Akt-4 Kit

Akt-4 Kit is a combination drug employed in tuberculosis treatment. It protects by inhibiting the growth of the infection-causing bacteria. Since it kills tuberculosis organisms, it is used in the treatment of the vicious disease. Till the effectiveness of the medicine is increased, it is supposed to be used with other medicines.

Created by Lupin Ltd, Akt-4 Kit is comprised of 3 tablets and a capsule. Out of these 3 tablets, the first tablet is a combination of Ethambutol and Isoniazid, two tablets are of Pyrazinamide and the capsule is comprised of Rifampicin, which is used for the treatment and prevention of tuberculosis.

The medicine has to be consumed 1-2 hours before meals and the dosage prescribed by the doctor is highly dependent on medical condition of the patient, the age, and the response of the patient’s body to the first dose of the medicine. It is known as a pro-drug as Akt-4 Kit medicine is an inactive compound.

The catalase of the bacteria is used to activate the compound. The drug then inhibits the synthesis of the mycolic acids once it has been activated. It avoids the growth of bacteria that facilitates tuberculosis, kills a huge range of infection causing bacteria and also restricting the growth of the cell wall of the bacteria. Since the drug is a prescription medicine, it should be taken only after a doctor’s consultation.

Akt-4 Kit is a prescription drug and should only be taken as instructed by the doctor, at a fixed time for better efficacy of the drug. The course of the therapy should be completed even after improvement in symptoms as discontinuing the medicines may alter the potency of the drug.

Before taking Akt-4 Kit, notify your doctor of any allergies, recent medications, and health conditions that may or may not interfere with the treatment. Caution should be taken in patients suffering from kidney and liver malfunctions.

In the case of pregnancy or breastfeeding, discuss with the doctor before starting Akt-4 Kit. The doctor may also require laboratory tests to see the effect of the drug on the body. It is recommended to rest and have a nutritious diet for a quick recovery.

This medication is primarily used for the following conditions:

• Tuberculosis

• Hypersensitivity

• Secondary Hyperuricemia

• Liver Disease

Following are some of the common side effects that may occur:

• Nausea

• Vomiting

• Rash

• Fever

• Dark Colored Urine

• Sweating

• Salivation

• Watery Eyes

• Peripheral Neuropathy

• Increased Liver Enzymes

• Jaundice

• Increased Uric Acid Level In Blood

• Visual Impairment

• Is It safe with alcohol?

  Alcohol consumption must be avoided while taking this medicine. Consult your doctor before using this drug.

• Are there any pregnancy warnings?

  This medicine is probably found to be unsafe. Thus women who are pregnant must consult doctor before using this drug.

• Are there any breast-feeding warnings?

  Akt can be used by breastfeeding women but only after consulting the doctor.

• Is it safe to drive while on this medicine?

  Akt-4 Kit can cause drowsiness in the patient which can be very dangerous while driving. The patient must refrain from performing any activity that requires alertness in the patient.

• Does this affect kidney function?

  Patients suffering from any renal infections don’t need any dose alterations since there are no interactions between the drug and the renal impairment.

• Does this affect liver function?

  Patients that have a history of liver damage must consult the doctor. As the drug individually taken or in combination is a potent hepatotoxic. But this may interaction may vary from person to person.

• How long is the duration of effect?

  The effect of Akt-4 Kit and its duration is not clinically known.

• What is the onset of action?

  The onset of the medicine and its peak effect timings are not clinically known.

• Is it habit forming?

  Akt-4 Kit doesn’t have any habit forming tendencies.

Below is the list of medicines, which have the same composition, strength and form as Akt-4 Kit , and hence can be used as its substitute.

• Rf 4 Kit

  Sunij Pharma Pvt Ltd

• Forecox Kit

  Macleods Pharmaceuticals Pvt Ltd

• Are there any missed dose instructions?

  For this tablet, the patient must take the missed dose as soon as possible and skip the dose if the time for the next dose as scheduled occurs. Doubling the dose is not advisable.

• Are there any overdose instructions?

  If the patient overdoses, the doctor must be consulted immediately and medical attention must be provided as soon as possible.

Akt-4 Kit is a pack of 3 tablets and one capsule. Isoniazide is an inactive compound which is known as a prodrug. It needs to be activated by the catalase of bacteria. Once isoniazid has been activated it brings about inhibition of the synthesis of the mycoloic acids. Ethambutol works by inhibiting the enzyme arabinosyl transferase and stops mycobacterium cell wall synthesis by inhibiting the polymerization of arabinolgycan which is an essential component of cell wall synthesis. Pyrazinamide works by inhibiting the growth of the organism by decreasing the pH inside the cell by converting into an active metabolite called pyrazinoic acid in the presence of pyrazinamidase. Rifampicin inhibits bacterial RNA polymerase which is the enzyme responsible for the transcription of DNA. Rifampicin binds and prevents RNA synthesis by blocking elongation and synthesis of bacterial proteins. It blocks the bond between nucleotides in the RNA backbone.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

• Interaction with Medicine

  Akt-4 Kit reacts severely with medicines and products such as Aluminium Hydroxide, Aprepitant, Bromazepam, Citalopram, Clopidogrel, Enalapril, Eplerenone, Halothane, Imatinib, Imidapril, Leflunomide, Mipomersen, NSAIDs, Nateglinide, Oxide, Probenecid, Repaglinide, Rifampin, and Tadalafil.

• Interaction with Disease

  Akt-4 Kit interacts strongly with heart diseases or arrhythmia with drugs that cause QT prolongation (Arrhythmia and antipsychotics) and should be reported as soon as possible to the doctor. People who have been suffering from colitis and have a history of gastrointestinal diseases must refrain from taking up this medicine because of how it will affect the patient. Abdominal pain and severe diarrhoea must be reported to the doctor immediately.