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Overview

Combither At 120 MG Injection

Manufacturer :  Aristo Pharmaceuticals Pvt.Ltd
Medicine Composition :  Artesunate
Prescription vs OTC : Prescription by Doctor required

About Combither At 120 MG Injection

Combither At 120 MG Injection very effective in the treatment of severe malaria caused by Plasmodium falciparum strains when other medicines fail to show positive results. However, it cannot be used to prevent malaria.

The active constituent of this medicine is a derivative of artemisinin is a water-soluble hemisuccinate. It can be given by injection into a vein or a muscle or taken by mouth.

This medicine is generally well-tolerated in the body. It appears to be safe to use during pregnancy or breastfeeding. If you have faced a previous severe allergic reaction to this drug then you should avoid the use of it.

This medicine should be avoided as it includes isoniazid, amiodarone, methoxsalen, desipramine, ketoconazole, letrozole, methoxsalen, and tranylcypromine.

The recommended dose for adults and children over 6 months is generally 5 mg and should be taken orally on the first day. The dose gradually increases and is used in combination with other medicines to cure malaria. If the administration of this medication is happening in the form of injections then that should be performed by a healthcare professional.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the uses of Combither At 120 MG Injection

    • Malaria

      This medicine is used to treat malaria caused by Plasmodium falciparum strain of the parasite. It may also be used for the treatment of malaria that are resistant to other medicines.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the contraindications of Combither At 120 MG Injection ?

    • Allergy

      This medicine is not recommended for use if you have a known history of allergy to Combither At 120 MG Injection.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the side effects of Combither At 120 MG Injection ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Key highlights of Combither At 120 MG Injection

    • How long is the duration of effect?

      The time duration for which the effect of this medicine persists is not established.

    • What is the onset of action?

      The time taken for this medicine to show its effect is not established. However, it reaches the peak level in the body within an hour of administration.

    • Are there any pregnancy warnings?

      Use of this medicine in pregnant women is not recommended unless absolutely necessary.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      Use of this medicine while breastfeeding is not recommended unless necessary.

    • Does this affect kidney function?

      Caution must be taken. Dose adjustment is needed in case of patients with impaired renal function.

    • Does this affect liver function?

      Caution must be taken. Dose adjustment is needed in case of patients with impaired liver function.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the substitutes for Combither At 120 MG Injection ?

    Below is the list of medicines, which have the same composition, strength and form as Combither At 120 MG Injection , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Contact your doctor immediately if you miss a scheduled dose of this medicine.

    • Are there any overdose instructions?

      Contact your doctor immediately if an overdose with this medicine is suspected.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Where is the Combither At 120 MG Injection approved?

    • India

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    How does this medication work?

    This medication acts on the schizonts (ring stage) in the blood and causes the lysis of the parasite.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

      What are the interactions of Combither At 120 MG Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Medicine

        Mefloquine

        Report the use of mefloquine or any other anti-malarial medicine to the doctor before receiving Combither At 120 MG Injection. You may require a dose adjustment and more frequent monitoring when using these medicines together.

        Pyrimethamine

        Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together.
      • Interaction with Disease

        Liver Disease

        This medicine should be administered with caution in patients having an impaired liver function. Appropriate diagnostic tests must be performed before determining the dose regimen. Suitable dose adjustment and frequent monitoring may be needed to ensure safe and effective use.

        Kidney Disease

        This medicine should be administered with caution in patients having an impaired kidney function. Suitable dose adjustment and frequent monitoring may be needed to ensure safe and effective use.
      • Interaction with Food

        Food

        Information not available.

      FAQs about Combither At 120 MG Injection

      • Ques : What is Combither At 120 MG Injection?

        Ans : This medication a derivative of artemisinin is a water-soluble hemisuccinate. It is very effective in the treatment of severe malaria caused by Plasmodium falciparum strains when other medicines fail to show positive results.

      • Ques : How long do I need to use Combither At 120 MG Injection before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Combither At 120 MG Injection?

        Ans : The recommended dose for adults and children over 6 months is generally 5 mg per kg orally on the first day. In a few areas, a higher dose of 25 mg may be required for a cure to be obtained.

      • Ques : Should I use Combither At 120 MG Injection empty stomach, before food or after food?

        Ans : This medication should be taken after food in a prescribed dosage.

      • Ques : What are the instructions for the storage and disposal of Combither At 120 MG Injection?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Artesunate- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 16 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/artesunate

      • Artesunate- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 16 December 2019]. Available from:

        https://www.drugbank.ca/drugs/DB09274

      • Artesunate- WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition [Internet]. apps.who.int 1995 [Cited 16 December 2019]. Available from:

        https://apps.who.int/medicinedocs/en/d/Jh2922e/2.5.11.html

      • Lumefantrine- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 16 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/lumefantrine

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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