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Overview

Zolorel 1 MG Tablet

Manufacturer :  Group Pharmaceuticals Ltd
Medicine Composition :  Alprazolam
Prescription vs OTC : Prescription by Doctor required

About Zolorel 1 MG Tablet

Zolorel 1 MG Tablet is an effective drug prescribed to patients who have panic disorders and anxiety disorders as a result of depression. The drug controls the levels of certain unbalanced chemicals released by the brain in patients who suffer from depression.

Zolorel 1 MG Tablet is a part of a group of medicines which go by the name of benzodiazepine. This class of drugs work in a way through which they calm the brain and the central nervous system, preventing panic attacks.

The drug is meant for oral consumption and should not be chewed or swallowed whole. Allow the tablet to dissolve when you place it in your mouth before gulping it down. In case you are taking the liquid form of Zolorel 1 MG Tablet, measure it properly and only take the dosage that has been prescribed.

Before you start the drug be sure to research some general information about it. For instance, the drug is not meant for patients who suffer from problems like glaucoma and allergies.

To ensure if Zolorel 1 MG Tablet is safe for consumption, inform your doctor if you have health issues like:

  • Epileptic seizures
  • Asthma
  • Depression and suicidal thoughts
  • Addiction to alcohol or drugs
  • Taking narcotic medication.

Zolorel 1 MG Tablet can result in birth defects. Therefore it cannot be taken by pregnant women. Traces of the drug has been found in breast milk too and can have a negative impact on the infant. Thus, nursing mothers are also advised not to take Zolorel 1 MG Tablet.

Some side effects of the drug include tiredness, feeling sleepy, memory issues, and developing anxiousness. Experiencing withdrawal symptoms is also a common side effect of Zolorel 1 MG Tablet. Misuse of Zolorel 1 MG Tablet can result in overdosage and even death in extreme cases. This drug can become addictive, thus it should be kept away from individuals who have a history of drug addiction.

Use Zolorel 1 MG Tablet with caution in patients with depression, particularly if suicidal risk may be present. Episodes of mania or hypomania have occurred in depressed patients treated with alprazolam.

May cause physical or psychological dependence - use with caution in patients with a history of drug dependence. Acute withdrawal, including seizures, may be precipitated in patients after administration of flumazenil to patients receiving long-term benzodiazepine therapy.

Use Zolorel 1 MG Tablet with caution in patients with depression, particularly if suicidal risk may be present. Episodes of mania or hypomania have occurred in depressed patients treated with alprazolam.

May cause physical or psychological dependence - use with caution in patients with a history of drug dependence. Acute withdrawal, including seizures, may be precipitated in patients after administration of flumazenil to patients receiving long-term benzodiazepine therapy.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the uses of Zolorel 1 MG Tablet

    • Anxiety

      Zolorel 1 MG Tablet is used in the treatment of anxiety disorders. Uneasiness, difficulty in sleeping, sweating of hands and feet are some of the symptoms of anxiety disorder.

    • Panic Disorder

      Zolorel 1 MG Tablet is used in the treatment of the panic disorder. Sweating, breathing problem, weakness and numbness in hands are some of the symptoms of panic disorder.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the contraindications of Zolorel 1 MG Tablet ?

    • Allergy

      Avoid taking this medicine if you have a known allergy to Zolorel 1 MG Tablet or other benzodiazepines.

    • Azole antifungal agents

      Avoid taking this medicine If you are using azole antifungal agents like Ketoconazole and Itraconazole. These medicines will increase the concentration of Zolorel 1 MG Tablet by increasing its availability in the body.

    • Narrow Angle Glaucoma

    • Pregnancy

    • Asthma

    • Depression

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the side effects of Zolorel 1 MG Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    Key highlights of Zolorel 1 MG Tablet

    • How long is the duration of effect?

      This medicine is excreted in urine and the effect lasts for a duration of 44 hours for an immediate release tablet and 52 hours for an extended release tablet / disintegrating tablet.

    • What is the onset of action?

      The peak effect can be observed in 1 to 2 hours for an immediate release tablet, 1.5 to 2 hours for a disintegrating tablet and 9 hours for an extended release tablet.

    • Is it habit forming?

      Habit forming tendency has been reported

    • Are there any breast-feeding warnings?

      This medicine is known to excreted through human breast milk. It is not recommended for breastfeeding women.

    • Are there any pregnancy warnings?

      This medicine is contraindicated during pregnancy. If you are pregnant, you must consult a doctor before taking this medication.

    • Does this affect liver function?

      It is advised to not consume the drug if you have any known problems in the organ. Talk to your doctor for further consultation. Reduce dose by 50% to 60% or avoid in cirrhosis.

    • Is It safe with alcohol?

      No, the drug should not be consumed if you have had alcohol before bed or during daytime because alcohol can add to the side effects experienced due to the tablet. Alcohol taken with Zolorel 1 MG Tablet can cause severe respiratory depression and breathlessness.

    • Is it safe to drive while on this medicine?

      It may affect the alertness of the patient taking this medicine. Thus it is suggested to avoid driving if taking this medication.

    • Does this affect kidney function?

      It is assumed to be safe to use in patients with kidney disease. Limited data is available to suggest requirement of dose adjustment. Kindly consult your doctor before taking this medication.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the substitutes for Zolorel 1 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Zolorel 1 MG Tablet , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      If you miss a dose of Zolorel 1 MG Tablet, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    Where is the Zolorel 1 MG Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    How does this medication work?

    This medicine, like other benzodiazepines, has a high affinity for the benzodiazepine binding site in the brain. It facilitates the inhibitory neurotransmitter action of gamma-aminobutyric acid, which mediates both pre- and postsynaptic inhibition in the central nervous system (CNS). Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to chloride ions. This shift in chloride ions results in hyperpolarization (a less excitable state) and stabilization.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

      What are the interactions of Zolorel 1 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Consumption of alcohol with this medicine is not recommended as it increases the risk of depression and breathlessness.
      • Interaction with Lab Test

        This medicine causes an increase in the level of alkaline phosphatase.
      • Interaction with Medicine

        Cetirizine

        Use of Zolorel 1 MG Tablet with cetirizine or levocetirizine should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Metoclopramide

        Use of Zolorel 1 MG Tablet with metoclopramide should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Opioids

        Opioids like morphine, codeine, tramadol, hydrocodone or any cough preparations containing these medicines should be avoided when you are on Zolorel 1 MG Tablet or other benzodiazepines. Appropriate dose adjustments are to be made if coadministration is needed and monitoring of sedation, breathlessness, and hypotension is necessary.

        Azole antifungal agents

        Azole antifungal agents like ketoconazole and itraconazole should be avoided when you are Zolorel 1 MG Tablet due to the risk of increased concentrations of the medicine in the body which may cause increased sedation and changes in ECG. Inform the doctor if you are receiving these medicines when you are prescribed with Zolorel 1 MG Tablet. If coadministration is needed then alternative medicines like lorazepam and oxazepam could be considered.

        Antihypertensives

        You may experience hypotensive effects like dizziness, lightheadedness if these medicines are used together. Regular monitoring of blood pressure is necessary. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Others

        This medicine interacts with Cimetidine, ciprofloxacin, clarithromycin, clozapine, CNS depressants, diltiazem, disulfiram, digoxin, erythromycin, ethanol, fluconazole, fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, labetalol, levodopa, loxapine, metoprolol, metronidazole, miconazole, nefazodone, omeprazole, phenytoin, protease inhibitors like amprenavir and ritonavir, rifabutin, rifampin, troleandomycin, valproic acid, verapamil may increase the serum level and/or toxicity of alprazolam; monitor for altered benzodiazepine response. Kindly consult your doctor and inform him if you are taking any of these.
      • Interaction with Disease

        Glaucoma

        Zolorel 1 MG Tablet is known to increase the fluid pressure inside the eye. It is contraindicated in acute narrow-angle glaucoma which is an eye disorder.

        Seizure Disorders

        The sudden stop of Zolorel 1 MG Tablet may cause withdrawal effects and can precipitate seizures. The dose should be reduced gradually. Do not stop taking this medicine without consulting the doctor.

        Others

        • Rebound or withdrawal symptoms, including seizures may occur 18 hours to 3 days following abrupt discontinuation or large decreases in dose (more common in patients receiving >4 mg/day or prolonged treatment). Dose reductions or tapering must be approached with extreme caution. Between dose, anxiety may also occur.
        • Use with caution in patients receiving concurrent CYP3A4 inhibitors, particularly when these agents are added to therapy. Has weak uricosuric properties, use with caution in renal impairment or predisposition to urate nephropathy. Use with caution in elderly or debilitated patients, patients with hepatic disease (including alcoholics), renal impairment, or obese patients.
        • Benzodiazepines have been associated with anterograde amnesia. Paradoxical reactions, including hyperactive or aggressive behavior, have been reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Does not have analgesic, antidepressant, or antipsychotic properties.
      • Interaction with Food

        It is recommended to consume the tablet after some time of having food. Do not consume on empty stomach. Consuming grapefruit juice, tea or coffee before or after taking the tablet can cause serious side effects.

      FAQs about Zolorel 1 MG Tablet

      • Ques : What conditions does Zolorel 1 MG Tablet treat?

        Ans : This medication is used to treat anxiety and panic disorders. It belongs to a class known as benzodiazepines which act on the brain and central nervous system to produce a calming effect.

      • Ques : Is Zolorel 1 MG Tablet a habit forming medicine?

        Ans : This medication can be habit-forming. Do not take it for a longer period of time than prescribed by your doctor.

      • Ques : How long do I need to use Zolorel 1 MG Tablet before I see improvement in my condition?

        Ans : This medication should be consumed, until the complete eradication of the disease. Thus it is advised to use as directed by your doctor.

      • Ques : Is there any special dietary instruction I should follow?

        Ans : Talk to your doctor about drinking grapefruit juice while taking this medicine.

      • Ques : What are the instructions for the storage and disposal of Zolorel 1 MG Tablet?

        Ans : Keep this medication in the container and out of reach of children. Store it at room temperature and away from excess heat and moisture.

      • Ques : What are the symptoms of Zolorel 1 MG Tablet overdose?

        Ans : Symptoms of overdose may include drowsiness, confusion, problems with coordination, loss of consciousness.

      • Ques : Is Zolorel 1 MG Tablet safe?

        Ans : This medication is safe if used at prescribed doses as advised by your medical practitioner.

      • Ques : Is Zolorel 1 MG Tablet addictive?

        Ans : Yes, the use of this drug has addictive potential. Its use is associated with the risk of addiction for physical or psychological effects.

      • Ques : Is Zolorel 1 MG Tablet an opioid?

        Ans : No, this medication is not an opioid, it belongs to a class of substances called benzodiazepines.

      • Ques : Is Zolorel 1 MG Tablet an anti-depressant?

        Ans : No, it is not an anti-depressant. This medication is used to relieve excess anxiety associated with depression.

      • Ques : Is Zolorel 1 MG Tablet a narcotic substance?

        Ans : No, it is not a narcotic substance. Zolorel 1 MG Tablet belongs to the class of medicines known as benzodiazepines.

      • Ques : Can I take Zolorel 1 MG Tablet for a hangover?

        Ans : No, this medication can not be consumed to manage hangovers.

      • Ques : Does Zolorel 1 MG Tablet reduce blood pressure?

        Ans : Yes, if you consume more than the prescribed dose of this medication, the lowering of blood pressure could be seen. It is advised to immediately consult the doctor if you experience a fall in BP.

      References

      • Alprazolam- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/alprazolam

      • Xanax Tablets 500 micrograms- EMC [Internet]. www.medicines.org.uk. 2021 [Cited 23 Nov 2021]. Available from:

        https://www.medicines.org.uk/emc/product/1656/smpc

      • ALPRAZOLAM ER- alprazolam tablet, extended release- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 23 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=79619e0f-1600-40ea-e053-2a91aa0a2700

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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