Common Specialities
{{speciality.keyWord}}
Common Issues
{{issue.keyWord}}
Common Treatments
{{treatment.keyWord}}

Overview

Corfen Ns Plus 100 Mg/500 Mg Tablet

Manufacturer: Cornel Pharmaceuticals Pvt Ltd
Medicine composition: Nimesulide, Paracetamol
Prescription vs.OTC: Prescription by Doctor required

Corfen Ns Plus 100 Mg/500 Mg Tablet is a non-steroidal anti-inflammatory painkiller. It works by blocking the production of Cyclooxygenase, which inhibits the production of prostaglandins in the body. Prostaglandins and cyclooxygenase are responsible for the process of inflammation, acute pain and swelling of joints. Therefore, it is used in the treatment of various conditions such as back pain, severe menstrual cramps, migraines, osteoarthritis, rheumatoid arthritis, fever and post-operative pain.

Corfen Ns Plus 100 Mg/500 Mg Tablet provides rapid relief from acute pain, in just fifteen minutes. However, due to the harmful side effects that can occur due to prolonged usage of this medication, it is advisable to discontinue the course within 15 days.

Corfen Ns Plus 100 Mg/500 Mg Tablet is a non-steroidal anti-inflammatory drug (NSAID). It provides efficient relief from acute pain that is a symptom of thrombophlebitis, rheumatoid arthritis, osteoarthritis, ear infections and dysmenorrhea. This medicine is also used to reduce fever and to inhibit the growth of cancerous cells. Corfen Ns Plus 100 Mg/500 Mg Tablet can treat mild to moderate pain from joint and muscle stains or sprains, effectively. It takes effect quickly and gives relief from pain, within fifteen minutes.

Cyclooxygenase (or COX 2) is an enzyme that synthesizes a compound called prostaglandin. The production of the prostaglandin compound in the body, results in inflammation, pain and swelling of the joints. Since Corfen Ns Plus 100 Mg/500 Mg Tablet is a COX 2 inhibitor, it alleviates these symptoms. This drug attacks all the components that contribute to the process of inflammation such as histamine, proteolytic enzymes, free radicals, prostaglandin as well as cyclooxygenase.

Corfen Ns Plus 100 Mg/500 Mg Tablet is available in tablet form. The standard dosage recommended per day is one or two tablets of 100 mg per day. Each patient’s symptoms and illness differs, and so it is important to follow the prescription that your doctor recommends. You can take this tablet either with or after food. However, it is essential to complete the course as per the doctor’s prescription and not to skip out on a dose. Children below the age of twelve years cannot consume this medication. Patients suffering from chronic conditions such as arthritis cannot continue to take this medication for prolonged periods since this can lead to harmful effects. It is suitable for short-term relief of acute pain. The course should not last for more than 15 days, else it can have severe consequences on your health.

Corfen Ns Plus 100 Mg/500 Mg Tablet can result in minor side effects such as acidity, nausea, stomach cramps or aches and vomiting. If you are allergic to this medicine, you can suffer an allergic reaction such as rashes, shortness of breath, hives and swelling of the tongue or face. In some cases, severe side effects such as Stevens - Johnson syndrome, blood clotting disorders, elevated enzymes of the liver and skin rashes, can occur. Although these occur rarely, it is important to consult your doctor immediately, if you detect any of these side effects. Corfen Ns Plus 100 Mg/500 Mg Tablet can have harmful effects on a developing infant. Hence, it is advisable for pregnant women, women planning to get pregnant and women who are breast-feeding, to avoid taking this medicine.

Corfen Ns Plus 100 Mg/500 Mg Tablet is used to treat symptoms like swelling, pain, and stiffness of joints associated with Rheumatoid Arthritis.
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to treat symptoms like tender and painful joints associated with Osteoarthritis.
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to treat symptoms like stiffness and pain associated with Ankylosing Spondylitis.
Dysmenorrhea
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to relieve excessive pain and cramps during menstruation.
Mild to moderate pain
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to relieve pain of sprains, strains, sports injuries etc.
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to relieve acute pain in migraine.
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to relieve swelling and pain in joints.
Tendinitis
Corfen Ns Plus 100 Mg/500 Mg Tablet is used to relieve pain and swelling associated with the tissue connecting the muscle and bones.
Corfen Ns Plus 100 Mg/500 Mg Tablet is not recommended if you have a known history of allergy to medicines belonging to NSAIDs. Severe allergic conditions like Asthma and Urticaria can be triggered in such cases.
Peptic Ulcer
Corfen Ns Plus 100 Mg/500 Mg Tablet is not recommended if you have peptic ulcer or are suspected of having it. It could cause severe swelling and bleeding in the stomach, colon and anus.
Coronary Artery Bypass Surgery (CABG)
Corfen Ns Plus 100 Mg/500 Mg Tablet is not recommended for relieving pain after you have undergone CABG.
In addition to its intended effect, Corfen Ns Plus 100 Mg/500 Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Abdominal pain Major Common
Symptoms like bloating, burning and cramps could also be associated with the use of Corfen Ns Plus 100 Mg/500 Mg Tablet
Constipation Major Common
Corfen Ns Plus 100 Mg/500 Mg Tablet can cause moderate to severe constipation.
Diarrhea Major Common
{[Diclofenac}} can cause loose stools with or without blood.
Nausea and vomiting Major Common
Corfen Ns Plus 100 Mg/500 Mg Tablet can cause nausea and vomiting in some patients.
Skin rash Moderate Common
Corfen Ns Plus 100 Mg/500 Mg Tablet can cause skin rashes and hives in some people.
Tinnitus Moderate Less Common
Corfen Ns Plus 100 Mg/500 Mg Tablet can cause a sensation of ringing or buzzing sound in the head or ears.
How long is the duration of effect?
The effect typically lasts for an average of 1-2 hours. However, the time might vary depending upon the dosage form administered.
What is the onset of action?
The effect can be observed within 10-30 minutes of consumption. Note: Potassium salts of Diclofenac act faster than the Sodium salts as they are absorbed faster from the Gastro-Intestinal Tract.
Are there any pregnancy warnings?
This medicine is not considered safe during pregnancy especially after 30 weeks of gestation. You should consult a doctor before using this medicine. Potential benefits and risks involved should be given due consideration before administration.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is not likely to pass into milk and cause any severe effect. But it is not recommended to use since there is a lack of conclusive evidence. A doctor must be consulted before taking the medicine.
Below is the list of medicines, which have the same composition, strength and form as Corfen Ns Plus 100 Mg/500 Mg Tablet, and hence can be used as its substitute.
Profic Organic Ltd
Lincoln Pharmaceuticals Ltd
Acekinetics Healthcare Pvt Ltd
Stallion Laboratories Pvt Ltd
Tas Med India Pvt Ltd
Ronyd Healthcare Pvt Ltd
Kentreck Laboratories Pvt Ltd
Intas Pharmaceuticals Ltd
Lincoln Pharmaceuticals Ltd
Algen Healthcare Pvt Ltd
BestoChem Formulations India Ltd
Ipca Laboratories Ltd
Smart Laboratories Pvt Ltd
Alembic Pharmaceuticals Ltd
Panacea Biotec Ltd
Alkem Laboratories Ltd
Medoz Pharmaceutical Pvt. Ltd
Alliaance Biotech
Alchemist Life Science Ltd
PCI Pharmaceuticals
Aglowmed Drugs Pvt. Ltd.
Shreya Life Sciences Pvt Ltd
Anglo-French Drugs & Industries Ltd
Ind Swift Laboratories Ltd
Micro Labs Ltd
Shreya Life Sciences Pvt Ltd
Win-Medicare Pvt Ltd
Wockhardt Ltd
Biochem Pharmaceutical Industries
Intas Pharmaceuticals Ltd
Intas Pharmaceuticals Ltd
Agron Remedies Pvt Ltd
Morepen Laboratories Ltd
Elder Pharmaceuticals Ltd
Jagsonpal Pharmaceuticals Ltd
Sun Pharmaceutical Industries Ltd
Natco Pharma Ltd
Alembic Pharmaceuticals Ltd
Abbott India Ltd
Wockhardt Ltd
Gencure Pharmaceuticals
Psychotropics India Ltd
National Chemical & Pharmaceuticals Works Pvt Ltd
Menarini India Pvt Ltd
Stanford Biotech Pvt Ltd
Indica Laboratories Pvt Ltd
BestoChem Formulations India Ltd
Kaiser Drugs Pvt Ltd
Icon Pharma & Surgicals Pvt Ltd
Acron Pharmaceuticals
Proctor Organics P Ltd
Unison Pharmaceuticals Pvt Ltd
Bennet Pharmaceuticals Limited
Laborate Pharmaceuticals India Ltd
Winsome Laboratories Pvt Ltd
Rusi Remedies P Ltd
Moxy Laboratories Pvt Ltd
Winsome Laboratories Pvt Ltd
Prayas Pharmaceuticals
Stallion Laboratories Pvt Ltd
Simpson Brawn Pharmaceuticals
Vilco Laboratories Pvt Ltd
Abbott India Ltd
Euphoric Pharmaceuticals Pvt Ltd
Radicura Pharma pvt ltd
Stadchem Of India
Kamron Laboratories Ltd
Kentreck Laboratories Pvt Ltd
Psychotropics India Ltd
Talent Healthcare
Times Drugs & Pharmaceuticals Pvt Ltd
Omega Remedies Pvt Ltd
Divine Lifecare Pvt Ltd
GRAF Laboratories Pvt Ltd
Alpha Pharmaceuticals
Stadchem Of India
Meridian Medicare Ltd
G D Pharmaceuticals Pvt Ltd
Zota Health care Ltd
St Morrison
Alde Medi Impex Ltd
Paras Pharmaceuticals Ltd
Ajanta Pharma Ltd
Norwest Pharmaceuticals Inc
Aglowmed Drugs Pvt. Ltd.
Aaron Pharmaceuticals Pvt Ltd
Inga Laboratories Pvt Ltd
Rekvina Laboratories Ltd
Zydus Cadila
Adcock Ingram Healthcare Pvt Ltd
Jaywin Remedies Pvt Ltd
Organic Laboratories
Genesis Biotech Inc
Synokem Pharmaceuticals Ltd
Corona Remedies Pvt Ltd
Gujarat Terce Laboratories Ltd
Tas Med India Pvt Ltd
Kenn Pharmaceuticals Pvt Ltd
Targof Pure Drugs Td
Samarth Life Sciences Pvt Ltd
Times Drugs & Pharmaceuticals Pvt Ltd
Axon Drugs Pvt Ltd
Scott Edil Pharmacia Ltd
Dr. Johns Laboratories Pvt Ltd
Sanify Healthcare Pvt Ltd
Khandelwal Laboratories Pvt Ltd
Zydus Cadila
Seagull Labs (I) Pvt Ltd
Proctor Organics P Ltd
Swiss Pharma Pvt Ltd
Brawn Laboratories Ltd
Laborate Pharmaceuticals India Ltd
Allentis Pharmaceuticals Pvt Ltd
Sresan Pharmaceuticals
Ozone Pharmaceuticals Ltd
Aarpik Pharmaceuticals Pvt Ltd
Psychotropics India Ltd
Vintage Labs Pvt Ltd
Kaizen Pharmaceuticals Pvt Ltd
Corona Remedies Pvt Ltd
Zaneka Healthcare Pvt Ltd
Acme Pharmaceutical
Panjon Pharma Ltd
Ceras Pharmaceutical
Lancer Health Care Pvt Ltd
Ortin Laboratories Ltd
Unichem Laboratories Ltd
Numark Ltd
Innovative Pharmaceuticals
Senate Laboratories
Total Healthcare
Zydus Cadila
Imed Healthcare
Active Healthcare
Lancer Health Care Pvt Ltd
Mankind Pharma Ltd
M D C Pharmaceuticals P Ltd
Baksun Healthcare Pvt Ltd
Helios Pharmaceuticals
Concept Pharmaceuticals Ltd
Helios Pharmaceuticals
Maneesh Pharmaceuticals Ltd
Ramose Laboratories Pvt Ltd
Nri Vision Care Pvt Ltd
Iatros Pharmaceuticals Pvt Ltd
DWD Pharmaceuticals Ltd
Indoco Remedies Ltd
Thrift Pharmaceuticals
Almet Corporation Ltd
Shrinivas Gujarat Laboratories Pvt Ltd
Intel Pharmaceuticals
Octane Biotech Pvt Ltd
Bio Vitamins
Intas Pharmaceuticals Ltd
Rhombus Pharma Pvt Ltd
Elder Pharmaceuticals Ltd
Cadila Pharmaceuticals Ltd
Exotic Laboratories Pvt Ltd
Torque Pharmaceuticals Pvt Ltd
Troikaa Pharmaceuticals Ltd
Embiotic Laboratories Pvt Ltd
Aurz Pharmaceuticals Pvt Ltd
J B Chemicals and Pharmaceuticals Ltd
Strides shasun Ltd
Waves Bio-Tech Pvt Ltd
Indoco Remedies Ltd
Baksun Healthcare Pvt Ltd
Win-Medicare Pvt Ltd
P & B Pharmaceuticals Ltd
Mac Millon Pharmaceuticals Pvt Ltd
Embiotic Laboratories Pvt Ltd
Maneesh Pharmaceuticals Ltd
Dr. Johns Laboratories Pvt Ltd
Navil Laboratories Pvt Ltd
Are there any missed dose instructions?
The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for the next dose.
Are there any overdose instructions?
A doctor should be contacted immediately if an overdose of Corfen Ns Plus 100 Mg/500 Mg Tablet is suspected. Signs and symptoms of overdose include rashes on the skin, confusion, pain in the chest, blurred vision etc. Immediate medical attention is needed if an overdose is confirmed.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Asthma Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should not be taken if you have NSAID-sensitive asthma. Any such history should be reported to the doctor so that appropriate substitution can be done.
Fluid retention and Edema Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken only after consulting a doctor. Monitoring of blood pressure and heart conditions is necessary on a regular level during the course of therapy.
Gastro-Intestinal toxicity Major
Corfen Ns Plus 100 Mg/500 Mg Tablet and other NSAIDs should be taken after consulting a doctor especially if the intended duration is longer than a month. Any symptom indicating ulceration and bleeding like chronic indigestion, appearance of coffee colored dry blood in stools or vomiting of blood should be reported immediately.
Skin rash Major
Corfen Ns Plus 100 Mg/500 Mg Tablet can cause these fatal skin allergies without any warnings. Signs and symptoms like rashes, hives, fever or other allergic symptoms should be reported without any delay. This condition requires immediate medical intervention.
Impaired kidney function Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken after consulting a doctor if you are having a kidney disease. Suitable adjustment in dosage and monitoring of kidney functions is required in such situations.
Heart attack and stroke Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken only after consulting a doctor. The dose needs to be optimized based on the severity of the heart condition. Additional medicines are to be taken to minimize the risk. Symptoms indicating heart attack like chest pain, shallow breathing, speech slurring, and weakness should be immediately reported to the doctor.
Interaction with Alcohol
Moderate
This medicine should not be consumed with alcohol. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Adefovir Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken with Adefovir only after consulting a doctor. Usage of either of the drugs should be reported so that suitable substitutes can be prescribed.
Apixaban Major
Corfen Ns Plus 100 Mg/500 Mg Tablet can be taken with Apixaban only under the supervision of a doctor. Any signs and symptoms like dizziness, black and tarry stools, presence of dried and coffee grounds like blood in cough or vomit should be attended to immediately.
Methotrexate Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken with Methotrexate only after consulting a doctor. The doctor needs to make suitable adjustments so that unwanted effects and toxicity can be prevented.
Ramipril Moderate
Corfen Ns Plus 100 Mg/500 Mg Tablet should be taken with Ramipril only after consulting a doctor since dosage adjustment is required to minimize the harmful effect. Signs and symptoms like swelling, nausea, vomiting, muscle cramps, confusion, and weakness should be reported to the doctor.
Ketorolac Major
Corfen Ns Plus 100 Mg/500 Mg Tablet should not be taken along with ketorolac. You should read the instructions before taking any over the counter medication. A doctor should be consulted before taking medicines containing these components.

Popular Questions & Answers

When should we go for ns1 test, at which stage of dengue. Now the platelets are 1.81. Do the platelets go down because of typhoid also? Please help.

BAMS
Ayurveda, Bangalore
When should we go for ns1 test, at which stage of dengue. Now the platelets are 1.81. Do the platelets go down becaus...
Right now your platelet count is in normal range. If it goes below 1.5l, then get your blood tested for igg, igm and ns1. Typhoid doesn't cause a drop in the platelet count.
1 person found this helpful

What is the range of NS 1 antigen, which confirms that a person is positive for dengue!

MD - Alternate Medicine, BHMS
Homeopath, Surat
What is the range of NS 1 antigen, which confirms that a person is positive for dengue!
Around 24 or more shows positive result. Below 7 is negative. Between 7 - 24 can be false positive or negative.

My dengue test NS1 index is 5.7, what should I do now? I can not afford hospital treatment.

MD - General Medicine
General Physician, Delhi
My dengue test NS1 index is 5.7, what should I do now? I can not afford hospital treatment.
Drink ors 3 liters daily and tab pcm for fever and body ache. Drink fresh fruit juices also. No need to worry until any rashes or bleeding occurs. Get a platelet count done also after fever comes down.

She is suffering from dengue ns1 antigen and typhoid fever from yesterday please suggest us.

Diploma in Child Health (DCH), MBBS
General Physician, Bangalore
She is suffering from dengue ns1 antigen and typhoid fever from yesterday please suggest us.
Sir, You will have to tell me, the complaints. And complete blood reports. She must be under care of a doctor. Ask everything from the treating doctor.

In elisa test they detected DENGUE NS1 antigen 10.8 units, how it is dangerous to me?

MBBS
General Physician, Mumbai
In elisa test they detected DENGUE NS1 antigen 10.8 units, how it is dangerous to me?
It's not dangerous but there is mild attack of virus and which needs to be treated with rest and symptomatic treatment.

Popular Health Tips

Critical Care Training, MD - Internal Medicine, MBBS
General Physician, Delhi
Dengue - Important Information

Dengue fever is a painful mosquito-borne disease. It is caused by any one of four types of dengue virus, which is transmitted by the bite of an infected female Aedes aegypti mosquito.

Previous dengue infection with similar serotype provides immunity but different serotype causes more severe infection.

Common symptoms of dengue include high fever, runny nose, a mild skin rash, cough, and pain behind the eyes and in the joints. However, some people may develop a red and white patchy skin rash followed by loss of appetite, nausea, vomiting, etc.

Patients suffering from dengue should seek medical advice, rest and drink plenty of fluids. Paracetamol can be taken to bring down fever and reduce joint pains. However, aspirin or ibuprofen should not be taken since they can increase the risk of bleeding.

The risk of complications is in less than 1% of dengue cases and, if warning signals are known to the public, all deaths from dengue can be avoided.

Lab Test

NS1
Best test is NS1, specific
Cannot be false +ve
Is + from day 1 to 7 ideally.
If on day 1 is -ve, repeat it next day.
Always ask for ELISA based NS1 tests as card tests are misleading.


IgG & IgM dengue

In a pt with reduced platelets and looking "sick" on day 3 or 4 of illness, a very high titre of IgG with borderline rise in IgM signifies secondary dengue. These pts are more prone to complications.
In primary dengue IgG becomes + at end of 7 days, while IgM is + after day 4.

Immature Platelet fraction (IPF)

A very useful test in Dengue for patients with thrombocytopenia.

If IPF in such a pt is > 10%, despite a platelet count of 20, 000, he is out of danger & platelets will rise in 24 hrs.

If its 6%, repeat the same next day. Now if IPF has increased to 8% his platelets will certainly increase within 48 hrs.

If its less then 5%, then his bone marrow will not respond for 3-4 days & may be a likely candidate for platelet transfusion.

Better to do an IPF even with borderline low platelet count.



A low Mean Platelet volume or MPV means platelets are functionally inefficient and such patients need more attention.


The primary cause of death in patients suffering from dengue is capillary leakage, which causes fluid deficiency in the intravascular compartment, leading to multi-organ failure. Platelet deficiency is not the cause of death in most of the patient suffering from Dengue .

According to International guidelines, unless a patient’s platelet count is below 10,000 or there is spontaneous, active bleeding, no platelet transfusion is required. The outbreak of dengue in the City and Hospital beds are full and families are seen running around in search of platelets for transfusion. However what most people do not realize is that the first line of treatment for dengue is not platelet transfusion. In fact, it does more harm than good if used in a patient whose counts are over 10,000.

At the first instance of plasma leakage from the intravascular compartment to the extravascular compartment, fluid replacement amounting to 20 ml per kg body weight per hour must be administered. This must be continued till the difference between the upper and lower blood pressure is over 40 mmHg, or the patient passes adequate urine. This is all that is required to treat the patient. Giving unnecessary platelet transfusion can make the patient more sick.

“While treating dengue patients, physicians should remember the ‘Formula of 20' i.e. rise in pulse by more than 20; fall of BP by more than 20; difference between lower and upper BP of less than 20 and presence of more than 20 hemorrhagic spots on the arm after a tourniquet test suggest a high-risk situation and the person needs immediate medical attention.”

Read WHO guidelines for further fluid management strategies & Hematocrit monitoring.

Nephrotic Syndrome In Childhood- What Parents Need To Know!

MD - Paediatrics, MBBS, FISPN & FISPN - Pediatric Nephrology
Pediatrician, Noida
Nephrotic Syndrome In Childhood- What Parents Need To Know!

Nephrotic syndrome is a type of kidney disorder wherein, the body passes out the excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes. 

The main feature of nephrotic syndrome is that the kidneys leak a lot of protein. Normally, urine contains virtually no protein. In nephrotic syndrome the urine contains large amounts of protein. What happens is that filters in the kidneys (the glomeruli) become 'leaky' and protein, instead of remaining in the blood, leaks out into the urine. Protein in the urine is called proteinuria. 

The other key features of nephrotic syndrome are: 

  1. A low level of protein in the blood as a result of protein loss in the urine. Although there is a drop in many of the proteins normally found in the bloodstream, the main protein that leaks from the blood into the urine is called albumin. A low blood level of albumin is main feature of nephrotic syndrome. 
  2. Fluid retention (oedema). This is a consequence of the low level of albumin in the bloodstream, and other complex factors not fully understood. 
  3. A high blood level of cholesterol and other fats (lipids). This is due to the change in the balance of various protein levels in the blood due to the protein leakage. 
  4. Normal kidney function, at least initially. This means that the 'waste clearing' function of the kidneys is not affected - at least not at first. However, some of the conditions that cause nephrotic syndrome can progress to cause chronic kidney disease. 
  5. Other typical symptoms and signs of nephrotic syndrome are discussed later. 

Common causes behind it 

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys.. Most common cause almost 90% of children have this entity. No body knows why the Minimal change disease nephrotic syndrome occurs. Other reasons for nephrotic syndrome are infections, autoimmunity mediated and few medications. 

Nephrotic syndrome (NS) is the name given to a collection of kidney-related findings in your child’s body. These include: 

  1. proteinuria—high levels of protein in the urine (based on your child’s age and size) 
  2. hypoalbuminemia—low levels of protein in your child’s blood, since it’s being passed out of his body in his urine 
  3. edema—swelling. This happens because the proteins in your child’s blood act as a sponge to keep fluid in the blood. With fewer proteins to do this, the fluid may leak out of the blood into your child’s tissues, causing them to swell, especially around the stomach area.
  4. high cholesterol (blood fat) levels—low levels of protein in the blood stimulate the body to overproduce certain kinds of blood fats
  5. While nephrotic syndrome is not a disease, it can be the first sign of disease that can damage the kidney's tiny blood-filtering unit (glomeruli) where urine is made. 

Here’s what you need to know about nephrotic syndrome: 

  1. In the vast majority of children, NS is idiopathic, meaning that doctors don’t yet know what causes it. 
  2. Nephrotic syndrome always affects both kidneys. 
  3. It usually appears between the toddler and elementary school years, although it may appear later. 
  4. There are thought to be two forms of nephrotic syndrome, minimal change disease (MCD) and focal sclerosis (FSGS). 
  5. MCD is much more common in children, and likely to respond to therapy. 
  6. FSGS is a more aggressive disease, and may lead to kidney damage. 
  7. Most children with NS outgrow it by young adulthood. 

Treatment Available 

Pediatric Nephrotic syndrome is mainly treated by high dose steroids. So we classify Nephrotic syndrome as Steroid sensitive Nephrotic syndrome and Steroid Resistant Nephrotic syndrome. As long as the Nephrotic syndrome is steroid sensitive, kidneys usually do not fail and eventually the child recovers. Other aspect of management of Nephrotic syndrome in kids is, that is a relapsing and remitting disease in more than 2/3 of patients, so parents must be making a Nephrotic diary as suggested by the doctor so that the relapse of disease is picked before the swelling appears. Target of Nephrotic syndrome treatment is to make the child grow normally and using steroid sparing agents in kids with frequent relapses and Steroid dependence else they can develop high blood pressure, short stature, cataract, glaucoma and diabetes which all are irreversible. Never start or stop the steroids on your own considering the side effect profile. All vaccines including oral polio drops are not to be given in children receiving daily dose steroids. If you wish to discuss about any specific problem, you can consult a pediatrician.

Nephrotic Syndrome In Childhood- What Parents Need To Know!

MD - Paediatrics, MBBS, FISPN & FISPN - Pediatric Nephrology
Pediatrician, Noida
Nephrotic Syndrome In Childhood- What Parents Need To Know!

Nephrotic syndrome is a type of kidney disorder wherein, the body passes out the excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes. 

The main feature of nephrotic syndrome is that the kidneys leak a lot of protein. Normally, urine contains virtually no protein. In nephrotic syndrome the urine contains large amounts of protein. What happens is that filters in the kidneys (the glomeruli) become 'leaky' and protein, instead of remaining in the blood, leaks out into the urine. Protein in the urine is called proteinuria. 

The other key features of nephrotic syndrome are: 

  1. A low level of protein in the blood as a result of protein loss in the urine. Although there is a drop in many of the proteins normally found in the bloodstream, the main protein that leaks from the blood into the urine is called albumin. A low blood level of albumin is main feature of nephrotic syndrome. 
  2. Fluid retention (oedema). This is a consequence of the low level of albumin in the bloodstream, and other complex factors not fully understood. 
  3. A high blood level of cholesterol and other fats (lipids). This is due to the change in the balance of various protein levels in the blood due to the protein leakage. 
  4. Normal kidney function, at least initially. This means that the 'waste clearing' function of the kidneys is not affected - at least not at first. However, some of the conditions that cause nephrotic syndrome can progress to cause chronic kidney disease. 
  5. Other typical symptoms and signs of nephrotic syndrome are discussed later. 

Common causes behind it 

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys.. Most common cause almost 90% of children have this entity. No body knows why the Minimal change disease nephrotic syndrome occurs. Other reasons for nephrotic syndrome are infections, autoimmunity mediated and few medications. 

Nephrotic syndrome (NS) is the name given to a collection of kidney-related findings in your child’s body. These include: 

  1. proteinuria—high levels of protein in the urine (based on your child’s age and size) 
  2. hypoalbuminemia—low levels of protein in your child’s blood, since it’s being passed out of his body in his urine 
  3. edema—swelling. This happens because the proteins in your child’s blood act as a sponge to keep fluid in the blood. With fewer proteins to do this, the fluid may leak out of the blood into your child’s tissues, causing them to swell, especially around the stomach area.
  4. high cholesterol (blood fat) levels—low levels of protein in the blood stimulate the body to overproduce certain kinds of blood fats
  5. While nephrotic syndrome is not a disease, it can be the first sign of disease that can damage the kidney's tiny blood-filtering unit (glomeruli) where urine is made. 

Here’s what you need to know about nephrotic syndrome: 

  1. In the vast majority of children, NS is idiopathic, meaning that doctors don’t yet know what causes it. 
  2. Nephrotic syndrome always affects both kidneys. 
  3. It usually appears between the toddler and elementary school years, although it may appear later. 
  4. There are thought to be two forms of nephrotic syndrome, minimal change disease (MCD) and focal sclerosis (FSGS). 
  5. MCD is much more common in children, and likely to respond to therapy. 
  6. FSGS is a more aggressive disease, and may lead to kidney damage. 
  7. Most children with NS outgrow it by young adulthood. 

Treatment Available 

Pediatric Nephrotic syndrome is mainly treated by high dose steroids. So we classify Nephrotic syndrome as Steroid sensitive Nephrotic syndrome and Steroid Resistant Nephrotic syndrome. As long as the Nephrotic syndrome is steroid sensitive, kidneys usually do not fail and eventually the child recovers. Other aspect of management of Nephrotic syndrome in kids is, that is a relapsing and remitting disease in more than 2/3 of patients, so parents must be making a Nephrotic diary as suggested by the doctor so that the relapse of disease is picked before the swelling appears. Target of Nephrotic syndrome treatment is to make the child grow normally and using steroid sparing agents in kids with frequent relapses and Steroid dependence else they can develop high blood pressure, short stature, cataract, glaucoma and diabetes which all are irreversible. Never start or stop the steroids on your own considering the side effect profile. All vaccines including oral polio drops are not to be given in children receiving daily dose steroids. If you wish to discuss about any specific problem, you can consult a pediatrician.

3558 people found this helpful

Nephrotic Syndrome In Childhood- What Parents Need To Know!

MBBS, MD - Paediatrics
Pediatrician, Jaipur
Nephrotic Syndrome In Childhood- What Parents Need To Know!

Nephrotic syndrome is a type of kidney disorder wherein, the body passes out the excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes. 

The main feature of nephrotic syndrome is that the kidneys leak a lot of protein. Normally, urine contains virtually no protein. In nephrotic syndrome the urine contains large amounts of protein. What happens is that filters in the kidneys (the glomeruli) become 'leaky' and protein, instead of remaining in the blood, leaks out into the urine. Protein in the urine is called proteinuria. 

The other key features of nephrotic syndrome are: 

  1. A low level of protein in the blood as a result of protein loss in the urine. Although there is a drop in many of the proteins normally found in the bloodstream, the main protein that leaks from the blood into the urine is called albumin. A low blood level of albumin is main feature of nephrotic syndrome. 
  2. Fluid retention (oedema). This is a consequence of the low level of albumin in the bloodstream, and other complex factors not fully understood. 
  3. A high blood level of cholesterol and other fats (lipids). This is due to the change in the balance of various protein levels in the blood due to the protein leakage. 
  4. Normal kidney function, at least initially. This means that the 'waste clearing' function of the kidneys is not affected - at least not at first. However, some of the conditions that cause nephrotic syndrome can progress to cause chronic kidney disease. 
  5. Other typical symptoms and signs of nephrotic syndrome are discussed later. 

Common causes behind it 

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys.. Most common cause almost 90% of children have this entity. No body knows why the Minimal change disease nephrotic syndrome occurs. Other reasons for nephrotic syndrome are infections, autoimmunity mediated and few medications. 

Nephrotic syndrome (NS) is the name given to a collection of kidney-related findings in your child’s body. These include: 

  1. proteinuria—high levels of protein in the urine (based on your child’s age and size) 
  2. hypoalbuminemia—low levels of protein in your child’s blood, since it’s being passed out of his body in his urine 
  3. edema—swelling. This happens because the proteins in your child’s blood act as a sponge to keep fluid in the blood. With fewer proteins to do this, the fluid may leak out of the blood into your child’s tissues, causing them to swell, especially around the stomach area.
  4. high cholesterol (blood fat) levels—low levels of protein in the blood stimulate the body to overproduce certain kinds of blood fats
  5. While nephrotic syndrome is not a disease, it can be the first sign of disease that can damage the kidney's tiny blood-filtering unit (glomeruli) where urine is made. 

Here’s what you need to know about nephrotic syndrome: 

  1. In the vast majority of children, NS is idiopathic, meaning that doctors don’t yet know what causes it. 
  2. Nephrotic syndrome always affects both kidneys. 
  3. It usually appears between the toddler and elementary school years, although it may appear later. 
  4. There are thought to be two forms of nephrotic syndrome, minimal change disease (MCD) and focal sclerosis (FSGS). 
  5. MCD is much more common in children, and likely to respond to therapy. 
  6. FSGS is a more aggressive disease, and may lead to kidney damage. 
  7. Most children with NS outgrow it by young adulthood. 

Treatment Available 

Pediatric Nephrotic syndrome is mainly treated by high dose steroids. So we classify Nephrotic syndrome as Steroid sensitive Nephrotic syndrome and Steroid Resistant Nephrotic syndrome. As long as the Nephrotic syndrome is steroid sensitive, kidneys usually do not fail and eventually the child recovers. Other aspect of management of Nephrotic syndrome in kids is, that is a relapsing and remitting disease in more than 2/3 of patients, so parents must be making a Nephrotic diary as suggested by the doctor so that the relapse of disease is picked before the swelling appears. Target of Nephrotic syndrome treatment is to make the child grow normally and using steroid sparing agents in kids with frequent relapses and Steroid dependence else they can develop high blood pressure, short stature, cataract, glaucoma and diabetes which all are irreversible. Never start or stop the steroids on your own considering the side effect profile. All vaccines including oral polio drops are not to be given in children receiving daily dose steroids. If you wish to discuss about any specific problem, you can consult a pediatrician.

MD , MBBS
General Physician, Aligarh
Dengue fever symptoms include high-grade fever, severe headache and pain behind the eyes?

The dengue fever season which is usually synonymous with the monsoons in India is showing no signs of abating. The numbers are much higher in cities like Delhi and Mumbai, whose already overworked hospitals and civic bodies are struggling to contain the ailment and treat the ill.

Dr Arvind Aggarwal, senior consultant, internal medicine at the Sri Balaji Action Medical Institute, Delhi has something to say about the disease, why it won?t go away and how people should pay more attention to the onset of the fever:

Is there any significant change in the disease trend this year? Are the elderly or people with lower immunity likelier to suffer from dengue?

This year we are seeing a large number of healthy young adults, especially teenagers suffering from the ailment. The reason for this is that they are more likely to travel or stay outdoors as compared to aged people or immune compromised people. Normally, every family tries to keep their homes free of mosquitoes and maintain hygiene when people go out, they are likelier to be bitten by dengue-carrying mosquitoes. (Read: Dengue fever: Symptoms, medication and prevention)

What are the symptoms of dengue fever? How can people recognise it early?

The most glaring symptoms are high-grade fever, chills, severe headache and pain behind the eyes (retro-orbital pain), severe headaches and body aches. After the second day of onset of the aforementioned symptoms, they may even start vomiting or feel extremely restless. In many patients we can diagnose the disease in a day itself, but in some cases people stay home when they have fever and self-medicate. Only when it becomes very severe and they are not able to bear the headaches and retro-orbital pain do they come to a doctor.

 It is important that we recognise the possibility of a patient possibly suffering from dengue. Even doctors should take these complaints seriously. This is important because if it is diagnosed early the complications are much lower and can be handled effectively. (Read: Can papaya leaves help cure dengue?)

Should all patients presenting with high fever be aggressively tested for dengue?

Yes, it is essential that physicians have a high suspicion of dengue fever, especially in these two months when it is epidemic.

What are the tests that are done to detect the presence of dengue?

 A test called NS1 (a test for the presence of the viral antigen) and other tests for the antibodies against the dengue virus can be done. The NS1 test is more accurate on the first seven days of the infection. If the patient comes to us after seven days, then we perform serological tests, where we test for the presence of theantibodies against the virus. Since these antibodies are produced by the body only after five to seven days, they are more effective. The most important thing here is that this antigen can be tested at any point during the infection, unlike in malaria where the test yields proper results only while the patient is having fever. Of course, the tests give better results at the peak of the disease.

What complications can dengue fever lead to?

Patients may suffer from very low blood pressure and very low platelet count. The patient?s also likely to bleed from various orifices like the nose and mouth and they might even notice blood in their urine. When it gets worse, the patient is likely to suffer from dengue haemorrhagic fever and dengue shock syndrome.  

Table of Content

About Corfen Ns Plus 100 Mg/500 Mg Tablet
When is Corfen Ns Plus 100 Mg/500 Mg Tablet prescribed?
What are the contraindications of Corfen Ns Plus 100 Mg/500 Mg Tablet?
What are the side effects of Corfen Ns Plus 100 Mg/500 Mg Tablet?
Key highlights of Corfen Ns Plus 100 Mg/500 Mg Tablet
What are the substitutes for Corfen Ns Plus 100 Mg/500 Mg Tablet?
What are the dosage instructions?
Where is the Corfen Ns Plus 100 Mg/500 Mg Tablet approved?
What are the interactions for Corfen Ns Plus 100 Mg/500 Mg Tablet?