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Manforce 50 MG Tablet Tips

When Not to Use Prescription Drugs for an Erect Penis!

When Not to Use Prescription Drugs for an Erect Penis!

When Not to Use Prescription Drugs for an Erect Penis


Advances in treatments that enable a man to more easily attain an erect penis have made a huge difference among men in whom erectile dysfunction can be an issue. These developments have had a clear impact on sexual and penis health and have benefitted many, many men (and their partners). One of the more popular treatments involves the drug sildenafil, which is marketed under various popular brand names. While sildenafil can be very effective at helping a man achieve an erect penis, there are times when a guy should refrain from using the drug.

More about sildenafil

Although sildenafil has been used for more than 20 years to help men achieve an erect penis, that was not its original purpose. It is an artificial compound originally developed to treat hypertension and angina. While studying the drug in clinical trials for these conditions, the scientists discovered that men who took the drug developed firm erections a half hour or so after ingesting the drug. This prompted them to change the focus of their studies, to the benefit of millions of men since. Sildenafil works by helping the smooth muscle of the penis to relax, which opens up penile blood vessels more fully. More blood is able to therefore invade the penis quickly, filling up the spongy tissue which results in an erect penis.

When not to take

Though sildenafil has been very helpful, there are circumstances under which a man should not use the drug. These include the following:

- If erectile dysfunction isn't a problem. Some men may think they can use sildenafil even if they have no problem getting an erect penis. They may think this could somehow make their erection even harder than it is or that it may enable them to last longer during sex. But studies have indicated that sildenafil provides no real benefit to a man without erectile problems. More importantly, some doctors suggest that using the drug when it's not needed could over time lead the body to expect and depend on it - so that a man could have difficulty getting or maintaining an erection without using it.

- If it may not be real. Unscrupulous people peddle fake versions of many different drugs - including sildenafil. They usually charge a much cheaper price than one would pay for the real thing, but it doesn't offer the benefits. And depending on what ingredients are actually in it, a fake version could cause harm. Only use sildenafil prescribed by a qualified and reliable doctor.

- If other conditions are present. Many drugs are good at treating one condition but may exacerbate other conditions. It's recommended that a man with heart disease, heart attack, stroke, low blood pressure, liver problems and some kinds of vision problems may want to avoid sildenafil. It's important for a man to check with his doctor to determine if using sildenafil will have a negative impact on other health issues.

- If he is on some other medications. By the same token, some drugs are not meant to be taken at the same time and can cause interactions, some minor and some major. Again, checking with a doctor is advised.

- If partying. Drinking too much alcohol or ingesting illegal substances can potentially cause a problem with sildenafil.

The long and the short of it is that a man should check with his doctor if he has any questions about under what circumstances he should use sildenafil - or any drug, really.

Sildenafil can help give a man an erect penis, but he needs to take other steps to keep it healthy - such as by daily applying a top notch penis health crème (health professionals recommend Man 1 Man Oil, which is clinically proven mild and safe for skin) to the equipment. For best results, the crème should include a range of vitamins, like A, B5, C, D and E. It also should include L-arginine, which helps keep penile blood vessels open and ready for increased flow.

 

8 people found this helpful

When Not to Use Prescription Drugs for an Erect Penis

When Not to Use Prescription Drugs for an Erect Penis

When Not to Use Prescription Drugs for an Erect Penis

Advances in treatments that enable a man to more easily attain an erect penis have made a huge difference among men in whom erectile dysfunction can be an issue. These developments have had a clear impact on sexual and penis health and have benefitted many, many men (and their partners). One of the more popular treatments involves the drug sildenafil, which is marketed under various popular brand names. While sildenafil can be very effective at helping a man achieve an erect penis, there are times when a guy should refrain from using the drug.

More about sildenafil

Although sildenafil has been used for more than 20 years to help men achieve an erect penis, that was not its original purpose. It is an artificial compound originally developed to treat hypertension and angina. While studying the drug in clinical trials for these conditions, the scientists discovered that men who took the drug developed firm erections a half hour or so after ingesting the drug. This prompted them to change the focus of their studies, to the benefit of millions of men since.

Sildenafil works by helping the smooth muscle of the penis to relax, which opens up penile blood vessels more fully. More blood is able to therefore invade the penis quickly, filling up the spongy tissue which results in an erect penis.

When not to take

Though sildenafil has been very helpful, there are circumstances under which a man should not use the drug. These include the following:

  • If erectile dysfunction isn't a problem. Some men may think they can use sildenafil even if they have no problem getting an erect penis. They may think this could somehow make their erection even harder than it is or that it may enable them to last longer during sex. But studies have indicated that sildenafil provides no real benefit to a man without erectile problems. More importantly, some doctors suggest that using the drug when it's not needed could over time lead the body to expect and depend on it - so that a man could have difficulty getting or maintaining an erection without using it.
  • If it may not be real. Unscrupulous people peddle fake versions of many different drugs - including sildenafil. They usually charge a much cheaper price than one would pay for the real thing, but it doesn't offer the benefits. And depending on what ingredients are actually in it, a fake version could cause harm. Only use sildenafil prescribed by a qualified and reliable doctor.
  • If other conditions are present. Many drugs are good at treating one condition but may exacerbate other conditions. It's recommended that a man with heart disease, heart attack, stroke, low blood pressure, liver problems and some kinds of vision problems may want to avoid sildenafil. It's important for a man to check with his doctor to determine if using sildenafil will have a negative impact on other health issues.
  • If he is on some other medications. By the same token, some drugs are not meant to be taken at the same time and can cause interactions, some minor and some major. Again, checking with a doctor is advised.
  • If partying. Drinking too much alcohol or ingesting illegal substances can potentially cause a problem with sildenafil.

The long and the short of it is that a man should check with his doctor if he has any questions about under what circumstances he should use sildenafil - or any drug, really.

Sildenafil can help give a man an erect penis, but he needs to take other steps to keep it healthy - such as by daily applying a top notch penis health crème (health professionals recommend Man 1 Man Oil, which is clinically proven mild and safe for skin) to the equipment. For best results, the crème should include a range of vitamins, like A, B5, C, D and E. It also should include L-arginine, which helps keep penile blood vessels open and ready for increased flow.

14 people found this helpful

Are Viagra & Skin Cancer Connected?

Are Viagra & Skin Cancer Connected?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.

3593 people found this helpful

Can Viagra Cause Skin Cancer?

Can Viagra Cause Skin Cancer?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss any specific problem, you can consult a sexologist.

6666 people found this helpful

Skin Cancer - Can Viagra Be The Cause?

Skin Cancer - Can Viagra Be The Cause?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss about any specific problem, you can consult a Sexologist.

5198 people found this helpful

Viagra - Can It Cause Skin Cancer?

Viagra - Can It Cause Skin Cancer?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss about any specific problem, you can consult a sexologist.

5358 people found this helpful

Can Viagra Cause Skin Cancer?

Can Viagra Cause Skin Cancer?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.

Are Viagra & Skin Cancer Connected?

Are Viagra & Skin Cancer Connected?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.

5185 people found this helpful

Are Viagra & Skin Cancer Connected?

Are Viagra & Skin Cancer Connected?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.

Sildenafil and Melanoma Risk
Sildenafil may be associated with increased melanoma risk, according a recent study published in JAMA Internal Medicine.
However, a cause and effect relationship has not been found and there is not enough evidence to warrant treatment changes.
Sildenafil is a phosphodiesterase (PDE) 5A inhibitor that is frequently prescribed to men with erectile dysfunction. It is the active ingredient in Viagra.
Previous lab research conducted in vitro has shown that PDE5A inhibition could spur the development of melanoma cells and melanoma cell invasion.
For this study, the research team, led by Dr. Wen-Qing Li of Brigham and Women’s Hospital (Boston, USA) and Harvard Medical School, looked at data from the Health Professionals’ Follow-Up study, which started in 1986. This biennial health survey included men between the ages of 40 and 75.
Specifically, the researchers analyzed data from 25,848 men recorded between 2000 and 2010. The men’s mean age was 64.8 years. Recent sildenafil use (during the previous three months) was reported by 5.3% of the men; 6.3% had used it at some point in the past.
Over this period, 142 cases of melanoma, 580 cases of squamous cell carcinoma, and 3,030 cases of basal cell carcinoma (all types of skin cancer) were reported.
The researchers found that men who took sildenafil – either recently or ever – were at higher risk of developing invasive melanoma. They were not at higher risk of developing the other types of skin cancer, however.
Media reports have suggested that the risk of skin cancer increases by 84% for men who take sildenafil. As Daniel Pendick explained in a recent Harvard Health Blog post, this statistic is misleading, as it refers to the relative risk, comparing two specific groups - the study’s participants who did not take sildenafil and the participants who did.
The absolute risk, Pendick notes, is 0.43%, meaning that the number of cases per 1,000 men increased from 4.3 among the men who didn’t take sildenafil to 8.6 among the men who did.
Other erectile dysfunction drugs, such as tadalafil (Cialis) and vardenafil (Levitra) were not included in the study, as they had not been approved when the research began.
The authors noted that future studies might examine different populations, different dosing regimens, longer follow-up periods, and latency of exposure.
“Our results should be interpreted cautiously and are insufficient to alter current clinical recommendations,” they wrote. “Nevertheless, our data provide epidemiological evidence on possible skin adverse effects of PDE5A inhibitors and support continued investigation of this relationship.”
In a JAMA Internal Medicine Invited Commentary, Dr. June K. Robinson recommended that physicians screen men for melanoma when writing prescriptions for sildenafil. Older men with a history of serious sunburns are among the most vulnerable.
Additional training on melanomas might be required for some physicians, but the end result could be quite beneficial, Robinson explained. For example, after eight hours of training in Germany, a group of primary care physicians screened men for melanoma and decreased mortality from 1.9/100,000 men before screening to 1.0/100,000 men after screening.
“Early detection, which may make melanoma a curable disease, may be achieved by physicians performing screening in the at-risk population for melanoma,” Robinson wrote.
4 people found this helpful