Lybrate Logo
Get the App
For Doctors
Login/Sign-up
tab_logos
About
tab_logos
Feed
Overview

Domperidone

Prescription vs OTC : Prescription by Doctor required

About Domperidone

Domperidone is indicated for treating the symptoms caused by vestibular disorders. It is also prescribed in vertigo/motion sickness, nausea, dizziness, headache, vomiting, the sensation of fullness when there is a delay in gastric emptying.

The active ingredient domperidone fall under the class of dopamine antagonist. The medicine tightens the muscles near the entrance of the stomach and relaxes the ones present at the exit.

The action of this medication helps to speed up the passing of the food that you intake - from your stomach to your intestine, reducing the feeling of nausea and sickness, also preventing vomiting.

This medicine also works by blocking or reducing the stimulation in the ‘vomiting centre’ of your brain, which will eventually reduce the feeling of nausea and vomiting. The possible side effects of taking this medication can be nausea, dryness in mouth, indigestion, sleepiness or weight gain.

You are advised not to take Domperidone if you have the following conditions:

  • An allergy to Domperidone or any other ingredient of this medicine
  • Bleeding problems or blockage in your stomach or in the intestine
  • Tumour in the pituitary gland
  • Cardiac disease
  • Incorrect levels of magnesium, potassium or calcium in the blood
  • Severe/moderate liver impairment

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the uses of Domperidone

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the contraindications of Domperidone ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the side effects of Domperidone ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    Key highlights of Domperidone

    • How long is the duration of effect?

      The effect of this medicine lasts up to 6 hours.

    • What is the onset of action?

      The peak effect of this medicine can be observed within 30 to 60 minutes of administration.

    • Are there any pregnancy warnings?

      This medicine is not recommended for use in pregnant women unless the potential benefits outweigh the risks involved. The effect of this medicine on the fetus is not clearly established and hence you are advised to consult a doctor before taking this medicine.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is not recommended for use by breastfeeding mothers as there is a risk of side effects on the infant. You are advised to consult your doctors and consider the potential benefit and risks before consuming this medication.

    • Is It safe with alcohol?

      This fact remain unknown, whether it is safe or not to consume this medicine along with alcohol. Please consult the doctor before taking it.

    • Is it safe to drive while on this medicine?

      This medicine may affect the alertness of the patient taking this medicine. Do not drive if you feel side effects affecting your alertness.

    • Does this affect kidney function?

      Caution must be taken in patients with kidney disease. Dose adjustment is needed. Consult your doctor before taking this.

    • Does this affect liver function?

      Caution must be taken in patients with liver disease. Dose adjustment is needed. Consult your doctor before taking this.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      Skip the missed dose and resume with the next scheduled dose at the right time. The dose should not get doubled in an attempt to make up for the missed dose.

    • Are there any overdose instructions?

      Contact your doctor if an overdose is suspected. Symptoms of overdose may include drowsiness, agitation, and convulsions and may be more prevalent in infants and children. Immediate medical attention including gastric lavage may be required in severe cases.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    Where is the Domperidone approved?

    • India

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    Medicines containing Domperidone

    Below is the list of medicines, which contains Domperidone as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    How does this medication work?

    This medication attaches to the dopaminergic receptors without causing any release of the chemical dopamine. It, in turn, facilitates gastric emptying and decreases small bowel transit time. Also, it prevents the relay of repetitive messages from the nerves in the inner ear to the vomiting centre in the brain. Thus altogether alleviates the symptoms.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

      What are the interactions of Domperidone ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Lab

        The patients taking this medicine have been reported for false results, as it interacts with investigations of Neuroendocrine Tumors, Secretin Stimulation Test, Urine Tests for THC. Thus an alternative confirmatory test should be considered to verify the results.

        Skin sensitivity test

        Report the use of this medicine to the doctor before a skin sensitivity test. This medicine may interfere with the procedure and may give false negative results. Use of this medicine should stop at least 4 days before the test is conducted.
      • Interaction with Medicine

        Concomitant use of Antiretrovirals, warfarin, methotrexate, digoxin, Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole), tacrolimus, antiarrhythmics, apomorphine, protease inhibitors, systemic azole antifungals, some macrolides (erythromycin, clarithromycin and telithromycin) is contraindicated.
      • Interaction with Disease

        Kidney Disease

        Domperidone should be used with caution if you are suffering from impaired kidney function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is severe.

        Liver Disease

        Domperidone should be used with caution if you are suffering from impaired liver function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is mild to moderate. For severe impairment, use of this medicine is not recommended.

        Intestinal Disorders

        Domperidone should be used with extreme caution in people having serious intestinal problems like internal bleeding, an obstruction or perforation of the stomach and intestine. Use of an alternate medicine is advised in such cases.

        Parkinson's Disease

        This medicine should be used with caution in patients suffering from Parkinson's disease. It should be used only when the potential benefits outweigh the risks involved with use.
      • Interaction with Food

        Information not available.

      FAQs about Domperidone

      • Ques : What is Domperidone used for?

        Ans : This medication is used to prevent symptoms including vestibular disorders, vertigo/motion sickness, nausea, the sensation of fullness when there is a delay in gastric emptying.

      • Ques : Is Domperidone safe during pregnancy?

        Ans : You are advised to consult the doctor before consuming this drug if you are a pregnant woman.

      • Ques : What is the best time of day to take Domperidone?

        Ans : The best time to take this medication is to consume it empty stomach or before the first meal. But it is not adequate for the patients who have known allergies to Domperidone or other medication of the same group.

      • Ques : Is Domperidone safe while breastfeeding?

        Ans : This medicine is not adequate for the use of breastfeeding unless it’s extremely necessary. Consult your doctor about all the risks and benefits before consuming this medication.

      • Ques : How long do I need to use Domperidone before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Domperidone?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : What are the instructions for the storage and disposal of Domperidone?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      • Ques : Is Domperidone an over the counter drug?

        Ans : This drug is not over the counter (OTC) medicine and it is not advisable to take it without a prescription.

      References

      • Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/domperidone

      • EQUIDONE- domperidone gel- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 23 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e55d075e-2fe2-4405-b57a-59b85067e0c0

      • Domperidone 10mg Tablets- EMC [Internet]. www.medicines.org.uk. 2021 [Cited 23 Nov 2021]. Available from:

        https://www.medicines.org.uk/emc/product/556/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
      swan-banner
      Sponsored

      Popular Questions & Answers

      View All

      In case of acid reflux which is more safer comp...

      related_content_doctor

      Dr Swathi Goudagunta

      Gastroenterologist

      Itopride is comparatively safe, but both are not safe for long term use. Medications should be us...

      I am 83 years old suffering from gas and discom...

      related_content_doctor

      Dr. Karuna Chawla

      Homeopathy Doctor

      What r other symptoms that you r experiencing? By doing what like walking, exertion, eating or em...

      How to get rid of acidity? I have been sufferin...

      related_content_doctor

      Dr. Sandhya Krishnamurthy

      Ayurvedic Doctor

      Hi, Inadequate sleep, untimely intake of food, intake of very hot and spicy food, mental worries ...

      How to take pantoprazole & domperidone tbs and ...

      related_content_doctor

      Dr. Karuna Chawla

      Homeopathy Doctor

      Uses of pantoprazole tablet gastroesophageal reflux disease (acid reflux) peptic ulcer disease us...

      I adopted a baby. I want to breast feed her is ...

      related_content_doctor

      Dr. Ashmina Rekhi

      Gynaecologist

      Hi lybrate-user very noble of you to adopt. But since your body hasn't had the natural priming wi...

      Table of content

      Content Details
      Profile Image
      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
      Profile Image
      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
      chat_icon

      Ask a free question

      Get FREE multiple opinions from Doctors

      posted anonymously
      swan-banner