pheniramine
284 betamethasone + fusidic acid + gentamycin + tolnaftate + lodochlorhydroxyquinoline (ichq
285 clobetasol + ofloxacin + miconazole + zinc sulphate
286 clobetasole + gentamicin + miconazole + zinc sulphate
287 levocetirizine + ambroxol + phenylephrine + paracetamol
288 permethrin + cetrimide + menthol
289 beclomethasone + clotimazole + neomycin + lodochlorohydroxyquinone
290 neomycin + doxycycline
291 ciprofloxacin + fluocinolone + clotrimazole + neomycin + chlorocresol
292 clobetasol + ofloxacin + ketoconazol + zinc sulphate
293 betamethasone + gentamicin + tolnaftate + lodochlorhydroxyquinoline
294 clobetasol + gentamicin + tolnaftate + lodochlorhydroxyquinone + ketoconazole
295 allantoin + dimethieone + urea + propylene + glycerin + liquid paraffin
296 acriflavine + thymol + cetrimide
297 betamethasone + neomycin + tolnaftate + lodochlorohydroxyquinoline + cholorocresol
298 clobetasol + neomycin + miconazole + clotrimazole
299 ketoconazole + tea tree oil + allantion + zinc oxide + aloe vera + jojoba oil +
Lavander oil + soa noodels
300 clobetasol propionate + ofloxacin + ornidazole + terbinafine
301 clobetasol + neomycin + miconazole + zinc sulphate
302 beclomethasone diproprionate + neomycin + tolnaftate + lodochlorhydroxyquinoline +
Chlorocresol
303 betamethasone + gentamycin + zinc sulphate + clotrimoazole + chlorocresol
304 borax + boric acid + naphazoline + menthol + camphor + methyl hydroxy benzoate
305 bromhexine + dextromethorphan
306 dextromethophan + chlopheniramine + bromhexine
307 menthol + anesthetic ether
308 dextrometharphan + chlopheniramine + ammonium + sodium citrate + menthol
309 ergotamine tartrate + belladona dry extarct+caffeine + paracetamol
310 phenytoin + phenobarbitone
311 gliclazide 40mg + metformin 400mg
312 paracetamol + ambroxol + phenylephrine + chlorpheniramine
313 oflaxacin + ornidazole suspension
314 albuterol + etofylline + bromhexine + menthol
315 albuterol + bromhexine + theophylline
316 salbutamol+hydroxyethyltheophylline (etofylline) + bromhexine
317 paracetamol+phenylephrine+levocetirizine+sodium citrate
318 paracetamol + propyphenazone + caffeine
319 guaifenesin + diphenhydramine + bromhexine + phenylephrine
320 dried alumnium hydroxie gel + prophantheline + diazepam
321 bromhenxine + phenylephrine + chlorpheniramine + paracetamol
322 beclomethasone + clotrimazole + gentamicin + lodochlorhydroxyquinoline
323 telmisartan + metformin
324 ammonium citrate + vitamin b 12 + folic acid + zinc sulphate
325 levothyroxine + phyridoxine + nicotinamide
326 benfotiamine + metformin
327 thyroid + thiamine + riboflavin + phyridoxine + calcium pantothenate + tocopheryl acetate +
Nicotinamide
328 ascorbic acid + manadione sodium bisulphate + rutin + dibasic calcium phosphate +
Adrenochrome mono semicarbazone
329 phenylephrine + chlorpheniramine + paracetamol + bromhexine + caffeine
330 clotrimazole + beclomethasone + lignocaine + ofloxacin + acetic aicd + sodium methyl paraben +
Propyl paraben

Avoid this combinations and be safe.

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Dr.Aravinda Jawali 91% (1523ratings)
Psychiatrist, Bangalore
Understanding the Brainband Mental Illnessbhelping families & friends find better ways
The biological basis of mental illness
Mental illness is, in part, an illness of the brain. Learning about the brain can:
? give information from a biological and medical perspective (and some idea of its complexity)
? help you understand and support treatment
? assist you in dealing with the stigmas of mental illness
? support the realisation that no one is to blame for the onset of mental illness.
About brain research
A lot of what the community commonly thinks and knows about mental illness is based on previous experience and social stigma. It is often information that is out of date and leaves us with an impression of hopelessness. In fact:
? Over half of what we know about the brain in relation to mental illness we have learnt in the last 10 years. As a consequence, medications and treatments have improved significantly and people who are now being diagnosed with mental illness have a better prognosis than people diagnosed before that time.
? New imaging technology allows the brain to be examined while the person is experiencing mental illness, whereas before we relied on autopsy information.
? Research indicates that physical changes commonly occur within the brain in
mental illness.
? The brain pathways responsible for ?higher? mental functioning (feeling emotions, interpreting information) are affected.
? The linking of an illness to particular changes in the brain is extremely difficult. (Brain scanning techniques are used alongside assessment of behaviour and symptoms.)
? Brain research has already achieved much, and has further capacity to improve medications and other physical treatments.
What changes in the brain when mental illness is present?
Like other body parts, the brain is susceptible to injury and change.
Both the chemical messaging system and the physical structures of the brain can be
altered in mental illness.
The chemical, or neurotransmission system in the brain Neurons.The brain is made up of billions of cells called neurons. Each neuron is a link in a chain and can have thousands of connections to other neurons. These connections of neurons form chains through which messages are relayed in the brain.
Synapses
The synapse is the meeting point of two neurons. A signal must be transmitted from one neuron across the synapse to the other neuron. These events occur within
milliseconds.
Neurotransmitters
? Neurotransmitters are the chemicals that conduct the messages across the
synapse.
? When a signal arrives at the end of a neuron, the neurotransmitter spills into the gap and crosses the gap.
? Scientists have identified over 50 neurotransmitters that are messengers communicating information from one part of the brain to another, and to all
parts of the body.
? From this simple system, complicated brains are built. And this system seems
affected in many mental illnesses.
Neurotransmitter malfunctions can occur because there is:
? not enough neurotransmitter
? too much neurotransmitter
? malabsorption of the neurotransmitter.
Some important neurotransmitters and their roles are:
? dopamine: activation level, mood, movement Understanding the Brain and
Mental Illness continued.
? norepinephrine: mood, activation level
? serotonin: mood, sleep, appetite, aggression
? acetylcholine: mood, autonomic nervous system.
Malfunction in these neurotransmitters is found in many forms of mental illness. It is possible that, in biologically vulnerable individuals, high stress levels ?trigger? malfunctioning in neurotransmitters (e.G. Production of neurotransmitters cannot
keep up with the body?s demands or the neurotransmitters are
not effectively removed from the system).
Brain structures
There is evidence to strongly suggest that some brain structures are altered or damaged in mental illness. It is clear, however, that many parts of the brain are affected by mental illness, including the following:
Frontal lobe
The main purpose of the frontal lobe is control of movement
(co-ordination).
It is also thought to be responsible for behaviour, character, emotional state, short-term memory and planning.
Think of the behaviours that are often displayed when someone is psychotic. They often have poor concentration, they can be emotional or lack emotion and display odd behaviours.
Movement can also be random and disjointed.
Parietal lobe
The parietal lobe is involved in:
? long-term memory
? obtaining and retaining accurate knowledge of objects
? sensory speech (responsible for perceiving the spoken word).
When a person develops certain mental illnesses, these pathways/speech may be affected. Hence someone with schizophrenia, when psychotic, may develop a language of their own or words of their own, called neologisms. Often people?s
ability to retain information is limited.
Temporal lobe
Roles of the temporal lobe include:
? auditory (hearing), the area that receives and interprets
impulses from the inner ear
? olfactory (smell), the area that receives and interprets
impulses from the nose
? taste, the area that interprets nerve impulses from the tongue.
The cells in this area receive and interpret impulses from the various parts of the body, i.E. Nose, taste buds and ear. When someone is psychotic they may be hearing voices, but the parts of the ear usually involved in hearing (the anvil hammer, etc.)
are not physically moving from sound waves. However, the impulses in the brain are working and sending messages, as if the person is hearing. This also occurs in relation to smell and taste ? people may think the food is being poisoned because it
tastes different.
Message Occipital lobe
The occipital lobe receives impulses from the eye and interprets them as visual impressions. The eyes do not actually do the seeing ? it is the brain that receives the impulses from the eyes and interprets them. When someone experiences visual
hallucinations, the occipital lobe is seen to be very active ? impulses are interpreted and processed ? thus the person sees objects that may not be present.
Basal ganglia
Thought to influence muscle tone ? if control is inadequate, movements are uncoordinated.
Thalamus
Receives impulses from the body?s sensory nerves associated with pain, temperature, pressure and touch. Here crude, uncritical sensations reach consciousness (e.G. Awareness of pain but not the ability to identify the body part involved). People with schizophrenia may wear lots of clothes on hot days because
this part of their brain is affected by the illness.
Hypothalamus
Involved in the pituitary gland?s orchestration of hormone release and in the autonomic nervous system (hunger, thirst, body temperature, heart and blood vessels, and defensive reactions such as fear and rage).
The cerebellum
? Controls and co-ordinates the movements of various muscle groups to ensure smooth, even and precise actions.
? Maintains balance and equilibrium of the body.
? Jerky, unco-ordinated movements indicate the involvement of the cerebellum in mental illness.
The limbic system
? Is more a functional than an anatomical entity.
? Involves parts of the brain essential for organising emotional responses and processing information.
? Is involved in schizophrenia, which affects the emotions of the person and their ability to process information.
Applying the knowledge ? theories about what happens in the brain relating to
schizophrenia, depression and obsessive compulsive disorder
Schizophrenia
Current research indicates the following theories about what is happening in the brain in relation to schizophrenia:
There is an excess of the neurotransmitter dopamine. Dopamine is involved in regulating thoughts and feelings, both of which are disturbed in schizophrenia. It is also thought that high dopamine levels make someone more sensitive to stress.
Research indicates that some people with schizophrenia appear to have larger ventricles. Research also indicates that some people experiencing schizophrenia seem to have a loss of tissue in the anterior hippocampus, which may account for memory problems and irrationality. Recent research carried out in Melbourne seems
to indicate some people have this tissue reduction before the onset of psychosis, which leads to the hope that results of
Magnetic Resonance Imaging (MRI) can be used as a predictor
of schizophrenia.
Depression
In depression, not enough neurotransmitter appears to be released into the gap between neurons, or too much of it is removed before it has completed its function.
When antidepressants are used, there is more neurotransmitter is available in the gap between neurons, which eases a depressed mood.
Obsessive compulsive disorder
Researchers think obsessive compulsive disorder (OCD) may be linked to parts of the basal ganglia involved in fixed patterns of behaviour resulting in an imbalance among a variety of neurotransmitters.
One hypothesis is that the brain signals for a contaminant (like dirty hands) cause the cortex to send signals to preprogrammed cells in an area of the basal ganglia that produce the neurotransmitter serotonin, with other neurotransmitters also involved.

Conclusion

In short, we provide this basic information about the brain and mental illness for the following reasons:
To increase your familiarity with the terms so that when they are described by people in the treating profession, you might recognise them and be able to engage in a discussion that is fruitful for you.
For you to understand more about some of the behaviours associated with mental illness and their origins.
Because our experience is that many families when they first come into contact with mental illness believe that it is due solely to a negative psychological experience early in life (that the family may have caused). More information about the biological origins of mental illness gives you an opportunity to revisit these ideas. Mental Illness Fellowship Victoria - for people with mental illness, their families and friends

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