Pyrazinamide
About Pyrazinamide
Pyrazinamide is an anti-tubercular medicine, which is used alongside other medicines to treat tuberculosis. It also prevents the infection from spreading. If you notice some unwanted effects like a fever, tenderness in the abdomen, jaundice, nausea, vomiting or lack of appetite inform your doctor immediately.
This medicine is not recommended during pregnancy or breastfeeding unless absolutely necessary. Consult your doctor about the potential risks and benefits before starting your treatment with this medicine.
If you suffer from the medical conditions mentioned here, inform your doctor so extra care can be taken during the treatment:
- pregnant or breast-feeding.
- kidney or liver problems, alcoholism, acute gout, diabetes or porphyria.
- If you are taking any other medicines including those which are available without a prescription as well as herbal and complementary medicines.
- Allergic to any medicine.
This medicine will be prescribed to you and you will be asked to take it three times a week during the first two months of your treatment under the supervision of a healthcare provider. Taking the tablets regularly and on time is very important.
It is also important to complete the course of treatment so that there are no chances of the infection to come back. The effect of this medicine can be observed within the first 2 hours of taking it and lasts for an average duration of 27 to 30 hours.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
What are the uses of Pyrazinamide
Tuberculosis
This medication is used in the treatment of tuberculosis which is a lung disease caused by Mycobacterium tuberculosis.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
What are the contraindications of Pyrazinamide ?
Not recommended in patients with known allergy to this medication.
Severe Liver Impairment
Not recommended in the patients with severe liver impairment.
Acute Gout
Not recommended in patients with increased uric acid levels or acute gout.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
What are the side effects of Pyrazinamide ?
Loss Of Appetite
Unusual Tiredness And Weakness
Yellow Colored Eyes Or Skin
Flushing
Pruritus
Urticaria
Photosensitivity
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
Key highlights of Pyrazinamide
How long is the duration of effect?
The effect of this medicine lasts for an average duration of 27 to 30 hours.
What is the onset of action?
The effect of this medicine can be observed in 2 hours.
Are there any pregnancy warnings?
This medicine is not recommended for use during pregnancy unless absolutely necessary.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is excreted in breast milk. It is recommended for breastfeeding women only if clearly needed.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
What are the dosage instructions?
Missed Dose instructions
If you miss a dose of medication, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Are there any overdose instructions?
Seek emergency medical treatment or contact the doctor in case of an overdose.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
Where is the Pyrazinamide approved?
India
United States
Japan
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
Medicines containing Pyrazinamide
Below is the list of medicines, which contains Pyrazinamide as ingredient
- Macrozide 1000 MG Tablet
Macleods Pharmaceuticals Pvt.Ltd
- Koxymide 450 MG Tablet
Lark Laboratories Ltd
- Macrozide 750 MG Tablet
Macleods Pharmaceuticals Pvt.Ltd
- Forecox -150 Tablet
Macleods Pharmaceuticals Pvt Ltd
- Pyra 1200 MG Tablet
Maneesh Pharmaceuticals Ltd
- Mzide 1000 MG Tablet
Marc Pharma
- Pza Ciba 1000 MG Tablet
Novartis India Ltd
- Macrozide 1200 MG Tablet
Macleods Pharmaceuticals Pvt.Ltd
- Actizid 1500 MG Tablet
Overseas Healthcare Pvt Ltd.
- Pyzina 1000 MG Tablet
Lupin Ltd
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
How does this medication work?
This medicine belongs to an antitubercular class of drugs. It works by inhibiting the growth of the organism by decreasing the pH inside the cell by converting it into an active metabolite called pyrazinoic acid in the presence of pyrazinamidase.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.
What are the interactions of Pyrazinamide ?
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
- test
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Interaction with Medicine
Methotrexate
These medicines may increase the risk of liver injury. Inform the doctor if you are receiving these medicines. The baseline of liver function tests should be obtained before starting the treatment. Any signs and symptoms of elevated liver enzymes, yellow colored eyes, and skin, dark urine should be reported to the doctor.Cholera Vaccine
If you have taken this medication, then it is advisable to wait for 14 days before taking the Cholera vaccine. Usage of other antibiotics and vaccines should be reported to the doctor.Interaction with Disease
Gout
This medicine is not recommended in patients with gout. Inform the doctor about your medical condition. Serum uric acid levels should be monitored carefully. Discontinue the treatment if the symptoms persist.Interaction with Food
Food
Information not available.
FAQs about Pyrazinamide
Ques : What is Pyrazinamide?
Ans : is an anti-tuberculosis medicine which is used alongside other medicines to treat tuberculosis.
Ques : How long do I need to use Pyrazinamide before I see improvement in my condition?
Ans : This medication is to be taken till the time you see an improvement in your health conditions.
Ques : At what frequency do I need to use Pyrazinamide?
Ans : This medication will be prescribed to you and you will be asked to take it three times a week, during the first two months of your treatment
Ques : Should I use Pyrazinamide empty stomach, before food or after food?
Ans : This medication should be taken after food in a prescribed dosage.
Ques : What are the instructions for the storage and disposal of Pyrazinamide?
Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
References
Pyrazinamide- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 11 December 2019]. Available from:
https://druginfo.nlm.nih.gov/drugportal/name/pyrazinamide
Pyrazinamide- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 11 December 2019]. Available from:
https://www.drugbank.ca/drugs/DB00339
Zinamide 500mg Tablets- EMC [Internet] medicines.org.uk. 2015 [Cited 11 December 2019]. Available from:
https://www.medicines.org.uk/emc/product/5273/smpc
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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