Oflokem D Eye/Ear Drops

Oflokem D Eye/Ear Drops is an antibiotic drug that fights against ocular (eye) bacterial infections. The medicine comprised of ofloxacin-dexamethasone combination. This combination is indicated against inflammatory ocular conditions which are steroid-responsive and corticosteroids should be prescribed.

The conditions in which this medication is indicated involved bacterial ocular infection or a risk of getting a bacterial ocular infection exists. The common ocular inflammatory conditions involving the administration of ocular steroids include acne rosacea, herpes zoster keratitis, allergic conjunctivitis, superficial punctuate keratitis, cyclitis, iritis and also selected infective conjunctivitis.

It is advised when the inherent hazard of using steroids is acceptable to obtain an advisable deduction in inflammation and oedema. It is also prescribed in chemical radiation-induced corneal injury, chronic anterior uveitis, penetration of foreign bodies, or thermal burns.

Do not use this drug without consulting a doctor. Follow the instructions on the label regarding dosage. It is advised not to use these drops in larger or smaller amounts than prescribed. Consult the doctor immediately if you experience any undesirable side effects.

• Eye Infection

• Eye Infections By Herpes Simplex Virus

• Allergy

• Superficial Keratitis

• Blurred Vision

• Eye Irritation

• Eye Discomfort

• Increased Intraocular Pressure

• How long is the duration of effect?

  The effect of this medicine lasts for a duration of 12 to 20 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 1 to 2 hours of administration of the dose.

• Are there any pregnancy warnings?

  Use of this medicine is not recommended in pregnant women. Use only if clearly needed under the supervision of the doctor.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Use of this medicine is not recommended in women who breastfeed due to the adverse effect on development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Avoid breastfeeding for about 3 to 4 hours to decrease the infant's risk exposure. Monitoring of undesired effects like diarrhea, diaper rash is necessary.

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

This drop is a combination of Ofloxacin and Dexamethasone. The active ingredients fall under the class of fluoroquinolones and corticosteroid, respectively. This medicine alleviates the symptoms of the patient by working via a dual mechanism of action.

Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death. It also works by reducing the excitation of the brain cells by inhibiting the sodium channels thus inhibits the repetitive firing of brain cells.

Secondly, it enters the cells through passive diffusion and binds to glucocorticoid receptors, forming a complex. This complex undergoes activation, enters the cell nucleus and binds to the DNA. This induces the natural effects of biological hormones.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Medicine

  Corticosteroids

  You may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.

  Escitalopram

  You may experience dizziness, lightheadedness, shortness of breath, or heart palpitations if these medicines are used together. This interaction is more likely to happen if you suffer from any heart disease (Arrhythmia) or have a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Quinidine

  You may experience dizziness, lightheadedness, and heart palpitations if these medicines are used together. Regular cardiac function tests are to be performed if you have any heart disease (Arrhythmia) or a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Antidiabetic medicines

  You may experience hypoglycemic effects like dizziness, headache, nervousness, confusion, tremor and weakness if these medicines are used together. Hyperglycemic effects like increased thirst, urination and hunger are less likely to occur. Regular blood glucose checkups are to be performed if you are diabetic or has any kidney disease. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Aspirin

  You may experience tremors, involuntary muscle movements, hallucinations, or seizures if these medicines are used together. This interaction is more likely to happen if you have a history of seizures or family history of seizures. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Ethinyl Estradiol

  The desired effect of contraceptive pills will not be achieved if these medicines are used together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

• Interaction with Disease

  Central Nervous System Depression

  If you suffer from CNS disorder and you take Oflokem D Eye/Ear Drops, then you may experience tremors, restlessness, anxiety, confusion and hallucinations. Avoid consuming caffeine containing products like coffee, chocolates and energy drinks.

  Colitis

  Avoid taking Oflokem D Eye/Ear Drops if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

  Qt Prolongation

  Avoid using Oflokem D Eye/Ear Drops if you experience any chest discomfort. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.

• Interaction with Food

  Dairy products

  The desired effect of Oflokem D Eye/Ear Drops is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Oflokem D Eye/Ear Drops and dairy products.

• Ques : What is Oflokem D Eye/Ear Drops?

  Ans : This medication is a combination of Ofloxacin and Dexamethasone. This medicine performs its action by obstructing the production of bacteria in the bacterial cell wall.

• Ques : How long do I need to use Oflokem D Eye/Ear Drops before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Oflokem D Eye/Ear Drops?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Oflokem D Eye/Ear Drops empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Oflokem D Eye/Ear Drops?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ofloxacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/ofloxacin

• Ofloxacin- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01165

• Dexamethasone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/dexamethasone

• Dexamethasone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01234