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Nextop 25 MG Tablet

Manufacturer: Torrent Pharmaceuticals Ltd
Medicine composition: Topiramate
Prescription vs.OTC: Prescription by Doctor required

Nextop 25 MG Tablet, an anti-convulsing, aids in the treatment of seizures. The doctor may prescribe the drug with a combination of other medicines or all on its own, depending on the condition of the patient. The drug also effectively prevents headaches that occur because of migraine. Nextop 25 MG Tablet controls certain chemicals present in the brain, thus treating seizures and preventing headaches.

The drug should only be used if it is prescribed by a doctor. Before starting the drug provide your medical history and discuss the benefits and risks of taking it. The drug is not meant for patients who are allergic to any ingredient in it or those who suffer from metabolic acidosis, that is, high levels of acid in the blood. Also inform your doctor if you are pregnant or trying to conceive or breast feeding before starting Nextop 25 MG Tablet. Give him a list of medicines that you are taking presently. Ensure that you include prescribed, non-prescribed as well as any herbal medicines that you are taking. This is primarily because there are some medicines which tend to react with Nextop 25 MG Tablet resulting in severe complications. Tell the doctor about any allergies related to food or other medicines that you may have.

Some side effects will occur when you take Nextop 25 MG Tablet. A few common side effects of this drug are-

  • constipation
  • dizziness
  • headache
  • appetite loss
  • dryness of the mouth
  • flushing
  • pain in the stomach

Some patients may also experience severe side effects like-

  • pain in the bones
  • fever accompanied with chills
  • pain in the chest
  • problems with concentration and coordination
  • behavioral changes, like mood swings
  • fainting spells

A doctor should be consulted if the side effects persist or become worse.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Psychiatrist before using this medicine.

Nextop 25 MG Tablet is used in the treatment of seizures which is a brain disorder characterized by uncontrolled jerking movements and loss of consciousness.
Nextop 25 MG Tablet is used in the treatment of Lennox-Gastaut syndrome which is a type of seizures characterized by multiple seizures.

Migraine Headache

Nextop 25 MG Tablet is used in the treatment of a severe headache in migraine patients.
Not recommended in patients known allergy to Nextop 25 MG Tablet.
In addition to its intended effect, Nextop 25 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Blurred vision

Major Common


Major Common

Unusual tiredness and weakness

Major Common

Abdominal pain

Major Less Common

Loss of appetite

Major Less Common

Hair loss

Major Less Common

Pale skin

Major Less Common


Minor Common

Back pain

Minor Less Common


Minor Less Common

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 2 to 3 days.

What is the onset of action?

The effect of this medicine can be observed in 1 to 2 hours.

Are there any pregnancy warnings?

This medicine is not recommended for pregnant women.

Is it habit forming?

No habit forming tendency has been reported

Are there any breast-feeding warnings?

This medicine is known to excreted in breast milk. It is recommended only if necessary. Monitoring of undesired effects like diarrhea, drowsiness is necessary.
Below is the list of medicines, which have the same composition, strength and form as Nextop 25 MG Tablet , and hence can be used as its substitute.
Micro Labs Ltd
Ranbaxy Laboratories Ltd
Intas Pharmaceuticals Ltd
Alkem Laboratories Ltd

Missed Dose instructions

Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose instructions

Seek emergency medical treatment or contact the doctor if any symptoms of the overdose like drowsiness, slurred speech appear.


United States


Nextop 25 MG Tablet belongs to anticonvulsant. It works by blocking sodium channels and increases the release of gamma-aminobutyric acid (GABA) which is an inhibitory neurotransmitter and thus reduces the excitation of the brain cells.,
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Blood disorders

Nextop 25 MG Tablet may lower the blood cell count and may lead to a fatal condition. Close monitoring of blood cell count is necessary. Inform the doctor if you have any blood disorder. An alternate class of medicine may be considered based on the clinical condition.

Interaction with Alcohol


Consumption of alcohol is not recommended if the patient is receiving Nextop 25 MG Tablet. Inform the doctor if you are an alcoholic. Any symptoms of dizziness, difficulty in concentration should be reported to the doctor. Dose adjustments or an alternate medicine should be considered based on the clinical condition.

Interaction with Lab Test


Information not available.

Interaction with Food


Information not available.

Interaction with Medicine


These medicines may increase the body temperature and decreases sweating. This interaction is more common is children. Any symptoms of increase in the body temperature and decreased sweating should be informed to the dcotor.


These medicines may increase the risk of lactic acidosis. Inform the doctor if you are receiving antidiabetic medications. Seek immediate medical treatment if you have any symptoms of weakness, muscle pain, vomiting and irregular heartbeat.

Ethinyl Estradiol

The desired effect of contraceptive pills will not achieve if these medicines are taken together. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.
What are you using Nextop 25 MG Tablet for?
Migraine Headache
How much was the improvement?
How long did it take before seeing improvement?
More than 2 days
Within 2 days
Within a day
Within 2 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
How did you take this medicine?
With Food
With or without food
What were the side effects of this medicine?
Unusual tiredness and weakness
Loss of appetite
Blurred vision
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I was taking nextop 50 for a month for migraine but it didn't do much relieve so I have abruptly stopped having those tablets. Now after few weeks I am getting convulsions when I get severe headache. To reduce headache I use nicotine 500.

MD - Homeopathy, BHMS
Homeopath, Vadodara
Hi I can help you in your migraine with Homoeopathic medicine without side effects. You can consult me through lybrate for Homoeopathic treatment and further guidance

I was taking nextop50 for a month for migraine but it didn't do much relieve so I have abruptly stopped having those tablets. Now after few weeks I am getting convulsions when I get severe headache. To reduce headache I use nicotine 500.

Diploma In Gastroenterology, Diploma In Dermatology, BHMS
Homeopath, Hyderabad
Weather changes Stress or fatigue All of the above Answer - E: All of the above Everyone has different migraine triggers. Some common ones are: Strong smells, like perfumes and detergents Hormonal changes (menstruation, pregnancy, and Homeopathy has best solution for your problem with out any side effects but history of the patient is necessary.....

My psychiatrist has prescribed librium 10 TDS, topiramate 25 BD and bupropionSR 150 OD. I have read that there is life threatening interaction between bupropionSR and benzodiazepine. I have been using this combination for long time. Earlier lithium carbonate and etizolam were also given now they have been stopped. I am very scared. My psychiatrist is not responding to my calls and messages. Please help me.

MD - Psychiatry
Psychiatrist, Chennai
My psychiatrist has prescribed librium 10 TDS, topiramate 25 BD and bupropionSR 150 OD. I have read that there is lif...
There is no life threatening drug interaction between the three as mentioned by you, only excessive sedation can be there, which can be adjusted with dosage. Consult your psychiatrist in person if you have more sedation rather than calling and sending sms. All the best.

In the year 2005 I was diagnosed with a dot like calcification in the left parietal area of the brain. Is it migraine? Since then I'm taking topiramate tablets daily. Is it safe? Is it ever curable? Will it be risky in future? I still have frequent headaches. I have asthma too and overweight. Thanks.

MD, Fellowship in Intergrative Medicine, MBBS
Integrated Medicine Specialist, Kochi
Asthma, overweight migraine all a re lifestyle diseases which are curable without medicines You have to treat the root cause and not the symptom -Headache alone .Your Dr. Has to treat the reversible causes and triggers for headache first. The cause for the headache may not be in your head it can be due to problems arising elsewhere in the body like Gastric issues, BP ,food sensitivity, Stress, Eye, ENT, problems ,environmental toxins. They can be the cause either alone or in combination. Do not blindly believe your Dr. because he may have vested monetary interests. Always take second opinion if you do not want to get misguided .Change your doctor for sure if he is spending less time with you and asking you to do only CT and MRI Scans without coming to a diagnosis and If he is not answering your questions properly, and is rushing through your appointment and not spending the complete allotted time for your consultation for which you have paid, is not educating you about the disease and not offering non medical healthy alternative options. He will fix your money for sure but make sure he fixes your disease also Your headache will remain if your Doctor 1) Has not taken detailed dietary, lifestyle, environmental,occupational, social,family history and not identified the triggers. 2) Not done the comprehensive lab testing which should include tests for inflammation, mineral and vitamin deficiency. These 2 steps needs to be done correctly before suggesting the correct treatment. Take a. Consultation after sending feedback with name and contact number .Find the triggers of your headache and eliminate them All diseases begin in the gut. Your Dr. may not be aware of this. Headache can only be fixed permanently by fixing your nutrition, lifestyle, and identifying the triggers and fixing them.
1 person found this helpful

Popular Health Tips

Seizures - 3 Ways It Can Be Treated!

MCh - Neurosurgery, MS-General Surgery, MBBS
Neurosurgeon, Delhi
Seizures - 3 Ways It Can Be Treated!

The primary aim of the treatment in patients suffering from seizure is leasing a seizure-free life without giving way to any adverse effects. This goal can be accomplished in over 60 percent people with the help of anticonvulsants. Some patients also experience adverse effects since they suffer from a seizure which is refractory to medical therapy. Here are some of the common treatment options for seizures:

  1. Monotherapy: Sometimes, monotherapy is given as it reduces the chance of all sorts of adverse effects and even avoids drug interactions. Moreover, this type of treatment approach is much less expensive than polytherapy since many older generation of the anticonvulsant agent comprises of hepatic enzyme which is responsible for reducing the serum level of the concomitant drug which leads to an increase in the dosage level of such medicines.
  2. Social And vocational rehabilitation: People suffering from problems in psychosocial adjustments after the diagnosis may also need social and vocational rehabilitation. Many physicians do not pay enough attention to the consequences that an epilepsy diagnosis may leave on the patient. For instance, people with epilepsy may have a fear of experiencing next attack of seizure and they may be unable to work at heights or drive.
  3. Consulting an expert: It is important to refer patients with intractable spells to epileptologist or neurologist for subsequent workup. A neurosurgical consultation may also be needed when the patient has to be treated surgically.

Importance of anticonvulsant therapy

Patients who have had already suffered from recurrent attacks of unprovoked seizure may need treatment with an anticonvulsant. This treatment is not recommended until the person has risk factors for suffering from the problem yet again. The primary means of treating seizure is anticonvulsant therapy where the most suitable drug is chosen based on accurate diagnosis of the syndrome as a response to specific anticonvulsants may vary from one patient to another. The difference in response may reflect the various pathophysiologic mechanisms in different types of seizures.

Types of anticonvulsant therapy
Some of the anticonvulsant therapy medication may have multiple action mechanism while some have an only single mechanism of action. Some of the most common variants of the therapy include:

  1. Neuronal potassium channel referred to as KCNQ opener
  2. Blockers of unique binding sites such as perampanel, gabapentin, and levetiracetam
  3. H-current modulators such as lamotrigine and gabapentin
  4. Carbonic anhydrase inhibitors such as zonisamide and topiramate
  5. Alpha-amino 3-hydroxy 5-methyl 4-isoxazole propionic acid receptor blockers like topiramate and perampanel.
  6. N and L-calcium channel blockers like zonisamide, valproate, topiramate, and lamotrigine

Even though there are so many types of drugs available, all of them cannot be used for the treatment of seizures. Doctors would evaluate the condition thoroughly before prescribing a medication that can be helpful in reducing the severity of the condition.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2746 people found this helpful


MBBS, MD - General Medicine, DM - Neurology
Neurologist, Hyderabad

Epilepsy is a common illness and therefore, we commonly encounter women with epilepsy (WWE), who are either pregnant or contemplating pregnancy. There are a lot of apprehensions and misconceptions regarding managing epilepsy in this group of WWE. Here, I wish to highlight some of the important aspects of managing epilepsy in women who are planning a pregnancy or are currently pregnant.

1. If a woman is seizure-free for at least two years, she can consider withdrawing anti-epileptic drugs (aeds) under the supervision of neurologist, and then plan for pregnancy.

2. If a woman has seizures, it is better to continue aeds during pregnancy, as the risk to the baby is several times higher with seizures, as compared to that with aeds.

3. Sodium valproate has the highest risk to the developing baby, and it should be avoided in pregnancy.

4. Aeds such as levetiracetam, lamotrigine, oxcarbazepine, topiramate, etc are safe and may be continued during pregnancy.

5. The lowest effective dose of aed should be used.

6. Try to use only a single anti-epileptic drug, if possible.

7. Folic acid vitamin supplements should be used in pregnancy.

8. The dose of anti-epileptic medication may have to be increased during the last three months of pregnancy.

9. Ct scan of the brain should be avoided, as far as possible, during pregnancy, as radiation exposure due to it may harm the baby.

10. Mri brain is reasonably safe for baby, especially after the first three months of pregnancy. So, if needed, it may be performed.


16 people found this helpful

Severe Headache - Can it Be Migraine?

MBBS, MD - Internal Medicine
Internal Medicine Specialist, Faridabad
Severe Headache - Can it Be Migraine?

One of the most debilitating conditions that anyone can experience is migraine. They can severely limit you by affecting your personal and professional life as you are in constant pain. Migraine can manifest in a type of headache with intense pain, an acute sensitivity to light, nausea and vomiting. Often described as a severe throbbing pain in the head, it may stop you from completing regular daily tasks and may delay or postpone your work.

How can migraines be treated?
The exact cause for these debilitating migraine pain hasn't been pointed out yet, but certain triggers such as stress, hormonal changes in the menstrual cycle, sun exposure, bright or flashing lights, among many others have been identified. The first line of defense for you would be to understand and identify what your triggers are. Once that is done, you can try and avoid them. If these still trigger a migraine or are about to trigger one, you can immediately take medications or steps to control it or at least lessen the pain to go through your day. Some of the options you can employ to this effect are mentioned below.

  1. Medications to prevent a migraine attack: The medications mentioned here are specialized treatments and can only be taken after a consultation with a doctor. If you are deemed as a candidate for preventative medication for migraines, then either one or a combination of drugs from the following may be prescribed to you.
    • Valproate and Topiramate are anti-seizure medications which can be used to prevent migraines.
    • Propranolol, a type of beta blocker and used for cardio vascular problems, has proven to be very effective in preventing migraines.
    • Onabotulinumtoxin A or a type of Botox, has shown a lot of promise in preventing migraines and is being slowly rolled out as a proper drug as a treatment option.
    • Certain antidepressants have also shown to be quite effective in reducing the symptoms of migraines as well.
  2. Medications to relieve pain: Some of the go to medications that help relieve your pain from migraine are mentioned below. Although some of them are OTC (over the counter) drugs, it is best advised that you consult with your doctor for medications which suit you better. The side effects of these medications can be bad and thus, it is not advised to continue them in the long run and to find other means to control pain from migraines. Some of the medications to relieve pain temporarily are:
    • Triptan is a drug used to treat severe migraines
    • Caffeine along with Ergotamine can also help dull the pain and deal with it.
    • Ibuprofen and aspirin and Acetaminophen are common pain killers that you can use
    • Codeine, which contains opioids are also used to treat this problem.
    • Metoclopramide and chlorpromazine are two examples of anti-nausea medications as vomiting along with nausea may frequently accompany your migraine.

Always remember that these medications can have strong side effects if not taken properly, therefore do not just pop a pill, consult your physician first and know which one should you take and how frequently. If you wish to discuss about any specific problem, you can ask a free question.

5502 people found this helpful

How to Control Recurrent Headaches?

Fellowship in Interventional Pain management , Diploma in Anesthesia, DA, MBBS
Pain Management Specialist, Jaipur
How to Control Recurrent Headaches?

Headaches arise due to various reasons. Stress, tension, migraine, overwork and several medical conditions may cause headaches of different types. Such headaches are also called chronic headaches, and many cases of headaches are recurrent in nature. This indicates that the headaches might reappear or reoccur.

Headaches are quite frustrating and affect your entire health and performance. Recurrent headaches are even more troublesome as they strike back when you almost thought they were gone. There are several ways to deal with or control recurrent headaches. They include the following:

A. Medical treatment: Medicines can be used to treat the underlying cause of a headache and if these fail, medicines to cure the headache are used.

The different preventive medicines for recurrent headaches are:

  1. Antidepressants: Tricyclic antidepressants by the likes of nortriptyline can be prescribed for treating recurrent headaches. These medications help in curing any kind of depression, anxiety and disturbances in sleep, which usually lead to recurrent headaches. Antidepressants like the selective serotonin reuptake inhibitor or SSRI and fluoxetines are also used.
  2. Beta blockers: Beta blockers, commonly used to treat hypertension, also prevent migraine-related headaches. They include atenolol, metoprolol and propranolol.
  3. Anti-seizure medicines: Several anti-seizure medicines help in the prevention of migraine and also cure daily, recurrent headaches. They include topiramate, divalproex sodium and gabapentin.
  4. NSAIDs: Prescribed nonsteroidal anti-inflammatory drugs like naproxen sodium also help in reducing headaches, which appear daily. NSAIDs are used in cases of severe headache.
  5. Botulinum toxin: Onabotulinum toxin A or Botox injections can be used to get relief from recurrent headaches and are ideal for people whose daily medications are not effective enough.

B. Alternative medicine procedures
Other than medications, alternative therapies to get relief from concurrent headaches can be utilized. They include:

  1. Acupuncture: This ancient procedure involves the use of thin needles, which are inserted into certain areas of the skin at defined points. Acupuncture reduces the frequency and intensity of headaches.
  2. Massage therapy: Massage therapy reduces stress, gives relief to pain and provides relaxation. Massaging of the tight muscles at the back of the head provides relief.
  3. Herbs and nutrients: Several organic herbs help in preventing migraine headaches and reduce the intensity of headaches. They include butterbur and feverfew. Vitamin and mineral supplements can be taken to reduce headaches and prevent them from reoccurring. Coenzyme Q10 supplements, magnesium sulfate supplements can reduce the frequency of several headaches as well.
  4. Investigational approach: A surgical implant, which is a battery operated electrode, can be placed around the occipital nerve. The electrode implant sends energy pulses to the nerve, and headache is eased.

Recurrent headaches can be controlled in various ways, which include medicines and several alternative procedures. You should consult a doctor before you start using some method.

4570 people found this helpful

Treatment of Grand Mal Seizure!

MD - Acupuncture, Diploma In Accupuncture, Advanced Diploma In Accupuncture
Acupuncturist, Delhi
Treatment of Grand Mal Seizure!

Treatment of Grand mal seizure

Homeopathic Treatment of Grand mal seizure
Acupuncture & Acupressure Treatment of Grand mal seizure
Psychotherapy Treatment of Grand mal seizure
Conventional / Allopathic Treatment of Grand mal seizure
Surgical Treatment of Grand mal seizure
Dietary & Herbal Treatment of Grand mal seizure
Other Treatment of Grand mal seizure
What is Grand mal seizure
Symptoms of Grand mal seizure
Causes of Grand mal seizure
Risk factors of Grand mal seizure
Complications of Grand mal seizure
Lab Investigations and Diagnosis of Grand mal seizure
Precautions & Prevention of Grand mal seizure
Treatment of Grand mal seizure 

Homeopathic Treatment of Grand Mal Seizure

Homeopathy calms nervous system. It has reputation of curing seizures and convulsions. It treats the person as a whole. Treatment is constitutional. It means that homeopathic treatment focuses on the patient as a person, as well as his pathological condition. It balances the energy system, improves immunity and body functions. It naturally cures the root cause of disorder. Some of the homeopathic medicines for treatment of Grand Mal seizure are:

Calc ars

Acupuncture and Acupressure Treatment of Grand Mal Seizure

Acupuncture has unique reputation in treatment of all neurological disorders. It uses condition specific acupoints to re-establish normal energy flow along channels and improves organ system physiology.

Conventional / Allopathic Treatment of Grand mal seizure

In the allopathic Treatment of Grand mal seizure, medications used are Oxcarbazepine, Gabapentin, Topiramate, Phenytoin, Valproic acid, Pregabalin, Zonisamide, and Levetiracetam etc.

Surgical Treatment of Grand mal seizure

For brain lesions or tumors, a neurosurgeon may surgically remove the tissue causing grand mal seizures.

Dietary & Herbal Treatment of Grand mal seizure

Low carbohydrate diet increases ketones in the body, which may decrease overall seizures.

What is Grand mal seizure?

A grand mal seizure features a loss of consciousness and violent muscle contractions. It is also known as a tonic-clonic seizure.

 Symptoms of Grand mal seizure

A warning feeling (aura) before a grand mal seizure
Loss of bowel and bladder control
Unresponsiveness after convulsions
Severe headache
People may cry out at the beginning of a seizure

Causes of Grand mal seizure

Brain tumors
Very low blood levels of glucose, sodium, calcium or magnesium
Traumatic head injuries
Using or withdrawing from drugs, including alcohol
Encephalitis or meningitis
Injury due to a previous lack of oxygen
Blood vessel malformations in the brain
Genetic syndromes

Risk factors of Grand mal seizure

Any injury to the brain
Family history of seizure disorders
Sleep deprivation
Medical problems that affect electrolyte balance
Alcohol and drug abuse

Complications of Grand mal seizure

Changes in brain function and structure
Joint dislocations
Head injuries
Bone fractures 

Diagnosis of Grand mal seizure

Diagnosis of Grand mal seizure involves the following tests:

Medical history
Neurological exam
Blood tests
Electroencephalogram (EEG)
Magnetic resonance imaging (MRI)

Table of Content
About Nextop 25 MG Tablet
When is Nextop 25 MG Tablet prescribed?
What are the contraindications of Nextop 25 MG Tablet ?
What are the side effects of Nextop 25 MG Tablet ?
Key highlights of Nextop 25 MG Tablet
What are the substitutes for Nextop 25 MG Tablet ?
What are the dosage instructions?
Where is the Nextop 25 MG Tablet approved?
How does medicine works?
What are the interactions for Nextop 25 MG Tablet ?