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Paracetamol 650 MG Tablet

Manufacturer :  Novartis India Ltd
Medicine Composition :  Paracetamol
Prescription vs OTC : Prescription by Doctor not required

About Paracetamol 650 MG Tablet

Paracetamol 650 MG Tablet, classified as a mild analgesic, is used to treat fever and is the most commonly used pain reliever. It is used to relieve pain in case of a backache, a headache, arthritis and a toothache. This medication reduces pain in the body caused due to fever.

The active ingredient falls under the class of analgesics, belonging to the category of NSAID. This medication also reduces pain in the body caused due to fever.

It is often given to patients who suffer from cancer or have undergone surgery, to help them cope up with the pain. You should not take tablet if –

  • You are allergic to this medication.
  • You are suffering from a serious liver disorder.
  • You normally consume more than 3 alcohol beverages per day or have a history of alcoholism.

There are several drugs that may interact with this tablet. Inform your doctor about all the other medications that you take including vitamins, minerals, prescribed drugs, over the counter drugs, and herbal products. For adults, the general dose for fever and pain is 325-650 mg tablets once every 4 to 6 hours or 1000mg tablets once every 6 to 8 hours.

You must not take the medicine in more than the amount prescribed or longer than the prescribed period. It can be taken with food or without it, but you must take it, in the same way, every day.

The medicine must be swallowed whole, without trying to crush, break or mixing it in water. As it is a pain reliever, it is unlikely that you will miss a dose. In case you do, refrain from taking two doses together to make up for the missed one.

There are several drugs that may interact with Paracetamol. Inform your doctor about all the other medications that you take including vitamins, minerals, prescribed drugs, over the counter drugs and herbal products.

For adults Paracetamol the general dose for fever and pain is 325-650 mg tablets once in every 4 to 6 hours or 1000mg tablets once in every 6 to 8 hours. It is advised to be guided by the doctor’s prescription and never to exceed the prescribed dosage.

For treating Paracetamol toxicity, Acetylcysteine 140 mg/kg is administered orally (loading) followed by 70 mg/kg every 4 hours for 17 doses.

Therapy should be initiated based upon laboratory analysis suggesting high probability of hepatotoxic potential. Activated charcoal is very effective at binding acetaminophen.

Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). This medication will not reduce inflammation; consult prescriber for anti-inflammatory, if needed.

Also Read: Nor TZ Tablet Uses and Side Effects

    What are the uses of Paracetamol 650 MG Tablet

    • Fever

    • Headache

    • Muscle Pain

    • Menstrual Cramps

    • Post Immunization Pyrexia

    • Arthritis

    What are the contraindications of Paracetamol 650 MG Tablet ?

    What are the side effects of Paracetamol 650 MG Tablet ?

    Key highlights of Paracetamol 650 MG Tablet

    • How long is the duration of effect?

      The effect lasts for an average of 4-6 hours.

    • What is the onset of action?

      The effect of Paracetamol (primary constituent of Paracetamol 650 MG Tablet) can be observed within an hour of oral administration. For fever reduction, the time taken is about 30 minutes.

    • Are there any pregnancy warnings?

      Paracetamol 650 MG tablet is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is not safe to use during breastfeeding. Women who are breastfeeding should consult doctor before using this medication.

    • Is It safe with alcohol?

      Excessive intake of alcohol may increase the risk of acetaminophen-induced hepatotoxicity; avoid or limit alcohol intake

    • Is it safe to drive while on this medicine?

      It usually does not affect the patients ability to drive.

    • Does this affect kidney function?

      Dose adjustment is needed in case of renal impairment. Dosing interval in renal impairment:

      • Clcr 10-50 mL/minute: Administer every 6 hours.
      • Clcr <10 mL/minute: Administer every 8 hours (metabolites accumulate)
      • Hemodialysis: Moderately dialyzable (20% to 50%).
      Consult your doctor before taking this medication.

    • Does this affect liver function?

      Caution must be taken in patients liver disease. Appears to be well tolerated in cirrhosis; serum levels may need monitoring with long-term use. Consult your doctor before taking this medication.

    What are the substitutes for Paracetamol 650 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Paracetamol 650 MG Tablet , and hence can be used as its substitute.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.

    • Are there any overdose instructions?

      Consult your doctor in case of overdose.

    How does this medication work?

    Paracetamol 650 MG tablet selectively inhibits enzyme function in the brain which allows it to treat pain and fever. It activates certain receptors in the brain that inhibit pain signals.

      What are the interactions of Paracetamol 650 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

      • Interaction with Alcohol

        You should avoid consuming alcohol while taking this medicine. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.
      • Interaction with Lab Test

        5-HIAA Urine Test

        You may get a false-positive result for this test if you take Paracetamol.
      • Interaction with Medicine

        One must take caution while taking this medicine. This medication may interact with other medication like Ketoconazole, Metformin, Anti-hypertensives if administered concomitantly. Also, Barbiturates, carbamazepine, hydantoins, sulfinpyrazone can increase the hepatotoxic potential of acetaminophen; chronic ethanol abuse increases the risk for acetaminophen toxicity; effect of warfarin may be enhanced.
      • Interaction with Disease

        Patients suffering from liver disease should use some other safer alternative.
      • Interaction with Food

        May slightly delay absorption of extended-release preparations; rate of absorption may be decreased when given with food high in carbohydrates

      FAQs about Paracetamol 650 MG Tablet

      • Ques : What is Paracetamol 650 mg tablet?

        Ans : Paracetamol tablet is used to temporarily relieve fever and moderate pain like muscle ache, headache, toothache, arthritis, and backache. It contains Paracetamol as an active ingredient. Paracetamol 650 MG Tablet is classified as a mild analgesic and is used to treat fever and is the most commonly used pain reliever.

      • Ques : What are the uses of Paracetamol 650 mg tablet?

        Ans : Paracetamol is used for the treatment and prevention from conditions and symptoms of diseases like fever, headache, muscle pain, menstrual cramps, post immunization, and pyrexia arthritis.

      • Ques : What are the Side Effects of Paracetamol 650 mg tablet?

        Ans : Some of the side-effects include nausea or vomiting, fever, allergic skin reaction, and mouth ulcer.

      • Ques : What are the instructions for storage and disposal Paracetamol 650 mg tablet?

        Ans : Paracetamol should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

      • Ques : How long do I need to use Paracetamol 650 MG Tablet before I see improvement of my conditions?

        Ans : It is a medicine which takes 1 or 2 days before you see an improvement in your health conditions.

      • Ques : What are the contraindications to Paracetamol 650 MG Tablet?

        Ans : This medication should not be used if you have the conditions such as skin rashes, skin reddening, and skin blisters.

      • Ques : Is Paracetamol 650 MG Tablet safe to use when pregnant?

        Ans : Paracetamol 650 MG tablet is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

      • Ques : Will Paracetamol 650 MG Tablet be more effective if taken in more than the recommended dose?

        Ans : No, taking higher than the recommended dose of this medication can lead to increased chances of side effects such as bleeding, breathing problems, itching, mouth ulcers, skin rash, swelling of the face, swelling of the lips, swelling of the throat, and swelling of the tongue, etc.

      • Ques : Is there any food or drink I need to avoid, while taking Paracetamol 650 MG Tablet?

        Ans : You can follow your normal diet under the usage of this medication.

      • Ques : Will Paracetamol 650 MG Tablet be more effective if taken in more than the recommended dose?

        Ans : There is no need to take this medication more than its recommended doses.

      • Ques : Can I take other medications along with Paracetamol 650 MG Tablet?

        Ans : Do not use any OTC for cough, cold, allergy, or pain medication without consulting your doctor or pharmacist. Paracetamol 650 MG Tablet contains many combination of medicines. If you use certain products together you may accidentally use too much of Paracetamol 650 MG Tablet.

      • Ques : Can I take Paracetamol 650 MG Tablet with antibiotics?

        Ans : There are hundreds of antibiotics used to treat infections, so once you receive your prescription, ask your doctor or pharmacist if you can also take this medication at the same time that you take the antibiotic.

      • Ques : Is Paracetamol 650 MG Tablet an NSAID drug?

        Ans : No, this medication is not classified as an NSAID (nonsteroidal anti-inflammatory drug). It is classified as a miscellaneous analgesic for mild to moderate pain and fever.


      • Acetaminophen- Drug Information Portal [Internet]. 2019 [Cited 23 April 2019]. Available from:

      • Anadin Paracetamol Tablets- EMC [Internet]. 2016 [Cited 24 April 2019]. Available from:

      • Acetaminophen- DrugBank [Internet]. 2019 [Cited 27 April 2019]. Available from:

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Yuvraj Arora MongaMD-Pharmacology, MBBSSexology

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