Neomycin is used orally to prepare GI tract for surgery. When applied topically, it is used to treat minor skin infections. The primary use of this medicine is to treat diarrhoea caused by E. coli. It is also used as an adjunct in the treatment of hepatic encephalopathy.
Used to reduce bacteria in the intestines, Neomycin is an aminoglycoside antibiotic. It works by destroying sensitive bacteria by cutting off the production of certain proteins needed for them to survive. Keeping this in mind, it is used to stave off the risk of infections during intestinal surgeries. It can also be used along with a certain diet to treat hepatic encephalopathy.
Neomycin is not to be used if you are allergic to any of its ingredients or to other aminoglycosides such as gentamicin. If you have bowel ulcers, inflammatory bowel disease or any intestinal obstruction, the drug is not advised to be taken. Medicines like penicillin and fludarabine and can interfere with its functioning.
Neomycin is to be taken orally with or without food. Do not use it for more than two weeks unless advised by your doctor. Continue using it for the full course of treatment to clear off the infection, even if you feel better.
To keep away any side effects, it may be taken at the lowest possible dosage and for the shortest period. Some of the side effects include stomach cramps, severe diarrhea, nausea and bloody stool.
Symptoms of overdose (rare due to poor oral bioavailability) include ototoxicity, nephrotoxicity, and neuromuscular toxicity. The treatment of choice following a single acute overdose appears to be the maintenance of good urine output of at least 3 mL/kg/hour.
Dialysis is of questionable value in the enhancement of aminoglycoside elimination. If required, hemodialysis is preferred over peritoneal dialysis in patients with normal renal function. Chelation with penicillin may be of benefit.
The medicine is useful against the following conditions:
Is It safe with alcohol?Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?Neopred tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Are there any breast-feeding warnings?Neopred tablet is probably safe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?There is no data available. Please consult doctor before consuming the drug.
Does this affect kidney function?There is no data available. Please consult doctor before consuming the drug.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
How long is the duration of effect?The effect of this medicine will be initiated with 1 - 2 hours after its administration.
What is the onset of action?This medicine will remain active for about 6 - 8 hours.
Are there any missed dose instructions?If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
Below is the list of medicines, which contains Neomycin as ingredient
This medication belongs to the class of an Aminoglycosides. It binds itself to 30S-subunit proteins and also 16S rRNA. It attaches irreversibly to a total of four nucleotides of 16S rRNA and one protein S12 amino acid. This causes interference when it comes to decoding the site.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Medicine
- Decreased effect: May decrease GI absorption of digoxin and methotrexate.
- Increased effect: Synergistic effects with penicillins.
- Increased toxicity:
- Oral neomycin may potentiate the effects of oral anticoagulants.
- Increased adverse effects with other neurotoxic, ototoxic, or nephrotoxic drugs.
Interaction with Disease
- Use with caution in patients with renal impairment, pre-existing hearing impairment, neuromuscular disorders. Neomycin is more toxic than other aminoglycosides when given parenterally.
- Do not administer parenterally.
- Topical neomycin is a contact sensitizer with sensitivity occurring in 5% to 15% of patients treated with the drug. It might cause symptoms include itching, reddening, edema, and failure to heal.
- Do not use as peritoneal lavage due to significant systemic adsorption of the drug.
Ques: What is Neomycin? What is it used for?
Ques: Is Neomycin effective?
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Ques: Is Neomycin safe?
Neomycin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/neomycin
NEOMYCIN liquid- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 23 Nov 2021]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b46a696a-c49e-406a-90fa-8e06eff9d231
Nivemycin 500 mg Tablets- EMC [Internet]. www.medicines.org.uk. 2014 [Cited 23 Nov 2021]. Available from:https://www.medicines.org.uk/emc/product/6709/smpc
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