Klorum 250 MG Capsule

Klorum 250 MG Capsule is primarily used for the management of oedema associated with congestive heart failure and hepatic or renal disease; alone or in combination with antihypertensives in treatment of hypertension.

Klorum 250 MG Capsule is known to be a loop diuretic, also known as a water pill. The drug when taken reduces the amount of salt that the body absorbs. The excess salt is then excreted by the body through the urine.

The drug is used to control fluid retention in the body of patients suffering from liver disease, kidney problems and congestive heart failure. Thus, the drug helps in the creation of more urine which gets rid of excess fluid and salt produced in the body.

You can take this medicine orally with a meal or without. Try not to take the drug around your bedtime so as to prevent the urge to urinate throughout the night. The dosage prescribed, usually depends on your age, your health and your body’s response to the drug.

In case of children the dosage is also determined according to their weight. You doctor will first start you off with a low dose to see how your body accepts the drug. If you do not develop any side effects he may increase the dosage.

Side effects are a common occurrence when you take any medication. While some side effects are quite common and disappear as your body adjusts to the drug, others are more severe and can create complications. Klorum 250 MG Capsule can cause some minor side effects like dizziness, problems with vision, headache and faint feeling. If you do experience dizziness, ensure that you move slowly to avoid any accidents.

Klorum 250 MG Capsule can result in severe dehydration as it creates the need to urinate frequently. Very rarely do patients suffer from an allergic reaction to Klorum 250 MG Capsule. But if it does occur consult your doctor and get the treatment done.

Symptoms of overdose include electrolyte imbalance, volume depletion, hypotension, dehydration, hypokalemia and hypochloremic alkalosis. Following GI decontamination, treatment is supportive; hypotension responds to fluids and Trendelenburg position.

The primary use of this medication is as follows:

• Hypertension

• Congestive Heart Failure (Chf)

• Edema (Swelling)

• Allergy

• Anuria

Side effects that might occur after the consumption of this medicine include:

• Low Potassium And Magnesium

• Decreased Calcium Level

• Hearing Impairment

• Headache

• Weakness

• Increased Sensitivity Of The Eyes To Sunlight

• Muscle Spasm

• Skin Rash

• Anemia

• Anorexia

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 6 to 8 hours after an oral dose and 2 hours after an intravenous dose.

• What is the onset of action?

  The effect of this medicine can be observed in 30 to 60 minutes after an oral dose, 30 minutes after an intramuscular dose and 5 min after an intravenous dose.

• Are there any pregnancy warnings?

  This medicine is not recommended for pregnant women.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for women who are breastfeeding.

• Does this affect kidney function?

  Caution must be taken in patient with renal disease. Adjustment of dose is needed.
  • Acute renal failure: High doses (up to 1-3 g/day - oral/I.V.) have been used to initiate desired response; avoid use in oliguric states.
  • Dialysis: Not removed by hemo- or peritoneal dialysis; supplemental dose is not necessary.
  Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patient with liver disease. Diminished natriuretic effect with increased sensitivity to hypokalemia and volume depletion in cirrhosis; monitor effects, particularly with high doses. Kindly consult your doctor before taking it.

Below is the list of medicines, which have the same composition, strength and form as Klorum 250 MG Capsule , and hence can be used as its substitute.

• Cadimycetin 250 MG Capsule

  Zydus Cadila

• Chloromycetin 250 MG Capsule

  Pfizer Ltd

• Microcetin 250 MG Capsule

  Micro Labs Ltd

• Nicophenicol 250 MG Capsule

  Abbott Healthcare Pvt. Ltd

• Paraxin 250 MG Capsule

  Abbott Healthcare Pvt. Ltd

• Missed Dose instructions

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Overdose instructions

  Seek emergency medical treatment or contact the doctor in case of overdose.

• Missed Dose instructions

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Overdose instructions

  Seek emergency medical treatment or contact the doctor in case of overdose.

• India

• United States

• Japan

• India

• United States

• Japan

This medication works by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the ascending limb of the loop of Henle. This, in turn, prevents sodium, potassium and chloride from being absorbed which increases urine output.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

• Interaction with Alcohol

  Consumption of alcohol is not recommended while you are taking this medicine. It may increase the risk of dizziness and fainting. Avoid performing activities that need mental alertness like operating machinery or driving a vehicle.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  • ACE inhibitors: Hypotensive effects and/or renal effects are potentiated by hypovolemia.
  • Antidiabetic agents: Glucose tolerance may be decreased.
  • Antihypertensive agents: Hypotensive effects may be enhanced.
  • Cephaloridine or cephalexin: Nephrotoxicity may occur.
  • Cholestyramine or colestipol may reduce bioavailability of furosemide.
  • Clofibrate: Protein binding may be altered in hypoalbuminemic patients receiving furosemide, potentially increasing toxicity.
  • Digoxin: Furosemide-induced hypokalemia may predispose to digoxin toxicity. Monitor potassium.
  • Indomethacin (and other NSAIDs) may reduce natriuretic and hypotensive effects of furosemide.
  • Lithium: Renal clearance may be reduced. Isolated reports of lithium toxicity have occurred; monitor lithium levels.
  • Metformin may decrease furosemide concentrations.
  • Metformin blood levels may be increased by furosemide.
  • NSAIDs: Risk of renal impairment may increase when used in conjunction with furosemide.
  • Ototoxic drugs (aminoglycosides, cis-platinum): Concomitant use of furosemide may increase risk of ototoxicity, especially in patients with renal dysfunction.
  • Peripheral adrenergic-blocking drugs or ganglionic blockers: Effects may be increased.
  • Phenobarbital or phenytoin may reduce diuretic response to furosemide.
  • Salicylates (high-dose) with furosemide may predispose patients to salicylate toxicity due to reduced renal excretion or alter renal function.
  • Sparfloxacin, gatifloxacin, and moxifloxacin: Risk of hypokalemia and cardiotoxicity may be increased Avoid use.
  • Succinylcholine: Action may be potentiated by furosemide.
  • Sucralfate may limit absorption of furosemide, effects may be significantly decreased; separate oral administration by 2 hours.
  • Thiazides: Synergistic diuretic effects occur.
  • Tubocurarine: The skeletal muscle-relaxing effect may be attenuated by furosemide.

• Interaction with Food

  Information not available.

• Interaction with Disease

  • Adjust dose to avoid dehydration.
  • In cirrhosis, avoid electrolyte and acid/base imbalances that might lead to hepatic encephalopathy.
  • Ototoxicity is associated with rapid I.V. administration, renal impairment, excessive doses, and concurrent use of other ototoxins.
  • Hypersensitivity reactions can rarely occur.
  • Monitor fluid status and renal function in an attempt to prevent oliguria, azotemia, and reversible increases in BUN and creatinine. Close medical supervision of aggressive diuresis required.
  • Monitor closely for electrolyte imbalances particularly hypokalemia. Watch for and correct electrolyte disturbances.