Calpol 650 MG Tablet

Manufacturer: Glaxosmithkline Pharmaceuticals Ltd
Medicine composition: Paracetamol
Prescription vs OTC: Prescription by Doctor not required

Calpol 650 MG Tablet is used a pain-relieving medication. It is primarily used to treat acute pain. The conditions of acute pain include backache, headache, arthritis and toothache, etc.

The active ingredient falls under the class of analgesics, belonging to the category of NSAID. This medication also reduces pain in the body caused due to fever.

Also, it reduces pain in the body caused due to fever. This medication is often given to patients who suffer from cancer or have undergone surgery, to help them cope up with the pain. You should not consume this tablet if you are:

  • Allergic to this medicine.
  • Suffering from a serious liver disorder.
  • Normally consume more than 3 alcohol beverages per day or have a history of alcoholism.

You must not take the medicine in more than the amount prescribed or longer than the prescribed period. It can be taken with food or without it, but you must take it, in the same way, every day.

The medicine must be swallowed whole, without trying to crush, break or mixing it in water. As it is a pain reliever, it is unlikely that you will miss a dose. In case you do, refrain from taking two doses together to make up for the missed one.

This medication does not have any serious side effects. It is safe to use this medicine during pregnancy and breastfeeding. However, in rare cases, skin rashes may occur accompanied by nausea, stomach pain, and loss of appetite.

There are several drugs that may interact with Calpol. Inform your doctor about all the other medications that you take including vitamins, minerals, prescribed drugs, over-the-counter drugs, and herbal products.

For adults Paracetamol the general dose for fever and pain is 325-650 mg tablets once in every 4 to 6 hours or 1000mg tablets once in every 6 to 8 hours. It is advised to be guided by the doctor’s prescription and never to exceed the prescribed dosage.

For treating Paracetamol toxicity, Acetylcysteine 140 mg/kg is administered orally (loading) followed by 70 mg/kg every 4 hours for 17 doses.

Therapy should be initiated based upon laboratory analysis suggesting high probability of hepatotoxic potential. Activated charcoal is very effective at binding acetaminophen.

Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). This medication will not reduce inflammation; consult prescriber for anti-inflammatory, if needed.

For treating Paracetamol toxicity, Acetylcysteine 140 mg/kg is administered orally (loading) followed by 70 mg/kg every 4 hours for 17 doses.

Take exactly as directed (do not increase dose or frequency); most adverse effects are related to excessive use. Take with food or milk. While using this medication, avoid alcohol and other prescription or OTC medications that contain acetaminophen or Paracetamol.

The medicine is useful against the following conditions:

  • Fever

  • Headache

  • Muscle Pain

  • Menstrual Cramps

  • Post Immunization Pyrexia

  • Arthritis

Common side effects of this medicine include:

  • How long is the duration of effect?

    The effect lasts for an average of 4-6 hours.
  • What is the onset of action?

    The effect of medication can be observed within an hour of oral administration.
  • Are there any pregnancy warnings?

    This medication should be avoided by pregnant women unless suggested by the doctor. The effect of this medication on fetus is not clearly established and hence, doctor consultation is recommended before consumption.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This medication is safe to use during breastfeeding. Before using this medicine consultation from a doctor is recommended. If you see any incidence of rashes on skin or diarrhea in the infant report it.
  • Does this affect liver function?

    Appears to be well tolerated in cirrhosis; serum levels may need monitoring with long-term use.
  • Does this affect kidney function?

    Dose adjustment is needed in case of renal impairment. Dosing interval in renal impairment:
    • Clcr 10-50 mL/minute: Administer every 6 hours.
    • Clcr <10 mL/minute: Administer every 8 hours (metabolites accumulate)
    • Hemodialysis: Moderately dialyzable (20% to 50%).
    Consult your doctor before taking this medication.
  • Is It safe with alcohol?

    Excessive intake of alcohol may increase the risk of acetaminophen-induced hepatotoxicity; avoid or limit alcohol intake.

Below is the list of medicines, which have the same composition, strength and form as Calpol 650 MG Tablet , and hence can be used as its substitute.

  • Missed Dose instructions

    This medication is usually taken as and when required. If the medicine is taken on a regular basis, then the missed dose should be taken as soon as possible. You should not take the missed dose if it is time for taking the next scheduled dose.
  • Overdose instructions

    This medication overdosage could cause harmful effects to the body.

The drug is a pain relief medication that selectively inhibits enzyme function in the brain which allows it to treat pain and fever. It activates certain receptors in the brain that inhibit pain signals.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    You should avoid consuming alcohol while taking this medicine. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.
  • Interaction with Lab Test

    5-HIAA Urine Test

    You may get a false-positive result for this test if you take Calpol 650 MG Tablet.
  • Interaction with Medicine

    One must take caution while taking this medicine. This medication may interact with other medication like Ketoconazole, Metformin, Anti-hypertensives if administered concomitantly. Also, Barbiturates, carbamazepine, hydantoins, sulfinpyrazone can increase the hepatotoxic potential of acetaminophen; chronic ethanol abuse increases the risk for acetaminophen toxicity; effect of warfarin may be enhanced
  • Interaction with Disease

    This medication should be used with caution in patients with an active liver disease.
  • Interaction with Food

    May slightly delay absorption of extended-release preparations; rate of absorption may be decreased when given with food high in carbohydrates.

Ques: What is Calpol 650 MG Tablet?

Ans: This medication has Paracetamol as an active ingredient present. It performs its action by increasing the loss of heat from the body.

Ques: What are the uses of Calpol 650 MG Tablet?

Ans: This medication is used for the treatment and prevention from conditions and symptoms of diseases like migraine attacks, arthritis, high fever, Post immunization symptoms, headache and muscle pain symptoms.

Ques: What are the Side Effects of Calpol 650 MG Tablet?

Ans: This is a list of possible side-effects which may occur due to the constituting ingredients of this medication. These include nausea, vomiting, blood in urine, gastric ulcers, anemia, fever, allergic reactions and fatigue.

Ques: What are the instructions for storage and disposal Calpol 650 MG Tablet?

Ans: This medication should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets. A doctor should be consulted regarding the dosage of Calpol.

Ques: How long do I need to use Calpol 650 MG Tablet before I see improvement of my conditions?

Ans: This medicine takes 1 or 2 days before you see an improvement in your health conditions. It would be ideal if you note, it doesn't mean you will begin to notice such health improvement in a similar time span as different patients.

Ques: What are the contraindications to Calpol 650 MG Tablet?

Ans: Contraindication to calpol. In addition, this medication should not be used if you have the following conditions such as skin rashes, skin reddening, skin blister, etc.

Ques: Is Calpol 650 MG Tablet safe to use when pregnant?

Ans: This medication is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Ques: Will Calpol 650 MG Tablet be more effective if taken in more than the recommended dose?

Ans: No, taking higher than the recommended dose of this medication can lead to increased chances of side effects such as bleeding, breathing problems, itching, mouth ulcers, skin rash, swelling of the face, swelling of the lips, swelling of the throat, etc.

Ques: Should I use Calpol 650 MG Tablet empty stomach, before food or after food?

Ans: If you take this medication with the food, the reactions that took place in the body carry-outs in a much effective manner.

Ques: Is there any food or drink I need to avoid while taking Calpol 650 MG Tablet?

Ans: You can follow your normal diet under the usage of this medication.

Ques: Will Calpol 650 MG Tablet be more effective if taken in more than the recommended dose?

Ans: There is no need to take this medication more than its recommended doses.

Ques: Can I take other medications along with Calpol 650 MG Tablet?

Ans: Do not use any OTC for cough, cold, allergy, or pain medication without consulting your doctor or pharmacist. Calpol 650 MG Tablet contains many combination of medicines. If you use certain products together you may accidentally use too much of Calpol 650 MG Tablet.

Ques: Can I take Calpol 650 MG Tablet with antibiotics?

Ans: There are hundreds of antibiotics used to treat infections, so once you receive your prescription, ask your doctor or pharmacist if you can also take this medication at the same time that you take the antibiotic.

Ques: Is Calpol 650 MG Tablet an NSAID drug?

Ans: No, this medication is not classified as an NSAID (nonsteroidal anti-inflammatory drug). It is classified as a miscellaneous analgesic for mild to moderate pain and fever.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Calpol 650 MG Tablet
What are the uses of Calpol 650 MG Tablet
What are the contraindications of Calpol 650 MG Tablet ?
What are the side effects of Calpol 650 MG Tablet ?
Key highlights of Calpol 650 MG Tablet
What are the substitutes for Calpol 650 MG Tablet ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Calpol 650 MG Tablet ?
FAQs about Calpol 650 MG Tablet