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Overview

Panazep 12.5Mg Tablet

Manufacturer :  Sun Pharmaceutical Industries Ltd
Medicine Composition :  Paroxetine, Clonazepam
Prescription vs OTC : Prescription by Doctor not required

About Panazep 12.5Mg Tablet

Panazep 12.5 Tablet is an antidepressant along with anti-convulsant. It is used in the treatment of various mental disorders such as OCD, depression, anxiety, post-traumatic stress disorder (PTSD). The Brisdelle brand of this tablet is used in the treatment of hot flashes and night sweats that comes from menopause. On using this medication the common side effects that you may experience are

  • Dryness of the mouth
  • Reduced appetite
  • Drowsiness
  • Insomnia
  • Problems with ejaculation
  • Agitation
  • Chest pain
  • Skin rash
  • Difficulty in breathing
  • Lightheartedness

Take exactly as directed (do not increase dose or frequency). It may take 2-3 weeks to achieve desired results. This medicine may cause physical and/or psychological dependence. Take in the morning to reduce the incidence of insomnia.

Avoid excessive alcohol, caffeine, and other prescription or OTC medications not approved by prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

Symptoms of overdose include nausea, vomiting, drowsiness, sinus tachycardia, and dilated pupils. There are no specific antidotes, following attempts at decontamination, treatment is supportive and symptomatic; forced diuresis, dialysis, and hemoperfusion are unlikely to be beneficial.

As interaction with certain drugs especially anti-inflammatory ones such as NSAID may cause certain harmful reactions. This medication is available in tablet form. Generally, the usual dose in adults is about 20 mg orally once in a day.

Also Read: Pilorute Cream Side Effects

    What are the uses of Panazep 12.5Mg Tablet

    What are the contraindications of Panazep 12.5Mg Tablet ?

    • Monoamine oxidase inhibitors (MAOI)

    • Thioridazine

    • Pimozide

    • Allergy

    What are the side effects of Panazep 12.5Mg Tablet ?

    Key highlights of Panazep 12.5Mg Tablet

    • How long is the duration of effect?

      The time for which this medicine remains effective in the body is not clearly established. Dosing, duration and the condition for which this medication is given determine the effective time duration.

    • What is the onset of action?

      The effect of Panazep 12.5 Tablet is cumulative and may take months to show. It varies depending on the intended use and the dosing.

    • Are there any pregnancy warnings?

      Use of this medication by pregnant women is not recommended as the risk of adverse effect on the fetus is very high. Consult your doctor if you are pregnant or are planning a pregnancy while taking this medication.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      Use of this medication by breastfeeding women is not recommended unless necessary. If necessary, your doctor may advise you to stop breastfeeding before treatment with this medicine is initiated.

    • Is It safe with alcohol?

      It is found to be unsafe to consume alcohol with Panazep 12.5Mg Tablet.

    • Is it safe to drive while on this medicine?

      It may cause side effect that affects the patients ability to drive. Thus it is advised to drive while taking this medicine.

    • Does this affect kidney function?

      This medicine is probably found to be safe if given to patient with kidney disease. Limited data on it suggests that adjustment of dose is not needed. Kindly consult your doctor before taking it.

    • Does this affect liver function?

      Caution must be taken in patient with liver disease. adjustment of dose might be needed.Kindly consult the doctor before taking it.

    What are the substitutes for Panazep 12.5Mg Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Panazep 12.5Mg Tablet , and hence can be used as its substitute.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      Take the missed dose as soon as you remember. If the next scheduled dose is less than 4 hours away, then the missed dose should be skipped.

    • Are there any overdose instructions?

      Contact a doctor immediately if an overdose with this medication is suspected.

    How does this medication work?

    Panazep 12.5 Tablet works by selectively inhibiting the reuptake of serotonin. It results in higher concentrations of serotonin in the brain. Also, It inhibits the synaptic transmission that occurs in the central nervous system. It reduces the use of serotonin by neurons and is used to treat seizures and anxiety.

      What are the interactions of Panazep 12.5Mg Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Ethanol

        Avoid or limit the uptake of alcohol while using this medicine. It is advised to refrain from driving vehicles and operating heavy machinery while using this medicine.
      • Interaction with Lab Test

        Lab

        Information not available.
      • Interaction with Medicine

        • Panazep 12.5Mg Tablet may cause hyponatremia. Additive hyponatremic effects may be seen with combined use of a loop diuretic (bumetanide, furosemide, torsemide); monitor for hyponatremia.
        • Panazep 12.5Mg Tablet inhibits the reuptake of serotonin. Combined use with a serotonin agonist (buspirone) may cause serotonin syndrome.
        • Panazep 12.5Mg Tablet inhibits the metabolism of dextromethorphan; visual hallucinations occurred in a patient receiving this combination; monitor for serotonin syndrome.
        • Panazep 12.5Mg Tablet may inhibit the metabolism of haloperidol and cause extrapyramidal symptoms (EPS); monitor patients for EPS if combination is utilized.
        • Panazep 12.5Mg Tablet should not be used with nonselective MAOIs (isocarboxazid, phenelzine). Fatal reactions have been reported. Wait two weeks after stopping fluoxetine before starting an MAOI and two weeks after stopping an MAOI before starting fluoxetine.
        • Panazep 12.5Mg Tablet inhibits the reuptake of serotonin; combined use with other drugs which inhibit the reuptake (nefazodone, sibutramine) may cause serotonin syndrome. Monitor patient for altered response with nefazodone; avoid sibutramine combination.
        • Panazep 12.5Mg Tablet has been reported to cause mania or hypertension when combined with selegiline; this combination is best avoided.
        • Panazep 12.5Mg Tablet combined with tramadol (serotonergic effects) may cause serotonin syndrome; monitor.
        • Panazep 12.5Mg Tablet may alter the hypoprothombinemic response to warfarin; monitor.
        • Cimetidine may reduce the first-pass metabolism of Panazep 12.5Mg Tablet resulting in elevated Panazep 12.5Mg Tablet serum concentrations; consider an alternative H2 antagonist.
      • Interaction with Food

        Food

        Information not available.
      • Interaction with Disease

        Potential for severe reaction when used with MAO inhibitors - serotonin syndrome (hyperthermia, muscular rigidity, mental status changes/agitation, autonomic instability) may occur. May precipitate a shift to mania or hypomania in patients with bipolar disease. Has a low potential to impair cognitive or motor performance - caution operating hazardous machinery or driving. Low potential for sedation or anticholinergic effects relative to cyclic antidepressants. Use caution in patients with depression, particularly if suicidal risk may be present. Use caution in patients with a previous seizure disorder or condition predisposing to seizures such as brain damage, alcoholism, or concurrent therapy with other drugs which lower the seizure threshold. Use with caution in patients with hepatic or dysfunction and in elderly patients. May cause hyponatremia/SIADH. Use with caution in patients at risk of bleeding or receiving anticoagulant therapy - may cause impairment in platelet aggregation. Use with caution in patients with renal insufficiency or other concurrent illness (due to limited experience). May cause or exacerbate sexual dysfunction.

      FAQs about Panazep 12.5Mg Tablet

      • Ques : What is Panazep 12.5Mg Tablet used for?

        Ans : Panazep 12.5Mg Tablet is used in the treatment of various mental disorders such as OCD, depression, anxiety, post-traumatic stress disorder (PTSD).

      • Ques : Where is Panazep 12.5Mg Tablet approved?

        Ans : Panazep 12.5Mg Tablet is approved in India, Micronesia, Japan, and the USA.

      • Ques : Should Panazep 12.5Mg Tablet be taken with a meal or without a meal?

        Ans : The effectiveness of Panazep 12.5Mg Tablet does not depend on a meal, it can be taken either way.

      • Ques : Is Panazep 12.5Mg Tablet safe for usage in paediatrics?

        Ans : Panazep 12.5Mg Tablet is not recommended for usage in paediatrics as its safety and effectiveness are not known.

      • Ques : Does Panazep 12.5Mg Tablet lead to drug dependence?

        Ans : Panazep 12.5Mg Tablet should be used with caution as it may lead to drug dependence with prolonged use.

      • Ques : Does Panazep 12.5Mg Tablet cause withdrawal symptoms?

        Ans : It is advised to not stop taking Panazep 12.5Mg Tablet as it may cause severe withdrawal symptoms.

      • Ques : Is Panazep 12.5Mg Tablet safe for usage in geriatrics?

        Ans : Panazep 12.5Mg Tablet should be used with caution in geriatrics as its safety and effectiveness are not known.

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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