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Overview

Ursodeoxycholic Acid

Prescription vs OTC : Prescription by Doctor not required

About Ursodeoxycholic Acid

Ursodeoxycholic Acid is a bile acid which is used to treat gallstone problems. Gallstones can result in symptoms like jaundice, pain, inflammation of the pancreas and gallbladder too. The gall bladder creates stones when bile (generally a liquid) hardens. Calcium deposits in the gallbladder can also result in stone formation. This can cause severe pain.

This medication should be taken exactly as directed by your doctor. Your dosage will depend on the severity of your condition. The doctor will generally advise you to take the drug at bedtime daily. The drug works best when taken directly after a meal or with a light snack.

This medicine is not to be used with:

  • Cholesterol
  • Radiopaque
  • Bile pigment stones
  • Stones >20 mm in diameter
  • Allery to bile acids.

Gallbladder stone dissolution may take several months of therapy. Complete dissolution may not occur and recurrence of stones within 5 years has been observed in 50% of patients. Use with caution in patients with a non-visualizing gallbladder and those with chronic liver disease. This medicine is not recommended for children.

Ursodeoxycholic Acid must not to be used with cholesterol, radiopaque, bile pigment stones, or stones >20 mm in diameter; allergy to bile acids.

Frequent blood work will be necessary to follow drug effects. Drug will need to be taken for 1-3 months after stone is dissolved. Stones may recur. Report any persistent nausea, vomiting, abdominal pain, or yellowing of skin or eyes.

Usual Dosage: 8-10 mg/kg/day in 2-3 divided doses; use beyond 24 months is not established; obtain ultrasound images at 6-month intervals for the first year of therapy; 30% of patients have stone recurrence after dissolution.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the uses of Ursodeoxycholic Acid

    • Dissolution Of Cholesterol Rich Gallstones

    • Primary Biliary Cirrhosis

    • Cystic Fibrosis

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the contraindications of Ursodeoxycholic Acid ?

    • Allergy

    • Biliary Tract Disorder

    • Gallbladder Disorder

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the side effects of Ursodeoxycholic Acid ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Key highlights of Ursodeoxycholic Acid

    • How long is the duration of effect?

      The time for which this medicine remains effective in the body is subject to vary depending on the use.

    • What is the onset of action?

      The time taken for this medicine to show it's effect is variable depending on the intended use. The dissolving of gallstone starts to happen after 3-6 months of the administration.

    • Are there any pregnancy warnings?

      This medicine should be used by pregnant women only when clearly needed. Consult your doctor before taking this medicine.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine should be used with caution if you are breastfeeding. Consult your doctor before taking this medicine.

    • Is It safe with alcohol?

      Consumption of alcohol is not safe.

    • Is it safe to drive while on this medicine?

      This medicine does not affect the consciousness of the patient. Its safe to drive while taking this medicine.

    • Does this affect kidney function?

      Limited information is available regarding its use in patient with kidney disease. Kindly consult your doctor before taking this medication.

    • Does this affect liver function?

      Limited information is available regarding its use in patient with liver disease. Kindly consult your doctor before taking this medication.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

    • Are there any overdose instructions?

      Contact your doctor immediately if an overdose with this medicine is suspected.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Where is the Ursodeoxycholic Acid approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Medicines containing Ursodeoxycholic Acid

    Below is the list of medicines, which contains Ursodeoxycholic Acid as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    How does this medication work?

    This medication decreases the cholesterol content of bile and bile stones by reducing the secretion of cholesterol from the liver and the fractional reabsorption of cholesterol by the intestines

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

      What are the interactions of Ursodeoxycholic Acid ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Information not available.
      • Interaction with Medicine

        Decreased effect with aluminum-containing antacids, cholestyramine, colestipol, clofibrate, oral contraceptives (estrogens).
      • Interaction with Food

        Information not available.

      FAQs about Ursodeoxycholic Acid

      • Ques : When should I take Ursodeoxycholic Acid?

        Ans : You are advised to take Ursodeoxycholic Acid as prescribed by your doctor. Your doctor might instruct you to take 2 to 3 doses per day and suggest to take the last dose at bedtime.

      • Ques : How to consume Ursodeoxycholic Acid?

        Ans : It is advised to consume Ursodeoxycholic with water milk and can be taken with food or after food.

      • Ques : Is Ursodeoxycholic Acid safe?

        Ans : It is completely safe to use Ursodeoxycholic Acid. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs for a longer time, your doctor may reduce the dose or suggest you stop the use of Ursodeoxycholic Acid.

      • Ques : How does Ursodeoxycholic Acid help the liver?

        Ans : Ursodeoxycholic Acid acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile.

      • Ques : Does Ursodeoxycholic Acid cause weight gain?

        Ans : Yes, there is a chance of weight gain with Ursodeoxycholic Acid, but it is not common. Patients suffering from liver problems consuming Ursodeoxycholic Acid might gain weight.

      • Ques : What should I avoid while taking Ursodeoxycholic Acid?

        Ans : While taking Ursodeoxycholic Acid, avoid taking an antacid preparation without consulting your medical practitioner, as they decrease the effectiveness of Ursodeoxycholic Acid. You should also avoid taking drugs like cholestyramine or colestipol while you are on Ursodeoxycholic Acid.

      References

      • Ursodiol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/ursodeoxycholic%20acid

      • URUSA- ursodeoxycholic acid capsule- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 25 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7aa650ea-167b-cdd8-e053-2991aa0a7896

      • DESTOLIT 150 mg tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 25 Nov 2021]. Available from:

        https://www.medicines.org.uk/emc/product/1023/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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