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Akt-4 Kit

Manufacturer :  Lupin Ltd
Medicine Composition :  Isoniazid, Rifampicin, Ethambutol, Pyrazinamide
Prescription vs OTC : Prescription by Doctor not required

About Akt-4 Kit

Akt-4 Kit is a combination drug employed in tuberculosis treatment. It protects by inhibiting the growth of the infection-causing bacteria. Since it kills tuberculosis organisms, it is used in the treatment of the vicious disease. Till the effectiveness of the medicine is increased, it is supposed to be used with other medicines.

Created by Lupin Ltd, Akt-4 Kit is comprised of 3 tablets and a capsule. Out of these 3 tablets, the first tablet is a combination of Ethambutol and Isoniazid, two tablets are of Pyrazinamide and the capsule is comprised of Rifampicin, which is used for the treatment and prevention of tuberculosis.

The medicine has to be consumed 1-2 hours before meals and the dosage prescribed by the doctor is highly dependent on medical condition of the patient, the age, and the response of the patient’s body to the first dose of the medicine. It is known as a pro-drug as Akt-4 Kit medicine is an inactive compound.

The catalase of the bacteria is used to activate the compound. The drug then inhibits the synthesis of the mycolic acids once it has been activated. It avoids the growth of bacteria that facilitates tuberculosis, kills a huge range of infection causing bacteria and also restricting the growth of the cell wall of the bacteria. Since the drug is a prescription medicine, it should be taken only after a doctor’s consultation.

Akt-4 Kit is a prescription drug and should only be taken as instructed by the doctor, at a fixed time for better efficacy of the drug. The course of the therapy should be completed even after improvement in symptoms as discontinuing the medicines may alter the potency of the drug.

Before taking Akt-4 Kit, notify your doctor of any allergies, recent medications, and health conditions that may or may not interfere with the treatment. Caution should be taken in patients suffering from kidney and liver malfunctions.

In the case of pregnancy or breastfeeding, discuss with the doctor before starting Akt-4 Kit. The doctor may also require laboratory tests to see the effect of the drug on the body. It is recommended to rest and have a nutritious diet for a quick recovery.

    What are the uses of Akt-4 Kit

    • Tuberculosis

    What are the contraindications of Akt-4 Kit ?

    What are the side effects of Akt-4 Kit ?

    Key highlights of Akt-4 Kit

    • Is It safe with alcohol?

      Alcohol consumption must be avoided while taking this medicine. Consult your doctor before using this drug.

    • Are there any pregnancy warnings?

      This medicine is probably found to be unsafe. Thus women who are pregnant must consult doctor before using this drug.

    • Are there any breast-feeding warnings?

      Akt can be used by breastfeeding women but only after consulting the doctor.

    • Is it safe to drive while on this medicine?

      Akt-4 Kit can cause drowsiness in the patient which can be very dangerous while driving. The patient must refrain from performing any activity that requires alertness in the patient.

    • Does this affect kidney function?

      Patients suffering from any renal infections don’t need any dose alterations since there are no interactions between the drug and the renal impairment.

    • Does this affect liver function?

      Patients that have a history of liver damage must consult the doctor. As the drug individually taken or in combination is a potent hepatotoxic. But this may interaction may vary from person to person.

    • How long is the duration of effect?

      The effect of Akt-4 Kit and its duration is not clinically known.

    • What is the onset of action?

      The onset of the medicine and its peak effect timings are not clinically known.

    • Is it habit forming?

      Akt-4 Kit doesn’t have any habit forming tendencies.

    What are the substitutes for Akt-4 Kit ?

    Below is the list of medicines, which have the same composition, strength and form as Akt-4 Kit , and hence can be used as its substitute.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      For this tablet, the patient must take the missed dose as soon as possible and skip the dose if the time for the next dose as scheduled occurs. Doubling the dose is not advisable.

    • Are there any overdose instructions?

      If the patient overdoses, the doctor must be consulted immediately and medical attention must be provided as soon as possible.

    How does this medication work?

    Akt-4 Kit is a pack of 3 tablets and one capsule. Isoniazide is an inactive compound which is known as a prodrug. It needs to be activated by the catalase of bacteria. Once isoniazid has been activated it brings about inhibition of the synthesis of the mycoloic acids. Ethambutol works by inhibiting the enzyme arabinosyl transferase and stops mycobacterium cell wall synthesis by inhibiting the polymerization of arabinolgycan which is an essential component of cell wall synthesis. Pyrazinamide works by inhibiting the growth of the organism by decreasing the pH inside the cell by converting into an active metabolite called pyrazinoic acid in the presence of pyrazinamidase. Rifampicin inhibits bacterial RNA polymerase which is the enzyme responsible for the transcription of DNA. Rifampicin binds and prevents RNA synthesis by blocking elongation and synthesis of bacterial proteins. It blocks the bond between nucleotides in the RNA backbone.

      What are the interactions of Akt-4 Kit ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

      • Interaction with Medicine

        Akt-4 Kit reacts severely with medicines and products such as Aluminium Hydroxide, Aprepitant, Bromazepam, Citalopram, Clopidogrel, Enalapril, Eplerenone, Halothane, Imatinib, Imidapril, Leflunomide, Mipomersen, NSAIDs, Nateglinide, Oxide, Probenecid, Repaglinide, Rifampin, and Tadalafil.

      • Interaction with Disease

        Akt-4 Kit interacts strongly with heart diseases or arrhythmia with drugs that cause QT prolongation (Arrhythmia and antipsychotics) and should be reported as soon as possible to the doctor. People who have been suffering from colitis and have a history of gastrointestinal diseases must refrain from taking up this medicine because of how it will affect the patient. Abdominal pain and severe diarrhoea must be reported to the doctor immediately.

      FAQs about Akt-4 Kit

      • Ques : What is Akt-4 Kit?

        Ans : Akt is a medication which has Ethambutol, Isoniazid, Pyrazinamide, and Rifampin as active elements present in it. This medicine performs its action by preventing the growth of bacteria that causes tuberculosis, restraining the growth of tuberculosis-causing bacteria, killing a wide range of infection-causing bacteria, constricting the growth of bacterial cell wall.

      • Ques : What are the uses of Akt-4 Kit?

        Ans : Akt is used for the treatment and prevention from conditions such as Tuberculosis, Bacterial infection of membranes covering the spinal cord, Phthisis, and Contagious disease of the skin.

      • Ques : What are the Side Effects of Akt-4 Kit?

        Ans : Side effects include jaundice, skin rash, teary eyes, etc.

      • Ques : What are the instructions for storage and disposal Akt-4 Kit?

        Ans : Akt should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets.

      • Ques : Can Akt 4 Kit be used for tuberculosis and bacterial infection of membranes covering the spinal cord?

        Ans : Yes, AKT can be used for the treatment of tuberculosis and bacterial infection of membranes which covers the spinal cord. Please do not use this tablet for tuberculosis and bacterial infection of membranes covering the spinal cord without consulting first with your doctor. It is a prescribed kit.

      • Ques : How long do I need to use akt 4 kit before I see improvement of my conditions?

        Ans : This medication should be consumed till the complete eradication of disease. Thus it is advised to use, till the time directed by your doctor and moreover taking this medication longer than it was prescribed, can also cause inadequate effect on the patient. So please consult your doctor.

      • Ques : At what frequency do I need to use akt 4 kit ?

        Ans : This medication is generally used once or twice a day, as the time interval upto which this medication has an impact, is around 12 to 24 hours, but it is not the standard frequency for using this medication. It is advised to consult your doctor for the dosage, as the frequency also depends on the patient's condition.

      • Ques : Should I use akt 4 kit empty stomach, before food or after food?

        Ans : This medication is common to consume orally and the salts involved in this medication, work properly at an empty stomach. It is advised to consume this medication, 1 hour before having food and at least 2 hours after having food. Taking it with food, can cause stomach upset. Please consult the doctor before use.

      • Ques : What are the instructions for storage and disposal of akt 4 kit?

        Ans : Akt-4 Kit should be kept at 20 to 25 ℃, away from the humid environment and direct heat.

      • Ques : Does Akt-4 Kit lead to discolouration of urine?

        Ans : Akt-4 Kit may cause temporary discolouration of urine, sweat, teeth, and saliva as it contains Rifampicin.

      • Ques : Does Akt-4 Kit lead to visual impairment?

        Ans : Akt-4 Kit may cause visual impairment in some patients, consult with your doctor in case of a change in vision.

      • Ques : Should Akt-4 Kit be taken with a meal or without a meal?

        Ans : Akt-4 Kit should be taken without a meal on an empty stomach.

      • Ques : What are the dietary restrictions while taking Akt-4 Kit?

        Ans : There are no dietary restrictions while taking Akt-4 Kit unless the doctor instructs otherwise.


      • Pyrazinamide- Drug Information Portal [Internet]. 2019 [Cited 25 April 2019]. Available from:

      • Ethambutol- Drug Information Portal [Internet]. 2019 [Cited 25 April 2019]. Available from:

      • Rifampicin- Drug Information Portal [Internet]. 2019 [Cited 25 April 2019]. Available from:

      • Isoniazid- Drug Information Portal [Internet]. 2019 [Cited 25 April 2019]. Available from:

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Yuvraj Arora MongaMD-Pharmacology, MBBSSexology

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