An opioid agonist, Tramadol works as a pain reliever, providing relief from both moderate and severe pain. Similar to endorphins, it binds to the receptors in your body. These receptors will decrease the pain messages that your body generally sends to the brain when you are in pain.
The medicine has to be taken orally and is available in three forms - an immediate-release tablet, an extended-release tablet and a capsule. This medicine can be taken as a combination therapy, where you take it along with other medications for your treatment.
Your doctor will decide the dosage of Tramadol and ensure that you follow the instructions. You must not take the medicine in more than the amount prescribed or longer than the prescribed period.
This medicine can be taken with food or without it, but you must take it in the same way every day. The medicine must be swallowed wholly, without trying to crush, break or mixing it in water. As it is a pain reliever, it is unlikely that you will miss a dose. In case you do, refrain from taking two doses together to make up for the missed one.
Overdose of Tramadol can have severe side effects including extreme drowsiness, fainting, slow breathing or heart rate and cold/clammy skin. You must avoid taking Tramadol if you :
- Have an allergy to it or any of the ingredients in it,
- Have a stomach or intestinal blockage,
- Have consumed alcohol recently
- Are under narcotic medications.
Your doctor must be informed about whether you have a history of metabolic disorders, alcohol addiction and epilepsy. You must also inform the doctor about any prescription of antibiotic and antifungal medicines.
If self-administered, use exactly as directed (do not increase dose or frequency); may cause physical and/or psychological dependence. Take with food or milk. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).
While using this medication, do not use alcohol and other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or cough preparations) without consulting prescriber.
Report severe unresolved constipation; difficulty breathing or shortness of breath; excessive sedation or increased insomnia and restlessness; changes in urinary pattern or menstrual pattern; muscle weakness or tremors; or chest pain or palpitations.
The medicine is prescribed to treat the following condition:
Moderate To Severe Pain
How long is the duration of effect?The effect of this medicine lasts for a duration of 6 hours for an immediate-release tablet and 21 hours for an extended-release tablet.
What is the onset of action?The peak effect of this medicine is observed in 1.5 hours for an immediate release tablet and 6 hours for an extended release tablet.
Are there any pregnancy warnings?This medicine is not recommended for pregnant women. Use only if clearly needed when no safer alternative is available.
Is it habit forming?No habit forming tendency has been reported
Are there any breast-feeding warnings?This medicine is known to be excreted through human breast milk. It is not recommended for breastfeeding women. Use only if clearly needed when no safer alternative is available. Monitoring of undesired effects like drowsiness and delayed developmental milestones is necessary.
Does this affect kidney function?No relevant information is available. Consult your doctor before taking Tramadol.
Does this affect liver function?No relevant information is available. Consult your doctor before taking Tramadol.
Is it safe to drive while on this medicine?Avoid driving or operating machinery until the effect of drug wears off.
Is it habit forming?Tramadol has not been fully evaluated for its abuse potential, report cravings to your physician immediately.
Is It safe with alcohol?While using this medication, do not consume alcohol.
Are there any missed dose instructions?Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
Below is the list of medicines, which contains Tramadol as ingredient
This medicine acts on certain specific pain receptors in the brain and inhibits the reuptake of norepinephrine, serotonin. It also enhances the release of serotonin thereby changing the perception and response to pain.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Acute Alcohol IntoxicationConsumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving or operating machinery.
Interaction with Medicine
- Amphetamines may increase the risk of seizures with Tramadol.
- Cimetidine increases the half-life of Tramadol by 20% to 25%.
- SSRIs may increase the risk of seizures with Tramadol.
- Tricyclic antidepressants may increase the risk of seizures.
- MAOIs may increases the risk of seizures.
- Naloxone may increase the risk of seizures in Tramadol overdose.
- Neuroleptic agents may increase the risk of tramadol-associated seizures and may have additive CNS depressant effects.
- Opioids may increase the risk of seizures, and may have additive CNS depressant effects.
- Quinidine (and other inhibitors of CYP2D6) may increase the tramadol serum concentrations.
Interaction with Disease
- Use with caution and reduce dosage when administered to patients receiving other CNS depressants.
- Patients with a history of seizures, or with a risk of seizures (head trauma, metabolic disorders, CNS infection, or malignancy, or during alcohol/drug withdrawal) are also at increased risk.
- This medicine is not recommended in patients with dementia-related psychosis as it increases the risk of heart diseases like heart failure and infectious diseases like pneumonia. An alternate medicine should be considered based on the clinical condition.
Ques: What is Tramadol?
Ques: How long do I need to use Tramadol before I see improvement in my condition?
Ques: At what frequency do I need to use Tramadol?
Ques: Should I use Tramadol empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Tramadol?
Ques: Is there anything I need to be careful about while on therapy with Tramadol?
Tramadol%20hydrochloride-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:https://druginfo.nlm.nih.gov/drugportal/name/tramadol%20hydrochloride
Tramadol%20hydrochloride-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 25 May 2022].Available from:https://go.drugbank.com/drugs/DB00193
Tramadol%20hydrochloride injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=tramadol
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