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Ledipasvir

Prescription vs.OTC: Prescription by Doctor required

Ledipasvir helps in the treatment of chronic hepatitis C (HCV). This drug is used in a combination with another drug, to prevent the spread of HCV throughout the body.

Patients who have liver issues, or kidney problems and are undergoing dialysis, are not advised the use of Ledipasvir. Also inform your doctor about any other health issues you are suffering from and if you are taking any medicines to treat them.

Ledipasvir is meant to be taken orally, either with food or without. Antacids containing magnesium or aluminum should not be consumed for a few hours after taking the drug. The drug should be taken regularly, preferably at a particular time each day. Try not to miss any doses.

Ledipasvir may result in a few common side effects such as irritation, pain in the muscles, diarrhea, headache, cough, and problems with sleep. Side effects that are less common but may occur none the less are loss of appetite, discontentment, dizziness and problems with concentration. If these side effects persist or deteriorate, get in touch with your health care provider immediately.

In case of adults, 1 tablet is prescribed to be taken every day for about 12 weeks.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Hepatologist before using this medicine.

In addition to its intended effect, Ledipasvir may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Headache

Insomnia (difficulty in sleeping)

Is It safe with alcohol?

Interaction with alcohol is unknown. Please consult your doctor.

Are there any pregnancy warnings?

Reclaim-l tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Are there any breast-feeding warnings?

Unknown. Human and animal studies are not available. Please consult your doctor.

Is it safe to drive while on this medicine?

Caution is advised when driving or operating machinery.

Does this affect kidney function?

There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which contains Ledipasvir as ingredient
Lupin Ltd
Torrent Pharmaceuticals Ltd
Alkem Laboratories Ltd
Sun Pharmaceutical Industries Ltd
Abbott India Ltd
Hetero Drugs Ltd
Zuventus Healthcare Ltd
Natco Pharma Ltd
Zydus Cadila
Mylan Pharmaceuticals Pvt Ltd
Dr Reddy s Laboratories Ltd
Ledipasvir is used for the treatment of hepatitis C. It prevents the non-structural protein 5A (NS5A) replication which is a viral phosphoprotein. Therefore, Ledipasvir binds it self’s to NS5A to stop the secretion, replication and production of RNA viral infection.
What are you using Ledipasvir for?
Other
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Uncontrolled anger, took Daxid 50 for depression now stopped due to liver problem, Taking Ledipasvir and Sofosbuvir for liver cure, Gemer 1 to cure sugar. Extreme thoughts appears in mind to end the life, violent behaviour abusing, breaking valuable things etc. Lost a lot in life. Can be controlled?

Reparenting Technique, BA, BEd
Psychologist, Bangalore
Uncontrolled anger, took Daxid 50 for depression now stopped due to liver problem, Taking Ledipasvir and Sofosbuvir f...
Obviously, you are very depressed to contemplate death. In fact, I think that you have an anger related depression and it may have its roots somewhere in early childhood. You must talk to your parents to find out if there was anything that happened in your infancy, including the prenatal stage, which may have contributed to this depression. You may visit a counselor along with your parents and discuss the depression and follow a treatment plan, immediately. That person will certainly want you to consult a psychiatrist to introduce you to medication. I think that this is an urgent thing to do. It is very important to maintain working with the counselor for a long term, which is essential to your recovery. In the meantime, do as much as is permissible of the following: You must be active and work towards your reformation. Many lifestyle changes need to be made to progress away for the condition. When you are depressed, you will feel lazy though I would like to call it lethargy. There is an inertia and lack of energy to even think, let alone act. You are required to literally do the opposite of what you feel like doing. Depression makes you want to withdraw, lie down, sleep, become lethargic, slow down, make you too lazy to even think etc. So when I suggested doing the opposite, you will need to fight this condition. You must become active; stay upright during the daylight time; meet people; never sleep during the day, wake up by 6 am every day, play some active games, especially contact games, do physical exercises, talk to people and join some social clubs, eat more of proteins, nuts, fruits, and vegetables, attend Yoga classes etc. Watch sitcoms on TV or comedies and cheer yourself up. Go for excursions in groups, for outings, camps, conferences, and religious conventions. Get a pet dog and spend time training it, exercising it and relating to it. Expose yourself to some sunlight every day, at least 30 minutes but not in the scorching heat. Whatever happens, please incorporate these three important adaptations in your life: always be responsible, be respectful, and be functional. If you did these three, lots of things will go well in life. Please pray and have faith in God to alleviate your sufferings. Don’t wait for others to help. Use your own motivation, which might be at its lowest, but persevere and win this battle. The counselor is there only to facilitate you, all the hard word must come from you, and your cooperation with that person is very critical for your success. Please continue the medication and only under doctor's orders should you change them.
7 people found this helpful

My dad's creatinine level is presently 2.90 He is taking NEPRO LP 2scoops daily in the evening. Is is useful for him or harmful?

MS - General Surgery, FMAS.Laparoscopy
General Surgeon, Gandhinagar
My dad's creatinine level is presently 2.90
He is taking NEPRO LP 2scoops daily in the evening. Is is useful for him ...
Hello dear lybrate-user, hi Warm welcome to Lybrate.com I have evaluated your query for your father thoroughly.* Nepro LP will not harm to your dad, but if taking adquate food as per advise by the dietician and nephrologist, I do not recommend to consume it. Hope this clears your query. Wishing him fine recovery. Welcome for any further assistance. Regards take care.
2 people found this helpful

Recently I have undergone tests from thyrocare for various tests including cardiac risk markers. The test results are as follows APOLIPOPROTEIN - A1 (APO-A1) NEPHELOMETRY 100 mg/dl APO B / APO A1 RATIO (APO B/A1) CALCULATED 1.3 HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) NEPHELOMETRY mg/L TOTAL CHOLESTEROL PHOTOMETRY 237 mg/dl 125-200 HDL CHOLESTEROL - DIRECT PHOTOMETRY 25 mg/dl 35-80 LDL CHOLESTEROL - DIRECT PHOTOMETRY 138 mg/dl 85-130 TRIGLYCERIDES PHOTOMETRY 330 mg/dl 25-200 TC/ HDL CHOLESTEROL RATIO CALCULATED 9.4 Ratio 3 - 5 LDL / HDL RATIO CALCULATED 5.5 Ratio 1.5-3.5 VLDL CHOLESTEROL CALCULATED 66 mg/dl 5 - 40 NON-HDL CHOLESTEROL CALCULATED 211.8 mg/dl < 160 ALANINE TRANSAMINASE (SGPT) PHOTOMETRY 42.1 LIPOPROTEIN (A) [LP (A)] NEPHELOMETRY mg/dl 33.1 25-OH VITAMIN D (TOTAL) C.L.I.A ng/ml Reference Range :- 11.58 HbA1c - (HPLC - NGSP Certified H.P.L.C 7.5 % basophil - ABSOLUTE COUNT 0.01 X 10³ / μL 0.02 - 0.1 eosinophil - ABSOLUTE COUNT 0.31 X Total RBC 5.64 X 10^6/μL 4.5-5.5 MEAN CORP. HEMO.CONC (MCHC) 30.5 g/dL 31.5-34.5 RED CELL DISTRIBUTION WIDTH - SD (RDW-SD) 51.2 fL 39-46 RED CELL DISTRIBUTION WIDTH (RDW-CV) 15.1 % 11.6-14 I would like to know which doctors will give better treatment for me.

MBBS, MD - Internal Medicine, DM - Cardiology, Cardiac Device Specialist (CCDS - Physician )
Cardiologist, Delhi
Recently I have undergone tests from thyrocare for various tests including cardiac risk markers. The test results are...
Please consult a cardiologist as your cholesterol is deranged and you need further management and treatment for the same and also a baseline cardiac evaluation with tests. Also your hba1c if it is 7.5 then you need endocrinologist consult as well for diabetes.
1 person found this helpful

Dear Sir, I am Male 50 Yrs of age. I am suffering from High BP and Cholesterol since last 8 years. My creatinine level is 1.4 Mg/Dl since last 8 years. Doctor has suggest cinod 10 Mg For (BP) and Rozstat 10 Mg (cholesterol. I am attaching my LP and creatinine reports for your reference. Kindly suggest Diet and medication to me.

MBBS, MD - Internal Medicine, DM - Cardiology, Cardiac Device Specialist (CCDS - Physician )
Cardiologist, Delhi
Dear Sir, I am Male 50 Yrs of age. I am suffering from High BP and Cholesterol since last 8 years. My creatinine leve...
You have not mentioned your BP and your reports are not visible as well. But you can continue both the medicines you are taking. Also you should add lifestyle measures to this like - daily brisk walking for around 40 mins begin gradually and increase it to 40 mins, take a detailed diet consult for a heart healthy diet, restrict salt in your diet by avoiding high salt foods like chips, papads, namkeens, pickles etc and quit smoking and drinking. Re-check your cholesterol as well as BP after 6 weeks, if still high then you will require a change in dose or medicine.
1 person found this helpful

Popular Health Tips

How Can Hepatitis B and C Be Treated Through Internal Medicine?

MD - Internal Medicine, MBBS
Internal Medicine Specialist, Mumbai
How Can Hepatitis B and C Be Treated Through Internal Medicine?

Hepatitis B and C are considered the world’s chronic viral hepatitis which kills a huge number of people every year. Even though it accounts for massive suffering as well as early death, it could only attract relatively less national and international attention. While the deaths caused by tuberculosis, malaria and HIV/AIDS have reduced to a great extent since the early 2000s, deaths stemming from hepatitis B and C are rising at a fast pace. It kills around 1 million people across the world.

Can medicine help in the treatment of hepatitis B and C?
There are numerous FDA approved medications available for the treatment of Hepatitis B and C. Here are some of the best medicines for this, but before you take them, you must consult an expert who can evaluate your symptoms and recommend the right drugs for you.

Medicines for Hepatitis B:

  1. Entecavir: It is used in chronic hepatitis B virus infection and can treat active viral replication.
  2. Lamivudine: It is used for treating chronic hepatitis B which is associated with Hepatitis B viral replication along with active liver inflammation.
  3. Adefovir dipivoxil: This is used for the treatment of the disease in children below the age 12 years.
  4. Interferon alpha 2B: It can be used for young children aged 1 year who are affected by the disease along with compensated liver disease.
  5. Pegylated interferon: It is used for the treatment of adult patients with HBeAg positive and negative chronic hepatitis. If the patient has compensated liver disease along with liver inflammation and evidence of viral replication, then this medicine is usually given.
  6. Telbivudine: When there is chronic hepatitis with adult patients along with persistent elevations in ALT and AST or previously active disease, this medicine may have to be administered.
  7. Tenofovir alafenamide: It is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.

Medicines for Hepatitis C:

  1. Ribavirin: This medicine can be used in combination with other medicines for chronic hepatitis C virus infection. Ribavirin can be utilized for compensated liver disease in patients who have not been treated with interferon alpha.
  2. Daclatasvir: This is an NS5A replication complex inhibitor which is often given with sofosbuvir for the treatment of patients with chronic HCV genotype 3 infection.
  3. Sofosbuvir and Velpatasvir: The combination of these two medicines is used for the treatment of adult patients with chronic genotype 1 to 6 without any infection. It may be used in combination with ribavirin in patients with compensated or decompensated cirrhosis.
  4. Ledipasvir: A fixed-dose of a combination of hepatitis C virus inhibitor and Ledipasvir can be employed in the treatment of hepatitis genotype 1 infection in adults.

Both in the cases of Hepatitis B and C, it is important to diagnose the infection early. Prevention and cure are possible with precautionary measures and prescribed medications.

In case you have a concern or query you can always consult an expert & get answers to your questions!

5882 people found this helpful

10 Tips To Prevent Heart Disease And Stroke

M.Sc. in Dietetics and Food Service Management , Post Graduate Diploma In Computer Application, P.G.Diploma in Clinical Nutrition & Dietetics , B.Sc.Clinical Nutrition & Dietetics
Dietitian/Nutritionist, Mumbai
10 Tips To Prevent Heart Disease And Stroke

1. Take responsibility for your health.

Cardiovascular disease is the major cause of death in america, accounting for 34 percent of deaths, many suddenly and almost all of them premature. This is down from 40 percent just four decades ago, mainly due to treatment of common risk factors. If you have diabetes, your risk increases dramatically. The best prevention against heart disease and stroke is to understand the risks and treatment options. The greatest risk is ignorance or misinformation. The first step is to take responsibility for your health.

2. Know your risks.

The most influential risk factor for cardiovascular disease is age – the older you are, the greater your risk. The second is your genetic make-up. Although everyone is excited by the scientific progress in genomics research, conclusive gene tests are still in their infancy. But, as I tell our medical students, “a good family history is a poor man’s gene test.” we have long known that if your parents, grandparents, or other relatives were afflicted with or died of heart disease, diabetes or stroke, your risk is much greater.

3. Don’t smoke or expose yourself to second-hand smoke.

The evidence is overwhelming that cigarette smoking and second-hand exposure to smoke increases the risks of heart disease, lung disease, peripheral vascular disease and stroke.

4. Maintain a healthy blood pressure.

High blood pressure, called hypertension, is known as “the silent killer” as it goes without symptoms in most individuals. High blood pressure causes wear and tear of the delicate inner lining of your blood vessels. The higher your blood pressure (bp) the greater your risk. The risk begins to increase from a pressure of 115/70 mmhg and doubles for each 10 mmhg increase in systolic (the larger number) and 5 mmhg increase in the diastolic (the smaller number). Heredity and increasing age raise the risks. Measuring blood pressures at home reflects more accurately your risk than having the blood pressure taken at a physician’s office. It is worth the investment to get a cuffmeter.

It is best not to rely only on the readings at your doctor’s office as some individuals suffer from “white coat” hypertension – their bp is up only when they are at the doctor’s office. Others have “masked” hypertension – higher when not in the doctor’s office. Prognosis is best related to home bp. But for home blood pressure readings, you should not use finger or wrist units – only regular upper arm units.

5. Monitor your cholesterol (blood lipids).

Abnormal or high blood lipids (fats) are a major contributor to cardiovascular disease. Your blood lipids include the ldl (bad cholesterol; remember as “lousy cholesterol”), hdl (good cholesterol; remember as “healthy cholesterol”) and triglycerides. The lower your ldl and the higher your hdl, the better your prognosis. The amount of cholesterol in your blood is determined mainly by three factors: the amount produced by the liver (this is largely genetic), the amount absorbed from the intestinal tract (some from what you eat, but a lot more from cholesterol produced by the liver and excreted into the digestive tract) and, finally, age – your cholesterol increases with age. If you are at risk, medication is almost always necessary to lower the ldl or to raise your hdl. The ideal ratio of total cholesterol divided by hdl cholesterol is 3.0. If higher, you might need diet as therapy. The problem with diet is that, in general, it can only decrease total blood cholesterol by about 10 percent. If you have a strong family history or elevated lp (a) (a rare abnormal cholesterol that increases the risk), drug therapy is usually needed.

6. Limit your calories.

Fad diets do not work. If any of them did, we all would be on that one, wouldn’t we? the obesity rate in americans is alarming, contributing to a near epidemic of diabetes, which is a cardiovascular disease. If you have diabetes, your risk is the same as someone who already had a heart attack. Obesity is caused by consuming more calories than your body burns. Abdominal obesity is the major risk. Portion sizes and the amount of sugars in the american diet have dramatically increased over the past few decades. At the same time, the daily amount of exercise has been decreasing. It is good advice to “drink slim” (water, tea, coffee). Use portion control before you start eating and push away from the table before you are “full.”

7. Make exercise a daily habit.

The lack of exercise is contributing to the obesity epidemic in americans. Studies indicate that walking two miles a day is optimal for overall health, and those two miles of walking do not have to be done all at once. Exercise does more than burn calories; it also activates genes that are beneficial to health in other ways. Plus, exercise is one of the best treatments for depression and anxiety. However, exercise alone cannot control or reduce your weight – you must also modify your diet.

8. Pick your pills wisely.

There is a great interest in alternative medicine and understandably so, because patients want to be empowered to take responsibility for their own health. However, many take alternative medicines because of the way they are marketed. The mere fact that a substance is “natural” does not prove its health benefit. After all, nobody in their right mind would take arsenic simply because it is “natural.” it is important to know that research data are often lacking for alternative medications, supplements and vitamins, none of which are regulated by the U.S. Food and drug administration (fda).

Do we ever prescribe alternative medicines? on occasion we do! the major risk with many alternative medications is that the patient thinks they are doing something to improve health, when in fact they are not. Although some vitamins have been shown to possibly help some conditions, to date none have been shown to decrease the risk of cardiovascular disease. There are some rare exceptions, such as fish oils and niacin (vitamin b). It is also important to note that high doses of some vitamins may interfere or counteract the beneficial effects of some prescription drugs.

9. Reduce stress.

Stress contributes to cardiovascular disease and, if severe, can cause a heart attack or sudden death. There are plenty of options that help reduce stress, such as regular exercise, adequate sleep, striving for a good marriage, laughing, volunteering or attending religious services. Watching tv generally does not relieve, but can aggravate stress. Also, try to avoid situations and people who make you anxious or angry.

10. Stay informed: science changes constantly.

The only constant is change. This is especially true in medicine as new techniques and new insights develop constantly. Do not believe every piece of “scientific information” you find in the media or advertisements. An overwhelming number of research studies that make it into scientific publications are poorly designed or yield data that are not representative, E.G, due to a lack of a sufficient number of participants. Keep in mind that many studies are financed or sponsored by individuals or companies with a vested interest in gaining favorable results. The situation can be especially confusing when scientific studies yield different or even contradicting results, and this happens quite often.

4 people found this helpful

Tips on family history of high cholesterol

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Premature heart disease is when heart disease occurs before 55 years in men and 65 years in women. In premature heart disease, the prevalence of dyslipidemia (high cholesterol levels without symptoms) is 75-85%.

Fifty-four percent of all patients with premature heart disease and 70% of those with a lipid abnormality have a familial disorder. Hence, a screening test for lipids is recommended for first-degree relatives of patients with myocardial infarction, particularly if premature. Screening should begin with a standard lipid profile and if normal, further testing should be done for lp (a) and apolipoproteins b and a-i.

About 25% patients with premature heart disease and a normal standard lipid profile will have an abnormality in lp (a) or apo b. Elevated apo a-1 and hdl are likewise associated with reduced chd risk.

First-degree relatives are brothers, sisters, father, mother; second-degree relatives refer to aunts, uncles, grandparents, nieces, or nephews and third-degree relatives refer to first cousins, siblings, or siblings of grandparents.

Familial hypercholesterolemia (fh) is a genetic disorder, characterized by high cholesterol, specifically very high ldl (" bad cholesterol") levels and premature heart disease. Patients may develop premature cardiovascular disease at the age of 30 to 40. Heterozygous fh is a common genetic disorder, occurring in 1: 500 people in most countries. Homozygous fh is much rarer, occurring in 1 in a million births. Heterozygous fh is normally treated with drugs. Homozygous fh often does not respond to medical therapy and may require apheresis or liver transplant.

To detect familial high cholesterol levels, a universal screening must be done at age 16. The cholesterol levels in heterozygous patients are between 350 to 500 mg/dl, and in homozygous, the levels are between 700 to 1, 200 mg/dl.
13 people found this helpful
Table of Content
About Ledipasvir
What are the side effects of Ledipasvir ?
Key highlights of Ledipasvir
Medicines containing Ledipasvir
How does medicine works?