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Nitrofurantoin

Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 02, 2019

Nitrofurantoin is administered to cure UTIs caused by a few typical kinds of bacteria. Lung inflammation is one of the major but very rare side effects of Nitrofurantoin and usually occurs if the usage persists for more than half a year.

Damage to the liver is also another serious but infrequent adverse reaction of Nitrofurantoin. If the therapy is a long term one, then certain tests will be administered to check whether all is good with liver functioning or not. Signs of liver damage include persistent itching, yellowing of the eye’s whites or the skin, vomiting, dark colored urine, nausea and reduced appetite.

Nitrofurantoin can also result in damage to the nerves. Nerve damage is characterized by pain and numbness of the feet and the hands.

Another adverse effect of Nitrofurantoin is damage to the red blood cells. This condition is known as hemolysis, indicators of which include weakness, fatigue, tiredness and paling of the skin. This generally subsides once the usage is discontinued.

There are certain medications, administration of which is strictly advised against while using Nitrofurantoin. These include antacids that contain certain ingredients such as magnesium trisilicate, sulfinpyrazone and probenecid.

Pregnant women who are in their term of pregnancy (38 to 42 weeks) should talk to their doctor before using this drug. Also, Nitrofurantoin is usually advised against at the time of labor and delivery. This drug can be passed onto a mother’s breast milk and thus prove harmful for the baby that is being breastfed. In case of the elderly, their kidney functioning isn’t usually at their best. Hence, any medicine, once inside their system, tends to stay there for a longer time, thus increasing the risks of various side effects.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Urologist before using this medicine.
  • Nausea

  • Epigastric Pain

  • Diarrhoea

  • Chills

  • Fever

  • Neurological Disorder

  • Haemolytic Anemia

  • Liver Damage

  • Dark Colored Urine

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 1 to 3 hours.
  • What is the onset of action?

    This medicine is well observed orally. Food may increase the bioavailability of the medicine.
  • Are there any pregnancy warnings?

    This medicine is recommended for pregnant women. It is contraindicated in pregnant patients at term (38 to 42 weeks' gestation), during labor and delivery.
  • Is it habit forming?

    No habit forming tendencies were reported
  • Are there any breast-feeding warnings?

    This medicine is known to excreted through breast milk. This medicine is not contraindicated in children less than 3 months and glucose-6-phosphate dehydrogenase (G-6-PD) deficient infants.
  • Missed Dose instructions

    If you miss a dose of Nitrofurantoin, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Nitrofurantoin as ingredient

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The active constituent of this medication belongs to the class urinary anti-infectives. It works by inhibiting the cell wall synthesis by forming reactive intermediates by bacterial flavoproteins. These intermediates will alter the bacterial ribosomal proteins, DNA synthesis, RNA synthesis and cell wall synthesis.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Disease

    Glucose-6-Phosphate Dehydrogenase Deficiency

    This medicine may cause abnormal breakdown of blood cells. Close monitoring of blood cell count and hemoglobin is necessary. Discontinue the treatment if any signs of decreased hemoglobin and red blood cell count appear.

    Peripheral Neuropathy

    This medicine may cause nerve damage especially in elderly patients with kidney impairment and diabetes mellitus. Any symptoms of tingling or burning sensation should be reported to the doctor. Close monitoring of kidney function is necessary.
  • Interaction with Alcohol

    Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Lab

    Information not available.
  • Interaction with Food

    Food

    Information not available.
  • Interaction with Medicine

    Ethinyl Estradiol

    The desired effect of contraceptive pills will not be achieved if these medicines are taken together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

    Cholera Vaccine

    If you have taken Nitrofurantoin, then it is advisable to wait for 14 days before taking Cholera vaccine. Usage of other antibiotics and vaccines should be reported to the doctor.

    Atorvastatin

    These medicines may increase the risk of nerve damage if given together. Any symptoms of numbness, tingling or burning sensation in feet, hands should be informed to the doctor. An alternate medicine should be considered based on the clinical condition.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Nitrofurantoin
What are the uses of Nitrofurantoin
What are the contraindications of Nitrofurantoin ?
What are the side effects of Nitrofurantoin ?
Key highlights of Nitrofurantoin
What are the dosage instructions?
Where is the Nitrofurantoin approved?
Medicines containing Nitrofurantoin
How does this medication work?
What are the interactions of Nitrofurantoin ?