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Manforce 100 MG Tablet

Manufacturer: Mankind Pharmaceuticals Ltd
Medicine composition: Sildenafil
Prescription vs.OTC: Prescription by Doctor not required

Manforce 100 mg tablet is a prescription tablet used mainly in men to treat the sexual problem of erectile dysfunction (ED). The tablet is a phosphodiesterase type 5 inhibitor that relaxes and dilates the blood vessels to increase the blood flow in certain parts of the body. The good blood flow will activate the muscles of penis in men, helping them fix the erectile dysfunction issues they may be facing. Furthermore, the tablet also helps in the treatment of pulmonary arterial hypertension (PAH). This increases the exercising capacity in both men and women.

Men suffering from impotence or are unable to keep or get an erection should consume this tablet to solve the problem, but only after consulting it with a doctor. While consulting you must discuss about the diseases you possibly have or the medications you already are taking. This will help you avoid the possibility of experiencing any unexpected side effects.

The dosage depends on the purpose you are taking it for and it is mandatory that you stick to the prescribed dosages. Patients taking the medicine for PAH should consume it thrice a day as the duration of the effect lasts for 4-6 hours on average. The side effects of the tablet include dizziness, headache, blurred vision, stomach upset, back pain, bloody urine, migraine, bone pain and indigestion.

Erectile Dysfuntion

Someone who is suffering from impotence, where sustaining and achieving an erection is a problem during sexual intercourse, can use Manforce 100 MG Tablet. However, it will only work if there is sexual stimulation.

Pulmonary arterial hypertension

Manforce 100 MG Tablet improves exercise capacity of such patients. It is also used to treat high blood pressure of arteries present in the lungs and right side of the heart.
Manforce 100 MG Tablet is not recommended for use if you have a history of allergy to sildenafil or any other component of this medicine.

Nitrate containing medicines

Manforce 100 MG Tablet is not recommended if you are using any medicine containing nitrates.

Riociguat

Manforce 100 MG Tablet is not recommended for use if you are consuming a medicine named Riociguat (Popular trade name is Adempas).
In addition to its intended effect, Manforce 100 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

headache

Moderate Less Common

Flushing

Moderate Less Common

Indigestion

Moderate Less Common

Dizziness.

Moderate Less Common

Prolonged and painful erection

Moderate Less Common

Painful urination

Moderate Less Common

How long is the duration of effect?

The effects of this medicine usually last for about 4-6 hours after consumption.

What is the onset of action?

The onset of action can vary from person to person, but it usually ranges from between half an hour to two hours.

Is it habit forming?

No, people consuming the tablet have not shown any indications of a habit or addiction of the tablet being developed.

Is It safe with alcohol?

It is advisable that you keep the consumption of alcohol to a minimum, as it can cause increased dizziness, drowsiness, fainting or other such side effects.

Are there any pregnancy warnings?

Pregnant women must avoid this medication as much as possible. They should consume it only when specifically mentioned.

Are there any breast-feeding warnings?

Breastfeeding women must seek the advice of a practising doctor to get a substitute medicine if possible as consuming the Manforce 100 mg tablet can hamper your child’s health.

Is it safe to drive while on this medicine?

It is advised that you avoid driving while on this medication as you may experience side effects like headache, dizziness, drowsiness, migraine and others that affect your sense of judgement and coordination.

Does this affect kidney function?

Patients who are suffering from serious kidney related ailments must not consume the tablet as it can aggravate the conditions and lead to severe side effects as well. If the renal impairment is not of serious order then you may take the medicine with necessary changes in the dosages.

Does this affect liver function?

The tablet may or may not hamper the functioning of liver, so people having liver related issues must consult a doctor regarding whether they are fit to use the medicine or not.

Below is the list of medicines, which have the same composition, strength and form as Manforce 100 MG Tablet , and hence can be used as its substitute.
Glenmark Pharmaceuticals Ltd
Ranbaxy Laboratories Ltd
Cadila Pharmaceuticals Ltd
Zydus Cadila
Sun Pharma Laboratories Ltd

Are there any missed dose instructions?

Patients taking the medicine for PAH will have a fixed pattern of dosage. If they miss a dose then they must take it as soon as they remember but not if it is time for the next dose. For cases of ED, there is no fixed pattern of dosage.

Are there any overdose instructions?

If you suspect an overdose due to any reason, you must consult a doctor immediately.

Manforce 100 MG Tablet relaxes the smooth muscles by inhibiting Phosphodiesterase type-5. This results in the increase of cyclic guanosine monophosphate (cGMP) which relaxes the smooth muscles and increases the flow of blood.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Moderate

The tablet can interact with cardiovascular diseases, kidney diseases, priapism and diseases related to retina. If you are suffering from any of it, consumption of this tablet may aggravate the conditions. If you notice a prolonged or painful erection, it can be a symptom of leukaemia, cell anaemia or deformation of penis. Discuss your medical history with the doctor before you taking the medication.

Interaction with Alcohol

Moderate

It is advised that you do not consume too much alcohol while on this medication as you may experience the side effects like drowsiness, dizziness, flushing or fainting.

Interaction with Food

Moderate

You must avoid the usage of grapefruit juice in large quantities as it can reduce the effectiveness of the tablet. You may consult the doctor to get more information regarding food interactions.

Interaction with Medicine

Moderate

The tablet does interact with a few medicines to give negative results. You must avoid the medication if you are already using medicines that have nitrate as a component. The other medicines that can interact with the tablet are amlodipine, carbamazepine, clarithromycin, dexamethasone, ketoconazole, atazanavir, nitroglycerin and riociguat.

Ques: what is manforce 100 mg tablet?

Ans: Manforce 100 MG Tablet is used to treat high blood pressure of arteries located in the lungs and heart.it calms the smooth muscles present in the wall of blood vessels and results in increased flow of blood to some certain places in the body.

Ques: what is manforce 100 mg tablet used for?

Ans: It is used for the treatment of erection disorders and Pulmonary Hypertension which is high blood pressure of blood vessels along the lungs and the heart. It helps in the treatment of erectile dysfunction.The phosphodiesterase type 5 inhibitor (PDE5) relaxes and dilates your blood vessels that are present in your lungs, thus improving your exercising ability.

Ques: what is the side effect of manforce 100 mg tablet?

Ans: Common Side effects include Severe headache, Bloody Nose, Flushing, Indigestion and tendency to not being able to sleep.Dizziness, Bloody urine, Burning, numbness, tingling in the arms and feet are included in severe side effects. Also Sensitivity to light , painful urination and prolonged and painful erection aur rarely found side effects.

Ques: what are the dosage instruction?

Ans: Manforce 100 mg tablets help in curing erectile dysfunction and pulmonary arterial hypertension due to which the dosage of these tablets vary from person to person. These tablets should be taken only if prescribed by your doctor. Its further dosage depends on how your body reacts on the first dosage. In case of missed dosage unless you remember about it at almost the time of the next dosage, take your missed dose immediately.
What are you using Manforce 100 MG Tablet for?
Erectile Dysfuntion
Other
Pulmonary arterial hypertension
How much was the improvement?
Poor
Excellent
Average
How long did it take before seeing improvement?
Within 2 hours
More than 2 days
Within a day
Within 6 hours
Within 2 days
How frequently did you take this medicine?
Once a day
Not taking on daily level
Four times A Day
Twice a day
Thrice a day
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Headache
Other
Sleeplessness
Indigestion
Diarrhea
Flushing
Bloody nose
numbness
Burning
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am 26 years age Can I take manforce 100 tab for only 1 time? Is it safe for 1 time?

Md
General Physician, Bangalore
If you have any heart related problem or if you are taking nitrates or any other vasodilator medicines then it is better to avoid these medicines. If you don't have any of these problems then it is better to take 25 or 50 mg tablets first and see the response. If you want to take 100 mg then it is better to see a doctor for examination and if he says it's ok then you can think of taking it.
6 people found this helpful

Actually before 2 year I was good but I started manforce tab for mor power with my partner but slowly I got these problems. So I am depressed. I never drink tea and coffee and now I discharge fast within 5 to 7 min And my penis also small and thick Please suggest me any treatment or medicine.

MD-Ayurveda, Bachelor of Ayurveda, Medicine & Surgery (BAMS)
Sexologist, Haldwani
Actually before 2 year I was good but I started manforce tab for mor power with my partner but slowly I got these pro...
Hello- Repeated intake of Manforce/Viagra can cause impotence along with premature ejaculation. You can get back your lost endurance by consuming Omega 3 fatty acids in your diet. However it is best for you to consult a good ayurvedic doctor. Herbs can counteract the adverse effect of Manforce tablets on reproductive system, and can provide you natural strength from within.

I am planning to have sex for first time, I am looking for some medicine like manforce or Viagra. Please tell me which 1 I should use.

Bachelor of Unani Medicine & Surgery (B.U.M.S)
Ayurveda, Indore
This medicines are not for enjoyment purpose they are used only if you have erectile dysfunction. Tc.
3 people found this helpful

I want to take manforce 50 mg. Please tell me the dosage. And days gap between two dose.

MBBS
General Physician, Mumbai
I want to take manforce 50 mg. Please tell me the dosage. And days gap between two dose.
It’s better to avoid manforce tablet because it will lead to dependency and hypertension with restlessness in future

I am 19 years old and I have to increase my sex time. For that I bought manforce 50 mg sildenafil citrate tablets. So tell me how much it affects or not! Or what should I do?

BHMS
Homeopath, Murshidabad
I am 19 years old and I have to increase my sex time. For that I bought manforce 50 mg sildenafil citrate tablets. So...
There are many conventional allopathic sexual pills in market such as Adegra, Viagra, Penegra etc. Refrain yourself from using such pills as those pills contain a steroid called SILDENAFIL. This steroid has a unique temporary effect on erectile problems.  Patients using these pills for first time often report that their penis remain strong even after ejaculation. Such effects leads the patients to use SILDENAFIL for prolonged course of time as they often feel that a full erection is possible only after taking SILDENAFIL. Moreover it is very low cost & easy availability of this steroid has made it quite common as sexual medicine. But the bitter truth is prolonged use of SILDENAFIL will permanently disable the normal physiological process behind erection & will render your body to become solely dependent upon SILDENAFIL for erection. As a result you would not feel any slightest normal erection without taking SILDENAFIL. This is an irreversible condition & it cannot be treated by any means. Once you attain this condition you become a life-time customer of that steroid SILDENAFIL because you have to take SILDENAFIL in order to satisfy your partner. As prevention is always better than cure I would advise you to check the composition of any sexual pills before buying. Discard any sexual pills which contains SILDENAFIL in its composition.
6 people found this helpful

Popular Health Tips

Viagra - Why It Is Important To Consult Your Doctor Before Using It?

Bachelor of Ayurveda, Medicine and Surgery (BAMS), L.C.P.S, PhD ,D.P.S.M
Sexologist, Ahmednagar
Viagra - Why It Is Important To Consult Your Doctor Before Using It?

Some people experience symptoms of erectile dysfunction and think of consuming Viagra. Viagra is the market name of a substance called Sildenafil, which is used for the correction of erectile dysfunction. It creates hypertension in the blood vessels, enabling you to get an enhanced erection. Viagra is quite useful for boosting your sexual performance. However, you may experience several side effects on your health. Before deciding on using a pack of Viagra, it is advised to consult a doctor to know the exact dosage that would work for you.

Dosages

1. 50 mg is the recommended dosage for men in general. The dose can be sometimes increased up to 100 mg. It depends on tolerance and effectiveness. The dose may also be decreased to 25 mg in some cases. It is also advised not to take Viagra more than once a day. The dosage will have to be altered if you take other prescribed medicines.

2. Viagra single packs are also prescribed by doctors. Single packs are available in dosages of 25, 50 and 100 mg.

When should you avoid viagra?

Viagra should be avoided in some cases.

These include the following:

1. In case you take prescribed nitrates for chest pain or pulmonary disorder, your doctor would advise you not to use Viagra due as it increases the risk of high blood pressure, which can be quite disastrous for your health.

2. Many people are allergic to sildenafil, which is a substance present in Viagra.

Side effects of consuming viagra

Viagra causes several serious side effects on the body. Therefore, it is very important to take a doctor’s advice and know about the different adversities. The most common side effects include the following:

1. Priapism: This is a condition where your erection lasts for about four hours or longer and does not end. Permanent damage to the penis is indicated if this condition is not treated.

2. Loss of vision and hearing impairment: Viagra may cause Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). This disorder may lead to loss of vision in one or both the eyes. Tinnitus or hearing impairment is another condition, which may occur as a side effect of consuming Viagra.

You should always consult a doctor before you decide to take as he would know best about the dosage required by your body. He will also advise you about an ideal method of usage.

30 people found this helpful

Pulmonary Hypertension - What Type Of Treatment Is Given?

MD , MBBS
Pulmonologist, Delhi
Pulmonary Hypertension - What Type Of Treatment Is Given?

Pulmonary hypertension mainly occurs due to narrowing of the arteries of the lungs as a result of which the flow of blood is restricted. In this kind of condition, blood fails to carry oxygen to your heart and thus your heart gets adversely affected. The blood pressure of your body will get increased to a great extent if this situation remains untreated, thus leading to bdreadful consequenses, specifically situation like heart failure, serious pulmonary diseases, blood clots in lungs and congenial heart defects, etc.

There are certain forms of pulmonary hypertension, which are serious in nature and worsen with time, so much so that they are even fatal at times. It also includes forms which are non curable in nature, however, in order to improve the quality of life, symptoms can be reduced with proper treatment. The treatment for pulmonary hypertension is often complex and it takes some time to find the most appropriate treatment and requires extensive follow-up care. Your doctor might also need to change your treatment if it's no longer effective. However, when pulmonary hypertension is caused by another condition, your doctor will treat the underlying cause whenever possible.

Common Treatments for pulmonary hypertension:

Medications:

  1. Blood vessel dilators (vasodilators): Vasodilators open narrowed blood vessels. They are one of the most commonly prescribed vasodilators for pulmonary hypertension is epoprostenol (Flolan, Veletri). The drawback to epoprostenol is that the effect lasts only for few minutes. This drug is continuously injected through an intravenous (IV) catheter via a small pump that you wear in a pack on your belt or shoulder.
  2. Ventavis: Another form of the drug, iloprost (Ventavis), can be inhaled six to nine times a day through a nebulizer, a machine that vaporizes your medication. Because it's inhaled, it goes directly to the lungs.
  3. Treprostinil (Tyvaso, Remodulin, Orenitram): It is another form of the drug, which can be given four times a day and can be inhaled or can be taken as an oral medication and can also be administered through injection.
  4. Endothelin receptor antagonists: These medications reverse the effect of endothelin, a substance in the walls of blood vessels that causes them to narrow. These drugs may improve your energy level and symptoms. However, these drugs shouldn't be taken if you're pregnant. Also, these drugs can damage your liver and you may need monthly liver monitoring.
  5. Sildenafil and tadalafil: Sildenafil (Revatio, Viagra) and tadalafil (Cialis, Adcirca) are sometimes used to treat pulmonary hypertension. These drugs work by opening the blood vessels in the lungs to allow blood to flow through more easily.
  6. High-dose calcium channel blockers: These drugs help relax the muscles in the walls of your blood vessels. They include medications, such as amlodipine (Norvasc), diltiazem (Cardizem, Tiazac, others) and nifedipine (Procardia, others). Although calcium channel blockers can be effective, only a small number of people with pulmonary hypertension respond to them.
  7. Soluble guanylate cyclase (SGC) stimulator: Soluble guanylate cyclase (SGC) stimulators (Adempas) interact with nitric oxide and help relax the pulmonary arteries and lower the pressure within the arteries. These medications should not be taken if you're pregnant. They can sometimes cause dizziness or nausea.
  8. Anticoagulants: Your doctor is likely to prescribe the anticoagulant warfarin (Coumadin, Jantoven) to help prevent the formation of blood clots within the small pulmonary arteries. Because anticoagulants prevent normal blood coagulation, they increase your risk of bleeding complications. Take warfarin exactly as prescribed, because warfarin can cause severe side effects if taken incorrectly. If you're taking warfarin, your doctor will ask you to have periodic blood tests to check how well the drug is working. Many other drugs, herbal supplements and foods can interact with warfarin, so be sure your doctor knows all of the medications you're taking.
  9. Digoxin: Digoxin (Lanoxin) can help the heart beat stronger and pump more blood. It can help control the heart rate if you experience arrhythmias.
  10. Diuretics: Commonly known as water pills, these medications help eliminate excess fluid from your body. This reduces the amount of work your heart has to do. They may also be used to limit fluid buildup in your lungs.
  11. Oxygen: Your doctor might suggest that you sometimes breathe pure oxygen, a treatment known as oxygen therapy, to help treat pulmonary hypertension, especially if you live at a high altitude or have sleep apnea. Some people who have pulmonary hypertension eventually require continuous oxygen therapy.

Surgeries:

  1. Atrial Septostomy: If medications don't control your pulmonary hypertension, this open heart surgery might be an option. In an atrial septostomy, a surgeon will create an opening between the upper left and right chambers of your heart (atria) to relieve the pressure on the right side of your heart.
  2. Lung Transplantation: In some cases, a lung or heart lung transplant might be an option, especially for younger people who have idiopathic pulmonary arterial hypertension.

Reducing Complications:

  1. The complications need to be reduced by taking proper health care. Healthy diet needs to be taken regularly along with proper medications. Smoking should be stopped and exercising sessions should be attended daily without any fail
  2. Overweight or obesity needs to be controlled properly for reducing the complications. Specialized caring strategies need to be maintained for avoiding severe kinds of health complications that are quite annoying. If you wish to discuss about any specific problem, you can consult a Pulmonologist.
2516 people found this helpful

Erectile Dysfunction - Symptoms, Treatment & Prevention

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Sexologist, Allahabad
Erectile Dysfunction - Symptoms, Treatment & Prevention

Erectile dysfunction can be quite a depressing and stressful problem. It can jeopardize the sexual life of a person. In recent times, the problem has been on an exponential rise. As per a survey, 1 in every 1000 men suffers from erectile dysfunction. To top it, some men, out of embarrassment, delay the treatment and medications.

In Erectile Dysfunction, a person is unable to maintain an erection necessary for a sexual intercourse. A man's confidence and self-esteem often take a beating in such cases. In some cases, the affected person completely detaches himself from the outside world. The erectile dysfunction in men can be due to lifestyle habits, psychological problems, injury, and diseases, such as;

  1. Stress and anxiety.
  2. Hormonal imbalance.
  3. Medical conditions, which include, diabetes, cardiovascular problems, hypercholesterolemia, and hypertension.
  4. Treatment for prostate cancer can result in erectile dysfunction.
  5. Obesity.
  6. Older men are more likely (not always) to suffer from erectile dysfunction.
  7. Unhealthy lifestyle habits (drinking, smoking, and drug abuse).
  8. Peyronie's disease.
  9. Parkinson's disease.
  10. Injury to the pelvic area.

Symptoms of erectile dysfunction:
A person with erectile dysfunction may exhibit one or more of the following symptoms:

  1. A person with erectile dysfunction may have difficulties in getting an erection.
  2. There is a problem in holding on to the erection for a longer duration of time.
  3. Erectile dysfunction can also affect a person's sexual desire (low libido).

Diagnosis and Treatment:
As serious as it may appear, there is nothing to press the panic button. The problem is temporary. With timely diagnosis and treatment, erectile dysfunction can be easily managed and treated. Diagnosis of erectile dysfunction include;

  1. Blood and urine tests play a pivotal in identifying the root cause (diabetes, cardiac problems, hormonal imbalance or any other medical conditions) of the erectile dysfunction.
  2. Physical examination.
  3. An Ultrasound.

Treatment:

  1. Medications like Stendra (Avanafil), Viagra (Sildenafil), and Cialis (Tadalafil) can prove to be helpful in treating erectile dysfunction. The medications magnify the influence of nitric oxide (nitric oxide helps in relaxing the penis), thus enabling a person to get an erection on being sexually aroused.
  2. Low levels of the testosterone hormone interfere with and adversely affects erectile dysfunction. In such cases, the doctor may recommend testosterone replacement.
  3. Alprostadil Injection when injected helps in increased blood flow to the penis (by muscular relaxation of the penis), thus helping a person to get an erection.
  4. Penile implants are also helpful in case of erectile dysfunction.
  5. Many men with erectile dysfunction have benefitted immensely from counseling and sex therapy.

A person also needs to

  1. Maintain a healthy lifestyle.
  2. Exercise regularly.
  3. Indulge in limited alcohol consumption and smoking.
  4. Refrain from drug abuse.
  5. Maintain a healthy body weight.
  6. Seek expert help in case of severe depression, stress, and anxiety.
  7. Do not compromise with your sleep.
  8. If need be, discuss the problem with your partner. If you wish to discuss about any specific problem, you can consult a Sexologist.
3005 people found this helpful

Viagra: How Should You Use It?

MBBS, F R S T & H London , Fellowship of College of General Practice (FCGP)
Sexologist, Alwar
Viagra: How Should You Use It?

Viagra is a very common drug prescribed for treating erectile dysfunction. It works by enhancing the flow of blood to the penis during sexual intercourse to bring about erection. Viagra actually contains the active ingredient Sildenafil Citrate which is a selective inhibitor of Cyclic Guanosine Monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

This drug works efficiently with sexual stimulation. Erectile dysfunction is very common among older men whose sexual function tends to fall after they reach their 50s. But these days even younger men in their 30's and 40's are experiencing an increased incidence of erectile dysfunction.

Doctors can even recommend the drug to both younger and elder men who suffer from erection problems.

Solidification of the arteries, the blood vessels that supply blood to the penis, can occur during the teen years. The problem then develops by the time they reach the age of 20-30 years and more, hindering their ability to get and maintain an erection. Men suffering from diabetes and facing the problem of Erectile dysfunction can be assisted by this drug.


The drug should be ideally taken an hour before the sexual intercourse.

On the other hand, you can also take Viagra half an hour to 4 hours before the sexual intercourse. You don't require having food in order to take the drug. But you need to keep in mind that if you take it after a meal high in fats, it can take a little bit longer for you to experience its effects.

Most importantly, the misuse of Viagra should be avoided. It should be taken only under medical supervision. The drug doesn't have the power to help you ejaculate easily if you suffer from problems related to orgasm or even enhance your sexual appetite. It does not enhance sexual timing, so should not be used to treat premature ejaculation. Men also shouldn't expect the drug to take the erections to unexpected heights.

Word of Caution:
One should never take the drug for recreational purposes. One can end up suffering from minor erectile dysfunction due such abuse. If you wish to discuss any specific problem, you can consult a sexologist.

6236 people found this helpful

Can Viagra Cause Skin Cancer?

Bachelor of Ayurveda, Medicine & Surgery (BAMS)
Sexologist, Lucknow
Can Viagra Cause Skin Cancer?

Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.

Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.

The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.

However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se. 

Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss any specific problem, you can consult a sexologist.

6666 people found this helpful
Content Details
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Manforce 100 MG Tablet
When is Manforce 100 MG Tablet prescribed?
What are the contraindications of Manforce 100 MG Tablet ?
What are the side effects of Manforce 100 MG Tablet ?
Key highlights of Manforce 100 MG Tablet
What are the substitutes for Manforce 100 MG Tablet ?
What are the dosage instructions?
How does medicine works?
What are the interactions for Manforce 100 MG Tablet ?
Manforce 100 MG Tablet Frequently Asked Questions (FAQs):