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Deoxypyridinoline (DPD) Test

Deoxypyridinoline (DPD) Test

also known as: 5FU, Dihydropyrimidine Dehydrogenase

Deoxypyridinoline is nothing but one of two pyridinium cross-links that get to provide structural stiffness to type I collagen found in bones. The deoxypyridinoline (DPD) urine test is indeed used to measure the bone re-absorption rates and this in turn can be highly helpful in determining whether there’s any risk of enhanced bone diseases or not. This test can be helpful in determining the present of osteoporosis and several other bone diseases on the whole.

There’s a minimal preparation for this sort of test as it gets to follow the procedure of a simple urine test. Regarding the details of the meal to be followed, you’re free to intake anything and fasting is not at all required unless it is specified by the concerned physician. For this all one has to do is to take all the medications prescribed before taking the test and it would be highly advisable to reach the lab a few minutes before the specified time. Apart from that it’s recommended to give your sample before 10 A.M.

As mentioned earlier, this test is used to identify various bone diseases like osteoporosis etc. It has to be noted that high levels of DPD are found in postmenopausal women due to the deficiency of estrogen in the body where people with high bone turnover rates can be expected to have high levels of DPD. According the amount of DPD and the disease occurring, the doctor collectively concludes the treatment procedure that would be involved further.

As mentioned earlier, the procedure that is to be followed is quite simple and all one has to do is nothing but to get ready for a regular urine test. The following steps might be involved during the test. After reaching the lab, a urine collection cup might be given to the person undergoing the test The only thing the person has to do is to give his sample which sums up to more than half of the cup. The person is advised not to fill the collection cup completely for ease of testing. The sample is then sent to the laboratory for further proceedings.

LimitationsThis procedure will only detect the presence of the wild type or mutant allele for the DPD IVS14+1G>A mutation.
Whole blood or LabCorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)
7 mL whole blood or LabCorp buccal swab kit
Lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit.
Type Gender Age-Group Value
uninary DPD
All age groups
1.3-6.5 dpd/nm
uninary DPD
All age groups
1.5-6.9 dpd/nm

Table of Content

What is Deoxypyridinoline (DPD) Test?
Preparation for Deoxypyridinoline (DPD) Test
Uses of Deoxypyridinoline (DPD) Test
Procedure for Deoxypyridinoline (DPD) Test
Limitations of Deoxypyridinoline (DPD) Test
Specimen Requirements
Normal values for Deoxypyridinoline (DPD) Test
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