Comig 250 Tablet is a combination medication, primarily prescribed for the treatment and prevention of migraine attacks. This medication is comprized of two drugs, Naproxen and Domperidone, which belongs to the class of a non-steroidal anti-inflammatory drugs and dopamine antagonists, respectively.
On using this medicine some serious side effects may occur that include easy bruising or bleeding, painful swallowing, ringing in the ears, signs of kidney problems, mood changes, unusual tiredness, swelling of the ankles, feet and hands, unexplained stiff neck, unexplained weight gain and vision changes.
To ensure this medicine is safe for you tell your doctor if you have asthma, blood disorders, nasal polyps, liver disease, heart disease, stroke, high blood pressure or throat, stomach or intestinal problems.
Take this medicine by mouth as instructed by your doctor, usually 2 or 3 times in a day. Remember to not lie down for a minimum of 10 minutes after taking it. To prevent stomach upset, take this drug with milk, food or an antacid.
To reduce your risk of side effects, start the medication at the lowest effective dose for a short period of time. Take a higher dosage if needed, after consulting with a doctor.
The medication is primarily used for the following conditions:
Prevention Of Migraine Attacks
Is It safe with alcohol?Taking this medication with alcohol can increase the risk of stomach bleeding caused by naproxen.
Are there any pregnancy warnings?This medication may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Are there any breast-feeding warnings?Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?Do not drive, operate machinery.
Does this affect kidney function?This medicine should not be given in renal failure.
Caution should be used in patients with severe renal impairment.
Does this affect liver function?There is no interaction between liver impairment and consuming this drug. So dose alteration is not needed.
Below is the list of medicines, which have the same composition, strength and form as Comig 250 Tablet , and hence can be used as its substitute.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
Are there any missed dose instructions?If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
This medication is a combination of Naproxen and Domperidone. This medicine is prescribed for the treatment of migraine attacks. As both the drugs belong to two different classes, namely, NSAIDs (Non-Steroidal Anti Inflammatory Drug) and Dopamine antagonist, respectively, thus it works via dual mechanism
Firstly it inhibits prostaglandin synthesis by non selectively impeding the COX -1 and COX -2 enzymes. This helps in alleviating inflammation, as prostaglandin is a regulator for inflammation in muscles. Secondly, it gets attached to the dopaminergic receptors without causing any release of the chemical dopamine. This, in turn, eases gastric emptying and abate small bowel transit time.
Ques: What is Comig 250 Tablet used for?
Ques: What are the side effects of Comig 250 Tablet?
Some of the side effects are mentioned below;
- inability of concentration
- swelling of eyes and lips
Ques: Is Comig 250 Tablet safe during pregnancy?
Ques: How long do I need to use Comig 250 Tablet before I see improvement in my condition?
Ques: At what frequency do I need to use Comig 250 Tablet?
Ques: What are the instructions for the storage and disposal of Comig 250 Tablet?
Naproxen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/naproxen
Naproxen- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB00788
Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/domperidone
Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB01184
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