Epilan Tablet alternatively known as phenobarbitone or phenobarbital, it is used in treatment of all types of seizures barring absence seizures. It can also help to treat epilepsy, insomnia and the uncomfortable symptoms of drug withdrawal.
Epilan Tablet works by affecting GABA receptors. The drug facilitates the production of GABA (Gamma Amino Butryic Acid) an amino acid that helps in reducing excitability of neurons. Potential for drug dependency exists, abrupt cessation may precipitate withdrawal, including status epilepticus in epileptic patients.
The drug is contraindicated in patients who have suffered or are suffering from porphyria, hypersensitivity or allergy to barbiturates, respiratory insufficiency, hyperkinesia, liver cell deterioration and other liver problems. It has also been known to cause complications when used with drugs like aceprometazine, adipilon, etc.
Usage of Epilan Tablet can lead to temporary and common side effects like drowsiness, excitation, irritability, loss of balance or coordination, headache, loss of appetite, nausea, vomiting, constipation, etc. depending on the person’s health condition and medical history more severe side effects requiring medical assistance like insomnia, Hypoventilation, apnea, hypotension, syncope can also occur. Therefore, it is very essential to consult a doctor prior to the usage of the drug regarding the dosage to avoid any unwanted and severe side effects.
Symptoms of overdose include unsteady gait, slurred speech, confusion, jaundice, hypothermia, hypotension, respiratory depression, coma. If hypotension occurs, administer I.V. fluids and place the patient in the Trendelenburg position. If unresponsive, an I.V. vasopressor (eg, dopamine, epinephrine) may be required.
Repeated oral doses of activated charcoal significantly reduce the half-life of phenobarbital resulting from an enhancement of nonrenal elimination. The usual dose is 0.1-1 g/kg every 4-6 hours for 3-4 days unless the patient has no bowel movement causing the charcoal to remain in the GI tract.
Assure adequate hydration and renal function. Urinary alkalinization with I.V. sodium bicarbonate also helps to enhance elimination. Hemodialysis or hemoperfusion is of uncertain value. Patients in stage IV coma due to high serum barbiturate levels may require charcoal hemoperfusion.
Is It safe with alcohol?Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?This medicine is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?Caution is advised when driving or operating machinery.
Does this affect kidney function?There is no data available. Please consult doctor before consuming the drug.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
How long is the duration of effect?The effect of this medicine will remain for about 6 - 10 hours.
What is the onset of action?The effect of this medicine is initiated within 20 - 60 minutes after its administration.
Below is the list of medicines, which have the same composition, strength and form as Epilan Tablet , and hence can be used as its substitute.
Are there any missed dose instructions?If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
This medication works by affecting GABA receptors. The drug facilitates the production of GABA (Gamma AminoButyric Acid) an amino acid that helps in reducing the excitability of neurons.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
- Decreased effect: Epilan Tablet may reduce the efficacy of beta-blockers, chloramphenicol, cimetidine, clozapine, corticosteroids, cyclosporine, disopyramide, doxycycline, ethosuximide, furosemide, griseofulvin, haloperidol, lamotrigine, methadone, nifedipine, oral contraceptives, phenothiazine, phenytoin, propafenone, psychotropics, quinidine, tacrolimus, TCAs, theophylline, warfarin, and verapamil.
- Increased toxicity when combined with other CNS depressants, benzodiazepines, valproic acid, chloramphenicol, or antidepressants; respiratory and CNS depression may be additive.
- MAOIs may prolong the effect of Epilan Tablet.
- Barbiturates stimulate the metabolism of beta-blockers and decrease their serum concentrations; consider a renally-eliminated beta-blocker (atenolol, nadolol).
- Barbiturates may enhance the hepatotoxic potential of acetaminophen via an increased formation of toxic metabolites.
- Barbiturates may increase chloramphenicol metabolism and chloramphenicol may inhibit the metabolism of barbiturates.
- Barbiturates may increase the metabolism of corticosteroids, cyclosporine, disopyramide, griseofulvin, nifedipine, oral contraceptives, phenytoin, propafenone, quinidine, verapamil; dosage adjustments may be useful.
- Barbiturates may enhance the metabolism of methadone resulting in methadone withdrawal.
- Felbamate may increase Epilan Tablet concentrations leading to toxicity.
- Epilan Tablet may reduce the diuretic response to furosemide; monitor.
- Concurrent use of Epilan Tablet with meperidine may result in increased CNS depression.
- Concurrent use of Epilan Tablet with primidone may result in elevated Epilan Tablet serum concentrations.
- Valproic acid inhibits the metabolism of Epilan Tablet resulting in elevated serum phenobarbital concentrations.
Interaction with Food
- Protein-deficient diets: Increases duration of action of barbiturates. Should not restrict or delete protein from diet unless discussed with physician. Be consistent with protein intake during therapy with barbiturates.
- Fresh fruits containing vitamin C: Displaces drug from binding sites, resulting in increased urinary excretion of barbiturate. Educate patients regarding the potential for a decreased anticonvulsant effect of barbiturates with consumption of foods high in vitamin C.
- Vitamin D: Loss in vitamin D due to malabsorption; increase intake of foods rich in vitamin D. Supplementation of vitamin D may be necessary.
Interaction with Disease
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Ques: Should I use Epilan Tablet empty stomach, before food or after food?
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Ques: How is this Epilan Tablet administered?
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