Promal Tablet is used in combination with atovaquone, for the prevention and treatment of malaria. It is administered orally, and is available in the form of tablets of two types – one for adults and one for children. The dosage is different for the two. This medicine is mostly used to combat the type of malaria known as malignant malaria, the causative organism of which is a protozoan known as Plasmodium falciparum. It is mainly used in regions where a resistance to chloroquine has been widely reported.
The dose should be taken daily, along with food or milk. In case you face difficulty in swallowing, you may crush the tablet and mix it with condensed milk. In case of vomiting within an hour of taking the dose, the dose should be repeated.
The following side effects have been observed in some cases: seizures, hallucinations, anaphylaxis, urticaria, hepatitis, liver failure, sensitivity to sunlight and rashes. Do not take this medicine and Rifampin or Rifambutin simultaneously. Vomiting and nausea have been observed to occur in most patients with regularity. If severe or persistent vomiting or diarrhea occurs, it is highly recommended that the patient be given alternative anti-malarial therapy to treat their medical condition.
Malaria refers to the disease transmitted through the bite of an infected mosquito. The primary agent of transmission of this disease is the ‘Anopheles’ mosquito. This particular breed of mosquito carries the species causing organism, a parasitic protozoan, known as ‘Plasmodium species’.
The parasite, upon entering the bloodstream, attaches itself to the liver. It is at this location that the parasite matures and after a few days begins to infect the red blood cells that are secreted by the liver. The red blood cells that are infected tend to explode in about forty eight to seventy two hours due to the rapid multiplication of parasites inside them. The subtropical regions and regions that exist in a broad band around the equator are known to be the hotspots of species.
Upon being infected, the symptoms and signs show up within 10 days to 4 weeks. Some of the general symptoms include:
Moderate to severe chills
Pain in muscles
In some cases, malaria can lead to further severe complications, such as:
Kidney, spleen or liver failure
Cerebral malaria (swollen blood vessels in the brain)
Low blood sugar
Pulmonary oedema (fluid accumulation in the lungs which causes breathing difficulties)
The medications administered for malaria depend on factors such as:
Severity of the infection
Physical conditions such as allergies, pregnancy and other health problems,
Some of the most common medicines used to address malaria include: