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Overview

Ataclip 300 Mg/100 Mg Tablet

Manufacturer: Abbott India Ltd
Medicine composition: Atazanavir, Ritonavir
Prescription vs.OTC: Prescription by Doctor required

Ataclip 300 Mg/100 Mg Tablet is an antiretroviral medication which is used to treat and prevent HIV/AIDS. It is usually recommended to use with other antiretroviral. It may also be used for prevention after a needlestick injury or other potential exposure. It is directed to be taken via the mouth once a day. Ataclip 300 Mg/100 Mg Tablet binds itself to the active site of HIV protease and prevents it from splitting the pro-form of viral proteins into the working machinery of the virus. If the HIV protease enzyme does not work then the virus is not infectious, and no mature virions are made.

Common side effects include yellowish skin, headache, abdominal pain, nausea, trouble sleeping, and fever. Severe side effects include rashes such as erythema multiform and high blood sugar. Ataclip 300 Mg/100 Mg Tablet appears to be safe to use during pregnancy. It is of the protease inhibitor (PI) class and works by blocking HIV protease. Ataclip 300 Mg/100 Mg Tablet should not be taken by those with hypersensitivity. Ataclip 300 Mg/100 Mg Tablet should not be taken with other medications such as triazolam, lurasidone, alfuzosin, irinotecan, rifampin, pimozide, orally administered lovastatin, midazolam, cisapride, ergot derivatives.

hiv infection
In addition to its intended effect, Ataclip 300 Mg/100 Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Altered taste
Headache
Paresthesia (tingling or pricking sensation)
Throat pain
Peripheral neuropathy (tingling and numbness of feet and hand).
Is It safe with alcohol?
Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?
Ritovaz 300 mg/100 mg tabcap is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
Are there any breast-feeding warnings?
Ritovaz 300 mg/100 mg tabcap is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?
Patients should be informed that dizziness has been reported during treatment.
Does this affect kidney function?
There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which have the same composition, strength and form as Ataclip 300 Mg/100 Mg Tablet, and hence can be used as its substitute.
Cipla Ltd
Emcure Pharmaceuticals Ltd
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.

Popular Questions & Answers

What is the life time of HIV person. Please explain stage of HIV infected person based on given report TC: 9900 cells/cumm DC polymorph: 60% lymphocytes: 30% eosinophills: 08% HB: 70%(0.2grams) ESR: 21 mm/ 1hr HIV test (TRIDOT): positive HIV 1: positive HIV 2: negative.

MD-PhD, FIPS, Fellow of Academy of General Education (FAGE), DPM, MBBS
Psychiatrist, Ludhiana
The aim of HIV treatment HIV is a virus that attacks the body?s defence against infection and illness ? the immune system. you can take drugs to reduce... Talk to your doctor Taking antiretroviral therapy is a long-term commitment. At present, once you start the drugs, you are likely to be on them for the rest of your life.... How anti-HIV drugs are dispensed You will get a prescription for your HIV treatment, when you attend your regular HIV clinic appointment, which you take to either the specialist HIV pharmacy (in... Generic medicines Pharmaceutical drugs are given several names: A research name based on its chemical make-up or manufacturer, e.g. DMP266. A generic name which is the chemical name of the... Types of antiretroviral drugs There are six main types (?classes?) of antiretroviral drugs: Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse transcriptase inhibitors (NtRTIs), which target an HIV protein called reverse transcriptase. These are often... Single-tablet regimens There are now fixed-dose pills that combine three anti-HIV drugs, from more than one class of drug. These allow many people to take their HIV treatment in... Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) Most people now take these drugs in a fixed-dose pill that combines a number of drugs. These combination pills are listed first and there are also separate... Integrase inhibitors Names: Dolutegravir, Tivicay Dose: One yellow 50mg tablet once a day. Dolutegravir should be taken twice a day if taken with efavirenz, nevirapine or tipranavir, or for HIV... Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Names: Efavirenz, Sustiva Approved dosage: Efavirenz is available as a generic drug, so its appearance will depend on which type your clinic buys. Efavirenz typically comes as 600mg... Protease inhibitors (PIs) Most protease inhibitors are prescribed with another drug (also a protease inhibitor) called ritonavir. Ritonavir is used to boost the effects of the other protease inhibitor in... CCR5 inhibitors Names: Maraviroc, Celsentri Approved dosage: The dose of maraviroc is dependent on the other anti-HIV drugs you take. Your HIV doctor or pharmacist will talk to you... Fusion inhibitors There is currently one drug in the fusion inhibitor class, called enfuvirtide (T-20, Fuzeon). This is now only prescribed in very rare and specific circumstances. Anyone on... Summary Combination HIV treatment prevents HIV from damaging your immune system, and so prevents ill health and prolongs...
18 people found this helpful

Popular Health Tips

Hiv Treatment

MD - General Medicine
Sexologist, Delhi
Hiv Treatment

HIV treatment is done by antiviral drugs, there are number of antiviral drugs available in the market, usually HIV is treated with combination of drugs, usually two to three drugs are used in treating HIV in initial stage, we can change the combination of drugs according to requirement of the patient. Drugs can be adjusted or increased if there is resistance of HIV in the patient.

There are number of compounds (about 22 in number) which have been formally approved (by the US Food and Drug Administration) for the treatment of HIV infections (AIDS). According to their point of intervention with the HIV replicative cycle, these compounds can be classified in 5 categories: (1) NRTIs (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) NtRTIs (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form TDF (tenofovir disoproxil fumarate); (3) NNRTIs (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) PIs (HIV protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) FIs (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of AIDS, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood for drug resistance development. Such anti-HIV drug combination regimens were initiated about 10 years ago and have been generally referred to as HAART (for highly active antiretroviral therapy). While HAART originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, a all-in-one pill (teevir from myelin and virotrenz from Ranbaxy sun pharma) has become available, which contains three anti-HIV drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired on the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of TDF [and its combination with emtricitabine (Truvada) and/or Atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which are very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted , we can treat them if they come to us within 72 hours of direct contact, these medicines are called POST-EXPOSURE PROPHYLAXIS (PEP) drugs for HIV or prophylactic treatment for HIV, by using these drugs we can treat a patient and we can stop transfusion of HIV virus to the person.

PEP involves taking anti HIV drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender or with homosexual PrEP is a new HIV prevention method in which people who do not have HIV infection take pills of medicine daily to reduce the risk of becoming infected with HIV virus ,PEP should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, PEP consists of 2-3 antiretroviral drugs taken for 28 days.

5 people found this helpful

How is Hiv Treatment ?

MD - General Medicine
Sexologist, Delhi
How is Hiv  Treatment ?

Hiv treatment is done by antiviral drugs, there are a number of antiviral drugs available in the market, usually HIV is treated with a combination of drugs, usually two to three drugs are used in treating HIV in the initial stage, we can change the combination of drugs according to the requirement of the patient. Drugs can be adjusted or increased if there is the resistance of HIV in the patient.

There are a number of compounds (about 22 in number) which have been formally approved (by us food and drug administration) for the treatment of HIV infections (aids). According to their point of intervention with the HIV replicative cycle, these compounds can be classified into 5 categories: (1) nrtis (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) ntrtis (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form tdf (tenofovir disoproxil fumarate); (3) nnrtis (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) pis (hiv protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) fis (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of aids, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood of drug resistance development. Such anti-hiv drug combination regimes were initiated about 10 years ago and have been generally referred to as haart (for highly active antiretroviral therapy). While haart originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, an all-in-one pill (teevir from myelin and virotrenz from ranbaxy sun pharma) has become available, which contains three anti-hiv drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired for the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of tdf [and its combination with emtricitabine (truvada) and/or atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which is very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted, we can treat them if they come to us within 72 hours of direct contact, these medicines are called post-exposure prophylaxis (pep) drugs for hiv or prophylactic treatment for hiv, by using these drugs we can treat a patient and we can stop transfusion of hiv virus to the person.

Pep involves taking anti hiv drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender of with homosexual prep is a new hiv prevention method in which people who do not have hiv infection take pills of medicine daily to reduce the risk of becoming infected with hiv virus, pep should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, pep consists of 2-3 antiretroviral drugs taken for 28 days.

2 people found this helpful

HIV Infection and AIDS Treatment

MD - General Medicine
Sexologist, Delhi
HIV Infection and AIDS Treatment

If an HIV infection, treatment is primarily aimed at preventing evolve as long as possible and do not give way to the disease AIDS . In this case, the treatment is against HIV itself. If the emergence of AIDS and its accompanying diseases occur as a lung inflammation or bowel, treatment should include them. It is important to maintain a healthy lifestyle so that the immune system does not see further harmed. Many infected with HIV also have counseling and self-help centers with other affected. Drug Treatments Currently it has good information about certain steps in the single expansion of HIV infection. Thus, it has been possible to develop drugs that inhibit certain evolutions of cell infestation. HIV treatment is also called highly active antiretroviral therapy and its abbreviation is HAART. Specifically, this treatment includes the following medications: The entry inhibitors , which inhibit the entry of 'HIV virus' in human cells. VHI prevent adhesion of immune cells and / or dissolution of the viral envelope with the cell membrane (fusion). The excipient enfuvirtide eg prevents fusion. The reverse transcriptase inhibitor blocks a special top virus that can translate the genetic information of the virus (DNA) reverse transcriptase. This group of drugs includes, for example, substances such as lamivudine , the tenofovir or nevirapine . Another top virus, integrase, incorporating HIV DNA genetic information translated into immune cells. In this case, inhibitors of this enzyme, apply called integrase inhibitors . The drug raltegravir contains these integrase inhibitors. The protease inhibitors destroy other HIV enzyme, the HIV protease. If a cell is infected with HIV, forms a component of protein which could be born new HIV viruses. Protease HIV plays an important role in the composition of this protein. Inhibitors of this enzyme are involved in virus appear less capable of action in affected cells. Examples of protease inhibitors are drugs fosamprenavir , indinavir , nelfinavir, and ritonavir . Although 'AIDS' remains an incurable disease, it may be well with a combination therapy . This combination consists of at least three different drugs; usually several inhibitors of reverse transcriptase which are combined with a protease inhibitor.

 

1 person found this helpful

HIV - How It Affects Drug Resistance?

MBBS, MD - Dermatology
HIV Specialist, Mumbai
HIV - How It Affects Drug Resistance?

HIV infection is the causative factor of the acquired immune deficiency syndrome (AIDS). Worldwide research is being conducted and treatment strategies are being formulated to combat this fatal disease. Fighting HIV is not an easy task, since the disease cannot be completely reversed. However, worldwide use of anti-retroviral therapy has helped in controlling the spread and transmission of disease. Use of medications, regular screening and close contact with caregivers and physicians is necessary for proper management of the disease. Despite, available treatment options, a difficult obstacle that arises before or during the treatment is drug resistance.

Drugs are aimed at targeting the disease-causing pathogens like bacteria and viruses. These pathogens, over a period of time, develop the ability to acquire resistance against the targeted drugs. The pathogens continue multiplying despite the presence of the drug in the system. In today’s scenario, the potent drug combination of anti-retroviral therapy (ARV) has been successful in remarkably reducing HIV-related mortality. However, an increased emergence of resistance to the drug therapy is concerning.

Amongst the various drug classes available in the ARV, no drug is resistance-proof. The drugs belonging to the same class have a similar mechanism of action against the virus. So resistance developed against a particular class of drug inevitably leads to resistance against all the other drugs belonging to that class. An individual with HIV infection may have one or more drug-resistant mutations, which makes the person less sensitive to one or more anti-retroviral drugs. When the replication of virus in the system is not suppressed fully, a resistance towards it develops.

Non-compliance of the ARV results in resistance. Resistant viruses can spread the infection and affect ARV therapy. Drug resistance is usually attributed to inadequate adherence to the regimen. But in some cases, strict adherence to the drug is seen, yet there is a presence of resistance due to poor absorption. This implies that since the drug is not getting adequately absorbed in the body, it is unable to prevent the replication thus leading to drug resistance.

Anti-retroviral treatment is aimed at limiting the replication of HIV in the body. Various drug classes target different steps of replication, which stops further replicating and infecting of the cells. The nucleo-capsid contains viral genome and three enzymes vital to HIV life cycle:

  • Reverse transcriptase - Transcribes viral RNA genome into complementary deoxyribonucleic acid (DNA)
  • Integrase - Facilitates incorporation of pro-viral DNA into host cell genome
  • Protease - Cleaves viral polypeptide into individual functional enzymes

Drugs targeted on these steps are as follows

  • Nucleoside and non-nucleoside reverse transcriptase inhibitors like Nevirapine and Efavirenz act on the reverse transcriptase enzyme.
  • Integrase inhibitor Raltegravir acts on the Integrase enzyme.
  • Protease inhibitors like Ritonavir, Indinavir, Saquinavir act on the Protease enzyme.
  • Fusion inhibitor Enfuvirtide acts to prevent fusion of HIV with cell membranes.
  • CCR5 inhibitor Maraviroc block the CCR5 co-receptor.
  • A viral mutation occurring at any stage of this process can affect the efficacy of the drug therapy.

The emergence of drug resistance can be managed by evaluation of drug absorption and ensure strict adherence to the drug schedule. Genotype tests can be done to look for drug-resistant mutations in genes. Phenotype tests are done for measuring the ability of a virus in an individual to undergo replication in different drug concentrations. A successfully administered and effectively acted first-line drug treatment, preferably a 3-drug combination, reduces the chances of drug resistance in future.

In case you have a concern or query you can always consult an expert & get answers to your questions!

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