Zentel 400 MG Tablet

Manufacturer: Glaxosmithkline Pharmaceuticals Ltd
Medicine composition: Albendazole
Prescription vs.OTC: Prescription by Doctor not required
Last Updated: December 13, 2021

Created by GlaxoSmithKline Pharmaceuticals Ltd, Zentel 400 MG Tablet is generally prescribed to treat diseases like neurocysticercosis (affecting the brain, muscles and other tissues) and giardiasis (intestinal infection). This drug is an antiparasitic drug. It is used for treating several diseases caused by an infestation of parasitic worms.

It also treats hydatid disease, pinworm disease (intestinal infection), ascariasis (gastrointestinal infection), filariasis (affecting the lymph nodes and vessels) and others. The drug falls under the group of drugs known as anthelmintics.

It expels the parasitic worms either by stunning them or killing them without causing notable damage to the host body. The anthelmintic drug kills the sensitive parasites in your body.

Before you start this medication, you must inform your doctor if you have any of the following health conditions:

  • Blockage in the biliary tract
  • Liver disease
  • A low blood count (low platelet, white cell or red cell count)

Also inform the doctor if you are pregnant or planning to get pregnant, breast-feeding mother or In case you are allergic to Zentel 400 MG Tablet, or any other medicines or food.

In case you forget to take a dose of this medication, you can take it as soon as you remember it. Do not take two doses together just because you missed one. It should also be kept in mind not to stop your medicines before the prescribed time, even if you think you are feeling better.

Apart from that, you must consult your child’s paediatrician before using this tablet to treat your child’s condition. Take according to prescribed dosage schedule with meals.

You may experience loss of hair (reversible); dizziness or headaches (use caution when driving or engaging in tasks that require alertness until response to drug is known). Report unusual fever, abdominal pain, unresolved vomiting, yellowing of skin or eyes, darkening of urine, or light colored stools.

Below are the conditions for which this medicine is used:

Some of the side effects that may be observed in patients are:

  • How long is the duration of effect?

    The effect of Zentel is used for treating parasitic infections last for more than 8-9 hours after it is broken down by the liver.

  • What is the onset of action?

    Within 2-5 hours of administration, the peak level of tablet performance can be built as it is not absorbed from the gastrointestinal tracts.

  • Are there any pregnancy warnings?

    The growing fetus which is slowly developing in the patient’s body can be adversely affected by the consumption of Zentel. There have been no conclusive studies when it comes to humans, which is why Zentel is not recommended for pregnant women.

  • Is it habit forming?

    Zentel tablet doesn’t have any habit forming tendencies.

  • Are there any breast-feeding warnings?

    Zentelmust not be used by breastfeeding women until it has been deemed as absolutely necessary. The doctor must be notified before the medicine is consumed.

  • Is it safe to drive while on this medicine?

    Zentel can cause drowsiness in the patient, which can be very dangerous while driving. The patient must refrain from performing any activity that requires alertness in the patient.

  • Does this affect kidney function?

    For patients suffering from any kidney abnormalities, the consumption of Zentel can cause kidney disorders such as kidney failure. Consulting the doctor before consumption is a prudent idea.

  • Does this affect liver function?

    Patients that have a history of liver impairment can end up facing adverse effects as liver enzymes increase above a certain threshold.

  • Is It safe with alcohol?

    It is unknown whether it is safe or not to consume Zentel 400 MG Tablet with alcohol.
  • Is it safe to drive while on this medicine?

    Zentel 400 MG Tablet may affect the alertness of the patient taking it.

Below is the list of medicines, which have the same composition, strength and form as Zentel 400 MG Tablet , and hence can be used as its substitute.

  • Are there any missed dose instructions?

    The patient must take the missed dose as soon as possible and skip the dose if the time for the next dose as scheduled occurs.

  • Are there any overdose instructions?

    Consult your doctor before using this medication.

This drug gets converted into sulfoxide form and causes degeneration of cytoplasmic microtubules and tegmental cells. This results in depletion of energy and metabolic processes and the parasites are killed

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    The interaction of Zentel with alcohol is unknown which is why it is advisable to consult the doctor for such as case.

  • Interaction with Medicine

    • Clozapine : Any sign or symptom of infection should be properly reported. Usage of either of the drugs should be reported to the Doctor so that safer alternatives can be prescribed.
    • Dexamethasone : Suitable adjustments in the dosage is to be made under doctor's supervision before this drug is prescribed along with dexamethasone.
    • Praziquantel : Suitable adjustments in the dosage is to be made before this drug is prescribed along with Praziquantel
    • Carbamazepine : Suitable adjustments in the dosage of this medication along with monitoring of levels by the Doctor is recommended.
    • Phenytoin : Suitable adjustments in the dosage of it, along with monitoring of levels by the Doctor is recommended.
  • Interaction with Disease

    • Discontinue therapy if LFT elevations are significant; may restart treatment when decreased to pretreatment values.
    • Becoming pregnant within 1 month following therapy is not advised.
    • Corticosteroids should be administered 1-2 days before albendazole therapy in patients with neurocysticercosis to minimize inflammatory reactions and steroid and anticonvulsant therapy should be used concurrently during the first week of therapy for neurocysticercosis to prevent cerebral hypertension.
    • If retinal lesions exist in patients with neurocysticercosis, weigh risk of further retinal damage due to albendazole-induced changes to the retinal lesion vs benefit of disease treatment.
  • Interaction with Food

    Grapefruit Juice: Zentel 400 MG Tablet should not be taken with grapefruit juice in order to avoid the unpredictable effect. Administer with a high fatty diet.

Ques: What is Zentel 400 mg tablet?

Ans: Zentel is a prescription medicine which belongs to a class of drugs known as Anthelmintic. These are a class of antiparasitic medications that treat patients who have a symptoms known helminthiasis. These medicines remove parasitic worms (helminths) and other internal parasites from the body by killing the parasites such as roundworms, flukes, and tapeworms.

Ques: What is Zentel 400 mg tablet used for?

Ans: It is used for treating infections caused by ​worm-like parasites​, like the ​ human pinworm​, roundworm​, hookworms like Necator americanus, whipworm, chinese liver fluke​. It is advisable to take this drug only after consultation of a doctor as there are worms for which this medicine could be ineffective.

Ques: What are the side effects of Zentel 400 mg tablet?

Ans: Side effects include Reversible loss of hair, Stomach pain, Vertigo, Vomiting, Fever, Headache, Increased level of liver enzymes, Increased pressure inside the brain, Nausea, Dizziness, Lack of energy, Diarrhea and Blurred vision.

Ques: When should I take Zentel 400 mg tablet?

Ans: Zentel should usually be taken on an empty stomach. In some conditions the medicine should to be taken after meal.

Ques: Is Zentel an antibiotic?

Ans: Yes. Zentel is an antibiotic medication.

Ques: How does Zentel work?

Ans: Zentel is a medication that works by controlling worms to absorb sugar. It helps in maintaining the level of energy and treat infections.

Ques: Can I take Zentel with fluconazole?

Ans: Yes, Zentel can be taken with fluconazole altogether.

Ques: Is Zentel effective for treating pinworms?

Ans: Yes, Zentel is an effective medication that is used to treat pinworms.

Ques: How does Zentel 400 MG Tablet work?

Ans: It works by destroying larva and the adult form of the targeted worm by ​ impeding​ tubulin polymerization causing depletion of energy and reducing mobility of the specified worm, thus, killing it.

Ques: Is Zentel 400 MG Tablet considered as an over the counter product?

Ans: It’s a prescription medicine and not an over the counter (OTC) product.

Ques: Is Zentel 400 MG Tablet safe to take under G6PD deficiency?

Ans: Zentel 400 MG Tablet is safe to take for people having G6PD deficiency.

Ques: Can Zentel 400 MG Tablet be the reason diarrhoea?

Ans: Zentel 400 MG Tablet doesn’t commonly cause ​ diarrhoea​ . Please consult your doctor if you experience diarrhea after taking it.

Ques: Does Zentel 400 MG Tablet work efficiently?

Ans: Zentel 400 MG Tablet works efficiently if taken in doses prescribed by your doctor for specified duration of time.

Ques: Can Zentel 400 MG Tablet treat scabies?

Ans: Zentel 400 MG Tablet cannot treat scabies. You should visit your doctor and get yourself diagnosed properly if you think you are having scabies.

Ques: Can Zentel 400 MG Tablet kill eggs?

Ans: Zentel 400 MG Tablet cannot destroy or kill the eggs of the worms. It only acts for the impediment of larva and the adult form of the targeted worm.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MD-Pharmacology, MBBS
Table of Content
About Zentel 400 MG Tablet
What are the uses of Zentel 400 MG Tablet
What are the contraindications of Zentel 400 MG Tablet ?
What are the side effects of Zentel 400 MG Tablet ?
Key highlights of Zentel 400 MG Tablet
What are the substitutes for Zentel 400 MG Tablet ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Zentel 400 MG Tablet ?
FAQs about Zentel 400 MG Tablet