Fluconazole is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.
Fluconazole is indicated for oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-threatening Candida infections (eg, cystitis, esophagitis); treatment of hepatosplenic candidiasis and other Candida infections in persons unable to tolerate amphotericin B.
It is also prescribed for the treatment of cryptococcal infections; secondary prophylaxis for cryptococcal meningitis in persons with AIDS; antifungal prophylaxis in allogeneic bone marrow transplant recipients.
This medicine belongs to the class of triazole antifungal. Fluconazole is effectively used in the treatment of meningitis. It affects the membranes in the brain and spinal cord. This drug treats fungal infections like yeast infections in the mouth, throat, food pipe, lungs, vagina, etc.
It works by decreasing the production of ergosterol, which inhibits cell membrane formation in fungi. This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation.
Some serious side effects that may occur and need immediate medical attention are:
- Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage
- Severe rash or peeling of the skin in patients suffering from cancer or AIDS
- Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)
Symptoms of overdose include decreased lacrimation, salivation, respiration and motility, urinary incontinence, cyanosis. Treatment includes supportive measures, a 3-hour hemodialysis will remove 50%.
Take as directed, around-the-clock. Take full course of medication as ordered. Follow good hygiene measures to prevent reinfection. Frequent blood tests may be required. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).
This drug is primarily used for the following conditions
Fungal Infections (Tinea Strains)
How long is the duration of effect?
The action of this drug in the body lasts for up to 30 hours after administration.
What is the onset of action?
This drug starts its action within a couple of hours after oral use.
Are there any pregnancy warnings?This drug is extremely unsafe to be used during pregnancy. Studies carried out on humans and animals have shown significant adverse effects on the fetus. Doctor consultation is recommended in such cases.
Is it habit forming?
It does not have addictive tendencies.
Are there any breast-feeding warnings?The drug should not be consumed by breastfeeding mothers as there is a higher risk of side-effects on the infant. You are suggested to consult your doctor to discuss the potential benefits and risks before taking this medicine.
Does this affect kidney function?Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Fluconazole. Dosing adjustment/interval in renal impairment:
- No adjustment for vaginal candidiasis single-dose therapy.
- For multiple dosing, administer usual load then adjust daily doses.
- Clcr 11-50 mL/minute: Administer 50% of recommended dose or administer every 48 hours.
- Hemodialysis: One dose after each dialysis.
- Continuous arteriovenous or venovenous hemodiafiltration (CAVH) effects: Dose as for Clcr 10-50 mL/minute.
Does this affect liver function?No relevant information available. Consult your doctor before taking Fluconazole.
Is It safe with alcohol?Caution is advised in consuming alcohol, if you are taking this medicine. Please consult your doctor.
Is it safe to drive while on this medicine?This medicine causes side effects that affect the alertness of the patients. Thus it influences the driving ability of the patient.
Are there any missed dose instructions?
Missed dose of this medication may be taken later unless it is already time for the next dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
Below is the list of medicines, which contains Fluconazole as ingredient
This medication works by decreasing ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Microsporum.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
- Increased effect/toxicity:
- Coadministration with terfenadine or cisapride is contraindicated; use with caution with astemizole due to increased risk of significant cardiotoxicity.
- Hydrochlorothiazide may decrease fluconazole clearance.
- Fluconazole may also inhibit warfarin, phenytoin, cyclosporine, and theophylline, zidovudine, sulfonylureas, rifabutin, and warfarin clearance.
- Nephrotoxicity of tacrolimus may be increased.
- Should be used with caution in patients receiving cisapride or astemizole.
Interaction with Disease
Interaction with Food
Ques: What is Fluconazole?
Ques: How long do I need to use Fluconazole before I see improvement in my condition?
Ques: At what frequency do I need to use Fluconazole?
Ques: Should I use Fluconazole empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Fluconazole?
Ques: Can Fluconazole be taken with oral contraceptives (OCPs) or birth control pills?
Ques: I feel better now, can I stop taking Fluconazole?
Ques: Is Fluconazole safe to be used in pregnancy?
Ques: Can Fluconazole cause hair loss?
Ques: Is Fluconazole fungistatic or fungicidal?
Ques: Is Fluconazole over the counter (OTC)?
Ques: What if I forget to take a dose of Fluconazole?
Ques: Is Fluconazole effective?
Ques: Does Fluconazole treat bacterial vaginosis?
Ques: Does Fluconazole make you feel tired?
Ques: Is Fluconazole a steroid?
Ques: Can I take Fluconazole for yeast infection?
Fluconazole-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:https://druginfo.nlm.nih.gov/drugportal/name/fluconazole
-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:https://go.drugbank.com/drugs/DB00196
FLUCONAZOLE Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=FLUCONAZOLE
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