Prescription vs.OTC: Prescription by Doctor required
Last Updated: January 28, 2022

Glimepiride is used for the management of non-insulin-dependent diabetes mellitus (type 2) as an adjunct to diet and exercise to lower blood glucose. Used in combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent.

Glimepiride is a drug that is used on treating patients suffering from type 2 Diabetes, who can't control blood sugar levels through diet and exercise alone. Hence this drug is used to enhance the positive effects of diet and exercise with respect to blood sugar.

It is also used in combination with other antidiabetic medicines. It is a type of sulfonylurea antidiabetic medicine, that helps the pancreas in releasing insulin thus helping reduce the blood sugar level. It belongs to a class of drugs known as sulfonylureas.

Glimepiride is a type of sulfonylurea antidiabetic medicine which helps the pancreas in releasing insulin thus helping reduce the blood sugar level. It belongs to a class of drugs known as sulfonylureas. Glimepiride is available in oral tablet form.

Before starting a course of the medication, there are certain precautions that need to be taken. Firstly, any form of allergy must be mentioned to the consulting doctor. Also, if you have any history of kidney or liver diseases, it should be mentioned to the doctor.

Glimepiride makes the skin much more sensitive to the sun. Hence, if you are using this medication, use sunscreen to avoid skin problems. Limit the intake of alcohol during medication. Also, inform the doctor if you are currently using any prescribed drugs or diet supplement.

This drug shouldn’t be used by pregnant women. If you had a surgery recently, it is advisable not to take this medicine. The starting dose for Glimepiride is a 1mg tablet once every day. Glimepiride should be stored at a temperature between 20 to 25 degree Celcius. It should be kept away from heat, moisture and direct sunlight. Keep the drug away from the reach of the children and pets.

Symptoms of overdose include low blood sugar, tingling of lips and tongue, nausea, yawning, confusion, agitation, tachycardia, sweating, convulsions, stupor, and coma.

Intoxications with sulfonylureas can cause hypoglycemia and are best managed with glucose administration (oral for milder hypoglycemia or by injection in more severe forms). Patients should be monitored for a minimum of 24-48 hours after ingestion.

Glimepiride is used to control diabetes; it is not a cure. Other components of treatment plan are important: follow prescribed diet, medication, and exercise regimen. Take exactly as directed; 30 minutes before meal(s) at the same time each day.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Diabetologist before using this medicine.

Primary use of this medicine are as follows:

  • Type 2 Diabetes

  • Hyperglycemia

The side effects commonly occurred after the ingestion of this medicine:

  • Headache

  • Edema (Swelling)

  • Rash

  • Urticaria

  • Photosensitivity

  • Hypoglycemia

  • Anorexia

  • Nausea

  • Vomiting

  • Diarrhoea

  • Heartburn

  • Bone Marrow Suppression

  • Thrombocytopenia

  • How long is the duration of effect?

    The medicine remains active in the body for 24 hours after onset of action.
  • What is the onset of action?

    The effect can be observed within 2 - 3 hours of administration.
  • Are there any pregnancy warnings?

    This medicine is not recommended for women who are or may become pregnant.
  • Is it habit forming?

    No habit forming tendencies were reported
  • Are there any breast-feeding warnings?

    This medicine is not recommended for women who are breastfeeding due to a risk of severe adverse effect to the infant.
  • Does this affect kidney function?

    Dose adjustment of is needed in patients with renal impairment. Clcr <22 mL/minute: Initial starting dose should be 1 mg and dosage increments should be based on fasting blood glucose levels. Kindly consult your doctor before taking this medicine.
  • Does this affect liver function?

    Caution must be taken in patients with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking this medication.
  • Is It safe with alcohol?

    Consumption of alcohol is unsafe to be taken along with this medication.
  • Is it safe to drive while on this medicine?

    This medicine can affect the consciousness and alertness of the patient and driving must be avoided after taking it.
  • Are there any missed dose instructions?

    The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.
  • Are there any overdose instructions?

    It is recommended to discontinue the medication and contact your doctor immediately if an overdose is suspected.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Glimepiride as ingredient

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Glimepiride stimulates insulin release from the pancreatic beta cells; reduces glucose output from the liver; insulin sensitivity is increased at peripheral target sites.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Interaction of this medicine with alcohol is found to be unsafe. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine

    Concomitant use of this medicine along with the following must be avoided:
    • YP2C9 enzyme substrate
    • Increased effects: H2-antagonists, anticoagulants, androgens, beta-blockers, fluconazole, salicylates, gemfibrozil, sulfonamides, tricyclic antidepressants, probenecid, MAO inhibitors, methyldopa, NSAIDs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAO inhibitors, digitalis glycosides, urinary acidifiers.
    • Increased toxicity: Cimetidine may increase hypoglycemic effects; certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, and isoniazid.
  • Interaction with Food

    Consumption of grapefruit juice should be avoided while you are on Glimepiride. Signs and symptoms like muscle pain and weakness, fever, and chills, swelling of joints, skin rash, nausea, vomiting should be reported to the doctor.
  • Interaction with Disease

    • All sulfonylurea drugs are capable of producing severe hypoglycemia. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose-lowering drug is used.
    • The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin.
    • At higher dosages, sulfonylureas may block the ATP-sensitive potassium channels, which may correspond to an increased risk of cardiovascular events. In May, 2000, the National Diabetes Center issued a warning to avoid the use of sulfonylureas at higher dosages (glimepiride daily doses >1 mg).

Ques: What is Glimepiride?

Ans: Glimepiride is a salt which performs its action by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Glimepiride is used to treat conditions such as Type II Diabetes Mellitus.

Ques: What are the uses of Glimepiride?

Ans: Glimepiride is a medication, which is used for the treatment and prevention from conditions such as Type II Diabetes Mellitus. The patient should inform the doctor about any ongoing medications and treatment before using Glimepiride to avoid undesirable effects.

Ques: What are the Side Effects of Glimepiride?

Ans: Glimepiride is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Glimepiride which are as follows: Hypoglycemia, Dizziness, Headache, Nausea, Asthenia, Flu like symptoms, Allergic skin reaction, Elevated liver enzymes, Anemia, Jaundice, and Weight gain. It is a list of possible side-effects which may occur due to the constituting ingredients of Glimepiride.

Ques: What are the instructions for storage and disposal Glimepiride?

Ans: Glimepiride should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

Ques: Should I use Glimepiride empty stomach, before food or after food?

Ans: This medication is to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset your stomach. Please consult the doctor before using Glimepiride.

Ques: How long do I need to use Glimepiride before I see improvement of my conditions?

Ans: There is no specific time duration of using this medication in which you can see improvement in your condition. The doctor will prescribe you the doses according to your condition. It is advised to consult your doctor while you are under the usage of medication, to analyze your improvement and tell whether to stop using Glimepiride or not.

Ques: Is there any food or drink I need to avoid, while taking Glimepiride?

Ans: There is no specific food product to avoid, under usage of this medication. It will be beneficial to keep your diet healthy and to ignore street food in order to avoid any kind of harmful bacterial intake. It is also advised to stay away from drinking and smoking to uplift your health.

Ques: Will Glimepiride be more effective if taken in more than the recommended dose?

Ans: Please follow the doses of the medication, as prescribed by your doctor. If you take more than the recommended doses of Glimepiride, it may cause some side effects. It is advised to ask your doctor to re-examine your condition if the severity in the health is not reducing.

Ques: Does Glimepiride make you sleepy?

Ans: No, this drug does not cause sleepiness.

Ques: Is Glimepiride safe for kidneys?

Ans: Yes, this medicine does not affect kidneys in patients with normal kidney function. However, its use should be avoided in patients with severe kidney disease since Glimepiride is principally eliminated by the kidneys.

Ques: Does Glimepiride cause memory loss?

Ans: No, it is not known that Glimepiride causes memory loss. However, the consumption of Glimepiride may cause low blood sugar which may cause problems with concentration and reduced alertness.

Ques: What can happen if I take more than the recommended dose of Glimepiride?

Ans: This medicine should be taken strictly as advised by the doctor. Overdose of this drug may decrease your blood sugar levels (hypoglycemia).
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Glimepiride
What are the uses of Glimepiride
What are the contraindications of Glimepiride ?
What are the side effects of Glimepiride ?
Key highlights of Glimepiride
What are the dosage instructions?
Where is the Glimepiride approved?
Medicines containing Glimepiride
How does this medication work?
What are the interactions of Glimepiride ?
FAQs about Glimepiride