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Overview

Mifeprin 200 MG Tablet

Mifeprin 200 MG Tablet

Manufacturer: Sun Pharma Laboratories Ltd
Medicine composition: Mifepristone
Prescription vs.OTC: Prescription by Doctor required

Mifeprin 200 MG Tablet is used to bring about an abortion in women who have been pregnant for about seven weeks or 50 days. It is used in combination with misoprostol. Mifeprin 200 MG Tablet is also known as RU-486. Mifeprin 200 MG Tablet is a synthetic steroid which functions by interfering with the hormone that helps pregnancy to continue.

On using Mifeprin 200 MG Tablet you may experience some side effects. These reactions include vaginal bleeding, constant feelings of fatigue, chest pain, cough, fever, body sores, difficulty in urination, difficulty in breathing, sweating, diarrhea, anxiety, vomiting, nausea, lightheadedness, increased abdominal pain, paleness, tremors, insomnia, weakness, acidity and indigestion.

Before taking Mifeprin 200 MG Tablet you should have a discussion with your doctor and tell him if you have any of the conditions mentioned below:

  • You are allergic to any of the ingredients contained within Mifeprin 200 MG Tablet or any other medicine.
  • You are pregnant outside your uterus region.
  • You are taking any anticoagulants.
  • You are taking any prescriptive or non-prescriptive drugs, herbal medications, dietary supplements.
  • You are going to undergo anesthesia anytime soon.
  • You are older than 35 years.
  • You smoke 10 or more cigarettes.
  • You have asthma, liver, kidney or lung diseases.

The dosage for Mifeprin 200 MG Tablet is prescribed by your doctor depending on your age, weight, overall health and current condition. The usual dose in case of abortion is about 200 mg orally once. From day two or three, the dosage is about 800 mcg every 24 or 48 hours. While taking Mifeprin 200 MG Tablet you are meant to put the tablets in each cheek pouch and keep it there for around half an hour. Should any remnants remain, swallow it with water. After 7 days, you are required to visit your doctor to check if you are still pregnant and also to monitor the quantity and frequency of the bleeding.

Termination Of Pregnancy
Mifeprin 200 MG Tablet is used for terminating pregnancies which are less than 10 weeks old. It is also used for labor induction in case of fetal death or before surgical procedures are performed to terminate a pregnancy.
Cushing's syndrome
Mifeprin 200 MG Tablet is used for managing elevated blood sugar levels in patients having Cushing's syndrome coupled with type 2 diabetes mellitus or glucose intolerance.
Allergy
This medicine is not recommended for use if you have a known history of allergy to it or any other medicine that are classified under the category of prostaglandin analogue.
Ectopic Pregnancy
This medicine is not recommended for termination of pregnancy in women who are suspected to have the fertilized egg to be present outside the uterus (Ectopic pregnancy).
Current use of intra-uterine device
This medicine is not recommended for use in women who have an intra-uterine device in place.
Chronic adrenal failure
This medicine is not recommended for use if you have a long term adrenal gland malfunction.
Corticosteroids
This medicine is not recommended for use in patients who are using Corticosteroids for serious conditions like immune system disorder.
Unexplained vaginal bleeding
This medicine is not recommended for use in women who have an active or historic case of severe and unexplained vaginal bleeding. The bleeding may be intermittent and after the menopause indicative of uterine cancer.
Other bleeding disorders
This medicine is not recommended for use in patients who have a bleeding disorder and are receiving anticoagulants for the same.
Porphyria
This medicine is not recommended for use in patients having this inherited disorder of the disease of the blood affecting the nervous system and skin (Porphyria).
In addition to its intended effect, Mifeprin 200 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Heavy vaginal bleeding Major Less Common
Infections Major Rare
Unusual tiredness and weakness Major Less Common
Abdominal pain and cramps Moderate Common
Uterine cramping Moderate Common
Nausea and Vomiting Moderate Common
Headache Moderate Common
Dizziness Moderate Common
Diarrhea Minor Common
Pain in the arms and legs Minor Less Common
Decreased appetite Minor Rare
Sleeplessness Minor Rare
Difficult or painful urination Major Rare
Loss of strength Minor Less Common
Difficult and painful breathing Moderate Rare
How long is the duration of effect?
The effect of this medicine lasts for an average duration of 7-10 days.
What is the onset of action?
This medicine is rapidly absorbed into the bloodstream upon oral administration and reaches the peak levels within 1-2 hours.
Are there any pregnancy warnings?
The use of this medicine is acceptable for medical termination of intrauterine pregnancy which is 63-70 days old. However, use of this medicine for control of elevated blood sugar levels along with elevated cortisol level is not recommended for pregnant women. It should be noted that a failed attempt to terminate pregnancy might result in severe complications.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
The use of this medicine should be avoided by women who are breastfeeding. However, if it becomes necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor regarding the potential benefits and risks involved before taking this medicine.
Below is the list of medicines, which have the same composition, strength and form as Mifeprin 200 MG Tablet, and hence can be used as its substitute.
Lupin Ltd
Cipla Ltd
Lupin Ltd
Fdc Ltd
Mankind Pharmaceuticals Ltd
Missed Dose instructions
Take the missed dose as soon as you remember if the intended use is to control elevated blood sugar levels. If it is almost time for the next scheduled dose then the missed dose should be skipped. For medical termination of pregnancy, it is a single dose therapy and hence missing a dose is not possible.
Overdose instructions
Contact your doctor and seek immediate help if an overdose with mifepristone is suspected.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Disease
Information not available.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Grapefruit juice Moderate
Avoid the consumption of large quantities of grapefruit juice while taking mifepristone as it can alter the levels of this medicine in the blood.
Interaction with Medicine
Dexamethasone Major
Use of dexamethasone with mifepristone is not recommended. If it is absolutely necessary to use these medicines together then suitable dose adjustments and clinical safety monitoring are recommended. Report the use of either of the medicine to the doctor so that the best course of treatment could be determined.
Erythromycin Major
Report the use of erythromycin to the doctor before receiving Mifeprin 200 MG Tablet. The risk of adverse effect on heart and electrolyte levels in the body are significantly high when these medicines are used together. Your doctor may determine the best course of treatment in such cases.
Hydrocortisone Major
Using hydrocortisone with mifepristone is generally not recommended. Report the use of this medicine before receiving mifepristone. Your doctor may determine the best course of treatment in such cases. Do not stop the use of any medicine without consulting your doctor.
Ketoconazole Major
Report the use of either of the medicine to the doctor. In order to decrease the risk of adverse effects, you may a require a dose adjustment and more frequent monitoring. Do not stop the use of any medicine without consulting your doctor.
Simvastatin Major
Report the use of simvastatin to the doctor before receiving mifepristone. The risk of adverse effects is significantly high when these medicines are used together. Your doctor may ask you to temporarily stop the use of Simvastatin till the course of Mifeprin 200 MG Tablet is completed.
Pimozide Major
Report the use of pimozide to the doctor before receiving Mifeprin 200 MG Tablet. The risk of adverse effect on heart and electrolyte levels in the body are significantly high when these medicines are used together. Your doctor may determine the best course of treatment in such cases.
Warfarin Major
Report the use of warfarin or any other medicine used for bleeding disorders to the doctor before receiving mifepristone. The risk of adverse effects is significantly high in women. Appropriate precautionary measures and clinical monitoring of symptoms are recommended in such cases.
Ergotamine Major
Report the use of ergotamine to the doctor before receiving mifepristone. The risk of adverse effects is significantly high when these medicines are used together. Your doctor may ask you to temporarily stop the use of ergotamine or prescribe an alternate medicine till the course of Mifeprin 200 MG Tablet is completed.

Popular Questions & Answers

My wife is pregnant of 3 weeks nd 2 days. Can she get mifeprin kit 4 tab fr terminate of pregnancy. Will any side effect occur in future? Experts plzz help me nd give me a suitable advice nd if need give d medicine name in place of mifeprin.

Diploma in Gastroenterology, Diploma in Dermatology, BHMS
Homeopath, Hyderabad
My wife is pregnant of 3 weeks nd 2 days. Can she get mifeprin kit 4 tab fr terminate of pregnancy. Will any side eff...
There are several chances of hormonal imbalances, pcod,ovarian cysts, fibroids and several other complications. And terminating pregnancy is not advice able.

I am an 18 year old girl and I had unprotected sex 10/3/16. It's been 3 days and I am experiencing red patches on my breast and hands along with frequent urination trips. What should I do? Am I pregnant? Is Mifeprin advisable?

Diploma in Obstetrics & Gynaecology, MBBS, MD - Community Medicine
Gynaecologist, Lucknow
Hello the patches are not due to sex, it may be some allergic reaction. Take medicine and get a urine test done to rule out infection.
1 person found this helpful

Please tell me the process to take abortion pills (MIFTY KIT, Mifepristone & Misoprostol Tablets)

Diploma in Obstetrics & Gynaecology, MBBS
General Physician, Delhi
Follow the instructions written on pack let's repeat there are 5 tablets 1 is different and 4 are similar take diffently shaped tablet on day one next day take either of identical tablets twice a day with a gap of 12 hours repeat on day 3 also bleeding may start on day one complete the course to prevent chances of incomplete abortion.

Should I take misoprostol if I start get normal bleeding after taking mifepristone?

Masters of Surgery Obstetrics & Gynaecology
Gynaecologist, Pune
Should I take misoprostol if I start get normal bleeding after taking mifepristone?
Yes. Mifepristone just seperates the fetus from uterus. Whereas misoprostol helps to expel it out only on mifepristone, there are more chances of incomplete abortion.

I took abortion kit last night and had bleeding after 3 hours I was bleeding till morning n afternoon slightly n not much so should I take more of misoprostol? Please suggest me.

MD - Obstetrtics & Gynaecology, MBBS, Diploma in Clinical ART ( Infertility)
Gynaecologist, Ghaziabad
Hello! I could not gauge from your question whether you bled after mifepristone alone or after a partial dose of misoprostol, either way complete your misoprostol as otherwise there is a possibility of retained products of conception.

Popular Health Tips

Uterine Fibroids - How They Can Be Managed?

Fellowship in Gynae Endoscopy, FMAS, DNB, DGO, MBBS
Gynaecologist, Delhi
Uterine Fibroids - How They Can Be Managed?

The uterine fibroids are one of the most common gynecologic problems, with over 40-50% of women having them at some point in their life. The number and size of the fibroids, the age of onset, associated symptoms like dysfunctional bleeding and pelvic pain will determine the management of fibroid. The following is a series of management measures, starting from the most conservative to the most invasive. 

1. Wait and watch: In women who are asymptomatic, it is best to watch them for the development of symptoms without any intervention. Also, in women nearing menopause, it is best to just watch the fibroids as they just shrink once menstruation ceases. 

2. Medical therapy: In some women, menstrual cycles could be heavy or irregular and require hormonal replacement. They could also have occasional pain, and so may require painkillers. 

  1. Tranexamic acid is a non-hormonal medication that can be used on heavy bleeding days only to ease the heavy menstrual flow. 
  2. Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful in pain control. Iron and vitamin supplements are also useful in managing anemia and weakness associated with heavy bleeding. 
  3. Oral contraceptives and/or progestins are also used to control abnormal menstrual bleeding. They do not have any effect on fibroid size though. 
  4. Progestin could also be delivered through an intrauterine device (Mirena) to relieve heavy bleeding and prevent pregnancy
  5. Gonadotropin-releasing hormone (Gn-RH) agonists: They block the production of oestrogen and progesterone, and so induce a temporary postmenopausal state. This can also be used to shrink the fibroid so it is easier to remove it surgically. This is not used for more than 3 to 6 months as they can cause hot flashes and bone loss. 
  6. Newer drugs like Mifepristone and Ulipristal acetate are being used to shrink the size of fibroids. 

3. Noninvasive procedure: MRI-guided focused ultrasound surgery is when the women are inside the MRI scanner and an ultrasonic transducer is used for treatment. The exact location of the fibroids are identified and sound waves are used to destroy the fibroid. Done on an outpatient basis, it is safe and effective. 

4. Minimally invasive procedures: Uterine artery embolization is where the arterial supply is cut off to reduce fibroid growth. Myolysis is where laparoscopically heat or cold waves are used to lyse off the fibroids. Endometrial ablation is where the uterine lining is destroyed through high-intensity heat or cold waves. 

5. Invasive procedures: Abdominal or Laparoscopic myomectomy is where the fibroids are removed through an abdominal incision or keyhole surgery. If fibroids are extensive and completed family, hysterectomy is the choice of treatment. Given their high incidence, fibroids require management based on symptoms, age, and other considerations as discussed and decided between the patient and the doctor.

3 people found this helpful

Methods of Abortion for Unwanted Pregnancy

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
Methods of Abortion for Unwanted Pregnancy

There are two methods by which abortion can be done:

  • Medical Abortion - Non-surgical abortion in which medicines are used to induce abortion
  • Surgical Abortion - Use of transcervical procedures for terminating a pregnancy, including vacuum aspiration, and dilatation and evacuation (D and E).

Surgical or Medical Abortion for Unwanted Pregnancy

  • If pregnancy is lesser than = 7 weeks; medical method with Mifepristone with Misoprostol is favorable as the success rate is as high as 97%.
  • If pregnancy is between 7-12 weeks; surgical abortion is the only option.
  • If pregnancy is beyond 12 weeks - 20 weeks, then the woman needs to be hospitalized and will be given either Mifepristone followed by Misoprostol tablet or only Misoprostol tablets and woman will then abort like a miscarriage in the hospital. If any products are remaining, then it will be evacuated surgically.

Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion. If a woman fulfills the criteria for selecting either method i.e. before 7 weeks, final choice has to be given to the woman.

Summary of choice between Surgical or Medical abortion in India

  • Lesser than = 7 weeks - Medical method or surgical method
  • 7-12 weeks - Surgical abortion
  • 12 - 20 weeks - Medicines with or without surgical procedure in hospital

Advantages of Medical Abortion

  • Avoid surgery - Controlled by the woman and may take place at home
  • No need for admission to the hospital
  • Usually, well tolerated by women, if properly counselled and motivated
  • No need to take leave from work, as bleeding can be managed with menstrual pads even while in the office or at work.

Disadvantages of medical abortion

  • Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

  • Quick procedure
  • Complete abortion easily verified by evaluation of aspirated products of conception
  • Takes place in a hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled

Disadvantages of surgical abortion

  • Requires instrumentation of the uterus
  • Small risk of uterine or cervical injury
  • Timing of abortion controlled by the doctor and hospital
  • Anaesthesia needs to be administered. Most doctors perform this procedure under short general anaesthesia. A woman needs to be in the hospital for at least 6 hours. Effect of sedation will be there throughout the day.

Related Tip: Why eating fish is essential for a healthy pregnancy??

3904 people found this helpful

Choice between Surgical and Medical Abortion

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
There are two methods by which abortion can be done

Medical Abortion -non-surgical abortion in which medicines are used to induce abortion
Surgical Abortion - Use of transcervical procedures for terminating pregnancy, including vacuum aspiration, and dilatation and evacuation (D&E).

Surgical or Medical Abortion for Unwanted Pregnancy

If pregnancy is <= 7 weeks; medical Method with Mifepristone with misoprostol is favorable as success rate is as high as 97%.
If pregnancy is between 7-12 weeks; surgical abortion is the only option.
If pregnancy is beyond 12 weeks ? 20 weeks, then woman needs to be hopsitalized and will be given either Mifepristone followed by Misoprostol tablet or only misoprostol tablets and woman will then abort like a miscarriage in the Hospital. If any products are remaining then it will be evacuated surgically.
Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion.
If a woman fulfills the criteria for selecting either method i.e. Before 7 weeks), final choice to be given to the woman.

Summary of Choice between Surgical or Medical abortion in India

<= 7 weeks ? Medical method or Surgical method
7-12 weeks ? Surgical abortion
12 ? 20 weeks ? Medicines with or without surgical procedure in Hospital.

Advantages of Medical Abortion

Avoids surgery. Controlled by the woman and may take place at home. No need for admission to the Hospital. Usually well tolerated by women if properly counselled and motivated. No need to take leave from work, as bleeding can be manged with menstrual pads even while in office or at work.

Disadvantages of Medical abortion

Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

Quick procedure. Complete abortion easily verified by evaluation of aspirated products of conception. Takes place in a Hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled.

Disadvantages of Surgical abortion

Requires instrumentation of the uterus. Small risk of uterine or cervical injury. Timing of abortion controlled by the Doctor and Hospital. Anaesthesia wneeds to be administered. Most doctors perform this procedure under short general anaesthesia. Woman needs to be in the Hospital for at least 6 hours. Effect of sedation will be there throuout the day.
5 people found this helpful

Thyroid Problems And Its Homeopathic Treatments!

Diploma in Emergency Medicine, MD - Homeopathy, BHMS
Homeopath, Pune
Thyroid Problems And Its Homeopathic Treatments!

It is extremely remarkable to note how homeopathic treatments have gained immense acceptance and recognition in the field of modern-day treatment procedures, offering the most effective and safe medication options. A number of thyroid problems can, in fact, be alleviated with the help of homeopathic remedies, also saving you the trouble of encountering unwanted and unforeseen side effects of the normal prescription drugs. The most common problems pertaining to the thyroid gland are possibly hypothyroidism and hyperthyroidism. Both the conditions can be cured with utmost efficacy when the right drugs are prescribed.

Hypothyroidism And Homeopathy

Hypothyroidism is the medical condition wherein the thyroid gland underperforms and produces insufficient amount of hormones required for the normal functioning of the body. The most effective homeopathic remedies for hypothyroidism are:

  1. Nux Vomica: This remedy is usually recommended to those patients who suffer from extreme temperament and ones who feel chilly often without any particular reason. Obstinate constipation in the patients is also curbed by this medicine. Women with prolonged periods are also prescribed Nux Vomica to decrease the incidence of period related problems.
  2. Lycopodium Clavatum: Patients of hypothyroidism who complain of gastric troubles are the ones who usually opt for Lycopodium Clavatum. Excessive hair fall as a result of hypothyroidism can also be cured with it.
  3. Calcera Carbonica: It is usually ranked as the best medicine for treating hypothyroidism, especially in patients who suffer from cold feet, extreme fatigue, and bowel problems.

Hyperthyroidism And Homeopathy

A condition wherein the thyroid gland tends to be overactive and produces more than the requisite level of hormones is usually referred to as a classic case of hyperthyroidism. Homeopathic treatments for this abnormality aim at treating the root causes to achieve best results:

  1. Lachesis Mutus: Hyperthyroidism patients who persistently complain of rising body heat are prescribed this. It also lessens the problems of fatigue and queasiness.
  2. Iodium: Patients who lose their weight quickly despite maintaining a healthy diet are prescribed doses of Iodium. Anxiousness and fatigue are also cured along with other problems.
  3. Conium Maculatum: Patients who suffer from acute depression and refuse to participate in day-to-day activities are generally given this. Trembling and profuse perspiration are treated effectively with the help of Conium Maculatum.
5 people found this helpful

Bloating: Causes and Remedies- Pure Inside Out

MBBS,MD, DM
Gastroenterologist, Kolkata
Bloating: Causes and Remedies- Pure Inside Out

Bloating isn't a medical condition. It doesn't necessarily mean that a person has eaten too much. It can be a case of eating wrong food which has not been digested by the body. Bloating occurs when air and water get trapped inside the stomach or intestine. As a result, the stomach gets swollen well past its normal level.

Culprits of bloating:Bloating can result from a number of cases. Fatty or junk foods are one of the biggest culprits of bloating. It hinders the digestion process and doesn't let the stomach empty on time. Carbohydrates too can cause bloating. Even carbonated drinks can play spoilsport. It creates bubbles in the stomach leading to indigestion and bloating. Some food items related to gas include cauliflower, lettuce, hard candy, beans, Brussels sprouts, broccoli etc. Apart from this, consumption of excessive junk food and soft drinks can lead to bloating.

Steps to avoid bloating: The best way to avoid bloating is to refrain from bloat causing foods as mentioned earlier. If you wear dentures, it should be ensured that it fits properly. There are instances when excess air gets inside the stomach due to an improper fixture of denture leading to bloating. Eating or drinking slowly is another good way of staying away from bloating. When you eat slowly, there are fewer chances of extra air getting inside the stomach. In the case of beverage consumption, avoiding the straw is a good idea. This way the unwanted air cannot make their way inside the tummy and play foul.

Taking a small walk after every meal is another good way of staying away from bloating. This way the gas inside the tummy cannot rise above the surface. The practice of calming technique such as yoga, deep breathing and meditation also goes a long way in giving relief from bloating.

Some home remedies to get rid of bloating include:

  • A cup of ginger, lemon and honey in a cup of hot water once everyday
  • 1 cup of herbal peppermint tea freshly prepared in boiled water
  • In the case of regular stomach bloating, intake of one caraway seed on a daily basis fetches immediate results
  • Consumption of a cup of baked pumpkin twice a week
  • Consumption of warm lemon water before you start your day is another good way of keeping bloating at bay.

Bloating can also be a symptom of other intestinal related problems as well. If the general method of control and measured diet doesn't suffice, it is time to visit a doctor to find the underlying cause of your problem. Doctors perform a series of tests to understand the problem and prescribe the required medicine to control or cure the problem.

17 people found this helpful