Fzhh 150 MG Tablet

Fzhh 150 MG Tablet is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.

Fzhh 150 MG Tablet is indicated for oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-threatening Candida infections (eg, cystitis, esophagitis); treatment of hepatosplenic candidiasis and other Candida infections in persons unable to tolerate amphotericin B.

It is also prescribed for the treatment of cryptococcal infections; secondary prophylaxis for cryptococcal meningitis in persons with AIDS; antifungal prophylaxis in allogeneic bone marrow transplant recipients.

This medicine belongs to the class of triazole antifungal. Fzhh 150 MG Tablet is effectively used in the treatment of meningitis. It affects the membranes in the brain and spinal cord. This drug treats fungal infections like yeast infections in the mouth, throat, food pipe, lungs, vagina, etc.

It works by decreasing the production of ergosterol, which inhibits cell membrane formation in fungi. This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation.

Some serious side effects that may occur and need immediate medical attention are:

• Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage
• Severe rash or peeling of the skin in patients suffering from cancer or AIDS
• Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)

Symptoms of overdose include decreased lacrimation, salivation, respiration and motility, urinary incontinence, cyanosis. Treatment includes supportive measures, a 3-hour hemodialysis will remove 50%.

Take as directed, around-the-clock. Take full course of medication as ordered. Follow good hygiene measures to prevent reinfection. Frequent blood tests may be required. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

This drug is primarily used for the following conditions

• Oropharyngeal Candidiasis

• Vaginal Candidiasis

• Fungal Infections (Tinea Strains)

• Cryptococcal Meningitis

• Coccidioidomycosis

• Hypersensitivity

Side effects of this drug are as follows

• Headache

• Rash

• Nausea

• Vomiting

• Abdominal Pain

• Diarrhoea

• Dizziness

• Hypokalemia

• How long is the duration of effect?

  The action of this drug in the body lasts for up to 30 hours after administration.

• What is the onset of action?

  This drug starts its action within a couple of hours after oral use.

• Are there any pregnancy warnings?

  This drug is extremely unsafe to be used during pregnancy. Studies carried out on humans and animals have shown significant adverse effects on the fetus. Doctor consultation is recommended in such cases.

• Is it habit forming?

  It does not have addictive tendencies.

• Are there any breast-feeding warnings?

  The drug should not be consumed by breastfeeding mothers as there is a higher risk of side-effects on the infant. You are suggested to consult your doctor to discuss the potential benefits and risks before taking this medicine.

• Does this affect kidney function?

  Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Fzhh 150 MG Tablet. Dosing adjustment/interval in renal impairment:
  • No adjustment for vaginal candidiasis single-dose therapy.
  • For multiple dosing, administer usual load then adjust daily doses.
  • Clcr 11-50 mL/minute: Administer 50% of recommended dose or administer every 48 hours.
  • Hemodialysis: One dose after each dialysis.
  • Continuous arteriovenous or venovenous hemodiafiltration (CAVH) effects: Dose as for Clcr 10-50 mL/minute.

• Does this affect liver function?

  No relevant information available. Consult your doctor before taking Fzhh 150 MG Tablet.

• Is It safe with alcohol?

  Caution is advised in consuming alcohol, if you are taking this medicine. Please consult your doctor.

• Is it safe to drive while on this medicine?

  This medicine causes side effects that affect the alertness of the patients. Thus it influences the driving ability of the patient.

Below is the list of medicines, which have the same composition, strength and form as Fzhh 150 MG Tablet , and hence can be used as its substitute.

• Fabizol 150 MG Tablet

  Unichem Laboratories Ltd

• Fcn 150 MG Tablet

  Intas Pharmaceuticals Ltd

• Alflucoz 150 MG Tablet

  Alembic Ltd

• Fusys 150 MG Tablet

  Zydus Cadila

• Freecan 150 MG Tablet

  Glorious Health Care

• Are there any missed dose instructions?

  Missed dose of this medication may be taken later unless it is already time for the next dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• India

• United States

• Japan

This medication works by decreasing ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Microsporum.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Keep monitoring periodic liver function tests (AST, ALT, alkaline phosphatase) and renal function tests, potassium. As these might drastically be affected by the action of the Fzhh 150 MG Tablet.

• Interaction with Medicine

  • Increased effect/toxicity:
  • Coadministration with terfenadine or cisapride is contraindicated; use with caution with astemizole due to increased risk of significant cardiotoxicity.
  • Hydrochlorothiazide may decrease fluconazole clearance.
  • Fluconazole may also inhibit warfarin, phenytoin, cyclosporine, and theophylline, zidovudine, sulfonylureas, rifabutin, and warfarin clearance.
  • Nephrotoxicity of tacrolimus may be increased.
  • Should be used with caution in patients receiving cisapride or astemizole.

• Interaction with Disease

  Should be used with caution in patients with renal and hepatic dysfunction or previous hepatotoxicity from other azole derivatives. Patients who develop abnormal liver function tests during fluconazole therapy should be monitored closely and discontinued if symptoms consistent with liver disease develop.

• Interaction with Food

  No data reported