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Overview

Flofre 10 MG Tablet

Manufacturer :  Emcure Pharmaceuticals Ltd
Medicine Composition :  Torsemide
Prescription vs OTC : Prescription by Doctor required

About Flofre 10 MG Tablet

Flofre 10 MG Tablet treats edema and reduces the presence of extra fluid that develops in the body as a result of health problems like kidney or liver disease and heart failure. Thus, the drug helps in the relief of related symptoms which may include swelling of the abdomen or hand and legs and problems with breathing.

It also effectively treats hypertension, that is, high blood pressure. This medication is known to be a water pill, encouraging the body to create more urine and helps in flushing out the extra liquid and salts.

This medication is mostly prescribed for daily consumption and can be taken before or after food. Patients are generally advised not to take this medication for about 4 hours before bedtime, as you may develop the need to urinate frequently in the middle of the night.

The dosage prescribed to you generally depends on the severity of your condition and how your body reacts to the medicine. It may interfere with your sleeping pattern. In case of patients with edema because of congestive heart failure, the dosage may vary from 10mg - 20mg in a day. Those with renal problems may be prescribed about 20mg daily.

Patients with hypertension are generally prescribed about 5mg-10mg of the drug to be taken once a day. This medication should not be discontinued prior to the doctor’s consent. It is primarily because if you stop taking this medication, it can suddenly aggravate your symptoms. This medication is meant for oral consumption and is available in tablet form.

Take recommended dosage with food or milk at the same time each day (preferably not in the evening to avoid sleep interruption). Do not miss doses, alter dosage, or discontinue without consulting prescriber. Include orange juice or bananas (or other potassium-rich foods) in daily diet; do not take potassium supplements without consulting prescriber.

Do not use alcohol or OTC medications without consulting prescriber. You may experience postural hypotension; change position slowly when rising from sitting or lying.

May cause transient drowsiness, blurred vision, or dizziness; avoid driving or engaging in tasks that require alertness until response to drug is known. You may have reduced tolerance to heat (avoid strenuous activity in hot weather or excessively hot showers).

Increased exercise and increased dietary fiber, fruit, and fluids may reduce constipation. Report unusual weight gain or loss (>5 lb/week), swelling of ankles and hands, persistent fatigue, unresolved constipation or diarrhea, weakness, fatigue, dizziness, vomiting, cramps, change in hearing, or chest pain or palpitations.

Flofre 10 MG Tablet may cause agranulocytosis; use caution with clozapine and carbamazepine; may decrease lithium clearance resulting in an increase in serum lithium levels and potential lithium toxicity.

However, this is much more common and significant with the thiazide diuretics; monitor serum lithium levels; concurrent use with chloral hydrate may produce hot flashes and hypertension.

Symptoms include electrolyte depletion, volume depletion, hypotension, dehydration, circulatory collapse; electrolyte depletion may be manifested by weakness, dizziness, mental confusion, anorexia, lethargy, vomiting, and cramps.

Following GI decontamination, treatment is supportive; hypotension responds to fluids and Trendelenburg position. Flofre 10 MG Tablet may induce potent diuretic effects and, as with other potent diuretics, electrolytes and volume status needs to be closely monitored.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    What are the uses of Flofre 10 MG Tablet

    • Edema (Swelling)

      This medication is used in the treatment of edema which is a swelling due to the accumulation of fluid in the hands, feet, and ankles.

    • Hypertension

      This medication is used in the treatment of hypertension which is an increase in the blood pressure caused by a fluid overload due to genetic and environmental factors.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    What are the contraindications of Flofre 10 MG Tablet ?

    • Allergy

      Avoid taking this medicine if you have a known allergy to it or any other medicine of the same class. Also, avoid taking this medicine if you are allergic to the medicines belonging to the class Sulfonylureas.

    • Anuria

      Avoid taking this medicine if you are suffering from Anuria (a condition wherein the kidney is unable to produce urine).

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    What are the side effects of Flofre 10 MG Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    Key highlights of Flofre 10 MG Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 6 to 8 hours after an oral dose and 6 hours after an intravenous dose.

    • What is the onset of action?

      The peak effect of this medicine can be observed within 1 hour of oral administration.

    • Are there any pregnancy warnings?

      This medicine is not recommended for pregnant women.

    • Is it habit forming?

      No habit forming tendency has been reported.

    • Is It safe with alcohol?

      It is unknown whether the consumption of this medicine along with alcohol is safe or not.

    • Is it safe to drive while on this medicine?

      This medicine may affect the alertness of the patient taking it. Thus if you feel dizziness or sleepiness, avoid driving.

    • Does this affect kidney function?

      It is safe to use in the patient with kidney disease. For further details consult your doctor.

    • Does this affect liver function?

      Caution must be taken in patients with liver disease. Dose adjustment might be needed. Kindly consult your doctor before taking this medication.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    What are the substitutes for Flofre 10 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Flofre 10 MG Tablet , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    Where is the Flofre 10 MG Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

    How does this medication work?

    This medication belongs to the class loop diuretics. It reduces the blood pressure by inhibiting Na-K-2Cl reabsorption at the ascending loop of Henle. This helps in increasing the excretion of water and sodium.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

      What are the interactions of Flofre 10 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Consumption of alcohol is not recommended while you are taking this medicine. It may increase the risk of dizziness and fainting. Avoid performing activities that need mental alertness like operating machinery or driving a vehicle.
      • Interaction with Medicine

        • Aminoglycosides: Ototoxicity may be increased.
        • Anticoagulant activity is enhanced.
        • Antidiabetic agents: Glucose tolerance may be decreased.
        • Antihypertensive agents: Effects may be enhanced.
        • Beta-blockers: Plasma concentrations of beta-blockers may be increased with torsemide.
        • Chloral hydrate: Transient diaphoresis, hot flashes, hypertension may occur.
        • Cisplatin: Ototoxicity may be increased.
        • Digitalis: Arrhythmias may occur with diuretic-induced electrolyte disturbances.
        • Enzyme inducers (phenytoin, phenobarbital, carbamazepine) theoretically may reduce efficacy of torsemide.
        • Lithium: Plasma concentrations of lithium may be increased; monitor lithium levels.
        • NSAIDs: Torsemide efficacy may be decreased.
        • Probenecid: Torsemide action may be reduced.
        • Salicylates: Diuretic action may be impaired in patients with cirrhosis and ascites.
        • Thiazides: Synergistic effects may result.
      • Interaction with Food

        Information not available.
      • Interaction with Disease

        Adjust dose to avoid dehydration. In cirrhosis, avoid electrolyte and acid/base imbalances that might lead to hepatic encephalopathy. Ototoxicity is associated with rapid I.V. administration of other loop diuretics and has been seen with oral torsemide. Do not administer intravenously in less than 2 minutes; single doses should not exceed 200 mg. Hypersensitivity reactions can rarely occur. Monitor fluid status and renal function in an attempt to prevent oliguria, azotemia, and reversible increases in BUN and creatinine. Close medical supervision of aggressive diuresis is required. Monitor closely for electrolyte imbalances particularly hypokalemia and correct when necessary. Coadministration with antihypertensives may increase the risk of hypotension. Use caution in patients with known hypersensitivity to sulfonamides or thiazides (due to possible cross-sensitivity); avoid in patients with history of severe reactions.

      FAQs about Flofre 10 MG Tablet

      • Ques : What is Flofre 10 MG Tablet?

        Ans : This medication treats edema, that is, it reduces the presence of extra fluid that develops in the body as a result of health problems like kidney or liver disease and heart failure.

      • Ques : How long do I need to use Flofre 10 MG Tablet before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Flofre 10 MG Tablet?

        Ans : In the case of patients with edema because of congestive heart failure, the dosage may vary from 10mg -20mg in a day. Those with renal problems may be prescribed about 20mg daily. Patients with hypertension are generally prescribed about 5mg-10mg of the drug to be taken once a day.

      • Ques : Should I use Flofre 10 MG Tablet empty stomach, before food or after food?

        Ans : This medication is mostly prescribed for daily consumption and can be taken before or after food.

      • Ques : What are the instructions for the storage and disposal of Flofre 10 MG Tablet?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      • Ques : Does Flofre 10 MG Tablet raise blood sugar?

        Ans : Yes, it may raise blood sugar levels causing hyperglycemia. Hence, it is important to keep track of your blood glucose levels during treatment with Flofre 10 MG Tablet.

      • Ques : What are the side effects of Flofre 10 MG Tablet?

        Ans : The side effects of Flofre 10 MG Tablet include headache, dizziness, dehydration, constipation, decreased blood pressure and stomach upset.

      • Ques : Does Flofre 10 MG Tablet increase creatinine?

        Ans : Yes, it may cause a mild increase in creatinine values depending on the dose you are taking. These increased creatinine levels may increase slightly more when this medicine is used for the long term.

      References

      • Torasemide- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 11 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/torsemide

      • Torasemide- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 11 December 2019]. Available from:

        https://www.drugbank.ca/drugs/DB00214

      • Torsemide- Drugs, Herbs and Supplements, MedlinePlus, NIH, U.S. National Library of Medicine. [Internet]. medlineplus.gov 2018 [Cited 11 December 2019]. Available from:

        https://medlineplus.gov/druginfo/meds/a601212.html

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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