Endobloc T Kit is a medication used to treat pulmonary hypertension in patients of WHO class II or WHO class III. It is an endothelin receptor antagonist that blocks certain substances present in the lungs, which in turn helps decrease the blood pressure inside the lungs.
You should refrain from using Endobloc T Kit if have any liver problems or lung problems, are allergic to any medicine, are pregnant, plan on becoming pregnant, or breastfeeding. You should also consult your doctor before taking Endobloc T Kit if you have history of heart failure, anemia, fluid retention problem, alcohol dependency or taking any medicines or supplements.
There are very few reported side effects of Endobloc T Kit. These include stuffy nose, irritation in nose or throat and flushing. You should see a doctor as soon as possible if any of these persist for prolonged duration.
Endobloc T Kit is available only as tablets to be taken orally. You can have them with or without food but you should consult your doctor regarding the appropiate dosage.
A man is considered to have erectile dysfunction if he regularly finds it difficult getting or keeping a firm enough erection to be able to have sex, or if it interferes with other sexual activity.
Most men have occasionally experienced some difficulty with their penis becoming hard or staying firm. However, erectile dysfunction (ed) is only considered a concern if satisfactory sexual performance has been impossible on a number of occasions for some time.
Since the discovery that the drug sildenafil, or viagra, affected penile erections, most people have become aware that ed is a treatable medical condition.
Men who have a problem with their sexual performance may be reluctant to talk with their doctor, seeing it can be an embarrassing issue.
However, ed is now well understood, and there are various treatments available.
This mnt knowledge center article offers helpful information for people experiencing this problem, or those close to them.
Fast facts on erectile dysfunction:
Erectile dysfunction (ed) is defined as persistent difficulty achieving and maintaining an erection sufficient to have sex.
Causes are usually medical but can also be psychological.
Organic causes are usually the result of an underlying medical condition affecting the blood vessels or nerves supplying the penis.
Numerous prescription drugs, recreational drugs, alcohol, and smoking, can all cause ed.
Normal erectile function can be affected by problems with any of the following systems:
Erectile dysfunction can cause embarrassment.
It is always worth consulting a physician about persistent erection problems, as it could be caused by a serious medical condition.
Whether the cause is simple or serious, a proper diagnosis can help to address any underlying medical issues and help resolve sexual difficulties.
The following list summarizes many of the most common physical or organic causes of ed:
Heart disease and narrowing of blood vessels
Treatments for prostate disease
Drugs that act on the central nervous system, including some sleeping pills and amphetamines
Antidepressants, including monoamine oxidase inhibitors (maois), selective serotonin reuptake inhibitors (ssris), and tricyclic antidepressants
Some cancer drugs, including chemotherapeutic agents
Prostate treatment drugs
The peptic ulcer medication cimetidine
Physical causes account for 90 percent of ed cases, with psychological causes much less common.
In rare cases, a man may always have had ed and may never have achieved an erection. This is called primary ed, and the cause is almost always psychological if there is no obvious anatomical deformity or physiological issue. Such psychological factors can include:
Most cases of ed are'secondary' this means that erectile function has been normal, but becomes problematic. Causes of a new and persistent problem are usually physical.
Less commonly, psychological factors cause or contribute to ed, with factors ranging from treatable mental health illnesses to everyday emotional states that most people experience at some time.
It is important to note that there can be overlap between medical and psychosocial causes. For instance, if a man is obese, blood flow changes can affect his ability to maintain an erection, which is a physical cause. However, he may also have low self-esteem, which can impact erectile function and is a psychosocial cause.
Does riding a bicycle cause ed?
Questions remain about the effects on men's health of riding a bicycle.
Some research has raised concerns that men who regularly cycle for long hours could have a higher risk of ed, in addition to other men's health issues such as infertilityand prostate cancer.
The most recent study to investigate this found that there was no link between riding a bike and ed, but it did find an association between longer hours of cycling and the risk of prostate cancer.
Prostate disease and ed
Prostate cancer does not cause ed.
However, prostate surgery to remove the cancer and radiation therapy to treat prostate cancer can cause ed.
Treatment of non-cancerous, benign prostate disease can also cause the condition.
The good news is that there are many treatments for ed, and most men will find a solution that works for them. Treatments include:
Men can take a group of drugs called pde-5 (phosphodiesterase-5) inhibitors.
Most of these pills are taken 30 to 60 minutes before sex - the best known being the blue-colored pill sildenafil (viagra). Other options are:
Tadalafil (taken as a once-daily pill called cialis)
Pde-5 inhibitors are only available on prescription. A doctor will check for heart conditions and ask about other medications being taken before prescribing.
Side-effects associated with pde-5 inhibitors include:
Less commonly used drug options include prostaglandin e1, which is applied locally by either injecting it into the penis or inserting it down the opening of the urethra.
Most men prefer a pill, however, so these locally acting drugs tend to be reserved for men who cannot take oral treatment.
It is possible to buy treatment over the internet for ed. However, caution is advised.
The united states (u. S.) food and drug administration (fda) has a consumer safety guide about this, including a recommendation to check that the online pharmacy:
Is located in the u. S. And licensed
Has a licensed pharmacist to answer questions.
Requires a prescription.
Offers direct contact with a person who can discuss any problems.
You can check whether the pharmacy is licensed using this list of verified internet pharmacy practice sites (vipps).
The fda also offers tips for spotting the dangers of an unsafe website, including watching out for the following clues:
There is no way to contact the website by phone.
Prices are dramatically lower than those offered by legal online pharmacies.
Prescription drugs are offered without requiring a prescription - which is illegal.
Personal information is not protected.
The fda adds that these illegal sites may send drugs of unknown quality and origin, even sending the wrong drug or a dangerous product.
Vacuum erection devices are a mechanical way of producing an erection for men who do not want or cannot use drug treatments, or find they are not working.
The penis is made rigid by the use of a vacuum pump sealed around it that draws up blood. This is prevented from then leaving the penis by the use of an accompanying band.
The lack of spontaneity with the use of vacuum devices means that many men find other treatments for ed preferable.
There are several surgical treatment options:
Penile implants: these are a final option reserved for men who have not had any success with drug treatments and other non-invasive options.
Vascular surgery: another surgical option for some men is vascular surgery, which attempts to correct some blood vessel causes of ed.
Surgery is a last resort and will only be used in the most extreme cases. Recovery time varies, but success rates are high.
Do dietary supplements and alternative treatments work?
The short answer is" no"
No guidelines followed by doctors, nor any established sources of evidence, support the use of dietary supplements, such as herbal pills.
In addition to there being no evidence in favor of non-prescription alternatives for ed, the fda has warned of hidden risks of" treatments" sold online.
Men may not always successfully achieve an erection, and if this rarely happens, it is not considered a medical problem.
However, ed does not only refer to a complete inability to achieve an erect penis. Symptoms can also include struggling to maintain an erection for long enough to complete intercourse or an inability to ejaculate.
There are often also emotional symptoms, such as embarrassment, shame, anxiety, and a reduced interest in sexual intercourse.
A man is considered to have ed when these symptoms occur regularly.
There are exercises a man can carry out to reduce the effects of ed.
The best way to treat erectile dysfunction without medication is by strengthening the pelvic floor muscles with kegel exercises. These are often associated with women looking to strengthen their pelvic area during pregnancy, but they can be effective for men looking to regain full function of the penis.
Firstly, find the pelvic floor muscles. You can achieve this by stopping mid-stream two or three times the next time you urinate. The muscles you can feel working during this process are the pelvic floor muscles, and they will be the focus of kegel exercises.
One kegel exercise consists of tightening and holding these muscles for 5 seconds and then releasing them. Try to do between 10 and 20 repetitions each day. This may not be possible when you first start doing the exercises. However, they should become easier over time.
You should be able to notice an improvement after 6 weeks.
Make sure you are breathing naturally throughout this process and avoid pushing down as if you are forcing urination. Instead, bring the muscles together in a squeezing motion.
Aerobic exercise, such a jog or even a brisk walk, can also help the blood to circulate better and can help improve ed in men who have circulation issues.
Pulmonary hypertension mainly occurs due to narrowing of the arteries of the lungs as a result of which the flow of blood is restricted. In this kind of condition, blood fails to carry oxygen to your heart and thus your heart gets adversely affected. The blood pressure of your body will get increased to a great extent if this situation remains untreated, thus leading to bdreadful consequenses, specifically situation like heart failure, serious pulmonary diseases, blood clots in lungs and congenial heart defects, etc.
There are certain forms of pulmonary hypertension, which are serious in nature and worsen with time, so much so that they are even fatal at times. It also includes forms which are non curable in nature, however, in order to improve the quality of life, symptoms can be reduced with proper treatment. The treatment for pulmonary hypertension is often complex and it takes some time to find the most appropriate treatment and requires extensive follow-up care. Your doctor might also need to change your treatment if it's no longer effective. However, when pulmonary hypertension is caused by another condition, your doctor will treat the underlying cause whenever possible.
Common Treatments for pulmonary hypertension:
Erectile dysfunction can be quite a depressing and stressful problem. It can jeopardize the sexual life of a person. In recent times, the problem has been on an exponential rise. As per a survey, 1 in every 1000 men suffers from erectile dysfunction. To top it, some men, out of embarrassment, delay the treatment and medications.
In Erectile Dysfunction, a person is unable to maintain an erection necessary for a sexual intercourse. A man's confidence and self-esteem often take a beating in such cases. In some cases, the affected person completely detaches himself from the outside world. The erectile dysfunction in men can be due to lifestyle habits, psychological problems, injury, and diseases, such as;
Symptoms of erectile dysfunction:
A person with erectile dysfunction may exhibit one or more of the following symptoms:
Diagnosis and Treatment:
As serious as it may appear, there is nothing to press the panic button. The problem is temporary. With timely diagnosis and treatment, erectile dysfunction can be easily managed and treated. Diagnosis of erectile dysfunction include;
A person also needs to
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss any specific problem, you can consult a sexologist.
A bent penis can be a source of genuine concern for a man. Yes, a little curvature in the penis is common, but when the curvature is severe, it can create both physical and emotional problems. Most men with a severely bent penis are considered to have Peyronie's disease, named after the doctor who first described it medically. Since sexual and penis health can be impacted by Peyronie's, it helps to be aware of what treatments are out there for this condition.
In 2016, the World Journal of Men's Health published "Nonsurgical Interventions for Peyronie's Disease: Update as of 2016," an overview of the existing treatments for a bent penis. Following is a distillation of the information contained in that article.
First, a little about Peyronie's disease. The Mayo Clinic describes this disorder as "the development of fibrous scar tissue inside the penis that causes curved, painful erections." This scar tissue usually develops due to injury to the penis. For example, a man might be struck in the penis by a baseball, might slam his erection into a hard surface or might simply experience repeated rough (if pleasurable) handling during sex. Such activities create trauma in the penis; as it heals (even from small traumas like rough handling), scar tissue forms. If that tissue forms repeatedly in one area, it prevents the skin from stretching properly, causing the penis to bend during an erection.
Among the treatment options are:
1. Oral options. A wide range of pills are sometimes used in treating Peyronie's, including vitamin E, tamoxifen, L-carnitine and tadalafil. Such options are typically employed first, as they are the easiest treatment available. Typically, these therapies show results in cases where the scar tissue is less intense. Some of these options are also available for topical application directly on the penis skin.
2. Injections. More persistent cases may respond to the injection of medication directly in the area where the scar tissue build-up is pronounced. As of this writing, only one drug is approved for this method in the U.S. Many men resist this treatment as, understandably, the idea of injecting a needle into the penis does not appeal to them.
3. Traction. Traction therapy essentially works to pull the penis back into shape. A man wears (for several hours each day), a device that attaches to the penis and exerts force to pull it in the opposite direction of the curve. Traction devices tend to work best in conjunction with other therapies rather than on their own.
4. Shock wave therapy. A more recent addition, shock wave therapy uses high amplitude pulses of energy directed at the penis. Typically used on joint and tendon issues, the therapy seems to help with the pain that some experience from Peyronie's but has not yet been shown to make much difference in the curvature.
5. Surgery. There are several surgical approaches to correct the curvature of Peyronie's. Because some cases correct themselves over time, surgery is usually recommended only when the bent penis has been an issue for a year or longer and/or when the physical or emotional distress it causes is significant.
Whatever approach a man may take to treat a bent penis due to Peyronie's disease, he is better positioned if his penis is in good health - and that is more easily obtained when he regularly utilizes a top drawer penis health crème (health professionals recommend Man1 Man Oil, which is clinically proven mild and safe for skin). Some of the best crème contains both vitamin E and L-carnitine, which are sometimes used to help treat Peyronie's. The best crème will also include vitamin D, the "miracle vitamin" that has proven benefits in fighting diseases and supporting healthy cellular function.