Prolet 25mg Tablet
Prolet 25mg Tablet is used either in combination with other anticonvulsants or by itself, to treat and to control grand mal, psychomotor and certain focal epileptic seizures. It is administered orally, and is available in the form of tablets. This medicine is prescribed differently for adults and children who are over 8 years of age and for children under 8 years of age.
The dosage of Prolet 25mg Tablet depends on whether the patient is already being given other anticonvulsants or not. The most common side effects of Prolet 25mg Tablet are vertigo and ataxia. These symptoms reduce over time, or with reduction in dosage.
There have been occasional reports of nausea, vomiting, anorexia, fatigue, extreme irritability, sexual impotency, emotional disturbances, drowsiness, and skin eruptions. Irregularities in blood cell counts have been infrequently reported. In cases of such severe side effects, doctors are advised to facilitate withdrawal of the drug.
Since this medicine is antiepileptic in nature, its withdrawal must be slow and gradual. The sudden withdrawal of such medication may lead to status epilepticus. As it were, a dosage regimen consisting of Prolet 25mg Tablet takes several weeks before its efficiency can be assessed.
Inform your health supervisor if you are allergic to any of the components of this medicine. Take exactly as directed (do not increase dose or frequency or discontinue without consulting prescriber); may cause physical and/or psychological dependence.
While using this medication, do not use alcohol and other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or hypnotics) without consulting prescriber.
Wear identification of epileptic status and medications. Report behavioral or CNS changes (confusion, depression, increased sedation, excitation, headache, insomnia, or lethargy); muscle weakness, or tremors; unusual bruising or bleeding (mouth, urine, stool); worsening of seizure activity, or loss of seizure control.
This tablet is helpful against the following conditions:
Is It safe with alcohol?This tablet may cause excessive drowsiness and calmness with alcohol.
Are there any pregnancy warnings?This medicine should be avoided by pregnant women unless suggested by the doctor.
Are there any breast-feeding warnings?The tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?Caution is advised when driving or operating machinery.
Does this affect kidney function?Caution to be advised in patients with impaired renal function.
Does this affect liver function?There is no data available. Please consult a doctor before consuming the drug.
Are there any missed dose instructions?Take the missed dose as soon as possible.
Are there any overdose instructions?Consult a doctor in case of overdose.
Though the precise mechanism of action of this drug is not known, it is evidenced that the drug changes seizure patterns. Primidone and its two metabolites, phenobarbital and phenylethylmalonamide have anticonvulsant activity.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Lab Test
Interaction with Medicine
- Primidone may reduce the efficacy of beta-blockers, chloramphenicol, cimetidine, clozapine, corticosteroids, cyclosporine, disopyramide, doxycycline, ethosuximide, furosemide, griseofulvin, haloperidol, lamotrigine, methadone, nifedipine, oral contraceptives, phenothiazine, phenytoin, propafenone, quinidine, tacrolimus, TCAs, theophylline, warfarin, and verapamil.
- Increased toxicity when combined with other CNS depressants, benzodiazepine, valproic acid, chloramphenicol, or antidepressants; respiratory and CNS depression may be additive.
- MAOIs may prolong the effect of primidone.
- Barbiturates inhibit the hypoprothombinemic response to warfarin.
Interaction with Disease
- Use with caution in patients with renal or hepatic impairment, pulmonary insufficiency; abrupt withdrawal may precipitate status epilepticus. Potential for drug dependency exists. Do not administer to patients in acute pain.
- Use caution in elderly, debilitated, or pediatric patients - may cause paradoxical responses. May cause CNS depression, which may impair physical or mental abilities. Patients must be cautioned about performing tasks which require mental alertness (ie, operating machinery or driving). Effects with other sedative drugs or ethanol may be potentiated.
- Use with caution in patients with depression or suicidal tendencies, or in patients with a history of drug abuse. Tolerance or psychological and physical dependence may occur with prolonged use.
- Primidone's metabolite, phenobarbital, has been associated with cognitive deficits in children.
- Use with caution in patients with hypoadrenalism.
Interaction with Food
- Folic acid: Low erythrocyte and CSF folate concentrations. Megaloblastic anemia has been reported. To avoid folic acid deficiency and megaloblastic anemia, some clinicians recommend giving patients on anticonvulsants prophylactic doses of folic acid and cyanocobalamin.
- Protein-deficient diets: Increases duration of action of primidone. Should not restrict or delete protein from diet unless discussed with physician. Be consistent with protein intake during primidone therapy.
- Fresh fruits containing vitamin C: Displaces drug from binding sites, resulting in increased urinary excretion of primidone. Educate patients regarding the potential for decreased primidone effect with consumption of foods high in vitamin C.
Ques: Is Prolet 25mg Tablet habit forming?
Ques: Can I stop taking Prolet 25mg Tablet?
Ques: What should I avoid while taking Prolet 25mg Tablet?
Ques: What are the serious side effects of using Prolet 25mg Tablet? How can I check for these side effects?
Ques: Can Prolet 25mg Tablet cause headache?
Ques: Does Prolet 25mg Tablet affect blood pressure?
Ques: Can I take Prolet 25mg Tablet and propranolol together?
Ques: How should I store Prolet 25mg Tablet?
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Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.