Promal Tablet is used in combination with atovaquone, for the prevention and treatment of malaria. It is administered orally, and is available in the form of tablets of two types – one for adults and one for children. The dosage is different for the two. This medicine is mostly used to combat the type of malaria known as malignant malaria, the causative organism of which is a protozoan known as Plasmodium falciparum. It is mainly used in regions where a resistance to chloroquine has been widely reported.
The dose should be taken daily, along with food or milk. In case you face difficulty in swallowing, you may crush the tablet and mix it with condensed milk. In case of vomiting within an hour of taking the dose, the dose should be repeated.
The following side effects have been observed in some cases: seizures, hallucinations, anaphylaxis, urticaria, hepatitis, liver failure, sensitivity to sunlight and rashes. Do not take this medicine and Rifampin or Rifambutin simultaneously. Vomiting and nausea have been observed to occur in most patients with regularity. If severe or persistent vomiting or diarrhea occurs, it is highly recommended that the patient be given alternative anti-malarial therapy to treat their medical condition.
Is It safe with alcohol?Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?Laveran tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Are there any breast-feeding warnings?Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?There is no interaction between driving and consuming this drug. So dose alteration is not needed.
Does this affect kidney function?Caution should be used in patients with renal impairment.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
Promal Tablet halts the biosynthesis of purines and pyrimidines, that are prerequisites of DNA synthesis and cell proliferation by preventing the dihydrofolate reductase of plasmodia. Therefore, nuclear division does not take place during the formation of schizont in erythrocytes and liver.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
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