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Overview

Tretiva 10 MG Capsule

Tretiva 10 MG Capsule

Manufacturer: Intas Pharmaceuticals Ltd
Medicine composition: Isotretinoin
Prescription vs.OTC: Prescription by Doctor required

Tretiva 10 MG Capsule belongs to a category of chemical compounds called retinoid. This medication helps in the treatment of cystic acne or nodular acne that has previously not responded to any other kinds of treatment. It lowers the production of facial oil and prevents hardening of the skin. If acne is not properly treated it can cause permanent scarring.

On using Tretiva 10 MG Capsule you may experience the following side effects: drying of skin around the lips and mouth, bleeding from the nose, stomach upset, hair loss. Should these reactions continue or worsen with time notify your health care provider right away. However, it is advised that before taking Tretiva 10 MG Capsule you should take preventive measures and consult your doctor if:

  • You are taking any prescriptive or over the counter drugs, vitamins, herbal or dietary supplements.
  • You are allergic to the ingredients contained within this drug or are allergic to any other medicines especially drugs containing vitamin A.
  • You are allergic to foods, particularly peanuts or soy.
  • You have a medical or family history of diabetes, liver disease, eating disorders, mental disorders or lowered bone density.
  • You are pregnant, are planning to become pregnant or are breastfeeding.
  • You have hearing problems, bowel problems or irregular periods.

Some medications may interact with Tretiva 10 MG Capsule and have some adverse effects, in such cases care should be taken to have a discussion with your doctor. Take Tretiva 10 MG Capsule as prescribed. Tretiva 10 MG Capsule comes in a capsule form and needs to be swallowed down with a glass of water. You may have it with our without food. It needs to be taken twice daily for a minimum of four to five months. In case of a missed dose try to take it as soon as you recall it or skip it entirely. Do not by any means try to have a double dose. In case of drug overdose notify your doctor promptly. It may take a few weeks before results start to show.

Acne vulgaris
This medicine is used for the prevention and treatment of severe and painful nodular acne.
This medicine is not recommended for use if you have a known history of allergy to tretinoin/isotretinoin/retinoids or any other component present in the dosage form.
This medicine is not recommended for use if you have an impairment of liver function.
Hypervitaminosis A
This medicine is not recommended for use if you have more than normal levels of vitamin A in the body.
In addition to its intended effect, Tretiva 10 MG Capsule may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Bone and joint pain Major Rare
Bleeding from nose Major Rare
Scaling, burning, redness, and swelling of skin Moderate Less Common
Nausea and Vomiting Moderate Rare
Stomach Pain Moderate Rare
Diarrhea Moderate Rare
Pain and tenderness of eyes Moderate Rare
Itchy and dry skin Minor Less Common
Heart burn Minor Common
Rectal bleeding Moderate Rare
Difficult or painful urination Moderate Less Common
Increased thirst Minor Less Common
Increased heartbeat Moderate Rare
Ringing or buzzing in the ears Moderate Less Common
How long is the duration of effect?
The time duration for which this medicine remains effective is not clinically established.
What is the onset of action?
The effect of this medicine can be observed within 2-4 weeks of topical application.
Are there any pregnancy warnings?
Use of this medicine by women are pregnant or suspecting a pregnancy is not recommended. It is advised to take extra precautionary measures and avoid intended/unintended pregnancy while using this medicine.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
Use of this medicine by women who are breastfeeding is not recommended. Your doctor may prescribe suitable alternatives after assessing your condition.
Below is the list of medicines, which have the same composition, strength and form as Tretiva 10 MG Capsule, and hence can be used as its substitute.
Glenmark Pharmaceuticals Ltd
Cipla Ltd
Ranbaxy Laboratories Ltd
Abbott Healthcare Pvt. Ltd
Wockhardt Ltd
Missed Dose instructions
Skip the missed dose and continue with the regularly scheduled dose. Do not take extra medicine to make up for the missed dose.
Overdose instructions
Contact a doctor immediately if an overdose with this medicine is suspected. Symptoms of overdose may include a headache, dizziness, vomiting, stomach pain, tingling and stinging sensation of the skin etc.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Increased pressure around the brain Major
This medicine is not recommended for use in patients having an increased pressure around the brain due to a disease or trauma. Your doctor may determine the best course of treatment in such cases.
Psychiatric disorders Moderate
Use of this medicine may worsen the symptoms of psychiatric disorders. It should be used with caution by patients suffering from mood changes, anxiety, agitation, depression etc.
Osteoporosis Minor
Use of this medicine may cause a reduction in bone density and hence should be used with caution in patients suffering from osteoporosis or other disorders affecting bone density.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Tetracycline Major
The oral form of isotretinoin should not be used with tetracycline or other antibiotics belonging to the same category. Your doctor will determine the best course of treatment in such cases.
Ethinyl Estradiol Major
The oral form of isotretinoin should not be used with Ethinyl estradiol or other hormonal preparations belonging to the same category. Your doctor will determine the best course of treatment in such cases. It is advised to take extra precautionary measures to avoid unintended pregnancies while using this medicine.
Natural Micronised Progesterone Major
The oral form of isotretinoin should not be used with progesterone or other hormonal preparations belonging to the same category. Your doctor will determine the best course of treatment in such cases.

Popular Questions & Answers

M 24 year old oily skin and I have acne problem. Doctor recommended me TRETIVA25 MG cap for 1 month. Is their any side effect like hair fall? Should I take dis medicine? Please suggest me.

International Academy of Classical Homeopathy, BHMS
Homeopath, Pune
M 24 year old oily skin and I have acne problem. Doctor recommended me TRETIVA25 MG cap for 1 month. Is their any sid...
Fairness diet carrot salmon spinach lemons HERE ARE THE BEAUTY TIPS FOR QUICK FAIRNESS: 1. Application of lemon juice on your face can give you quick fairness. Lemon juice is acidic. Hence it naturally bleaches your skin. However don?t apply it undiluted. You might find the sting of undiluted lemon juice unbearable. So mingle it with few drops of water. You can also use a face mask made out of lemon juice and other ingredients like chickpea flour and almond. You need to soak about 5-6 almonds overnight in water. Next morning peel off the almond skins, crush almonds to a smooth paste, adding lemon juice and 2 tbsp chickpea flour to your mixture. Mix all ingredients thoroughly and apply the mask all over face and neck. Keep for about 20 minutes and then rinse with cold water. Repeat thrice a week. 2. Dry out the orange rinds. Ground those into a fine powder. Mingle the powder with curd and honey and apply it all over your face. Massage in a circular pattern for about 10-15 minutes and wash off with cold water. Repeat this remedy too thrice a week. Inform Mr. progress.
1 person found this helpful

Popular Health Tips

Acne (Pimples)- Myths And Facts

MBBS, Diploma in Venerology & Dermatology (DVD)
Dermatologist, Bhavnagar
Acne (Pimples)- Myths And Facts

What is acne?
Acne [pimples] is an inflammatory skin disease, which affects millions of people throughout the world. The eruptions usually occur on the face, but can also affect the arms, back and chest.

What causes acne?
The oil producing glands in the skin are called the sebaceous glands. The hormone testosterone acts on these glands at puberty leading to increased secretion of sebum. The dead cells, bacteria and sebum form a plug at the outlet of the pilosebaceous follicle. The plug formed on the surface of the skin appears as a black dot-the ‘ blackhead’. If the plug remains just below the skin it appears as a whitish elevation-the ‘whitehead’. Sometimes, the plugged follicle bursts or becomes inflamed leading to the formation of small or large solid bumps, pus pimples [pustules] and cavities containing a sticky fluid [cysts].

When does acne start?
Acne usually starts with comedones at puberty i. E. Between 10 and 12 years of age, when the greasiness of the skin starts. It affects both boys and girls. Severe acne leading to scarring can occur in both sexes though commoner in men. Acne often reaches its peak between 13 and 19 years of age. Later it generally starts subsiding, though it may persist until the early or mid-twenties. Sometimes acne starts or reappears in mid-thirties when hormonal influences play a major role.

Is it hereditary?
When a person suffers from severe acne it is often found that one or both of his or her parents have had it like this; however this is not always so.

Does diet influence acne?
High caloric food can trigger or exacerbate existing acne. But here I want to put the fact that a high glycemic index diet act as single edged sword but milk and milk products act as double edged sword. So if you have serious type acne then you have to give up your love for milk. And also if if you are convinced that a particular food exacerbates acne then it might be worthwhile avoding the same. Have healthy food habits and eat a lot of fresh fruits, vegetables, salads and drink a lot of water.

Do I have to avoid cosmetics if I have acne?
Greasy [oil based cosmetics] block the pores on the skin and tend to bring on or increase preexisting acne. The same applies to moisturizers that are too heavy and may block the skin pores. A sudden bout of acne following facials, clean-up, bleaching ect…is common.

Can drugs cause acne?

Pills [oral contraceptives] can sometimes aggravate acne. Steroids, inh [given for tuberculosis] and anti-epileptics like phenobarbitone can produce acne. Topical steroids applied on the face often triggers acneform eruptions after they are withdrawn.

Are there any other predisposing factors?
A shower of new lesions often occurs a few days prior to the onset of menstruation in females. Tight fitting jeans may occlude the ducts leading to acne on the buttocks and thighs. Prolonged wearing of helmets can lead to pimples on the forehead. Both acne and dandruff occur on greasy skin and can coexist.

Why should acne be treated at all?

Acne can produce pustules and cysts, which can lead to pemanent disfiguring scars if left, untreated. Acne can scar not only the skin but also the psyche. It can produce low self-esteem, self-consciousness, anxiety, depression and introvert personality. Clear skin helps tremendously in boosting the self-confidence of an individual.

What is the right treatment for acne?
Consult your dermatologist for a proper scientific treatment. There are some general instructions to be followed by the patients:
1) wash your face 3-4 times daily with soap and water.
2) the scalp should be cleansed 2-3 times a week preferably with shampoo.
3) avoid all greasy cosmetics on the face.
4) do not squeeze pimples. It can cause severe scarring.

There are several topical agents and oral medications available for successful treatment which your doctor will decide. You may need long courses of antibiotics for several months in severe acne. For resistant, severe recalcitrant acne your doctor may suggest a medication called isotretinoin.

But you should have a lot of patience and take medications and take medications in the correct doses prescribed and for a proper length of time. Remember that it might take several weeks for acne medication to take effect and the face to clear.

 I ignored my acne and now I have scars. Can you do something for my scars?
It is always better to prevent scars by proper and early treatment of severe acne. Your doctor will advise you on treatment available for marks.

9 people found this helpful

Acne (Pimples)- Myths and Facts

MD - Dermatology , Venereology & Leprosy, MBBS
Dermatologist, Dehradun
Acne (Pimples)- Myths and Facts

What is acne?
Acne [pimples] is an inflammatory skin disease, which affects millions of people throughout the world. The eruptions usually occur on the face, but can also affect the arms, back and chest.

What causes acne? 
The oil producing glands in the skin are called the sebaceous glands. The hormone testosterone acts on these glands at puberty leading to increased secretion of sebum. The dead cells, bacteria and sebum form a plug at the outlet of the pilosebaceous follicle. The plug formed on the surface of the skin appears as a black dot-the ‘ blackhead’. If the plug remains just below the skin it appears as a whitish elevation-the ‘whitehead’. Sometimes, the plugged follicle bursts or becomes inflamed leading to the formation of small or large solid bumps, pus pimples [pustules] and cavities containing a sticky fluid [cysts]. 

When does acne start?
Acne usually starts with comedones at puberty i. E. Between 10 and 12 years of age, when the greasiness of the skin starts. It affects both boys and girls. Severe acne leading to scarring can occur in both sexes though commoner in men. Acne often reaches its peak between 13 and 19 years of age. Later it generally starts subsiding, though it may persist until the early or mid-twenties. Sometimes acne starts or reappears in mid-thirties when hormonal influences play a major role.

Is it hereditary?
When a person suffers from severe acne it is often found that one or both of his or her parents have had it like this; however this is not always so.

Does diet influence acne?
High caloric food can trigger or exacerbate existing acne. But here I want to put the fact that a high glycemic index diet act as single edged sword but milk and milk products act as double edged sword. So if you have serious type acne then you have to give up your love for milk. And also if if you are convinced that a particular food exacerbates acne then it might be worthwhile avoding the same. Have healthy food habits and eat a lot of fresh fruits, vegetables, salads and drink a lot of water. 

Do I have to avoid cosmetics if I have acne?
 Greasy [oil based cosmetics] block the pores on the skin and tend to bring on or increase preexisting acne. The same applies to moisturizers that are too heavy and may block the skin pores. A sudden bout of acne following facials, clean-up, bleaching ect…is common.

Can drugs cause acne? 

Pills [oral contraceptives] can sometimes aggravate acne. Steroids, inh [given for tuberculosis] and anti-epileptics like phenobarbitone can produce acne. Topical steroids applied on the face often triggers acneform eruptions after they are withdrawn.

Are there any other predisposing factors?
A shower of new lesions often occurs a few days prior to the onset of menstruation in females. Tight fitting jeans may occlude the ducts leading to acne on the buttocks and thighs. Prolonged wearing of helmets can lead to pimples on the forehead. Both acne and dandruff occur on greasy skin and can coexist.

Why should acne be treated at all?

Acne can produce pustules and cysts, which can lead to pemanent disfiguring scars if left, untreated. Acne can scar not only the skin but also the psyche. It can produce low self-esteem, self-consciousness, anxiety, depression and introvert personality. Clear skin helps tremendously in boosting the self-confidence of an individual.

What is the right treatment for acne? 
Consult your dermatologist for a proper scientific treatment. There are some general instructions to be followed by the patients: 
1) wash your face 3-4 times daily with soap and water.
2) the scalp should be cleansed 2-3 times a week preferably with shampoo.
3) avoid all greasy cosmetics on the face.
4) do not squeeze pimples. It can cause severe scarring.

There are several topical agents and oral medications available for successful treatment which your doctor will decide. You may need long courses of antibiotics for several months in severe acne. For resistant, severe recalcitrant acne your doctor may suggest a medication called isotretinoin.

But you should have a lot of patience and take medications and take medications in the correct doses prescribed and for a proper length of time. Remember that it might take several weeks for acne medication to take effect and the face to clear.

 I ignored my acne and now I have scars. Can you do something for my scars? 
It is always better to prevent scars by proper and early treatment of severe acne. Your doctor will advise you on treatment available for marks

4 people found this helpful

Whiteheads - What Are They & How You Can Get Rid Of Them?

Dermatologist
Dermatologist, Delhi
Whiteheads - What Are They & How You Can Get Rid Of Them?

Similar to blackheads are whiteheads, which develop on our skin. Both blackheads and whiteheads are caused due to clogged pores. However, as opposed to blackheads, whiteheads cannot be extracted by squeezing. Whiteheads are a form of acne that is referred to as closed comedo. They appear on the skin as small round white or light-coloured bumps. When excess oil is secreted in the skin, dead skin cells clog the pore area and block the pore opening, whiteheads are formed. Unlike blackheads that keep the pore open, whiteheads, on the other hand, block the pores.

Causes of whiteheads
Clogged pores are the prime reason that causes whiteheads, and they can occur due to any of the following reasons:

  • Excessive oil secretion or sebum
  • Hormonal changes occurring due to puberty, pregnancy, and menstruation
  • Birth control pills
  • Sweating and humidity
  • Use of certain cosmetics or products that are harmful
  • Eating excessive oily or greasy foods
  • Genetic predisposition


Treatment of whiteheads
Over-the-counter (OTC) creams or prescribed medications by a dermatologist are the ideal treatments for whiteheads. Self-care and some preventive measures will also keep them at bay. OTC creams that contain salicylic acid, benzoyl peroxide, resorcinol or sulphur may be helpful. With extreme conditions, oral medications like isotretinoin, or Accutane may be prescribed, but these come with potential side effects.

Self-care tips 
Practising some of the following preventive self-care measures will prevent formation of whiteheads:
Wash your skin twice daily with lukewarm water and mild soap.

  • Don’t squeeze pimples.
  • Practice caution while shaving.
  • Avoid excessive exposure to sunlight.
  • Use oil-free skin products.
  • Remove makeup before going to bed.
  • Opt for non-comedogenic or non-pore-clogging products.
  • Wear loose-fitting clothing made of non-synthetic fabrics to let your skin breathe.
  • Wash your hair regularly.
  • Use fragrance-free water-based emollient for dry skin.
  • Continue your skincare regimen.

Here are some remedies you can try to get rid of whiteheads:

  1. Baking soda scrub: Make a homemade scrub mixing one tsp. of baking soda with enough water to make a paste. Scrub it into the problem area. Let it dry for 15-20 minutes and wash it off with lukewarm water. Baking soda is a natural exfoliant and astringent that eradicates all impurities, which clog the pores. It also balances the oil production in the skin.
  2. Tea tree oil: Dab a cotton swab with tea tree oil and apply it on the whiteheads to prevent bacterial infection.

The above are just some measures to avoid whiteheads. If the problem persists, then it's time to seek medical assistance and schedule an appointment with a dermatologist to eradicate these pesky whiteheads.

In case you have a concern or query you can always consult an expert & get answers to your questions!

4343 people found this helpful

All About Acne Vulgaris

MBBS, DHMS-Harvard, Masters in Clinical Dermatology
Dermatologist, Chandigarh
All About Acne Vulgaris

Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present as noninflammatory lesions, inflammatory lesions, or a mixture of both, affecting mostly the face but also the back and chest.

Acne vulgaris has a multifactorial pathogenesis, of which the key factor is genetics. Acne develops as a result of an interplay of the following four factors: (1) follicular epidermal hyperproliferation with subsequent plugging of the follicle, (2) excess sebum production, (3) the presence and activity of the commensal bacteria Propionibacterium acnes, and (4) inflammation.

Acne occurs through the interplay of 4 major factors:

  • Excess sebum production
  • Follicular plugging with sebum and keratinocytes
  • Colonization of follicles by Propionibacterium acnes (a normal human anaerobe)
  • Release of multiple inflammatory mediators

The most common trigger is

  • Puberty

During puberty, surges in androgen stimulate sebum production and hyperproliferation of keratinocytes.

Other triggers include

  • Hormonal changes that occur with pregnancy or the menstrual cycle
  • Occlusive cosmetics, cleansers, lotions, and clothing
  • High humidity and sweating
  • Associations between acne exacerbation and diet, inadequate face washing, masturbation, and sex are unfounded. Some studies suggest a possible association with milk products and high-glycemic diets. Acne may abate in summer months because of sunlight’s anti-inflammatory effects. Proposed associations between acne and hyperinsulinism require further investigation. Some drugs and chemicals (eg, corticosteroids, lithium, phenytoin, isoniazid) worsen acne or cause acneiform eruptions.
  • Acne results in a variety of lesions. The most common acne locations include the face, neck, chest, and back, where the most sebaceous glands are located. Along the jaw line is a common location in adults. "Blackheads" (open comedones) and "whiteheads" (closed comedones) are follicular plugs that are either sitting below the skin surface (whitehead) or oxidized from being exposed to the air (blackhead). Papules are small pink to reddish-brown bumps, pustules are pus-filled lesions, and nodules or cysts are deeper pus-filled lesions.
  • Mild acne consists of a few papules/pustules and/or comedones. Moderate acne has an increased number of lesions. Severe acne has numerous comedones, papules, pustules, and may have painful nodules.
  • Acne can result in permanent scars, which can appear to be depressions in the skin or hyperpigmentation, which is dark red or brown flat marks where the acne lesions were.

Treatment

  • Comedones: Topical tretinoin
  • Mild inflammatory acne: Topical retinoid alone or with a topical antibiotic, benzoyl peroxide, or both
  • Moderate acne: Oral antibiotic plus topical therapy as for mild acne
  • Severe acne: Oral isotretinoin
  • Cystic acne: Intralesional triamcinolone
2 people found this helpful

What is Scarring Alopecia?

Dermatologist
Dermatologist, Delhi
What is Scarring Alopecia?

Scarring Alopecia, otherwise called Cicatricial Alopecia, alludes to a gathering of hair loss issue that might be diagnosed in up to 3% of hair loss patients. It happens worldwide in generally healthy men and women of any age.

Every particular diagnosis inside this class is genuinely uncommon, yet a few cases incorporate analyzing Cellulitis, Eosinophilic Pustular Folliculitis, Follicular Degeneration Disorder (beforehand called "Hot Brush" Alopecia), folliculitis decalvans, lichen planopilaris, and pseudopelade of Brocq, to give some examples. Scarring Alopecia may likewise be a piece of a significantly bigger condition, for example, Chronic Lupus Erythematosus, where numerous organs of the body can be influenced.

While there are many types of Scarring Alopecia, the normal topic is a conceivably changeless and irreversible demolition of hair follicles and their Replacement with scar tissue.

Most types of Scarring Alopecia initially happens as little Patches of Hair Loss that may extend with time. Now and again the hair loss is steady, without recognizable indications, and may go unnoticed for quite a while. In different examples, the hair loss is related with Serious Itching, Burning, and Pain, and is quickly dynamic.

The Scarring Alopecia Patches normally appear to be somewhat unique from Alopecia Areata in that the edges of the Bald Patches look more "battered." The annihilation of the hair follicle happens beneath the skin surface so there may not be much too really observe on the scalp skin surface other than Patchy Hair Loss. Influenced areas might be smooth and clean, or may have redness, scaling, expanded or diminished pigmentation, or may have risen rankles with fluids or Pus originating from the influenced area.

These visual markers may help with diagnosis; however it is hard to diagnose a Scarring Alopecia just from the pattern of the hair loss and the nature of the scalp skin. Regularly while Scarring Alopecia is suspected, at least one Skin Biopsies are done to affirm the diagnosis and help recognize the specific type of Scarring Alopecia. A little biopsy of 2 to 4 mm in distance across is taken and analyzed under a microscope. A Pathologist or Dermatologist will search for annihilation of the hair follicles, scar tissue deep in the skin, and the presence and area of aggravation in relation to the hair follicles.

Regularly, the early phases of a Scarring Alopecia will have Inflammatory Cells around the hair follicles, which, numerous scientists believe, actuates the demolition of the hair follicles and advancement of scar tissue. In any case, there is some argument about this among Dermatologists, as in some cases a biopsy from a Scarring Alopecia person shows very low irritation.

Scarring Alopecia quite often burns out. The Bald Patches quit growing and any irritation, tingling, burning, or pain goes away. In this end phase; another skin biopsy generally demonstrates no inflammation around hair follicles. Bald areas more often than not have no more hair follicles. Here and there, however, hair follicles, in any event those at the fringe of a Bald Patch, are not totally annihilated and they can re-grow, but rather frequently all that is left are only a couple of Longitudinal Scars deep in the skin to indicate where the hair follicles used to be.

Treatment

Scarring Alopecia can include a great deal of harm and lasting Hair Loss. Hence treatment of Scarring Alopecia ought to be very forceful. The nature of treatment changes relying upon the specific Diagnosis. Scarring Alopecia’s that include for the most part Lymphocyte Inflammation of hair follicles, for example, Lichen Planopilaris and Pseudopelade, are by and large treated with Corticosteroids in topical creams and by Injections into the affected skin. Likewise, Antimalarial and Isotretinoin Medications might be utilized.

For Scarring Alopecia’s with aggravation of generally Neutrophils or a blend of cells, treatment includes Antibiotics and Isotretinoin. All the more tentatively, drugs like Methotrexate, Tacrolimus, Cyclosporin, and even Thalidomide have been utilized to treat a few structures.

Once a Scarring Alopecia has achieved the burn out stage and there has been no more Hair Loss for a couple of years, Bald areas can be either surgically expelled on the off chance that they are not very huge or the Bald Patches can be transplanted with hair follicles taken from unaffected areas.

2 people found this helpful