Rabiplus-Ls Capsule

Rabiplus-Ls Capsule is a combination medication, primarily used for treating ulcerative GERD. It is also prescribed for erosive healing, maintenance of ulcerative GERD, duodenal ulcers, irritable bowel syndrome and chronic gastritis. Recently, it has also come to be used in the treatment of hypersecretory conditions that include Zollinger-Ellison syndrome.

On using Rabiplus-Ls Capsule the associated side effects that you may suffer from are disorientation, delirium, the elevation of thyroid-stimulating hormone (TSH), rhabdomyolysis, bullous, erythema multiforme, drug-induced diarrhoea, twitching, tremor, weight gain or akathisia.

In certain severe cases, you may experience jaundice, interstitial pneumonia, tardive dyskinesia, gynecomastia (a disorder of the endocrine system where there is an enlargement of the male breast size). In the latter case it will be necessary for you to seek medical attention.

Before using this medication it is advised that you consult your doctor and tell him/her if you had/have or are:

• Pregnant, or are planning to become pregnant.
• Nursing a baby
• Taking any prescriptive or over the counter drugs, herbals medications or dietary supplements.
• A recent surgery or are scheduled for one in the near future.
• Pheochromocytoma or gastrointestinal perforation.
• A history of cancer-related disease.
• A history of epilepsy or any other kind of seizures.
• Allergic to any medicine, food or substance.

The dosage of this medication will be as prescribed by your doctor as per the severity of your condition, your age, gender and overall medical history. But commonly a dose of 25 mg of this medicine is prescribed which needs to be taken three times in a day. Results may start to show within an hour or two of using. In case of drug overdose notify your physician right away.

• Gastroesophageal Reflux Disease

• Irritable Bowel Syndrome (Ibs)

• Duodenal Ulcer

• Intestinal Ulcer

• Allergy

• Epilepsy

• Bipolar Disorder

• Pheochromocytoma

• Breast Cancer

• Breast Tenderness

• Gynecomastia

• Weight Gain

• Unusual Tiredness And Weakness

• Decrease In Libido

• Fever

• Excessive Sweating

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 5-8 hours upon oral administration.

• What is the onset of action?

  The effect of this medicine can be observed within 1-2 hours of oral administration.

• Are there any pregnancy warnings?

  This medication is not recommended for use in pregnant women owing to the risk of abnormalities in the fetus. Alternate means of blood sugar control like insulin therapy should be considered during pregnancy.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medication is not recommended for use in breastfeeding women owing to the risk of adverse effects on the baby. Alternate means of blood sugar control like insulin therapy should be considered in such cases. If it becomes absolutely necessary to take this medicine, then breastfeeding should be discontinued.

• Is it safe to drive while on this medicine?

  This medicine affects the consciousness of the patient, thus driving must be avoided while taking this medicine.

• Is It safe with alcohol?

  It is found to be unsafe to consume alcohol while taking this medicine.

• Does this affect kidney function?

  Only limited information is available regarding its use in patients with kidney disease. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. Adjustment of dose is needed. Kindly consult your doctor before taking this medicine.

Below is the list of medicines, which have the same composition, strength and form as Rabiplus-Ls Capsule , and hence can be used as its substitute.

• R-Ppi-L 75Mg/20Mg Capsule

  Blue Cross Laboratories Ltd

• Rabopep L Capsule

  Seagull Labs (I) Pvt Ltd

• Rabetero-L Capsule

  Hetero Drugs Ltd

• Pepcia L 75Mg/20Mg Capsule

  FDC Ltd

• Rabera-L Capsule

  Jenburkt Pharmaceuticals Ltd

• Prorab-L Tablet

  Wockhardt Ltd

• Beepraz L 75Mg/20Mg Capsule

  Galpha Laboratories Ltd

• L Lyrab 75Mg/20Mg Capsule

  Lyka Labs

• Wokride 75 Mg/20 Mg Capsule

  Wockhardt Ltd

• RABIPEN PLUS CAPSULE

  Morepen Laboratories Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped.

• Are there any overdose instructions?

  Contact a doctor in case of overdose.

This medicine is a combination of Levosulpiride and Rabeprazole. These two belongs to neuroleptic and PPI class respectively. Thus this medicine works via the dual mechanism.

Firstly, it works by selectively binding to dopamine receptors in the brain and the periphery. This action results in an increased tone of muscles in the gastrointestinal tract. Secondly, it binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Ethanol

  Avoid or limit the uptake of alcohol while taking this medicine as the risk of adverse effects are increasingly high. Contact your doctor if an excess of drowsiness is experienced.

• Interaction with Others

  Ipratropium

  Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.

• Interaction with Lab Test

  Prolactin test

  Report the use of this medicine before undergoing a laboratory test to determine the levels of the hormone prolactin in the body. This medicine can interfere with the test and yield false positive results.

• Interaction with Medicine

  Gastrointestinal Bleeding

  This medicine should be used with extreme caution in patients suffering from perforation and bleeding of the stomach and the intestine. Report any instance of fever with chills, nausea, vomiting, presence of blood in stool to the doctor.

  Neuroleptic Malignant Syndrome (Nms)

  Use of this medicine is not recommended if the patient suffers from Neuroleptic malignant syndrome. Introduction or reintroduction of this medicine should be done with caution in patients having a known history of this syndrome.

  Diltiazem

  Report the use of diltiazem or any other medicine taking for managing high blood pressure to the doctor. These medicines should be used with caution as the risk of adverse effects are increasingly high. Your doctor may determine the best course of treatment after assessing the conditions.

  Pregabalin

  Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.

  Sucralfate

  Report the use of either of the medicine to the doctor. You may require a dose adjustment and frequent clinical monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.

  Diltiazem

  Report the use of diltiazem or any other medicine taking for managing high blood pressure to the doctor. These medicines should be used with caution as the risk of adverse effects are increasingly high. Your doctor may determine the best course of treatment after assessing the conditions.

  Pregabalin

  Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.

  Tramadol

  Report the use of any narcotic pain-killer medicine to the doctor. These medicines should be used with extreme caution as the risk of adverse effects are significantly high. Your doctor may decide the best course of treatment after assessing the conditions.

  Aluminium Hydroxide/Magnesium Hydroxide

  Report the use of any aluminum or magnesium containing antacids to the doctor before receiving this medicine. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together.

  Other medications

  Its action on GI motility could also be antagonized by concomitant use of narcotics, anticholinergic agents and analgesics.

• Interaction with Food

  Food

  Information not available.

• Interaction with Disease

  Lactic Acidosis

  You should report the incidence of conditions like kidney impairment, heart disease, severe diarrhea, septicemia to the doctor before taking Rabeprazole. Supervised dosing and monitoring of blood sugar levels might be required in such cases. Any signs and symptoms indicative of the above-mentioned conditions should be reported immediately.

  Vitamin B12 Deficiency

  Inform the doctor about incidences of anemia or Vitamin B12 deficiency so that suitable Vitamin supplements can be prescribed if needed.

• Ques : What is Rabiplus-Ls Capsule?

  Ans : This medicine is a combination of levosulpiride and rabeprazole. It is primarily used for the treatment of Gastroesophageal reflux disease and irritable bowel syndrome.

• Ques : What is the use of Rabiplus-Ls Capsule?

  Ans : It is prescribed for treating the following-

  • Healing of erosive or ulcerative gastro-oesophageal reflux disease (GERD)
  • Maintenance of healing of erosive or ulcerative GERD
  • Healing of duodenal ulcers
  • Treatment of pathological hypersecretory conditions, including Zollinger- Ellison syndrome
  • Irritable bowel syndrome
  • Chronic gastritis

• Ques : What are the side effects of Rabiplus-Ls Capsule?

  Ans : This medication has many common side effects such as Nausea, Stomach pain, Diarrhea, Flatulence, Constipation, Headache, Dizziness, Weakness, Sleepiness, Flu-like symptoms. In case of patients having any of the side effects or issues like allergic reactions or skin rashes. It is advised to stop the consumption of this medicine and contact to doctor as soon as possible.

• Ques : For what treatment Rabiplus-Ls Capsule used for?

  Ans : Levosulpiride is used to treat conditions like stomach and intestine disorders. It is also used for Gastroesophageal Reflux Disease and acidity. Levosulpiride helps to improve bowel system.

• Ques : How long do I need to use Rabiplus-Ls Capsule before I see improvement in my condition?

  Ans : This medication should be consumed, until the complete eradication of the disease.

• Ques : At what frequency do I need to use Rabiplus-Ls Capsule?

  Ans : The duration of effect for this medicine is dependent on the severity of the patient’s condition. Therefore the frequency of usage of this medication will vary from person to person. It is advised to follow the proper prescription of the doctor, directed according to the patient's condition.

• Ques : Should I use Rabiplus-Ls Capsule empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Rabiplus-Ls Capsule?

  Ans : This medication contains salts which are suitable to store only at room temperature, as keeping this medication above or below that, can cause an inadequate effect.

• Levosulpiride- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/levosulpiride

• Rabeprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/117976-89-3

• New Drugs Approved by CDSCO, Central Drugs Standard Control Organisation, Government of India [Internet]. cdscoonline.gov.in [Cited 23 January 2020]. Available from:

  https://cdscoonline.gov.in/CDSCO/Drugs