Levodopa is an amino acid that is produced and used as a part of the normal biology of human beings, also in some animals and plants. Levodopa crosses the protective blood–brain barrier as dopamine cannot. Thus, Levodopa is used to increase the dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. Besides the central nervous system, Levodopa can also be converted into dopamine from within the peripheral nervous system.
There are two types of responses seen with the administration of Levodopa : The short-duration response which is related to the half-life of the drug. The long-duration response depends directly on the accumulation of effects over at least a two week course, during which ΔFosB accumulates in nigrostriatal neurons. When used in the treatment of Parkinson's disease, this response is seen only in early therapy, as at that stage the inability of the brain to store dopamine is not yet a concern.
Some side effects include hypotension: a result of the dosage being too high, arrhythmias: although this is uncommon, nausea, which can be avoided by taking the drug with food, hair loss, disorientation and, or confusion, an extreme emotional state, particularly anxiety, but also excessive libido.
Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Neurologist before using this medicine.