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Glucocorticoid-remediable Aldosteronism is also called aldosterone synthase hyperactivity. Basically this is an autosomal dominant disorder where the body witnesses a drastic increase in aldosterone secretion - that is made by ACTH is no longer transient. There is an increase in plasma concentration and symptoms include fatigue, headaches, numbness, tingling sensation and also metabolic alkalosis.
HOW IS GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM DIAGNOSED?
The diagnosis of the condition includes a blood test that will help in unravelling whether or not the patient is carrying the faulty gene. Also, the doctor will be able to detect the cause and extent of the damage with the help of a study of the symptoms. The doctor will also check the blood pressure and potassium levels.
HOW IS GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM TREATED?
Hypertension typically develops in childhood, and may be refractory to standard therapies. Hypokalemia is uncommon in the absence of treatment with diuretics. The discovery of the genetic basis of the disorder has permitted the development of accurate diagnostic testing. Glucocorticoid suppression of ACTH is the mainstay of treatment, alternative treatments include mineralocorticoid receptor antagonists.
DID YOU KNOW?
This is a complicate problem because aldosterone actually leads to retention of sodium along with water in the tubules of the kidneys and in turn this leads to higher volumes of fluid in the body. Blood pressure goes up causing other chronic conditions.