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Overview

Endobloc T Kit

Endobloc T Kit

Manufacturer: Cipla Ltd
Medicine composition: Ambrisentan, Tadalafil
Prescription vs.OTC: Prescription by Doctor required

Endobloc T Kit is a medication used to treat pulmonary hypertension in patients of WHO class II or WHO class III. It is an endothelin receptor antagonist that blocks certain substances present in the lungs, which in turn helps decrease the blood pressure inside the lungs.

You should refrain from using Endobloc T Kit if have any liver problems or lung problems, are allergic to any medicine, are pregnant, plan on becoming pregnant, or breastfeeding. You should also consult your doctor before taking Endobloc T Kit if you have history of heart failure, anemia, fluid retention problem, alcohol dependency or taking any medicines or supplements.

There are very few reported side effects of Endobloc T Kit. These include stuffy nose, irritation in nose or throat and flushing. You should see a doctor as soon as possible if any of these persist for prolonged duration.

Endobloc T Kit is available only as tablets to be taken orally. You can have them with or without food but you should consult your doctor regarding the appropiate dosage.

In addition to its intended effect, Endobloc T Kit may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Headache
Nasopharyngitis
Flushing (sense of warmth in the face
ears
neck and trunk)
Dyspepsia
Muscle pain
Pain in extremity.
Is It safe with alcohol?
Tadalafil can lower blood pressure, and combining it with alcohol may further increase this effect.
Are there any pregnancy warnings?
Endobloc t kit is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
Are there any breast-feeding warnings?
Endobloc t kit is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?
Caution is advised when driving or operating machinery.
It may cause dizziness. Exercise caution if you have to drive or operate a machinery.
Does this affect kidney function?
No dose adjustment is needed for patients with the mild to moderate renal disease. Not advisable in patients with the severe renal disease.
Does this affect liver function?
No dose adjustment is needed for patients with the mild to moderate liver disease. Dose adjustment is required in patients with severe liver disease.
Below is the list of medicines, which have the same composition, strength and form as Endobloc T Kit, and hence can be used as its substitute.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.

Popular Questions & Answers

Will tadalafil tablets cure erectile dysfunction? Using tadalafil is dangerous to health? Please advice

MD, Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Pune
Will tadalafil tablets cure erectile dysfunction? Using tadalafil is dangerous to health? Please advice
Yes, it may be dangerous. By the way, This is happening due to insufficiency of hormones and improper functions of serotonin. The good news is that this is easily treatable with our herbal tablets. These tablets improve blood supply to penis and nourish muscles and blood vessels of penis thereby making erection long and hard. At the same time, these tablets improve functions of serotonin thereby delaying ejaculation significantly. As a proof of our Good work, you can check our Feedbacks on Lybrate website.
1 person found this helpful

Is it possible to make intercourse by taking other medicine where tadalafil 20 fails?

BHMS
Homeopath, Sindhudurg
Is it possible to make intercourse by taking other medicine where tadalafil 20 fails?
Yes. There are many medicines to prolong sex or increase sexual stability like sulph, avena, ashwagandha, lyco, china, cydo, nux vom, arg nit, damiana etc to select correct medicine for you I need few details.
1 person found this helpful

Is there any injection treatment for erectile dysfunction other than tadalafil or sildenafil because those tablets does not work on me.

MBBS, MD (AIIMS, Gold Medalist), Diploma in CBT (UWS, Glasgow)
Psychiatrist, Delhi
Is there any injection treatment for erectile dysfunction other than tadalafil or sildenafil because those tablets do...
Injection treatments are risky and associated with possibility of complications. Be careful about what you are doing. Upto 90% of erectile dysfunction is due to performance anxiety and are best treated with psychological techniques such as senate focus.
1 person found this helpful

I took tadalafil 10 Mg for 2 days .can I take it with homeopathic medicine. For ed.

MBBS, DIiploma in Yoga and Ayurveda, Diploma In Dermatology And Venerology And Leprosy (DDVL), PGDPC
Sexologist, Pune
I took tadalafil 10 Mg for 2 days .can I take it with homeopathic medicine. For ed.
Homeopathy will be dangerous to take with Tadalafil. Please take only one of them. As homeopathy actions not understood it will be hidden and more risky. Please contact me in private chat and get all doubts cleared.

Popular Health Tips

MD - Internal Medicine, CCMD(Diabetology), PG Course in Diabetology, ADVANCED CERTIFICATE COURSE IN DIABETES
Diabetologist, Dehradun
Diabetics facing ED should test your testosterone level .can try Tadalafil (if no contraindications).
9 people found this helpful

Erectile Dysfunction

md psychiatry , senior registerar, mbbs
Psychiatrist, Indore
Erectile Dysfunction

Erectile dysfunction (ed) is an important worldwide health issue that has a significant negative impact on the quality of life and sexual self-confidence of the affected individual. Numerous epidemiological studies report that prevalence of erectile dysfunction (ED) increases with aging. Moreover, complaints of ed even in younger men are becoming more frequent. However, the numbers of men seeking medical attention for ed along with the increased comfort of physicians treating it has resulted in enhanced management of this condition. It is advised to avoid alcohol, smoking and other substances which is a common causative for ED in young individuals. Treatment options include medicinal options like sildenafil and tadalafil. Surgical options are also available.

6 people found this helpful

Pulmonary Hypertension - What Type Of Treatment Is Given?

MD , MBBS
Pulmonologist, Delhi
Pulmonary Hypertension - What Type Of Treatment Is Given?

Pulmonary hypertension mainly occurs due to narrowing of the arteries of the lungs as a result of which the flow of blood is restricted. In this kind of condition, blood fails to carry oxygen to your heart and thus your heart gets adversely affected. The blood pressure of your body will get increased to a great extent if this situation remains untreated, thus leading to bdreadful consequenses, specifically situation like heart failure, serious pulmonary diseases, blood clots in lungs and congenial heart defects, etc.

There are certain forms of pulmonary hypertension, which are serious in nature and worsen with time, so much so that they are even fatal at times. It also includes forms which are non curable in nature, however, in order to improve the quality of life, symptoms can be reduced with proper treatment. The treatment for pulmonary hypertension is often complex and it takes some time to find the most appropriate treatment and requires extensive follow-up care. Your doctor might also need to change your treatment if it's no longer effective. However, when pulmonary hypertension is caused by another condition, your doctor will treat the underlying cause whenever possible.

Common Treatments for pulmonary hypertension:

Medications:

  1. Blood vessel dilators (vasodilators): Vasodilators open narrowed blood vessels. They are one of the most commonly prescribed vasodilators for pulmonary hypertension is epoprostenol (Flolan, Veletri). The drawback to epoprostenol is that the effect lasts only for few minutes. This drug is continuously injected through an intravenous (IV) catheter via a small pump that you wear in a pack on your belt or shoulder.
  2. Ventavis: Another form of the drug, iloprost (Ventavis), can be inhaled six to nine times a day through a nebulizer, a machine that vaporizes your medication. Because it's inhaled, it goes directly to the lungs.
  3. Treprostinil (Tyvaso, Remodulin, Orenitram): It is another form of the drug, which can be given four times a day and can be inhaled or can be taken as an oral medication and can also be administered through injection.
  4. Endothelin receptor antagonists: These medications reverse the effect of endothelin, a substance in the walls of blood vessels that causes them to narrow. These drugs may improve your energy level and symptoms. However, these drugs shouldn't be taken if you're pregnant. Also, these drugs can damage your liver and you may need monthly liver monitoring.
  5. Sildenafil and tadalafil: Sildenafil (Revatio, Viagra) and tadalafil (Cialis, Adcirca) are sometimes used to treat pulmonary hypertension. These drugs work by opening the blood vessels in the lungs to allow blood to flow through more easily.
  6. High-dose calcium channel blockers: These drugs help relax the muscles in the walls of your blood vessels. They include medications, such as amlodipine (Norvasc), diltiazem (Cardizem, Tiazac, others) and nifedipine (Procardia, others). Although calcium channel blockers can be effective, only a small number of people with pulmonary hypertension respond to them.
  7. Soluble guanylate cyclase (SGC) stimulator: Soluble guanylate cyclase (SGC) stimulators (Adempas) interact with nitric oxide and help relax the pulmonary arteries and lower the pressure within the arteries. These medications should not be taken if you're pregnant. They can sometimes cause dizziness or nausea.
  8. Anticoagulants: Your doctor is likely to prescribe the anticoagulant warfarin (Coumadin, Jantoven) to help prevent the formation of blood clots within the small pulmonary arteries. Because anticoagulants prevent normal blood coagulation, they increase your risk of bleeding complications. Take warfarin exactly as prescribed, because warfarin can cause severe side effects if taken incorrectly. If you're taking warfarin, your doctor will ask you to have periodic blood tests to check how well the drug is working. Many other drugs, herbal supplements and foods can interact with warfarin, so be sure your doctor knows all of the medications you're taking.
  9. Digoxin: Digoxin (Lanoxin) can help the heart beat stronger and pump more blood. It can help control the heart rate if you experience arrhythmias.
  10. Diuretics: Commonly known as water pills, these medications help eliminate excess fluid from your body. This reduces the amount of work your heart has to do. They may also be used to limit fluid buildup in your lungs.
  11. Oxygen: Your doctor might suggest that you sometimes breathe pure oxygen, a treatment known as oxygen therapy, to help treat pulmonary hypertension, especially if you live at a high altitude or have sleep apnea. Some people who have pulmonary hypertension eventually require continuous oxygen therapy.

Surgeries:

  1. Atrial Septostomy: If medications don't control your pulmonary hypertension, this open heart surgery might be an option. In an atrial septostomy, a surgeon will create an opening between the upper left and right chambers of your heart (atria) to relieve the pressure on the right side of your heart.
  2. Lung Transplantation: In some cases, a lung or heart lung transplant might be an option, especially for younger people who have idiopathic pulmonary arterial hypertension.

Reducing Complications:

  1. The complications need to be reduced by taking proper health care. Healthy diet needs to be taken regularly along with proper medications. Smoking should be stopped and exercising sessions should be attended daily without any fail
  2. Overweight or obesity needs to be controlled properly for reducing the complications. Specialized caring strategies need to be maintained for avoiding severe kinds of health complications that are quite annoying. If you wish to discuss about any specific problem, you can consult a Pulmonologist.
2489 people found this helpful

Are Viagra & Skin Cancer Connected?

PhD Human Genetics
Sexologist,
Are Viagra & Skin Cancer Connected?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too.

3591 people found this helpful

Treatment Options Available for Premature Ejaculation

MBBS
Sexologist, Jaipur
Treatment Options Available for Premature Ejaculation

Since long, ailments which can hamper your physical intimacy with your partner are of grave concern and amongst these premature ejaculation tops the list. Thus it is important that you discuss it out with your partner along with a therapist and resolve it through medical help. 

It is important that we understand what is premature ejaculation in order. Premature ejaculation is uncontrolled ejaculation either before or shortly after penetration.It may result in unsatisfactory intercourse for both partners. This can increase the anxiety of that person. It is one of the most common forms of male sexual dysfunction.
 
What are the causes behind PE?
The exact cause of premature ejaculation is unknown, but it's often rooted in physical, psychological, or emotional issues. In some cases, it may be related to a medical cause such as hormonal problems, injury, or a side effect of certain medicines.

Other causes may include:

  • Early experiences with masturbation and sex.
  • Erectile Dysfunction.
  • Relationship problems.
  • Intercourse with a new partner.

What are the symptoms?: The primary symptom of premature ejaculation is the inability to delay ejaculation for more than one minute after penetration. The main symptom is an uncontrolled ejaculation either before or shortly after intercourse begins. Ejaculation occurs before the person wishes it, with minimal sexual stimulation.
 
How it is diagnosed?: Premature ejaculation is diagnosed based on typical symptoms. To understand your problem, your doctor will need to discuss your sexual history with you. Be frank and open. The more your doctor knows, the better he or she can help you.
 
How it is treated?: In many cases premature ejaculation gets better on its own over time. Treatment may not be needed. But there are some serious conditions that need to be treated. If you are suffering from depression you should take medications to remove your depression, such as Paxil (paroxetine), Zoloft (sertraline), and Prozac (fluoxetine).

Practicing relaxation techniques or using distraction methods may help you delay ejaculation. You can try using a condom to reduce sensation to the penis. Or you can try a different position (such as lying on your back) during intercourse.

These therapies may be used together in different combinations to treat premature ejaculation and in turn improve your self-esteem and sex life. Behavioral therapy is one possible approach for treating premature ejaculation. Most commonly, the 'squeeze technique' is used. Some men with premature ejaculation may benefit from drugs called phosphodiesterase inhibitors, such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). If you wish to discuss any specific problem, you can consult a sexologist.

6378 people found this helpful