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Prescription vs.OTC: Prescription by Doctor required
Last Updated: August 31, 2020

An opioid agonist, Tramadol works as a pain reliever, providing relief from both moderate and severe pain. Similar to endorphins, it binds to the receptors in your body. These receptors will decrease the pain messages that your body generally sends to the brain when you are in pain.

The medicine has to be taken orally and is available in three forms - an immediate-release taablet, an extended-release tablet and a capsule. This medicine can be taken as a combination therapy, where you take it along with other medications for your treatment.

Your doctor will decide the dosage of Tramadol and ensure that you follow the instructions. You must not take the medicine in more than the amount prescribed or longer than the prescribed period.

This medicine can be taken with food or without it, but you must take it in the same way every day. The medicine must be swallowed wholly, without trying to crush, break or mixing it in water. As it is a pain reliever, it is unlikely that you will miss a dose. In case you do, refrain from taking two doses together to make up for the missed one.

Overdose of Tramadol can have severe side effects including extreme drowsiness, fainting, slow breathing or heart rate and cold/clammy skin.

You must avoid taking Tramadol if you :

  • Have an allergy to it or any of the ingredients in it,
  • Have a stomach or intestinal blockage,
  • Have consumed alcohol recently
  • Are under narcotic medications.

Your doctor must be informed about whether you have a history of metabolic disorders, alcohol addiction and epilepsy. You must also inform the doctor about any prescription of antibiotic and antifungal medicines.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

The medicine is prescribed to treat the following condition:

  • Moderate To Severe Pain

Intake of this medicine could lead to few common side effects like:

  • How long is the duration of effect?

    The effect of this medicine lasts for a duration of 6 hours for an immediate-release tablet and 21 hours for an extended-release tablet.
  • What is the onset of action?

    The peak effect of this medicine is observed in 1.5 hours for an immediate release tablet and 6 hours for an extended release tablet.
  • Are there any pregnancy warnings?

    This medicine is not recommended for pregnant women. Use only if clearly needed when no safer alternative is available.
  • Is it habit forming?

    No habit forming tendency has been reported
  • Are there any breast-feeding warnings?

    This medicine is known to be excreted through human breast milk. It is not recommended for breastfeeding women. Use only if clearly needed when no safer alternative is available. Monitoring of undesired effects like drowsiness and delayed developmental milestones is necessary.
  • Does this affect kidney function?

    No relevant information is available. Consult your doctor before taking Tramadol.
  • Does this affect liver function?

    No relevant information is available. Consult your doctor before taking Tramadol.
  • Are there any missed dose instructions?

    Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Are there any overdose instructions?

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Tramadol as ingredient

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This medicine acts on certain specific pain receptors in the brain and inhibits the reuptake of norepinephrine, serotonin. It also enhances the release of serotonin thereby changing the perception and response to pain.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Acute Alcohol Intoxication

    Consumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving or operating machinery.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine


    Tramadol may increase the risk of seizures when taken with Tramadol. This interaction is more likely to happen in the elderly population, and in the patients suffering from head injury. Inform the doctor if you are on either of the medicines. An alternate medicine should be considered based on the clinical condition under the doctor's supervision.


    Azole antifungal agents like Ketoconazole and Itraconazole should be avoided when you are Tramadol due to the risk of increased concentrations of the medicine in the body which may cause dizziness, dry mouth, and irregular heart beats. Inform the doctor if you are receiving these medicines when you are prescribed with Tramadol and dose adjustments or an alternative medicine should be considered based on the clinical condition.


    The desired effect of antidiabetic agents may not be achieved when taken with Tramadol. Regular monitoring of blood glucose levels is necessary. Inform the doctor if you develop any symptoms like excessive thirst, increased in the frequency of urination. Dose adjustments are to be made based on the clinical condition.


    You may experience hypotensive effects like dizziness, lightheadedness if these medicines are used together. Regular monitoring of blood pressure is necessary. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
  • Interaction with Disease


    This medicine is not recommended in the patients with dementia-related psychosis as it increases the risk of heart diseases like heart failure and infectious diseases like pneumonia. An alternate medicine should be considered based on the clinical condition.
  • Interaction with Food

    Information not available.

Ques: What is Tramadol?

Ans: This medicine contains tramadol as the key ingredient. This drug falls under the class of opioid analgesics, thus helps in relieving pain.

Ques: How long do I need to use Tramadol before I see improvement in my condition?

Ans: This medication is to be taken till the time you see an improvement in your health conditions.

Ques: At what frequency do I need to use Tramadol?

Ans: This medication should be taken in the dosage as prescribed by the doctor.

Ques: Should I use Tramadol empty stomach, before food or after food?

Ans: This medication should be taken after food in a prescribed dosage.

Ques: What are the instructions for the storage and disposal of Tramadol?

Ans: This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

Ques: Is there anything I need to be careful about while on therapy with Tramadol?

Ans: This drug may cause drowsiness and dizziness, especially in the beginning of the treatment. It is advised to consult a doctor before consuming this drug.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Tramadol
What are the uses of Tramadol
What are the contraindications of Tramadol ?
What are the side effects of Tramadol ?
Key highlights of Tramadol
What are the dosage instructions?
Where is the Tramadol approved?
Medicines containing Tramadol
How does this medication work?
What are the interactions of Tramadol ?
FAQs about Tramadol