Endobloc T Kit is a medication used to treat pulmonary hypertension in patients of WHO class II or WHO class III. It is an endothelin receptor antagonist that blocks certain substances present in the lungs, which in turn helps decrease the blood pressure inside the lungs.
You should refrain from using Endobloc T Kit if have any liver problems or lung problems, are allergic to any medicine, are pregnant, plan on becoming pregnant, or breastfeeding. You should also consult your doctor before taking Endobloc T Kit if you have history of heart failure, anemia, fluid retention problem, alcohol dependency or taking any medicines or supplements.
There are very few reported side effects of Endobloc T Kit. These include stuffy nose, irritation in nose or throat and flushing. You should see a doctor as soon as possible if any of these persist for prolonged duration.
Endobloc T Kit is available only as tablets to be taken orally. You can have them with or without food but you should consult your doctor regarding the appropiate dosage.
Erectile dysfunction (ed) is an important worldwide health issue that has a significant negative impact on the quality of life and sexual self-confidence of the affected individual. Numerous epidemiological studies report that prevalence of erectile dysfunction (ED) increases with aging. Moreover, complaints of ed even in younger men are becoming more frequent. However, the numbers of men seeking medical attention for ed along with the increased comfort of physicians treating it has resulted in enhanced management of this condition. It is advised to avoid alcohol, smoking and other substances which is a common causative for ED in young individuals. Treatment options include medicinal options like sildenafil and tadalafil. Surgical options are also available.
Pulmonary hypertension mainly occurs due to narrowing of the arteries of the lungs as a result of which the flow of blood is restricted. In this kind of condition, blood fails to carry oxygen to your heart and thus your heart gets adversely affected. The blood pressure of your body will get increased to a great extent if this situation remains untreated, thus leading to bdreadful consequenses, specifically situation like heart failure, serious pulmonary diseases, blood clots in lungs and congenial heart defects, etc.
There are certain forms of pulmonary hypertension, which are serious in nature and worsen with time, so much so that they are even fatal at times. It also includes forms which are non curable in nature, however, in order to improve the quality of life, symptoms can be reduced with proper treatment. The treatment for pulmonary hypertension is often complex and it takes some time to find the most appropriate treatment and requires extensive follow-up care. Your doctor might also need to change your treatment if it's no longer effective. However, when pulmonary hypertension is caused by another condition, your doctor will treat the underlying cause whenever possible.
Common Treatments for pulmonary hypertension:
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.
Since long, ailments which can hamper your physical intimacy with your partner are of grave concern and amongst these premature ejaculation tops the list. Thus it is important that you discuss it out with your partner along with a therapist and resolve it through medical help.
It is important that we understand what is premature ejaculation in order. Premature ejaculation is uncontrolled ejaculation either before or shortly after penetration.It may result in unsatisfactory intercourse for both partners. This can increase the anxiety of that person. It is one of the most common forms of male sexual dysfunction.
What are the causes behind PE?
The exact cause of premature ejaculation is unknown, but it's often rooted in physical, psychological, or emotional issues. In some cases, it may be related to a medical cause such as hormonal problems, injury, or a side effect of certain medicines.
Other causes may include:
What are the symptoms?: The primary symptom of premature ejaculation is the inability to delay ejaculation for more than one minute after penetration. The main symptom is an uncontrolled ejaculation either before or shortly after intercourse begins. Ejaculation occurs before the person wishes it, with minimal sexual stimulation.
How it is diagnosed?: Premature ejaculation is diagnosed based on typical symptoms. To understand your problem, your doctor will need to discuss your sexual history with you. Be frank and open. The more your doctor knows, the better he or she can help you.
How it is treated?: In many cases premature ejaculation gets better on its own over time. Treatment may not be needed. But there are some serious conditions that need to be treated. If you are suffering from depression you should take medications to remove your depression, such as Paxil (paroxetine), Zoloft (sertraline), and Prozac (fluoxetine).
Practicing relaxation techniques or using distraction methods may help you delay ejaculation. You can try using a condom to reduce sensation to the penis. Or you can try a different position (such as lying on your back) during intercourse.
These therapies may be used together in different combinations to treat premature ejaculation and in turn improve your self-esteem and sex life. Behavioral therapy is one possible approach for treating premature ejaculation. Most commonly, the 'squeeze technique' is used. Some men with premature ejaculation may benefit from drugs called phosphodiesterase inhibitors, such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). If you wish to discuss any specific problem, you can consult a sexologist.