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Alprostadil

Prescription vs.OTC: Prescription by Doctor required

Alprostadil is used in the treatment of erectile issues in males. The drug is considered as a prostaglandin (PGE-1). Alprostadil increases the flow of blood to the penis as it relaxes some muscles and widen the blood vessels effectively. As the effect of Alprostadil starts to reduce the blood flow through the penis also decreases and the erection goes away.

The drug is not recommended for use if you suffer from the following problems such as-

  • Allergy to any substance present in Alprostadil
  • Problems with the bone marrow, priapism, leukemia, sickle cell anemia and an erection that is painful
  • Penile implants, penis fibrosis and deformed penis
  • Any injury or other physical issues that prevents you from having sexual intercourse

In order to ensure safety give your doctor a detailed medical history, and inform him about any current health issues that you are facing. Give him information about all the medication prescribed as well as non-prescribed that you are using. Also tell him about any allergies that you may have.

One of the side effects that you may experience while using Alprostadil is dizziness. Thus you must take precautionary measures to prevent any complications. Avoid driving or indulging in some strenuous activity to prevent any accidents. Alcohol consumption should be avoid or very limited, as alcohol can worsen the side effects.

Some general side effects of Alprostadil are painful erection, dizziness, fever, pain or burning in the urethra, apnea and flushing. You may very rarely experience a curved penis, and erections that lasts for a long period of time, development of a blood clot in the penis.

When taking Alprostadil you will need to go for regular check-ups and keep your doctor updated about your health at all times.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Urologist before using this medicine.

Erectile Dysfuntion
Alprostadil is used for the treatment of impotence; where achieving and sustaining an erection is a problem while having sexual intercourse. However, it will work only if there is sexual stimulation. It is also sometimes used for the diagnosis of erectile dysfunction.
This medicine is also used for the supportive treatment of a birth defect where a temporary blood vessel does not close soon after birth.
This medicine is not recommended for use if you have a known history of allergy to Alprostadil/Prostaglandins or any other ingredient present with it.
This medicine is not recommended for use if you have prolonged and painful erection even in the absence of any stimulation. Certain conditions like Sickle cell anemia, leukemia, and Multiple myeloma may contribute to this condition and hence should not be used in such cases.
Deformation of penis
This medicine is not recommended for use if you have a deformed penis or have plaques due to a trauma (Peyronie's disease).
Sexual activity not recommended
This medicine is not recommended for use if your doctor has advised to refrain from any sexual activity due to health reasons.
In addition to its intended effect, Alprostadil may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Pain and burning sensation in the penis Moderate Common
Urethral route/Intravenous route
Urethral bleeding Moderate Less Common
Urethral route
Testicular pain Moderate Less Common
Urethral route
Headache Minor Less Common
Urethral route
Dizziness and fainting Minor Rare
Urethral route
Increased heartbeat Moderate Rare
Urethral route
Prolonged and painful erection Moderate Less Common
Intracavernosal route
Hardening of penile tissue Major Rare
Intracavernosal route
Injection site bruising and red coloration Minor Less Common
Intracavernosal route
Swelling and rashes at the penile region Moderate Less Common
Intracavernosal route
Bleeding at the injection site Moderate Less Common
Intracavernosal route
Swelling of veins Major Rare
Visual disturbances Major Rare
How long is the duration of effect?
The amount of time for which this medicine remains effective is subject to vary based on the intended use. However, this medicine is effective for 60-90 minutes when taken for erectile dysfunction.
What is the onset of action?
The amount of time taken for this medicine to show its effect is subject to vary depending on the intended use. The effect can be observed within 5-20 of administration when taken for erectile dysfunction.
Are there any pregnancy warnings?
This medicine is not recommended for use in pregnant women. Appropriate precautionary measures should be adopted if your partner is taking this medicine. Contact your doctor immediately if a pregnancy is suspected while your partner is using this medicine.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is not recommended for use in breastfeeding women.
Missed Dose instructions
This medicine is taken on a need basis and hence a dosing regimen is highly unlikely.
Overdose instructions
Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms may include fainting, feeling light-headed, prolonged and painful erection etc.
India
United States
Japan
Below is the list of medicines, which contains Alprostadil as ingredient
Samarth Life Sciences Pvt Ltd
United Biotech Pvt Ltd
Alprostadil is a naturally occurring Prostaglandin E1 analogue. It acts by relaxing the arterial smooth muscles causing dilation of blood vessels in the penile region. It also relaxes the smooth muscles present in the ductus arteriosus in children with a congenital defect of the heart.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Respiratory disorders of the neonates Major
This medicine should be used with extreme caution in newborn children having underdeveloped lungs. Suitable supportive measures like ventilation should be ensured before this medicine is used.
Bleeding disorders Moderate
This medicine should be used with caution in patients having a bleeding disorder. Use of this medicine may cause adverse effects and may also worsen the bleeding problems.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Minoxidil Moderate
Report the use of either of the medicine to the doctor. You may require a dose adjustment and frequent clinical monitoring to safely use this medicines together. Report any incidence of fainting, drowsiness, headache, and changed heart rate to the doctor.
Sodium Nitrite Moderate
Report the use of either of the medicine to the doctor. You may require close clinical monitoring while using these medicines together. Suitable precautionary measures should be taken to counter or manage the excessive lowering of blood pressure caused due to coadministration of these medicines.
Sildenafil Moderate
Report the use of either of the medicines to the doctor. You may experience a headache, drowsiness, fainting, and change in heart rate while using them together. Your doctor may determine the appropriate course of treatment in such cases.
Riociguat Moderate
Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring of blood pressure levels while using them together. Report any incidence of a headache, drowsiness, fainting, and change in heart rate to the doctor.
Pentoxifylline Moderate
Report the use of either of the medicines to the doctor. You may experience a headache, drowsiness, fainting, and change in heart rate while using them together. Your doctor may determine the appropriate course of treatment in such cases.
Papaverine Minor
Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent clinical monitoring to safely use these medicines together. Do not stop the use of any medicine without consulting your doctor.
What are you using Alprostadil for?
Erectile Dysfuntion
Other
Patent Ductus Arteriosus
Dizziness and fainting
How much was the improvement?
Average
Excellent
Poor
How long did it take before seeing improvement?
Within 2 hours
Within 2 days
More than 2 days
Within a day
Within 6 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
Four times A Day
Twice a day
How did you take this medicine?
With or without food
With Food
Empty stomach
What were the side effects of this medicine?
Headache
Hardening of penile tissue
Dizziness
Increased heartbeat
painful erection
burning sensation in the penis
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am trying to buy Alprostadil suppository for ed problem. Please advise as from where I can avail this.

MD - Homeopathy
Homeopath, Aurangabad
I am trying to buy Alprostadil suppository for ed problem. Please advise as from where I can avail this.
It is natural for a man to feel erection when he is sexually aroused. The muscles, nerves, hormones and blood vessels all work together and maintain an erection. If a man is unable to obtain and maintain erection of penis during sexual activity if a man has difficulty in getting firm or erection or is unable to maintain an erection during the sexual penetration, he is most likely has a condition called Erectile dysfunction. It is normal for a man not to be able to achieve erection on some occasions, but if it is regular then it needs attention. Inability to achieve full erection could be either due to psychological or medical reasons and can be treated with right guidance and treatment. Psychological reasons includes chemistry with your sexual partner, any guilt, fear of intimacy negative feelings depressions can affect the erection. Medical conditions like thickening of the walls of the arteries, obesity, heart diseases, prostate disorder, any injury to the pelvic region or any other such underlying diseases that affects the proper flow of blood to the penis can cause erectile dysfunction. External factors like tobacco use, alcohol consumption and drug abuse can also restrict the blood flow resulting in erectile dysfunction. In most of the cases erectile dysfunction is due to any underlying medical condition. Good diet and daily exercises are very important to keep you mentally and physically fit. It will improve both your psychological and medical well-being. If any psychological factor is causing trouble, then meditation, breathing exercises like Pranayam staying away from stress and anxiety, talking more with your partner about the problem may help. The best treatment option suitable to your problem can be considered after a detailed analysis of your symptoms and case history. Get in touch with your nearest homeopathy doctor to get right treatment advice.
1 person found this helpful

Dear doctor, I wanted to know that whether alprostadil penis injection has to be taken once in a year or every time before having sex. I also heard of caverject injection for erectile dysfunction. Whether both are same or different. Where it is available in India for treatment.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Dear doctor, I wanted to know that whether alprostadil penis injection has to be taken once in a year or every time b...
Alprostadil Injection is a prostaglandin (PGE-1). It works by relaxing certain muscles in the penis and widening blood vessels, which increases blood flow to the penis and helps to cause an erection. When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears. ANd Caverject also is a prostaglandin (PGE-1). It works by relaxing certain muscles in the penis and widening blood vessels, which increases blood flow to the penis and helps to cause an erection. Here also When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears. It is available. All medicines may cause side effects, but many people have no, or minor, side effects.
1 person found this helpful

I am 49 years old. For impotency problem what is the treatment procedure? Please tell me.

BHMS, Diploma in Dermatology
Homeopath, Hyderabad
I am 49 years old. For impotency problem what is the treatment procedure? Please tell me.
Penile Implants for ED A penile prosthesis or implant is an effective treatment for erectile dysfunction. Penile implant surgeries take about an hour and are typically done in an outpatient center. Alprostadil for ED Alprostadil, available as an injection or a suppository, is a drug that makes the blood vessels expand.

I want to become impotent. Is there is any treatment to become impotent. Why I want to become? Because it's the law of God. Restricted sex or no sex. Otherwise I won't be able to follow and then will not be able to come out of the cycle of birth and death.

BHMS, Diploma in Dermatology
Homeopath, Hyderabad
I want to become impotent. Is there is any treatment to become impotent. Why I want to become? Because it's the law o...
Medication used to treat erectile dysfunction is alprostadil (Caverject Impulse, Edex, Muse), which is Prostaglandin E1 therapy. This medication is either self-injected or inserted as a suppository into the penis.

Dear doctor, I have heard of penis injection is used for erectile dysfunction treatment. Injection is given on penis. Whether this type of treatment is available in India. Kindly guide me.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Dear doctor, I have heard of penis injection is used for erectile dysfunction treatment. Injection is given on penis....
Alprostadil is a medicine that men take for ED (erectile dysfunction). It's only available by prescription. That boosts blood flow throughout the body, including the penis, so it helps men with ED have an erection. You can get alprostadil injected directly into the penis. Trade NameAlpostin ManufacturerSamarth Pharma Pvt. Ltd. Unit5 mcg TypeInjection Quantity1 ml Price5900.

Popular Health Tips

Treatment For ED That Will Improve Your Erections

MD - General Medicine
Sexologist, Delhi
Treatment For ED That Will Improve Your Erections

Treatment For ED That Will Improve Your Erections

ED or erectile dysfunction is a common condition that affects the sexual life of many couples. So as not to compromise the relationship, you need to know the treatment for ED that will allow you to experience true bliss and pleasures in bed.

Seeking Doctor's Help

The doctor needs to determine which factors are actually causing the erection problem so that he can prescribe the best treatment. Aside from the causes of ED, the doctor will also assess how severe the problem is. The doctor can also explain to you what advantages and disadvantages of each treatment option is and will recommend to you an ideal treatment option according to your or your partner's preferences.

Oral Drugs

Medications administered orally may be prescribed by the health expert such as Sildenafil or Viagra, Tadalafil or Cialis and Vardenafil or Staxyn/Levitra. All three work similarly with one another. They can enhance nitric oxide effects on the body. Nitric oxide is a natural chemical produced by the body that helps penis muscles to relax. This will result to more blood flowing into the organ and achieve erection as response to a sexual stimulant.

They usually have varied dosages, amount of time to take effect and what possible adverse effects might occur. Your personal condition will be assessed by the doctor in order to choose which medication is most suitable for you. Some of the expected side effects from taking these medications include nasal congestion, flushing, stomach upset, visual changes and headache. It is possible these medications will not immediately take effect so you have to work closely with the doctor to find the right drug and the correct dosage.

Only take these drugs with the doctor's approval because not all men are fit to take them. High risks are involved if: you are taking nitrate drugs(nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) that are usually prescribed for angina or chest pains; you are taking an anticoagulant or blood-thinning drug, hypertension drug or alpha blockers (to ease prostate enlargement); you have heart failure or heart disease; had stroke; you have hypotension or too low blood pressure or hypertension (high blood pressure) out of control; you have diabetes.

Alprostadil self-injection

In this treatment option, fine needles will be injected to introduce alprostadil at the side or base of the male organ. Sometimes, the injection would also include drugs for other disorders like phentolamine, alprostadil and papaverine. The erection produced after the injection will typically last for an hour. Minor pains will be felt because the needles used are very fine. Possible side effects include fibrous tissue formation, prolonged erection and slight bleeding.

Alprostadil penis suppository

A tiny suppository will be placed inside the penile urethra. A special applicator will be used to insert the suppository. Erections, which will last 30-60 minutes, will start around five minutes after the insertion. Adverse effects may include minor bleeding, pain and fibrous tissue formation.

Testosterone Replacement

If the ED is caused by low testosterone levels, then the doctor will prescribe testosterone replacement.

Pumps/Surgery Or Implants

If medications are not applicable due to certain reasons, you will be recommended to use other modes of treatment like pumps. A pump is a vacuum erection device; a hollow cylinder powered either by hand or battery and is placed above the penis. The pump will suck out air from the cylinder to create a vacuum that will pull more blood into the penis to cause erection.

4 people found this helpful

Erectile Dysfunction - 4 Ways To Treat It

MBBS, F R S T & H London , Fellowship of College of General Practice (FCGP)
Sexologist, Alwar
Erectile Dysfunction - 4 Ways To Treat It

Almost 60% men are suffering from erectile dysfunction (ED), and these troubles are getting prominent day by day due to unhealthy lifestyle. Now, you will find various options for treating erectile dysfunction, and you got to get a fair idea about them. Not all medicines are suitable for you, and this is the reason doctors conduct a clinical examination before prescribing medicines.

Best drug options for treating erectile dysfunction:

  1. Topical administration: Macrochem and Nexmed are the two most popular options, and they are available in a gel form. This gel can be applied with ease over your weak or curved penis so that unwanted erections can be prevented. In this case, needles are not inserted, and thus you will face no adverse reactions. But proper medications are also required along with these medicated gels.
  2. Penile injections: Brindley and Virag are the two popular penile injections that can be easily injected so that you can get rid of erectile dysfunction. These injections are to be injected only under proper medical supervision otherwise you might face dreadful consequences. Alprostadil, phentolamine and papaverine deserve a special mention, and they are the safest options as per medical experts. Trial dosage can be easily administered, and on the other hand, combination medications need to be tried out for getting beneficial results.
  3. Intraurethral agents: There are many medical programs where these agents have been referred by experts. Though these agents are treated as alternative options, but you can still try them out in order to get some positive effects. In fact, the recovery process can be accelerated to a great extent by means of using these kinds of agents. You can get smoother and highly satisfactory penetration experienced with the use of these agents along with other prescribed medications for erectile dysfunction.
  4. Oral agents: though there are innumerable oral agents that can treat Ed trouble, but you have to choose quite carefully with the help of an experienced doctor. Some popular options in this regard are Cialis, Levitra, Staxyn, Stendra, Viagra and others. Only prescribed dosage needs to be taken, and thus you should take only those medicines that are only being prescribed by your doctor.

Do not choose medications as per your preference and never collect ED medicines over-the-counter. Before prescribing any ED medicine, doctor usually conducts a thorough examination in order to know the actual health condition of the patients and this clinical examination is important for referring the right ED medicines.

In case you have a concern or query you can always consult an expert & get answers to your questions!

7182 people found this helpful

Best Drug Options For Treating Erectile Dysfunction

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Sexologist, Delhi
Best Drug Options For Treating Erectile Dysfunction

Almost 60% men are suffering from erectile dysfunction (ED), and these troubles are getting prominent day by day due to unhealthy lifestyle. Now, you will find various options for treating erectile dysfunction, and you got to get a fair idea about them. Not all medicines are suitable for you, and this is the reason doctors conduct a clinical examination before prescribing medicines.

Best drug options for treating erectile dysfunction:

 

  1. Topical administration: Macrochem and Nexmed are the two most popular options, and they are available in a gel form. This gel can be applied with ease over your weak or curved penis so that unwanted erections can be prevented. In this case, needles are not inserted, and thus you will face no adverse reactions. But proper medications are also required along with these medicated gels.
  2. Penile injections: Brindley and Virag are the two popular penile injections that can be easily injected so that you can get rid of erectile dysfunction. These injections are to be injected only under proper medical supervision otherwise you might face dreadful consequences. Alprostadil, phentolamine and papaverine deserve a special mention, and they are the safest options as per medical experts. Trial dosage can be easily administered, and on the other hand, combination medications need to be tried out for getting beneficial results.
  3. Intraurethral agents: There are many medical programs where these agents have been referred by experts. Though these agents are treated as alternative options, but you can still try them out in order to get some positive effects. In fact, the recovery process can be accelerated to a great extent by means of using these kinds of agents. You can get smoother and highly satisfactory penetration experienced with the use of these agents along with other prescribed medications for erectile dysfunction.
  4. Oral agents: though there are innumerable oral agents that can treat Ed trouble, but you have to choose quite carefully with the help of an experienced doctor. Some popular options in this regard are Cialis, Levitra, Staxyn, Stendra, Viagra and others. Only prescribed dosage needs to be taken, and thus you should take only those medicines that are only being prescribed by your doctor.

Do not choose medications as per your preference and never collect ED medicines over-the-counter. Before prescribing any ED medicine, doctor usually conducts a thorough examination in order to know the actual health condition of the patients and this clinical examination is important for referring the right ED medicines. In case you have a concern or query you can always consult an expert & get answers to your questions!

6350 people found this helpful

4 Ways To Treat Erectile Dysfunction

MBBS, FASM (Andrology & Sexual Medicine), DCE (Embryology), PHD (Reprodcutive Medicine)
Sexologist, Chennai
4 Ways To Treat Erectile Dysfunction

Almost 60% men are suffering from erectile dysfunction (ED), and these troubles are getting prominent day by day due to unhealthy lifestyle. Now, you will find various options for treating erectile dysfunction, and you got to get a fair idea about them. Not all medicines are suitable for you, and this is the reason doctors conduct a clinical examination before prescribing medicines.

Best drug options for treating erectile dysfunction:

  1. Topical administration: Macrochem and Nexmed are the two most popular options, and they are available in a gel form. This gel can be applied with ease over your weak or curved penis so that unwanted erections can be prevented. In this case, needles are not inserted, and thus you will face no adverse reactions. But proper medications are also required along with these medicated gels.
  2. Penile injections: Brindley and Virag are the two popular penile injections that can be easily injected so that you can get rid of erectile dysfunction. These injections are to be injected only under proper medical supervision otherwise you might face dreadful consequences. Alprostadil, phentolamine and papaverine deserve a special mention, and they are the safest options as per medical experts. Trial dosage can be easily administered, and on the other hand, combination medications need to be tried out for getting beneficial results.
  3. Intraurethral agents: There are many medical programs where these agents have been referred by experts. Though these agents are treated as alternative options, but you can still try them out in order to get some positive effects. In fact, the recovery process can be accelerated to a great extent by means of using these kinds of agents. You can get smoother and highly satisfactory penetration experienced with the use of these agents along with other prescribed medications for erectile dysfunction.
  4. Oral agents: though there are innumerable oral agents that can treat Ed trouble, but you have to choose quite carefully with the help of an experienced doctor. Some popular options in this regard are Cialis, Levitra, Staxyn, Stendra, Viagra and others. Only prescribed dosage needs to be taken, and thus you should take only those medicines that are only being prescribed by your doctor.

Do not choose medications as per your preference and never collect ED medicines over-the-counter. Before prescribing any ED medicine, doctor usually conducts a thorough examination in order to know the actual health condition of the patients and this clinical examination is important for referring the right ED medicines.

5034 people found this helpful

Most Common Drugs that Successfully Treat Erectile Dysfunction

Graduate in Ayurvedic Medicine and Surgery ( GAMS )
Sexologist, Delhi
Most Common Drugs that Successfully Treat Erectile Dysfunction

Almost 60% men are suffering from erectile dysfunction (ED), and these troubles are getting prominent day by day due to unhealthy lifestyle. Now, you will find various options for treating erectile dysfunction, and you got to get a fair idea about them. Not all medicines are suitable for you, and this is the reason doctors conduct a clinical examination before prescribing medicines.

Best drug options for treating erectile dysfunction:

  1. Topical administration: Macrochem and Nexmed are the two most popular options, and they are available in a gel form. This gel can be applied with ease over your weak or curved penis so that unwanted erections can be prevented. In this case, needles are not inserted, and thus you will face no adverse reactions. But proper medications are also required along with these medicated gels.
  2. Penile injections: Brindley and Virag are the two popular penile injections that can be easily injected so that you can get rid of erectile dysfunction. These injections are to be injected only under proper medical supervision otherwise you might face dreadful consequences. Alprostadil, phentolamine and papaverine deserve a special mention, and they are the safest options as per medical experts. Trial dosage can be easily administered, and on the other hand, combination medications need to be tried out for getting beneficial results.
  3. Intraurethral agents: There are many medical programs where these agents have been referred by experts. Though these agents are treated as alternative options, but you can still try them out in order to get some positive effects. In fact, the recovery process can be accelerated to a great extent by means of using these kinds of agents. You can get smoother and highly satisfactory penetration experienced with the use of these agents along with other prescribed medications for erectile dysfunction.
  4. Oral agents: though there are innumerable oral agents that can treat Ed trouble, but you have to choose quite carefully with the help of an experienced doctor. Some popular options in this regard are Cialis, Levitra, Staxyn, Stendra, Viagra and others. Only prescribed dosage needs to be taken, and thus you should take only those medicines that are only being prescribed by your doctor.

Do not choose medications as per your preference and never collect ED medicines over-the-counter. Before prescribing any ED medicine, doctor usually conducts a thorough examination in order to know the actual health condition of the patients and this clinical examination is important for referring the right ED medicines.

9302 people found this helpful

Table of Content

About Alprostadil
When is Alprostadil prescribed?
What are the contraindications of Alprostadil ?
What are the side effects of Alprostadil ?
Key highlights of Alprostadil
What are the dosage instructions?
Where is the Alprostadil approved?
Medicines containing Alprostadil
How does medicine works?
What are the interactions for Alprostadil ?