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Prolet 25mg Tablet

Manufacturer: Alteus Biogenics Pvt Ltd
Medicine composition: Primidone
Prescription vs.OTC: Prescription by Doctor not required
Last Updated: April 29, 2021

Prolet 25mg Tablet is used either in combination with other anticonvulsants or by itself, to treat and to control grand mal, psychomotor and certain focal epileptic seizures. It is administered orally, and is available in the form of tablets. This medicine is prescribed differently for adults and children who are over 8 years of age and for children under 8 years of age.

The dosage of Prolet 25mg Tablet depends on whether the patient is already being given other anticonvulsants or not. The most common side effects of Prolet 25mg Tablet are vertigo and ataxia. These symptoms reduce over time, or with reduction in dosage.

There have been occasional reports of nausea, vomiting, anorexia, fatigue, extreme irritability, sexual impotency, emotional disturbances, drowsiness, and skin eruptions. Irregularities in blood cell counts have been infrequently reported. In cases of such severe side effects, doctors are advised to facilitate withdrawal of the drug.

Since this medicine is antiepileptic in nature, its withdrawal must be slow and gradual. The sudden withdrawal of such medication may lead to status epilepticus. As it were, a dosage regimen consisting of Prolet 25mg Tablet takes several weeks before its efficiency can be assessed.

Inform your health supervisor if you are allergic to any of the components of this medicine. Take exactly as directed (do not increase dose or frequency or discontinue without consulting prescriber); may cause physical and/or psychological dependence.

While using this medication, do not use alcohol and other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or hypnotics) without consulting prescriber.

Wear identification of epileptic status and medications. Report behavioral or CNS changes (confusion, depression, increased sedation, excitation, headache, insomnia, or lethargy); muscle weakness, or tremors; unusual bruising or bleeding (mouth, urine, stool); worsening of seizure activity, or loss of seizure control.

This tablet is helpful against the following conditions:

  • Hypersensitivity

  • Porphyria

  • Respiratory Depression

Some of the side effects that may be observed in patients are:

  • Is It safe with alcohol?

    This tablet may cause excessive drowsiness and calmness with alcohol.
  • Are there any pregnancy warnings?

    This medicine should be avoided by pregnant women unless suggested by the doctor.
  • Are there any breast-feeding warnings?

    The tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
  • Is it safe to drive while on this medicine?

    Caution is advised when driving or operating machinery.
  • Does this affect kidney function?

    Caution to be advised in patients with impaired renal function.
  • Does this affect liver function?

    There is no data available. Please consult a doctor before consuming the drug.
  • Are there any missed dose instructions?

    Take the missed dose as soon as possible.
  • Are there any overdose instructions?

    Consult a doctor in case of overdose.

Though the precise mechanism of action of this drug is not known, it is evidenced that the drug changes seizure patterns. Primidone and its two metabolites, phenobarbital and phenylethylmalonamide have anticonvulsant activity.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Lab Test

    False test report might result due to fluctuation of alkaline phosphatase (S); calcium (S) level.
  • Interaction with Medicine

    Concomitant use of this medicine with the following must be avoided:
    • Primidone may reduce the efficacy of beta-blockers, chloramphenicol, cimetidine, clozapine, corticosteroids, cyclosporine, disopyramide, doxycycline, ethosuximide, furosemide, griseofulvin, haloperidol, lamotrigine, methadone, nifedipine, oral contraceptives, phenothiazine, phenytoin, propafenone, quinidine, tacrolimus, TCAs, theophylline, warfarin, and verapamil.
    • Increased toxicity when combined with other CNS depressants, benzodiazepine, valproic acid, chloramphenicol, or antidepressants; respiratory and CNS depression may be additive.
    • MAOIs may prolong the effect of primidone.
    • Barbiturates inhibit the hypoprothombinemic response to warfarin.
  • Interaction with Disease

    • Use with caution in patients with renal or hepatic impairment, pulmonary insufficiency; abrupt withdrawal may precipitate status epilepticus. Potential for drug dependency exists. Do not administer to patients in acute pain.
    • Use caution in elderly, debilitated, or pediatric patients - may cause paradoxical responses. May cause CNS depression, which may impair physical or mental abilities. Patients must be cautioned about performing tasks which require mental alertness (ie, operating machinery or driving). Effects with other sedative drugs or ethanol may be potentiated.
    • Use with caution in patients with depression or suicidal tendencies, or in patients with a history of drug abuse. Tolerance or psychological and physical dependence may occur with prolonged use.
    • Primidone's metabolite, phenobarbital, has been associated with cognitive deficits in children.
    • Use with caution in patients with hypoadrenalism.
  • Interaction with Food

    • Folic acid: Low erythrocyte and CSF folate concentrations. Megaloblastic anemia has been reported. To avoid folic acid deficiency and megaloblastic anemia, some clinicians recommend giving patients on anticonvulsants prophylactic doses of folic acid and cyanocobalamin.
    • Protein-deficient diets: Increases duration of action of primidone. Should not restrict or delete protein from diet unless discussed with physician. Be consistent with protein intake during primidone therapy.
    • Fresh fruits containing vitamin C: Displaces drug from binding sites, resulting in increased urinary excretion of primidone. Educate patients regarding the potential for decreased primidone effect with consumption of foods high in vitamin C.

Ques: Is Prolet 25mg Tablet habit forming?

Ans: Yes, if you use Prolet 25mg Tablet for a long time, you may become dependent on it. Moreover, stopping the medicine suddenly may also lead to withdrawal symptoms. Therefore, you must inform your doctor before stopping the Prolet 25mg Tablet.

Ques: Can I stop taking Prolet 25mg Tablet?

Ans: Do not stop taking Prolet 25mg Tablet even if you are feeling well, unless your doctor advises so. Suddenly stopping Prolet 25mg Tablet may cause unwanted effects commonly known as withdrawal symptoms. To prevent this, the dose of Prolet 25mg Tablet needs to be reduced gradually before completely stopping it.

Ques: What should I avoid while taking Prolet 25mg Tablet?

Ans: If Prolet 25mg Tablet makes you feel sleepy, avoid driving or operating heavy machinery. Alcohol consumption should be avoided since taking both together may cause excessive sleepiness. You should avoid getting pregnant since Prolet 25mg Tablet is associated with an increased risk of abnormalities in babies.

Ques: What are the serious side effects of using Prolet 25mg Tablet? How can I check for these side effects?

Ans: Severe allergic reactions, skin reactions, abnormalities in blood cells, and worsening of seizures are some of the serious side effects of Prolet 25mg Tablet. Severe allergic reactions may result in difficulty in breathing, swelling of the lips, tongue, face, or hives. Skin reactions may cause redness, pain, ulcers, blisters, shedding the outer layer of skin. If you have an abnormality of the blood cells, your skin may appear pale. Additionally you may suffer from abnormal bleeding or frequent bruising, fever, or sore throat.

Ques: Can Prolet 25mg Tablet cause headache?

Ans: Though headache is not a very common side effect of Prolet 25mg Tablet, it can occur in a few patients.

Ques: Does Prolet 25mg Tablet affect blood pressure?

Ans: No, Prolet 25mg Tablet does not have any effect on blood pressure.

Ques: Can I take Prolet 25mg Tablet and propranolol together?

Ans: While taking propranolol and Prolet 25mg Tablet together, your blood pressure should be monitored as Prolet 25mg Tablet may interfere with working of propranolol. Your doctor may modify your dose if needed.

Ques: How should I store Prolet 25mg Tablet?

Ans: Keep it in a cool dry place where the temperature stays below 25°C. Do not leave it on a windowsill or in the car on hot days. Keep it out of reach of children.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Prolet 25mg Tablet
What are the uses of Prolet 25mg Tablet
What are the contraindications of Prolet 25mg Tablet ?
What are the side effects of Prolet 25mg Tablet ?
Key highlights of Prolet 25mg Tablet
What are the dosage instructions?
How does this medication work?
What are the interactions of Prolet 25mg Tablet ?
FAQs about Prolet 25mg Tablet