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Overview

Clobetasol

Prescription vs.OTC: Prescription by Doctor required

Clobetasol is a very strong corticosteroid having a very high potency. It reduces the actions of chemicals that cause inflammation in the body. It is used to treat inflammation, redness and itching caused by a number of skin conditions such as eczema, allergic reactions, dermatitis, rashes and psoriasis.It is also used to treat several autoimmune diseases including vitiligo, alopecia areata, lichen planus, lichen sclerosus. It comes in the form of a shampoo, ointment, mousse and an emollient cream.

This medicine may have a few side effects that occur in rare cases. Some of them include experiencing a burning sensation after application, dry skin, redness of skin, cough, body pain, headache, itching of skin and sore throat. These effects should disappear in a few days as your body adjusts to the medication. Let your doctor know right away if any of these unlikely but serious side effects occur : stretch marks, skin thinning or discolouration, acne, hair bumps or excessive hair growth.

This medicine is not recommended to patients with known allergy to Clobetasol. It should not be given to a anyone younger than 12 years old. Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding while using this medicine. If you have any skin infection then make sure your doctor knows about it before prescribing this medicine.

Apply Clobetasol to the affected area, usually twice everyday in the morning and evening or as directed by your doctor. Apply this medication only on the skin. Make sure to not use it on the face, groin or underarms unless directed by your doctor. Do not apply smaller or larger amounts than prescribed. Avoid contact with eyes and do not consume the medicine. Do not discontinue using this medicine without consulting the doctor.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Dermatologist before using this medicine.

Clobetasol is used in the treatment of dermatitis which is an inflammation of the skin characterized by itching, rash, and redness of the skin.
Clobetasol is used in the treatment of psoriasis which is an autoimmune disease characterized by itchy patches and red skin with silvery scales.
Lichen Planus
Clobetasol is used in the treatment of lichen planus which is an inflammation of the skin characterized by purplish, itchy, flat-topped bumps.
Not recommended in patients with known allergy to Clobetasol.
In addition to its intended effect, Clobetasol may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Burning sensation at the application site Major Common
Dry skin Major Less Common
Redness of skin Major Less Common
Itching of skin Major Less Common
Cough Minor Common
Sore throat Minor Common
Body pain Minor Common
Headache Minor Common
How long is the duration of effect?
The duration of action of this medicine is not clinically evaluated.
What is the onset of action?
This medicine is well observed systematically. The extent of absorption is based on the characteristics of the skin and preparation.
Are there any pregnancy warnings?
This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before receiving this medicine.
Is it habit forming?
No habit forming tendency has been reported.
Are there any breast-feeding warnings?
This medicine is not recommended in breastfeeding women. Short-term application of this medicine may not cause any harm to the baby. The benefits and risks should be discussed with the doctor before receiving this medicine.
Missed Dose instructions
Apply the missed dose as soon as you remember. Do not apply if it is almost time for your next dose.
Overdose instructions
Seek emergency medical treatment or contact the doctor in case of an overdose.
India
United States
Japan
Below is the list of medicines, which contains Clobetasol as ingredient
Blue Cross Laboratories Ltd
Sun Pharmaceutical Industries Ltd
KLM Laboratories Pvt Ltd
Hegde and Hegde Pharmaceutical LLP
Abbott India Ltd
Sun Pharmaceutical Industries Ltd
Alkem Laboratories Ltd
Macleods Pharmaceuticals Pvt Ltd
Merck Ltd
Glenmark Pharmaceuticals Ltd
La Pristine Bioceuticals Pvt Ltd
Amideep Pharmaceuticals
Fulford India Ltd
Alkem Laboratories Ltd
Jenburkt Pharmaceuticals Ltd
Karlin Pharmaceuticals & Exports Pvt Ltd
Blue Cross Laboratories Ltd
Zydus Cadila
Glenmark Pharmaceuticals Ltd
Cadila Pharmaceuticals Ltd
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Disease
Information not available.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Minor
Clobetasol may increase the blood glucose levels in patients with diabetes. This interaction is based on the amount applied, the concentration of the medicine and size of the application area. Inform the doctor if you are receiving any corticosteroids. Close monitoring of blood glucose levels is necessary.
Clobetasol belongs to corticosteroids. It works as an anti-inflammatory by inhibiting the metabolism of arachidonic acid by inhibiting phospholipase A2 thus inhibits the production of inflammatory mediators like prostaglandins and leukotrienes.
What are you using Clobetasol for?
Other
Dermatitis
Psoriasis
Lichen Planus
How much was the improvement?
Poor
Excellent
Average
How long did it take before seeing improvement?
More than 2 days
Within 2 days
Within a day
Within 2 hours
Within 6 hours
How frequently did you take this medicine?
Once a day
Twice a day
Not taking on daily level
Four times A Day
Thrice a day
How did you take this medicine?
With or without food
With Food
Empty stomach
What were the side effects of this medicine?
Dry skin
Other
Redness of skin
Burning sensation at the application site
Itching of skin
Sore Throat
No Side Effects
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I use clobetasol for dandruff. Any side effect? Or further suggestions or treatment.

DHMS (Diploma in Homeopathic Medicine and Surgery)
Homeopath, Ludhiana
Homoeopathic treatment A.C.4 ( Bakson) chew 1 tab 3 times daily ANTI DANDRUFF OIL ( Wilmar schwabe India) Apply atleast once weekly.Leave overnight Anti Dandruff Shampoo ( Wilmar Schwabe india) Diet Take lots of water daily Avoid cold drinks,junk nd fast ,fried food Take nutritious diet Exercise regularily

Please suggest Clobetasol propionate and salicylic acid used for? Is it cures ringworm?

Erasmus Mundus Master in Adapted Physical Activity, MPT, BPTh/BPT
Physiotherapist, Chennai
Use candid B creams which will help you to feel better from the current signs and symptoms which is available in the medical store.

Hello Sir, did the Tenovate clobetasol cream IP will be used for vitiligo treatment. Please suggest.

Diploma In Gastroenterology, Diploma In Dermatology, BHMS
Homeopath, Hyderabad
For vitiligo treatment,its not recommended by few doctors as its a high potency steroid.. Its always advicable to take under doctors prescription.. and in proper guidance..
1 person found this helpful

I am 28 years, I used" Clobetasol Propionate and Neomycin Sulphate cream" fore fairness any side effect.

CERTIFICATION IN BACH FLOWER REMEDIES OF ENGLAND, Ph.D DOCTOR OF PHILOSOPHY IN BIOCHEMISTRY, B.S.M.S BACHELOR OF SIDDHA MEDICINE AND SURGERY,
Alternative Medicine Specialist,
I am 28 years, I used" Clobetasol Propionate and Neomycin Sulphate cream" fore fairness any side effect.
After withdrawal of those cream, may lead to skin infections and discoloration of skin. So it might not applied on the face.
4 people found this helpful

Itching in my head and dandruff and hair fall can I use this clobetasol propionate salicylic acid and culture solution. Please tell me. thank you.

BHMS
Homeopath, Noida
Itching in my head and dandruff and hair fall can I use this clobetasol propionate salicylic acid and culture solutio...
Wash your hair every alternate day U can Mix Arnica Q (25 drops) and Jaborandi Q (15 drops). Apply on scalp. Wash hair next day. Do it twice a week You can contact me for a detailed consultation.
2 people found this helpful

Popular Health Tips

Protein Contact Dermatitis - How It Can Be Managed?

MBBS, MD - Dermatology , Venereology & Leprosy, DNB( Dermatology and Venereology), Clinical Observership in Pediatric Dermatology, Clinical Observer ship in Contact Dermatitis
Dermatologist, Delhi
Protein Contact Dermatitis - How It Can Be Managed?

Protein contact dermatitis (PCD) is an allergic skin reaction caused by proteins of either animal or plant origin. Four types of proteins can cause PCD: plant, animal, flour, and proteolytic chemicals. The risk factors for the improvement of PCD include a family history or general history of atopy, irritant dermatitis, an occupation or side interest, including exposure to one of these protein allergen agents. In PCD, avoiding these particular allergens is very important in order to avoid the reaction. Symptomatic help and relief might be found with transient corticosteroids, immunomodulatory operators, or antihistamines. Inpatient care might be important for PCD patients if the allergy is severe to the point that patients cannot take care of themselves or in the rare case that they encounter angioedema or extreme gastrointestinal problems.

Some short-term treatments may include high-power topical corticosteroids, for example, clobetasol propionate, to diminish the irritation and swelling. Topical tacrolimus 1% ointment might be a decent long-term solution for the allergies. Oral antihistamines might be prescribed also if highly serious allergy takes place. To enhance and improve the treatment of this condition, the initial steps are to recognise and maintain a strategic distance from the dependable allergen. PCD is a chronic procedure that tends to have phases of change during holidays and crumbles when you go back to work.


It is recommended that the patients should wear plastic gloves and try to avoid rubber ones because of the danger of building up a PCD or unfavourably allergic contact dermatitis in addition to this already existing problem. In specific cases, change of patient's occupation is the main compelling measure to understand and manage this skin condition. This is done so that one can determine what element is causing the allergies to take place. Sometimes, certain products are to be avoided so as to determine which out of the daily routine products might be an allergen.

PCD does not necessarily have to end up in a chronic state. Avoiding the causative material more often than not prompts fast mending of the problem. In extreme cases, corticosteroid creams or treatments accelerate the recovery procedure. Symptomatic alleviation might be provided with transient corticosteroids, immunomodulatory specialists, or antihistamines.

Hence, in conditions like protein contact dermatitis, the allergy could also develop in the later stages of life. It is not necessary that the patient be allergic to certain types of foods from their very birth. With changing body schematics, it is possible that the allergy could be developed in later stages of life. Therefore, it is important to keep an eye out for when the allergy occurred so that it is easier for you to determine the allergen behind it. If you wish to discuss about any specific problem, you can consult a Dermatologist.

2842 people found this helpful

Pityriasis Amiantacea - A Guide!

MBBS
Dermatologist, Pune
Pityriasis Amiantacea - A Guide!

Pityriasis amiantacea is a disorder of the scalp. Some of the visible signs of this condition include adherent, silver, thick scales. The scales resemble the color of the asbestos and often surrounds the tufts of hair. While the condition is manageable, care should be taken to manage this condition right from its inception. Here is a brief overview of this scalp condition.

Origin of Pityriasis Amiantacea:
Pityriasis Amiantacea is inflammatory in nature. It comes from the seborrheic and psoriasis dermatitis spectrum. Experts are of the view that this condition is a result of the exaggerated response of the body to a primary condition of the scalp. Earlier studies have suggested that there is a possibility that Pityriasis Amiantacea may have originated from lichen planus, pyogenic infection and superficial fungal. In most of the cases, it has been witnessed that fungus has a close relation to this condition.

Exposure of Pityriasis Amiantacea and its diagnosis:
This condition has low exposure among females. It is mostly observed among, young adults, children, and adolescents. The diagnosis is done clinically. A specialist might prescribe dermoscopy to rule out other conditions of the scalp. If the result is positive, the scaling will reveal a diffused yellowish or whitish pattern. While the condition is local, it has all the possibilities to spread to other hairy parts of the body. Some experts are of the view that Pityriasis Amiantacea has a close association with temporary alopecia. While histopathology is not prescribed by most doctors, however, biopsy of the scalp is suggested in many cases.


Does Pityriasis Amiantacea result in hair loss?
The answer is yes. As a result of the scaly crust, the encased hair tends to fall. This being said, it is entirely a reversible condition. The hair comes back in 9 out of 10 cases. Medical ointments and antibiotic shampoo can help to grow back the lost hair. Apart from this, home-made protein solutions can help in the regeneration of the hair and get back the original color of the hair.

Treatment options:
This is a treatable condition that might take some time for a complete cure. It involves the keratolytic and tropical anti-inflammatory treatment. This is accompanied with salicylic ointment and topical corticosteroids. A tropical mineral oil is often prescribed by doctors to ensure that the adherent scales are removed. Some doctors might also suggest a clobetasol propionate shampoo. Even ketoconazole and silver sulfadiazine is helpful to get rid of the scales. If in case the infection is accompanied with Staphylococcus aureus, antibiotics are prescribed to ensure that the condition does not turn from bad to worse. Systematic therapies are suggested if this condition is accompanied by an underlying condition such as psoriasis. In case you have a concern or query you can always consult an expert & get answers to your questions!

4306 people found this helpful

Protein Contact Dermatitis - Are You At Risk?

MBBS, MD - Dermatology , Venereology & Leprosy
Dermatologist, Ghaziabad
Protein Contact Dermatitis - Are You At Risk?

There are four types of protein contact dermatitis: animal, proteolytic enzymes, plant, and flour. The risk factors for this include protein allergens, atopy, and chronic dermatitis. There have been several theories proposed for protein contact dermatitis. Many Scientists are of the view that this occurs due to type 1 hypersensitivity.

Some are of the view that this results from type 1 and type 4 hypersensitivity reactions. Many also believe that this results due to a mediated immunoglobulin E hypersensitivity reaction. All the above three theories have been backed by enough proofs to support the model. No particular sexual or racial predilection is known for this infection. People can get affected with protein contact dermatitis at any age.

Proteins responsible for protein contact dermatitis:
There are four segments of proteins that can result in protein contact dermatitis.

  1. The first segment involves spices, fruits, plants, and vegetables. This is most commonly found in food vendors, gardeners, caterers etc. The source of protein comes from mugwort, asparagus, carrot, soy, peach, bean, apple and peanut.
  2. The second segment belongs to animal proteins and the possible victims are butchers, farmers, cooks and veterinarians. People who come in contact with the intestine of animals are more likely to get this disease. The source of protein comes from cow dander, blood, squid, worms, egg yolk, maggots, worms and meats.
  3. The third segment of protein contact dermatitis is very common among bakers. A form of dermatitis is observed. This being flour-associated proteins, the common culprits are rye and wheat. It is necessary to stay from the latter in order to avoid it.
  4. The fourth segment results from protein associated with a proteolytic enzyme. This form of protein contact dermatitis is mostly visible among workers of an enzyme factory, bakers, workers of a pharmaceutical company, soap factory workers etc. Patients mostly suffer from respiratory symptoms in this segment. Certain enzymes that are responsible for this segment of protein contact dermatitis include lactase, amylase, and glucoamylase.

Symptoms and diagnosis:
Protein contact dermatitis shows symptoms such as lichenification, erythematous papules, and dermatitis affecting the forearms. At times the fingertips get affected too. A doctor might prescribe a patch test followed by prick and scratch test. Other tests involve a fungal test, open application testing, radioallergosorbent testing, image studies, and biopsy.

The key to avoiding protein contact dermatitis is to stay away from the protein causing the disease. For short-term reliefs, a doctor can prescribe corticosteroids and antihistamines. A patient might have to get admitted to a hospital if the severity level of the disease is so much that the patient is suffering from gastrointestinal distress and angioedema. Medication involves oral dosage of antihistamines and clobetasol propionate.

2708 people found this helpful

Avoid The Ban Medicines To Be Safe

BHMS
Homeopath, Singrauli
Avoid The Ban Medicines To Be Safe

Govt bans 344 drugs, including phensedyl, corex
Sr. No. Product name (irrational fdc) 
1 aceclofenac + paracetamol + rabeprazole
2 nimesulide + diclofenac
3 nimesulide + cetirizine + caffeine
4 nimesulide + tizanidine
5 paracetamol + cetirizine + caffeine
6 diclofenac + tramadol + chlorzoxazone
7 dicyclomine + paracetamol + domperidone
8 nimesulide + paracetamol
9 paracetamol + phenylephrine + caffeine
10 diclofenac+ tramadol + paracetamol
11 diclofenac + paracetamol + chlorzoxazone + famotidine
12 naproxen + paracetamol
13 nimesulide + serratiopeptidase
14 paracetamol + diclofenac + famotidine
15 nimesulide + pifofenone + fenpiverinium + benzyl alcohol
16 omeprazole + paracetamol + diclofenac
17 nimesulide + paracetamol injection
18 tamsulosin + diclofenac
19 paracetamol + phenylephrine + chlorpheniramine + dextromethorphan + caffeine
20 diclofenac + zinc carnosine
21 diclofenac + paracetamol + chlorpheniramine maleate + magnesium trisillicate
22 paracetamol + pseudoephedrine + cetrizine
23 phenylbutazone + sodium salicylate
24 lornoxicam + paracetamol + trypsin
25 paracetamol + mefenamic acid + ranitidine + dicylomine
26 nimesulide + dicyclomine
27 heparin + diclofenac
28 glucosamine + methyl sulfonyl methane + vitamini d3 + maganese + boron + copper + zinc
29 paracetamol + tapentadol
30 tranexamic acid + proanthocyanidin
31 benzoxonium chloride + lidocaine
32 lornoxicam + paracetamol + tramadol
33 lornoxicam + paracetamol + serratiopeptidase
34 diclofenac + paracetamol + magnesium trisilicate
35 paracetamol + domperidone + caffeine
36 ammonium chloride + sodium citrate + chlorpheniramine maleate + menthol
37 paracetamol + prochlorperazine maleate
38 serratiopeptidase (enteric coated 20000 units) + diclofenac potassium & 2 tablets of doxycycline
39 nimesulide + paracetamol suspension
40 aceclofenac + paracetamol + famotidine
41 aceclofenac + zinc carnosine
42 paracetamol + disodium hydrogen citrate + caffeine
43 paracetamol + dl methionine
44 disodium hydrogen citrate + paracetamol
45 paracetamol + caffeine + codeine
46 aceclofenac (sr) + paracetamol
47 diclofenac + paracetamol injection
48 azithromycin + cefixime
49 amoxicillin + dicloxacillin
50 amoxicillin 250 mg + potassium clavulanate diluted 62.5 mg
51 azithromycin + levofloxacin
52 cefixime + linezolid
53 amoxicillin + cefixime + potassium clavulanic acid
54 ofloxacin + nitazoxanide
55 cefpodoxime proxetil + levofloxacin
56 azithromycin, secnidazole and fluconazole kit
57 levofloxacin + ornidazole + alpha tocopherol acetate
58 nimorazole + ofloxacin
59 azithromycin + ofloxacin
60 amoxycillin + tinidazole
61 doxycycline + serratiopeptidase
62 cefixime + levofloxacin
63 ofloxacin + metronidazole + zinc acetate
64 diphenoxylate + atropine + furazolidonee
65 fluconazole tablet, azithromycin tablet and ornidazole tablets
66 ciprofloxacin + phenazopyridine
67 amoxycillin + dicloxacillin + serratiopeptidase
68 azithromycin + cefpodoxime
69 lignocaine + clotrimazole + ofloxacin + beclomethasone
70 cefuroxime + linezolid
71 ofloxacin + ornidazole + zinc bisglycinate
72 metronidazole + norfloxacin
73 amoxicillin + bromhexine
74 ciprofloxacin + fluticasone + clotrimazole + neomycin is
75 metronidazole + tetracycline
76 cephalexin + neomycin + prednisolone
77 azithromycin + ambroxol
78 cilnidipine + metoprolol succinate + metoprolol tartrate
79 l-arginine + sildenafil
80 atorvastatin + vitamin d3 + folic acid + vitamin b12 + pyridoxine
81 metformin + atorvastatin
82 clindamycin + telmisartan
83 olmesartan + hydrochlorothiazide + chlorthalidone
84 l-5-methyltetrahydrofolate calcium + escitalopram
85 pholcodine + promethazine
86 paracetamol + promethazine
87 betahistine + ginkgo biloba extract + vinpocetine + piracetam
88 cetirizine + diethyl carbamazine
89 doxylamine + pyridoxine + mefenamic acid + paracetamol
90 drotaverine + clidinium + chlordiazepoxide
91 imipramine + diazepam
92 flupentixol + escitalopram
93 paracetamol + prochloperazine
94 gabapentin + mecobalamin + pyridoxine + thiamine
95 imipramine + chlordiazepoxide + trifluoperazine + trihexyphenidyl
96 chlorpromazine + trihexyphenidyl
97 ursodeoxycholic acid + silymarin
98 metformin 1000/1000/500/500mg + pioglitazone 7.5/7.5/7.5/7.5mg + glimepiride
99 gliclazide 80 mg + metformin 325 mg
100 voglibose+ metformin + chromium picolinate
101 pioglitazone 7.5/7.5mg + metformin 500/1000mg
102 glimepiride 1mg/2mg/3mg + pioglitazone 15mg/15mg/15mg + metformin 1000mg/1000mg/1000mg
103 glimepiride 1mg/2mg+ pioglitazone 15mg/15mg + metformin 850mg/850mg
104 metformin 850mg + pioglitazone 7.5 mg + glimepiride 2mg
105 metformin 850mg + pioglitazone 7.5 mg + glimepiride 1mg
106 metformin 500mg/500mg+gliclazide sr 30mg/60mg + pioglitazone 7.5mg/7.5mg
107 voglibose + pioglitazone + metformin
108 metformin + bromocriptine
109 metformin + glimepiride + methylcobalamin
110 pioglitazone 30 mg + metformin 500 mg
111 glimepiride + pioglitazone + metformin
112 glipizide 2.5mg + metformin 400 mg
113 pioglitazone 15mg + metformin 850 mg
114 metformin er + gliclazide Mr. + voglibose
115 chromium polynicotinate + metformin
116 metformin + gliclazide + piogllitazone + chromium polynicotinate
117 metformin + gliclazide + chromium polynicotinate
118 glibenclamide + metformin (sr)+ pioglitazone
119 metformin (sustainded release) 500mg + pioglitazone 15 mg + glimepiride 3mg
120 metformin (sr) 500mg + pioglitazone 5mg
121 chloramphenicol + beclomethasone + clomitrimazole + lignocaine
122 of clotrimazole + ofloxaxin + lignocaine + glycerine and propylene glycol
123 chloramphennicol + lignocaine + betamethasone + clotrimazole + ofloxacin + antipyrine
124 ofloxacin + clotrimazole + betamethasone + lignocaine
125 gentamicin sulphate + clotrimazole + betamethasone + lignocaine
126 clotrimazole + beclomethasone + ofloxacin + lignocaine
127 becloemthasone + clotrimazole + chloramphenicol + gentamycin + lignocaine ear
128 flunarizine + paracetamole + domperidone
129 rabeprazole + zinc carnosine
130 magaldrate + famotidine + simethicone
131 cyproheptadine + thiamine
132 magaldrate + ranitidine + pancreatin + domperidone
133 ranitidine + magaldrate + simethicone
134 magaldrate + papain + fungul diastase + simethicone
135 rabeprazole + zinc + domperidone
136 famotidine + oxytacaine + magaldrate
137 ranitidine + domperidone + simethicone
138 alginic acid + sodium bicarbonate + dried aluminium hydroxide + magnesium hydroxide
139 clidinium + paracetamol + dicyclomine + activated dimethicone
140 furazolidone + metronidazole + loperamide
141 rabeprazole + diclofenac + paracetamol
142 ranitidine + magaldrate
143 norfloxacin+ metronidazole + zinc acetate
144 zinc carnosine + oxetacaine
145 oxetacaine + magaldrate + famotidine
146 pantoprazole (as enteric coated tablet) + zinc carnosine (as film coated tablets)
147 zinc carnosine + magnesium hydroxide + dried aluminium hydroxide + simethicone
148 zinc carnosine + sucralfate
149 mebeverine & inner hpmc capsule (streptococcus faecalis + clostridium butyricum + bacillus
Mesentricus + lactic acid bacillus)
150 clindamycin + clotrimazole + lactic acid bacillus

151 sildenafil + estradiol valerate
152 clomifene citrate + ubidecarenone + zinc + folic acid + methylcobalamin + pyridoxine + lycopene
+ selenium + levocarnitine tartrate + l-arginine
153 thyroxine + pyridoxine + folic acid
154 gentamycin + dexamethasone + chloramphenicol + tobramycin + ofloxacin
155 dextromethorphan + levocetirizine + phenylephrine + zinc
156 nimesulide + loratadine + phenylephrine + ambroxol
157 bromhexine + phenylephrine + chlorepheniramine maleate
158 dextromethorphan + bromhexine + guaiphenesin
159 paracetamol + loratadine + phenylephrine + dextromethorphan + caffeine
160 nimesulide + phenylephrine + caffeine + levocetirizine
161 azithromycin + acebrophylline
162 diphenhydramine + terpine + ammonium chloride + sodium chloride + menthol
163 nimesulide + paracetamol + cetirizine + phenylephrine
164 paracetamol + loratadine + dextromethophan + pseudoepheridine + caffeine
165 chlorpheniramine maleate + dextromethorphan + dextromethophan + guaiphenesin + ammonium
Chloride + menthol
166 chlorpheniramine maleate + ammonium chloride + sodium citrate
167 cetirizine + phenylephrine + paracetamol + zinc gluconate
168 ambroxol
+ guaiphenesin + ammonium chloride + phenylephrine + chlorpheniramine maleate + menthol
169 dextromethorphen + bromhexine + chlorpheniramine maleate + guaiphenesin
170 levocetirizine + ambroxol + phenylephrine + guaiphenesin
171 dextromethorphan + chlorpheniramine + chlorpheniramine maleate 
172 cetirizine + ambroxol + guaiphenesin + ammonium chloride + phenylephrine +
Menthol
173 hlorpheniramine + phenylephrine + caffeine
174 dextromethorphan + triprolidine + phenylephrine
175 dextromethorphan + phenylephrine + zinc gluconate + menthol
176 chlorpheniramine + codeine + sodium citrate + menthol syrup
177 enrofloxacin + bromhexin
178 bromhexine + dextromethorphan + phenylephrine + menthol
179 levofloxacin + bromhexine
180 levocetirizine + phenylephrine + ambroxol + guaiphenesin + paracetamol
181 cetirizine + dextromethorphan + phenylephrine + zinc gluconate + paracetamol + menthol
182 paracetamol + pseudoephedrine + dextromethorphan+cetirizine
183 diphenhydramine + guaiphenesin + ammonium chloride + bromhexine
184 chlorpheniramine + dextromethorphan + phenylephrine + paracetamol
185 dextromethorphen + promethazine
186 diethylcabamazine citrate + cetirizine + guaiphenesin
187 chlorpheniramine + phenylephrine + dextromethophan + menthol
188 ambroxol + terbutaline + dextromethorphan
189 dextromethorphan + chlorpheniramine + guaiphenesin
190 terbutaline + bromhexine + guaiphenesin + dextromethorphan
191 dextromethorphan + tripolidine + phenylephirine
192 paracetamol + dextromethorphan + chlorpheniramine
193 codeine + levocetirizine + menthol
194 dextromethorphan + ambroxol + guaifenesin + phenylephrine + chlorpheniramine
195 cetirizine + phenylephrine + dextromethorphan + menthol
196 roxithromycin + serratiopeptidase
197 paracetamol + phenylephrine + triprolidine
198 cetirizine + acetaminophen + dextromethorphan + phenyephrine + zinc gluconate 
199 diphenhydramine + guaifenesin + bromhexine + ammonium chloride + menthol
200 chlopheniramine maleate + codeine syrup
201 cetirizine + dextromethorphan + zinc gluconate + menthol
202 paracetamol + phenylephrine + desloratadine + zinc gluconate + ambroxol
203 levocetirizine + montelukast + acebrophylline
204 dextromethorphan + phenylephrine + ammonium chloride + menthol
205 acrivastine + paracetamol + caffeine + phenylephrine
206 naphazoline + carboxy methyl cellulose + menthol + camphor + phenylephrine
207 dextromethorphan + cetirizine
208 nimesulide + paracetamol + levocetirizine + phenylephrine + caffeine
209 terbutaline + ambroxol + guaiphenesin + zinc + menthol
210 dextromethorphan + phenylephrine + guaifenesin + triprolidine
211 ammomium chloride + bromhexine + dextromethorphan 
212 diethylcarbamazine + cetirizine + ambroxol
213 ethylmorphine + noscapine + chlorpheniramine
214 cetirizine + dextromethorphan + ambroxol
215 ambroxol + guaifenesin + phenylephrine + chlorpheniramine
216 paracetamol + phenylephrine + chlorpheniramine + zinc gluconate
217 dextromethorphan + phenylephrine + cetirizine + paracetamol + caffeine
218 dextromethophan + chlorpheniramine + guaifenesin + ammonium chloride
219 levocetirizine + dextromethorphan + zinc
220 paracetamol + phenylephrine + levocetirizine + caffeine
221 chlorphaniramine + ammonium chloride + sodium chloride
222 paracetamol + dextromethorphan + bromhexine + phenylephrine + diphenhydramine
223 salbutamol + bromhexine + guaiphenesin + menthol
224 cetirizine + dextromethorphan + bromhexine + guaifenesin
225 diethyl carbamazine + chlorpheniramine + guaifenesin
226 ketotifen + cetirizine
227 terbutaline + bromhexine + etofylline
228 ketotifen + theophylline
229 ambroxol + salbutamol + theophylline
230 cetririzine + nimesulide + phenylephrine
231 chlorpheniramine + phenylephrine + paracetamol + zink gluconate
232 acetaminophen + guaifenesin + dextromethorphan + chlorpheniramine
233 cetirizine + dextromethorphan + phenylephrine + tulsi
234 cetirizine + phenylephrine + paracetamol + ambroxol + caffeine
235 guaifenesin + dextromethorphan
236 levocetirizine + paracetamol + phenylephirine + caffeine
237 caffeine + paracetamol + phenylephrine + chlorpheniramine
238 levocetirizine + paracetamol + phenylephirine + caffeine
239 caffeine + paracetamol + phenylephrine + chlorpheniramine
240 ketotifen + levocetrizine
241 paracetamol + levocetirizine + phenylephirine + zink gluconate
242 paracetamol + phenylephrine + triprolidine + caffeine
243 caffeine + paracetamol + phenylephrine + cetirizine
244 caffeine + paracetamol + chlorpheniramine
245 ammonium chloride + dextromethorphan + cetirizine + menthol
246 dextromethorphan + paracetamol + cetirizine + phenylephrine
247 chlorpheniramine + terpin + antimony potassium tartrate + ammonium chloride + sodium
Citrate + menthol
248 terbutaline + etofylline + ambroxol
249 paracetamol + codeine + chlorpheniramine
250 paracetamol+pseudoephedrine+certirizine+caffeine
251 chlorpheniramine+ammonium chloride + menthol
252 n-acetyl cysteine + ambroxol + phenylephrine + levocertirizine
253 dextromethorphan + phenylephrine + tripolidine + menthol
254 salbutamol + certirizine + ambroxol
255 dextromethorphan + phenylephrine + bromhexine + guaifenesin + chlorpheniramine
256 nimesulide + certirizine + phenylephrine
257 naphazoline + chlorpheniramine + zinc sulphate + boric acid + sodium chloride + chlorobutol
258 paracetamol + bromhexine + phenylephrine + chlorpheniramine + guaifenesin
259 salbutamol + bromhexine
260 dextromethorphan + phenylephrine + guaifenesin + certirizine + acetaminophen
261 guaifenesin + bromhexine + chlorpheniramine + paracetamo
262 chlorpheniramine + ammonium chloride + chloroform + menthol
263 salbutamol + choline theophylinate + ambroxol
264 chlorpheniramine + codeine phosphate + menthol syrup
265 pseudoephedrine + bromhexine
266 certirizine + phenylephrine + paracetamol + caffeine + nimesulide
267 dextromethorphan + cetirizine + guaifenesin + ammonium chloride
268 dextromethorphan + cetirizine + guaifenesin + ammonium chloride
269 ambroxol + salbutamol + choline theophyllinate + menthol
270 paracetamol + chlorpheniramine + ambroxol + guaifenesin + phenylephrine
271 chlorpheniramine + vasaka + tolubalsm + ammonium chloride + sodium citrate + menthol
272 bromhexine + cetrizine + phenylephrine ip+guaifenesin + menthol
273 dextromethorphan + ambroxol + ammonium chloride + chlorpheniramine + menthol
274 dextromethorphan + phenylephrine + cetirizine + zinc + menthol
275 terbutaline + n-acetyl l-cysteine + guaifenesin
276 calcium gluconate + levocetirizine
277 paracetamol + levocetirizine + pseudoephedrine
278 salbutamol + choline theophylinate + carbocisteine
279 chlorpheniramine + vitamin c
280 calcium gluconate + chlorpheniramine + vitamin c
281 chlorpheniramine + paracetamol + pseudoephedrine + caffeine
282 guaifenesin + bromhexine + chlorpheniramine + phenylephrine + paracetamol + serratiopeptidase
(as enteric coated granules) 10000 sp units
283 paracetamol + pheniramine
284 betamethasone + fusidic acid + gentamycin + tolnaftate + lodochlorhydroxyquinoline (ichq
285 clobetasol + ofloxacin + miconazole + zinc sulphate
286 clobetasole + gentamicin + miconazole + zinc sulphate
287 levocetirizine + ambroxol + phenylephrine + paracetamol
288 permethrin + cetrimide + menthol
289 beclomethasone + clotimazole + neomycin + lodochlorohydroxyquinone
290 neomycin + doxycycline
291 ciprofloxacin + fluocinolone + clotrimazole + neomycin + chlorocresol
292 clobetasol + ofloxacin + ketoconazol + zinc sulphate
293 betamethasone + gentamicin + tolnaftate + lodochlorhydroxyquinoline
294 clobetasol + gentamicin + tolnaftate + lodochlorhydroxyquinone + ketoconazole
295 allantoin + dimethieone + urea + propylene + glycerin + liquid paraffin
296 acriflavine + thymol + cetrimide
297 betamethasone + neomycin + tolnaftate + lodochlorohydroxyquinoline + cholorocresol
298 clobetasol + neomycin + miconazole + clotrimazole
299 ketoconazole + tea tree oil + allantion + zinc oxide + aloe vera + jojoba oil +
Lavander oil + soa noodels
300 clobetasol propionate + ofloxacin + ornidazole + terbinafine
301 clobetasol + neomycin + miconazole + zinc sulphate
302 beclomethasone diproprionate + neomycin + tolnaftate + lodochlorhydroxyquinoline +
Chlorocresol
303 betamethasone + gentamycin + zinc sulphate + clotrimoazole + chlorocresol
304 borax + boric acid + naphazoline + menthol + camphor + methyl hydroxy benzoate
305 bromhexine + dextromethorphan
306 dextromethophan + chlopheniramine + bromhexine
307 menthol + anesthetic ether
308 dextrometharphan + chlopheniramine + ammonium + sodium citrate + menthol
309 ergotamine tartrate + belladona dry extarct+caffeine + paracetamol
310 phenytoin + phenobarbitone
311 gliclazide 40mg + metformin 400mg
312 paracetamol + ambroxol + phenylephrine + chlorpheniramine
313 oflaxacin + ornidazole suspension
314 albuterol + etofylline + bromhexine + menthol
315 albuterol + bromhexine + theophylline
316 salbutamol+hydroxyethyltheophylline (etofylline) + bromhexine
317 paracetamol+phenylephrine+levocetirizine+sodium citrate
318 paracetamol + propyphenazone + caffeine
319 guaifenesin + diphenhydramine + bromhexine + phenylephrine
320 dried alumnium hydroxie gel + prophantheline + diazepam
321 bromhenxine + phenylephrine + chlorpheniramine + paracetamol
322 beclomethasone + clotrimazole + gentamicin + lodochlorhydroxyquinoline
323 telmisartan + metformin
324 ammonium citrate + vitamin b 12 + folic acid + zinc sulphate
325 levothyroxine + phyridoxine + nicotinamide
326 benfotiamine + metformin
327 thyroid + thiamine + riboflavin + phyridoxine + calcium pantothenate + tocopheryl acetate +
Nicotinamide
328 ascorbic acid + manadione sodium bisulphate + rutin + dibasic calcium phosphate +
Adrenochrome mono semicarbazone
329 phenylephrine + chlorpheniramine + paracetamol + bromhexine + caffeine
330 clotrimazole + beclomethasone + lignocaine + ofloxacin + acetic aicd + sodium methyl paraben +
Propyl paraben

Avoid this combinations and be safe.

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Vitiligo - Know How To Treat It!

MD - Bio-Chemistry, MF Homeo (London), DHMS (Diploma in Homeopathic Medicine and Surgery), BHMS
Homeopath, Kolkata
Vitiligo - Know How To Treat It!

Vitiligo is a long-term skin condition characterized by patches of the skin losing their pigment. The patches of skin affected become white and usually have sharp margins. The hair from the skin may also become white. The inside of the mouth and nose may also be involved. Typically both sides of the body are affected. often the patches begin on areas of skin that are exposed to the sun. It is more noticeable in people with dark skin. Vitiligo may result in psychological stress and those affected may be stigmatized. 
The exact cause of vitiligo is unknown. It is believed to be due to genetic susceptibility that is triggered by an environmental factor such that an autoimmune disease occurs. This results in the destruction of skin pigment cells. Risk factors include a family history of the condition or other autoimmune diseases, such as
Hyperthyroidism, alopecia areata, and pernicious anemia. It is not contagious. Vitiligo is classified into two main types: segmental and non-segmental. Most cases are non-segmental, meaning they affect both sides; and in these cases, the affected area of the skin typically expands with time. About 10% of cases are segmental, meaning they mostly involve one side of the body; and in these cases, the affected area of the skin typically does not expand with time. Diagnosis can be confirmed by tissue biopsy.
There is no known cure for vitiligo. For those with light skin, sunscreen and makeup are all that is typically recommended. Other treatment options may include
Steroid creams or phototherapy to darken the light patches. Alternatively, efforts to lighten the unaffected skin, such as with hydroquinone, may be tried. A number of surgical options are available for those who do not improve with other measures. A combination of treatments generally has better outcomes. Counselling to provide emotional support may be useful.
Globally about 1% of people are affected by vitiligo. Some populations have rates as high as 2–3%. Males and females are equally affected. About half show the disorder before age 20 and most develop it before age 40. Vitiligo has been described since ancient history. 
 

Signs and symptoms-

  • Vitiligo on lighter skin
  • Vitiligo on darker skin
  • The only sign of vitiligo is the presence of pale patchy areas of depigmented skin which tend to occur on the extremities. The patches are initially small, but often grow and change shape. When skin lesions occur, they are most prominent on the face, hands and wrists.
  •  The loss of skin pigmentation is particularly noticeable around body orifices, such as the mouth, eyes, nostrils,
  • Genitalia and umbilicus. Some lesions have increased skin pigment around the edges. Those affected by vitiligo who are stigmatized for their condition may experience depression and similar mood disorders.

Causes-

  • Although multiple hypotheses have been suggested as potential triggers that cause vitiligo, studies strongly imply that changes in the immune system are responsible for the condition. Vitiligo has been proposed to be a multifactorial disease with genetic susceptibility and environmental factors both thought to play a role.
  • The tyr gene encodes the protein tyrosinase, which is not a component of the immune system, but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo.  The nih states that sunburns can cause the disease but there is not good evidence to support this. 
  • Preliminary evidence suggests a possible association with eating gluten.

Immune-

  • Variations in genes that are part of the immune system or part of melanocytes have both been associated with vitiligo. It is also thought to be caused by the immune system attacking and destroying the melanocytes of the skin. A genomewide association study found approximately 36 independent susceptibility loci for generalized vitiligo. 
  • Autoimmune associations
  • Vitiligo is sometimes associated with autoimmune and
  • Inflammatory diseases such as hashimoto's thyroiditis,
  • Scleroderma, rheumatoid arthritis, type 1 diabetes mellitus, psoriasis, addison's disease, pernicious anemia,
  • Alopecia areata, systemic lupus erythematosus, and celiac disease.
  • Among the inflammatory products of nalp1 are caspase 1 and caspase 7, which activate the inflammatory cytokine
  • Interleukin-1β. Interleukin-1β and interleukin-18 are expressed at high levels in patients with vitiligo. In one of the mutations, the amino acid leucine in the nalp1 protein was replaced by histidine (leu155->His). The original protein and sequence is highly conserved in evolution, and is found in humans, chimpanzee, rhesus monkey, and the bush baby. Addison's disease (typically an autoimmune destruction of the adrenal glands) may also be seen in individuals with vitiligo. 

Diagnosis-

  • Uv photograph of a hand with vitiligo
  • Uv photograph of a foot with vitiligo
  • An ultraviolet light can be used in the early phase of this disease for identification and to determine the effectiveness of treatment. Skin with vitiligo, when exposed to a blacklight, will glow blue. In contrast, healthy skin will have no reaction.

Classification
Classification attempts to quantify vitiligo have been analyzed as being somewhat inconsistent, while recent consensus have agreed to a system of segmental vitiligo (sv) and non-segmental vitiligo (nsv). Nsv is the most common type of vitiligo.
Non-segmental

  • Eyelid vitiligo

In non-segmental vitiligo (nsv), there is usually some form of symmetry in the location of the patches of depigmentation. New patches also appear over time and can be generalized over large portions of the body or localized to a particular area. Extreme cases of vitiligo, to the extent that little pigmented skin remains, are referred to as vitiligo universalis. Nsv can come about at any age (unlike segmental vitiligo, which is far more prevalent in teenage years). 
Classes of non-segmental vitiligo include the following:

  • Generalized vitiligo: the most common pattern, wide and randomly distributed areas of depigmentation 
  • Universal vitiligo: depigmentation encompasses most of the body
  • Focal vitiligo: one or a few scattered macules in one area, most common in children 
  • Acrofacial vitiligo: fingers and periorificial areas 
  • Mucosal vitiligo: depigmentation of only the mucous membranes

Segmental-
Segmental vitiligo (sv) differs in appearance, cause, and frequency of associated illnesses. Its treatment is different from that of nsv. It tends to affect areas of skin that are associated with dorsal roots from the spinal cord and is most often unilateral. It is much more stable/static in course and its association with autoimmune diseases appears to be weaker than that of generalized vitiligo. SV does not improve with topical therapies or uv light, however surgical treatments such as cellular grafting can be effective. 
Differential diagnosis
Chemical leukoderma is a similar condition due to multiple exposures to chemicals. Vitiligo however is a risk factor. Triggers may include inflammatory skin conditions, burns, intralesional steroid injections and abrasions. 
Other conditions with similar symptoms include the following:

  • Pityriasis alba
  • Tuberculoid leprosy
  • Postinflammatory hypopigmentation
  • Tinea versicolor 
  • Albinism
  • Piebaldism
  • Idiopathic guttate hypomelanosis 
  • Progressive macular hypomelanosis
  • Primary adrenal insufficiency

Treatment
There is no cure for vitiligo but several treatment options are available. The best evidence is for applied steroids and the combination of ultraviolet light in combination with creams. Due to the higher risks of skin cancer, the united kingdom's national health service suggests phototherapy only be used if primary treatments are ineffective. Lesions located on the hands, feet, and joints are the most difficult to repigment; those on the face are easiest to return to the natural skin color as the skin is thinner in nature.

  • Immune mediators- Topical preparations of immune suppressing medications including glucocorticoids (such as 0.05% clobetasol or 0.10% betamethasone) and calcineurin inhibitors (such as Tacrolimus or pimecrolimus) are considered to be first-line vitiligo treatments. 
  • Phototherapy- Phototherapy is considered a second-line treatment for vitiligo. Exposing the skin to light from uvb lamps is the most common treatment for vitiligo. The treatments can be done at home with an uvb lamp or in a clinic. The exposure time is managed so that the skin does not suffer overexposure. Treatment can take a few weeks if the spots are on the neck and face and if they existed not more than 3 years. If the spots are on the hands and legs and have been there more than 3 years, it can take a few months. Phototherapy sessions are done 2–3 times a week. Spots on a large area of the body may require full body treatment in a clinic or hospital. Uvb broadband and narrowband lamps can be used, But narrowband ultraviolet picked around 311 nm is the choice. It has been constitutively reported that a combination of uvb phototherapy with other topical treatments improves re-pigmentation. However, some vitiligo patients may not see any changes to skin or re-pigmentation occurring. A serious potential side effect involves the risk of developing skin cancer, the same risk as an over-exposure to natural sunlight.Ultraviolet light (uva) treatments are normally carried out in a hospital clinic. Psoralen and ultraviolet a light (puva) treatment involves taking a drug that increases the skin's sensitivity to ultraviolet light, then exposing the skin to high doses of uva light. Treatment is required twice a week for 6–12 months or longer. Because of the high doses of uva and psoralen, puva may cause side effects such as sunburn-type reactions or skin freckling. Narrowband ultraviolet b (nbuvb) phototherapy lacks the side-effects caused by psoralens and is as effective as puva as with puva, treatment is carried out twice weekly in a clinic or every day at home, and there is no need to use psoralen.
  • Skin camouflage- In mild cases, vitiligo patches can be hidden with makeup or other cosmetic camouflage solutions. If the affected person is pale-skinned, the patches can be made less visible by avoiding tanning of unaffected skin. 
  • De-pigmenting- In cases of extensive vitiligo the option to de-pigment the unaffected skin with topical drugs like monobenzone, Mequinol, or hydroquinone may be considered to render the skin an even colour. The removal of all the skin pigment with monobenzone is permanent and vigorous. Sun-safety must be adhered to for life to avoid severe Sunburn and melanomas. Depigmentation takes about a year to complete.

Table of Content

About Clobetasol
When is Clobetasol prescribed?
What are the contraindications of Clobetasol ?
What are the side effects of Clobetasol ?
Key highlights of Clobetasol
What are the dosage instructions?
Where is the Clobetasol approved?
Medicines containing Clobetasol
What are the interactions for Clobetasol ?