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Amitone 10 MG Tablet

Manufacturer: Intas Pharmaceuticals Ltd
Medicine composition: Amitriptyline
Prescription vs.OTC: Prescription by Doctor not required
Last Updated: December 10, 2021

Prescribed for the treatment of depression and its symptoms, Amitone 10 MG Tablet acts as a tricyclic antidepressant. It basically controls brain chemicals that are unbalanced in patients who suffer from mental illness and depression.

Before you start using Amitone 10 MG Tablet ask your doctor more information about how it works and how the drug should be taken. The drug should not be used if you have suffered a heart attack recently. It is also not meant for consumption by breastfeeding mothers as the drug can pass into the milk and harm the baby.

You should take Amitone 10 MG Tablet as per instructions on the prescription and guide that comes with the drug. Take the exact dose that has been prescribed to you. It can take about 4 weeks before your symptoms of depression show improvement.

It is advised that Amitone 10 MG Tablet should not be stopped suddenly, as it can cause unpleasant withdrawal symptoms. If the need arises consult your doctor about stopping Amitone 10 MG Tablet. The drug should be stored at room temperature and kept safe from light, heat as well as moisture.

Often causes drowsiness/sedation, resulting in the impaired performance of tasks requiring alertness (ie, operating machinery or driving). Sedative effects may be additive with other CNS depressants and/or ethanol. The degree of sedation is very high relative to other antidepressants.

May worsen psychosis in some patients or precipitate a shift to mania or hypomania in patients with bipolar disease. May cause hyponatremia/SIADH. May increase the risks associated with electroconvulsive therapy. This agent should be discontinued, when possible, prior to elective surgery.

Therapy should not be abruptly discontinued in patients receiving high doses for prolonged periods. Use with caution in hyperthyroid patients or those receiving thyroid supplementation. Use with caution in patients with hepatic or renal dysfunction and in elderly patients. Not for use in patients <12 years of age.

Symptoms of overdose include agitation, confusion, hallucinations, urinary retention, hypothermia, hypotension, ventricular tachycardia, seizures. Following initiation of essential overdose management, toxic symptoms should be treated.

Sodium bicarbonate is indicated when QRS interval is >0.10 seconds or QTc >0.42 seconds. Ventricular arrhythmias often respond to phenytoin 15-20 mg/kg (adults) with concurrent systemic alkalinization (sodium bicarbonate 0.5-2 mEq/kg I.V.).

Seizures usually respond to diazepam I.V. boluses (5-10 mg for adults up to 30 mg or 0.25-0.4 mg/kg/dose for children up to 10 mg/dose). If seizures are unresponsive or recur, phenytoin or phenobarbital may be required.

This medication helps in treating the following problems in the human body:

Side effects of this medication which can be seen in a patient are:

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 4-7 weeks after onset of action. However, it is subject to variation based on a patient's response to the medicine after administration.
  • What is the onset of action?

    The effect of this medicine can be observed within 7-21 days of administration.
  • Are there any pregnancy warnings?

    This medicine should be used by pregnant women only when the benefits outweigh the risk associated with usage. This medicine can cause harmful effects on fetus. Hence, you are advised to consult your doctor before taking this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This medicine should not be used by women who are breastfeeding. If it is absolutely necessary to take this medicine then you should stop breastfeeding. Consult your doctor before using this medicine.
  • Is It safe with alcohol?

    It is advised that while taking this medicine, the patients either limit or completely restrict the consumption of alcohol. This is because the medication upon interaction with alcohol can induce symptoms such as excessive sweating, sleepiness, muscle stiffness and sudden alterations of pulse rate.
  • Is it safe to drive while on this medicine?

    This medicine can cause side effects such as weakness, headache, blurred vision, seizures and drowsiness and is therefore not recommended that people drive while under this medication therapy.
  • Does this affect kidney function?

    There is no information available as to how the medicine affects kidney functionalities.
  • Does this affect liver function?

    Use with caution and monitor plasma levels and patient response. Kindly consult your doctor before taking this.

Below is the list of medicines, which have the same composition, strength and form as Amitone 10 MG Tablet , and hence can be used as its substitute.

  • Are there any missed dose instructions?

    Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose then the missed dose should be skipped.
  • Are there any overdose instructions?

    Contact a doctor immediately if an overdose is suspected.

The exact mechanism of action for this medication is not established. However, it is believed to act by preventing the reuptake of neurotransmitters namely norepinephrine and serotonin. These chemicals are imbalanced in people with depression.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    You should restrict or minimize the use of alcohol while taking this medicine. Symptoms like sleepiness, excessive sweating, muscle stiffness and change in pulse should be reported to the doctor on priority.
  • Interaction with Lab Test

    The patient taking this medicine may show false positive blood glucose test. Kindly inform your doctor before under going any pathological tests.
  • Interaction with Medicine

    • Amitone 10 MG Tablet inhibits the antihypertensive response to bethanidine, clonidine, debrisoquin, guanadrel, guanethidine, guanabenz, guanfacine; monitor BP; consider alternate antihypertensive agent.
    • Abrupt discontinuation of clonidine may cause hypertensive crisis, Amitone 10 MG Tablet may enhance the response.
    • Use with altretamine may cause orthostatic hypertension.
    • Amitone 10 MG Tablet may be additive with or may potentiate the action of other CNS depressants (sedatives, hypnotics, or ethanol).
    • With MAO inhibitors, hyperpyrexia, hypertension, tachycardia, confusion, seizures, and deaths have been reported (serotonin syndrome); this combination should be avoided.
    • Amitone 10 MG Tablet may increase the prothrombin time in patients stabilized on warfarin.
    • Cimetidine and methylphenidate may decrease the metabolism of Amitone 10 MG Tablet.
    • Additive anticholinergic effects seen with other anticholinergic agents.
    • The SSRIs, to varying degrees, inhibit the metabolism of TCAs and clinical toxicity may result.
    • Use of lithium with a TCA may increase the risk for neurotoxicity.
    • Phenothiazines may increase concentration of some TCAs and TCAs may increase concentration of phenothiazines; monitor for altered clinical response.
    • TCAs may enhance the hypoglycemic effects of tolazamide, chlorpropamide, or insulin; monitor for changes in blood glucose levels.
    • Cholestyramine and colestipol may bind TCAs and reduce their absorption; monitor for altered response.
    • TCAs may enhance the effect of amphetamines; monitor for adverse CV effects.
    • Diltiazem and verapamil appear to decrease the metabolism of imipramine and potentially other TCAs; monitor for increased TCA concentrations.
    • The pressor response to I.V. epinephrine, norepinephrine, and phenylephrine may be enhanced in patients receiving TCAs; this combination is best avoided.
    • Grapefruit juice, amprenavir, indinavir, ritonavir may inhibit the metabolism of clomipramine and potentially other TCAs; monitor for altered effects; a decrease in TCA dosage may be required.
    • Quinidine may inhibit the metabolism of TCAs; monitor for altered effect.
    • Combined use of anticholinergics with TCAs may produce additive anticholinergic effects.
    • The combined use of beta-agonists with TCAs may predispose patients to cardiac arrhythmias.
  • Interaction with Disease

    • Use caution in patients with depression, particularly if suicidal risk may be present.
    • Use with caution in patients with a history of cardiovascular disease (including previous MI, stroke, tachycardia, or conduction abnormalities).
    • The risk of conduction abnormalities with this agent is high relative to other antidepressants.
    • May lower seizure threshold - use caution in patients with a previous seizure disorder or condition predisposing to seizures such as brain damage, alcoholism, or concurrent therapy with other drugs which lower the seizure threshold.
    • Use with caution in hyperthyroid patients or those receiving thyroid supplementation.
    • Use with caution in patients with hepatic or renal dysfunction and in elderly patients.
    • Not for use in patients <12 years of age.

Ques: What is Amitone 10 MG Tablet?

Ans: Amitone 10 MG Tablet is a medication that performs its action by transforming certain chemical levels in the brain. Amitone 10 MG Tablet is used to avoid depression and migraine attack symptoms. It is also used to treat conditions such as sadness, sleeplessness, irritability and headache.

Ques: What are the uses of Amitone 10 MG Tablet?

Ans: Amitone 10 MG Tablet is used for the treatment and prevention from conditions and symptoms of diseases like depression and migraine attack. Besides these, it can also be used to treat conditions like sadness, sleeplessness, irritability and headache. The patient should inform the doctor about any ongoing medications and treatment before using Amitone 10 MG Tablet to avoid undesirable effects.

Ques: What are the Side Effects of Amitone 10 MG Tablet?

Ans: This is a list of possible side-effects which may occur due to the constituting ingredients of Amitone 10 MG Tablet. This is not a comprehensive list. These side-effects have been observed and not necessarily occur. Some of these side-effects may be serious. These include Restlessness, Dizziness, Insomnia, Sedation, Fatigue, Anxiety, Cognitive Impairment, Seizures, Drug-Induced Extrapyramidal Symptoms, Urticaria and Photosensitivity. If any of these symptoms occur often or on a daily basis, a doctor should be urgently consulted.

Ques: What are the instructions for storage and disposal Amitone 10 MG Tablet?

Ans: Amitone 10 MG Tablet should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

Ques: I have been prescribed Amitone 10 MG Tablet for pain. When will I start feeling better?

Ans: One can feel better within 2 weeks of using this drug. Though, you may feel much better within 4-6 weeks of taking this drug.

Ques: Can I stop taking Amitone 10 MG Tablet when my pain is relieved?

Ans: Please do not stop consuming Amitone 10 MG Tablet once you feel slightly better as this can cause the problem to recur. Even if the pain is relieved, one must complete the course of medication. It is advised to consult a doctor before you stop taking it.

Ques: Is there anything I need to be careful about while using Amitone 10 MG Tablet?

Ans: Amitone 10 MG Tablet can lead to drowsiness and dizziness, hence do not drive or use heavy machinery after taking this medicine. It is also suggested to limit the consumption of alcohol as it can increase the risk of side effects.

Ques: Can the use of Amitone 10 MG Tablet affect my sex life?

Ans: Amitone 10 MG Tablet can affect sex life in some cases as it decreases sexual desire. Men can experience an inability to develop or maintain an erection during sexual activity and women might not be able to get an orgasm. Do not stop taking the medicine if you feel this way and instead consult your doctor.

Ques: Can Amitone 10 MG Tablet cause urinary problems?

Ans: Amitone 10 MG Tablet can cause urinary problems in some patients especially in elderly people. A person can encounter difficulty in passing urine or can have a urinary tract infection. Consult your doctor as soon as possible if you develop urinary problems after consuming this medicine.

Ques: If my pain is not relieved, can I take more than the recommended dose?

Ans: You must not use Amitone 10 MG Tablet more than the prescribed dose. In case of overdose, one can experience symptoms like drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discolouration of the skin and decreased heartbeat.

Ques: Does Amitone 10 MG Tablet cause any effect on pregnancy or the newborn?

Ans: One must not take this drug during pregnancy as it can harm the baby. It should only be used during pregnancy if no other alternative is available.

Ques: How long does Amitone 10 MG Tablet take to work?

Ans: It takes about 4 to 6 weeks for you to feel better. It is suggested not to stop using it after 1 or 2 weeks and complete the course of medication.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Amitone 10 MG Tablet
What are the uses of Amitone 10 MG Tablet
What are the contraindications of Amitone 10 MG Tablet ?
What are the side effects of Amitone 10 MG Tablet ?
Key highlights of Amitone 10 MG Tablet
What are the substitutes for Amitone 10 MG Tablet ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Amitone 10 MG Tablet ?
FAQs about Amitone 10 MG Tablet