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Sofosbuvir

Prescription vs.OTC: Prescription by Doctor required

Sofosbuvir is used in combination with other medications such as ribavirin, daclatasvir and peginterferon to treat chronic hepatitis C. It functions by reducing the hepatitis C virus in the body. This helps to keep liver disorders such as cirrhosis and liver cancer at bay.

On using this medication you may experience side effects such as diarrhoea, itchiness, headache, nausea, drowsiness, rapid breathing, rapid heartbeat and skin paleness. If your reactions persist, seek the help of your health care provider right away.

Before using this medication you should tell your doctor if: you are allergic to any ingredient contained within Sofosbuvir, you have any other allergies, you are taking any prescription or non-prescription drugs, you have liver/kidney disorders, you are below 18 years of age, you are pregnant or are planning to become pregnant or are nursing a baby.

The dosage should be prescribed by the doctor based on your age, overall medical history and current condition. The usual dose in adults for treating chronic hepatitis C is 400 mg to be taken orally once daily.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Hepatologist before using this medicine.

In addition to its intended effect, Sofosbuvir may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Headache

Insomnia (difficulty in sleeping)

Is It safe with alcohol?

Interaction with alcohol is unknown. Please consult your doctor.

Are there any pregnancy warnings?

Hepcinat 400mg tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Are there any breast-feeding warnings?

Unknown. Human and animal studies are not available. Please consult your doctor.

Is it safe to drive while on this medicine?

Caution is advised when driving or operating machinery.

Does this affect kidney function?

There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.

Are there any missed dose instructions?

If you miss a dose of Sofosbuvir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Below is the list of medicines, which contains Sofosbuvir as ingredient
Abbott India Ltd
Natco Pharma Ltd
Mylan Pharmaceuticals Pvt Ltd
Zuventus Healthcare Ltd
Zydus Cadila
Mylan Pharmaceuticals Pvt Ltd
Dr Reddy s Laboratories Ltd
Hetero Drugs Ltd
Lupin Ltd
Alkem Laboratories Ltd
Torrent Pharmaceuticals Ltd
Alkem Laboratories Ltd
Sun Pharmaceutical Industries Ltd
Abbott India Ltd
Hetero Drugs Ltd
Zuventus Healthcare Ltd
Natco Pharma Ltd
Sofosbuvir is an antiviral that metabolises to 2''-deoxy-2''-alpha-fluoro-beta-C-methyluridine-5''-monophosphate on ingestion which then forms an active triphosphate nucleotide. This nucleotide inhibits the enzyme NS5B polymerase which in turn prevents viral replication.
What are you using Sofosbuvir for?
Other
cirrhosis and liver cancer
How much was the improvement?
Poor
Excellent
Average
How long did it take before seeing improvement?
Within 6 hours
Within a day
How frequently did you take this medicine?
Once a day
How did you take this medicine?
With Food
With or without food
What were the side effects of this medicine?
Nausea
Other
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Uncontrolled anger, took Daxid 50 for depression now stopped due to liver problem, Taking Ledipasvir and Sofosbuvir for liver cure, Gemer 1 to cure sugar. Extreme thoughts appears in mind to end the life, violent behaviour abusing, breaking valuable things etc. Lost a lot in life. Can be controlled?

Reparenting Technique, BA, BEd
Psychologist, Bangalore
Uncontrolled anger, took Daxid 50 for depression now stopped due to liver problem, Taking Ledipasvir and Sofosbuvir f...
Obviously, you are very depressed to contemplate death. In fact, I think that you have an anger related depression and it may have its roots somewhere in early childhood. You must talk to your parents to find out if there was anything that happened in your infancy, including the prenatal stage, which may have contributed to this depression. You may visit a counselor along with your parents and discuss the depression and follow a treatment plan, immediately. That person will certainly want you to consult a psychiatrist to introduce you to medication. I think that this is an urgent thing to do. It is very important to maintain working with the counselor for a long term, which is essential to your recovery. In the meantime, do as much as is permissible of the following: You must be active and work towards your reformation. Many lifestyle changes need to be made to progress away for the condition. When you are depressed, you will feel lazy though I would like to call it lethargy. There is an inertia and lack of energy to even think, let alone act. You are required to literally do the opposite of what you feel like doing. Depression makes you want to withdraw, lie down, sleep, become lethargic, slow down, make you too lazy to even think etc. So when I suggested doing the opposite, you will need to fight this condition. You must become active; stay upright during the daylight time; meet people; never sleep during the day, wake up by 6 am every day, play some active games, especially contact games, do physical exercises, talk to people and join some social clubs, eat more of proteins, nuts, fruits, and vegetables, attend Yoga classes etc. Watch sitcoms on TV or comedies and cheer yourself up. Go for excursions in groups, for outings, camps, conferences, and religious conventions. Get a pet dog and spend time training it, exercising it and relating to it. Expose yourself to some sunlight every day, at least 30 minutes but not in the scorching heat. Whatever happens, please incorporate these three important adaptations in your life: always be responsible, be respectful, and be functional. If you did these three, lots of things will go well in life. Please pray and have faith in God to alleviate your sufferings. Don’t wait for others to help. Use your own motivation, which might be at its lowest, but persevere and win this battle. The counselor is there only to facilitate you, all the hard word must come from you, and your cooperation with that person is very critical for your success. Please continue the medication and only under doctor's orders should you change them.
7 people found this helpful

I am HCV positive since january 17. Usg abdomen normal fibroscan. 6.3 kpa Hcv Rna. 433800 with genotype 3a. I was on medication from 22 December 1017 to 14 march 2018. Tablets was sofosbuvir 400 mg and Daclatasuvir 60 mg. Now can I go for again hcv rna test.

MBBS
General Physician, Mumbai
I am HCV positive since january 17.
Usg abdomen normal
fibroscan. 6.3 kpa
Hcv Rna. 433800 with genotype 3a.
I was on ...
IF you are asymptomatic and if you are having sgpt sgot within normal limits than get your blood checked for hcv ma test after two months.
1 person found this helpful

My father affected by hcv genotype 1a virus. Now he's doing dialysis. Is there any best medicine to recover him. And when we can do kidney transplant.

AUTLS, CCEDM, MD - Internal Medicine, MBBS
General Physician, Faridabad
Tablet sofosbuvir ...simeprevir are very good medications to control hep c virus...but these are not OTC drugs... get in touch with nearest Gastroenterologist for that who will guide u through this
1 person found this helpful

Hello I am 25 years old male I am suffer from hepatitis c What can I do Cells is 40000.

AUTLS, CCEDM, MD - Internal Medicine, MBBS
General Physician, Faridabad
what is ur liver function tests report??there are a lot of medications available for hepatitis c infection like sofosbuvir,simeprevir....get in touch with nearby gastroenterologist for that
1 person found this helpful

Popular Health Tips

DOMS, FRVS,FRCS
Ophthalmologist, Mumbai
Do you know how well your child sees and if hep or she sees equally with both eyes ......
Amblyopia or lazy eyes is a childhood eye problem that is treatable till the age of 8 only....
So act now get in touch with your eye specialist.... record your childs vision help them lead a normal life....
1 person found this helpful

MBBS, PGDDCN
General Physician, Bangalore
Vaccine Schedule

Epi schedules as recommended by govt. Of india 

-birth -15 days- bcg + opv (zero dose)
-6 weeks- opv1 + dpwt1 + hep b1 + hib 1*
-10 weeks- opv2 + dpwt2 + hep b2+ hib 2*
-14 weeks- opv3 + dpwt3 + hep b3+ hib 2*
-9 months- measles vaccine
-15 months-18 months- 1st booster of opv/ dpwt + mmr*
-5 years -6 years- 2nd booster of dpwt
-10 years- tetanus toxoid
-16 years- tetanus toxoid


* these vaccines have been introduced in few states currently, hep b = hepatitis b vaccine.

MD - Paediatrics, MBBS
Pediatrician, Faridabad
ADULT VACCINATION.

When most of us were, born many vaccines which are available now were not available at that time. Many of these deadly diseases can be prevented by vaccines. When we all adults or adolescents, go to the pediatrician for the vaccination of our baby, we opt for the best and most costly vaccines. Most of the doctors and parents do not ever discuss adult vaccine preventable diseases .Mr. Amitabh Bachan had Hepatitis B disease after multiple blood transfusions after the trauma in the movie coolie. Now he cannot be cured but his disease is preventable. Now days we i.E. All adults can be vaccinated against Hep A, Hep B, M.M.R, Chickenpox, Flu, Typhoid, Tdap and Cervical Cancer only for woman. It is transmitted as HIV i.E. Blood transfusion, needle prick, sexual, and mother to baby. It is highly contagious and hundred times more common than HIV. It causes acute hepatitis (jaundice), chronic hepatitis (shirking of liver),hepatocellular carcinoma(cancer of liver).Hepatitis B is potentially fatal but we have an excellent vaccine that gives almost 100percent protection after complete schedule. Three doses at day zero, one month and six month is the schedule. One third packed syringes are contaminated but recycled. Any one of us may suffer an accident or may require hospital care. We do not know about the next injection or blood transfusion that we may get. Everyone must get hepatitis B vaccine.
1 person found this helpful

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
IMMUNISATION OF CHILDREN FROM BIRTH.
=====================================

There are many schedules of immunisation followed and varies from country to country, In india, we widely follow the National Immunisation Schedule.mainly in government hospitals. Many private institutions follow their own schedules.Both are effective,though the private hospitals use costly vaccines whereas the government supply is free.Depending on your purchasing power you can choose either.By and large INDIAN ACADEMY OF PEDIATRICS the largest and most authoritative body in India . Their schedule is fair combination of both types of vaccines newer but costly and cheap ( but effective & safe ) selected appropriately.Apart from the main or essential vaccines there are some optional vaccines for diseases which are not as fatal or life threatening which are covered in national immunisation schedule. I shall explain all important schedule.
RECOMMENDED IMMUNIZATION SCHEDULE FOLLOWED IN INDIA
Text zoom - +


Sl No. Age Disease Vaccination Remarks*

1 AT BIRTH HEPATITIS B HEP B VACCINE -I


2 AT BIRTH POLIO ORAL PV 0 DOSE


3 BIRTH TO
6 WK TUBERCULOSIS BCG


4) 4 -6 WEEKS HEPATITIS B HEP B VACCINE -II


5) 6 WEEKS } DIPHTHERIA ,PERTUSIS,
}TETANUS,POLIO DPT-I OPV -I


6) 10 WK DIPHTHERIA PERTUSIS
TETANUS POLIO HEPATITIS B DPT-II OPV-II HEP B VACCINE III*

*
*DELHI GOVT RECOMMENDATION


7) 14 WEEKS DIPHTHERIA PERTUSIS
TETANUS POLIO DPT-III OPV- III HEP B VACCINE IV*

*DELHI GOVT RECOMMENDATION


8) 24 WEEKS HEPATITIS B HEP B VACCINE III*

*IAP RECOMMENDATION


9) 9 -12MTHS }- POLIO MEASLES OPV-IV MEASLES


10) 15-18 MTHS MUMPS MEASELES RUBELLA (MMR*)


11) 18 MTHS } DIPHTHERIA PERTUSIS
} TETANUS POLIO DPT –BOOSTER I OPV –V

*RECOMMENDED BY DELHI GOVT & IAP ONLY

12) 24 MTHS TYPHOID TYPHOID*

*IAP RECOMMENDATION

13) 4-5 YR } DIPHTHERIA PERTUSIS
} TETANUS POLIO DPT BOOSTER – II OPV -VI



YOU ARE WELCOME TO CLEAR ANY DOUBTS IN PRIVATE CONSULTATION IN THIS SITE



Complete Adult Immunization Schedule!

PGDMCH, MBA( CHA) , MBBS
General Physician, Gurgaon
Complete Adult Immunization Schedule!

If you think that immunisation is only for your infant, then you are living in a fool’s paradise. It’s a life-long process. You are never too old for this. It is a life-protecting job. You must get all your immunisation done in time to be protected against fatal diseases.

Here are some of the most common vaccines given to adults:

  1. Hepatitis A (Hep A): You should take this vaccine if you are exposed to a specific risk factor for hepatitis A virus infection. You may also opt for this to be simply protected from this disease. The vaccine is usually given in two doses. It should be given 6-18 months apart.
  2. Hepatitis B (Hep B): You will need this if you are exposed to a specific risk factor for hepatitis B virus infection. You may take it simply if you want to be protected from this disease. The vaccine is given in three doses over a period of six months.
  3. Human papillomavirus: This vaccine is given to women, who are 26 years of age or younger. In the case of men, the upper limit for age is 22. It can also be given to a man with risk factor in the age group 22 to 26. It is given in three doses over a period of six months.
  4. Influenza: It is a must for every individual. It should be given a dose every winter. It will not only provide protection to the immunised person, but also to others surrounding him.
  5. Measles, mumps, rubella (MMR): You may require at least a single dose of this vaccine if you were born after 1975.
  6. Meningococcal (MenACWY [MCV4], MenB, MPSV4): You may need MenACWY and/or MenB vaccine if you have been suffering from certain health conditions. It is given to adults who are not having a functioning spleen.
  7. Pneumococcal (Pneumovax [polysaccharide vaccine, PPSV]; Prevnar [conjugate vaccine] PCV): You will have to get both pneumococcal vaccines, Prevnar (if you haven’t had it before) and Pneumovax, if you are more than 65 years of age. You will have protection from diseases like asthma, heart, and lung, or kidney disease, immunosuppression. It is best to consult your doctor before injecting such vaccines.
  8. Tetanus, diphtheria, whooping cough (pertussis) (Tdap, Td): It must be given to all adults who have not got a dose of Tdap in adolescence. It is a must for pregnant women. You need a Td booster once in every 10 years.
  9. Varicella (Chickenpox): If you’ve never been exposed chickenpox or got vaccinated after receiving 1 dose, you must talk to your doctor to know when and what you should take.
  10. Zoster (shingles): If you are 60-year-old or above, you must definitely get a 1-time dose.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3507 people found this helpful
Table of Content
About Sofosbuvir
What are the side effects of Sofosbuvir ?
Key highlights of Sofosbuvir
What are the dosage instructions?
Medicines containing Sofosbuvir
How does medicine works?