Prescription vs OTC: Prescription by Doctor required

Progesterone is primarily used as intrauterine contraception in women who have had at least 1 child, are in a stable, mutually monogamous relationship, and have no history of the pelvic inflammatory disease; amenorrhea; functional uterine bleeding.

This medicine is also prescribed as replacement therapy. It is available as an intravaginal gel as part of assisted reproductive technology for infertile women with progesterone deficiency. Also it is used in secondary amenorrhea (8% gel is used in those who fail to respond to 4%).

Progesterone (active ingredient) is a synthetic version of the female hormone. This hormone is vital for the regulation of menstruation and ovulation. The medicine is primarily used to induce periods, specifically when it occurs due to a lack of hormone secretion.

It is also used to treat abnormal uterine bleeding and symptoms of premenstrual syndrome (PMS). Use of this medication could cause harm to the unborn baby if you do not let your doctor know that you are pregnant. The route of administration of this medicine is either intra-vaginal or intrauterine. Take this medication as per the prescription of the doctor.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

This drug can be used in below-mentioned conditions

  • Hypersensitivity

  • Pregnancy

  • Thrombophlebitis

  • Vaginal Bleeding

  • Liver Dysfunction

This drug can cause below-mentioned side effects

  • Edema (Swelling)

  • Bleeding

  • Increased Menstrual Flow

  • Amenorrhea

  • Anorexia

  • Weakness

  • Embolism

  • Central Nervous System Depression

  • Fever

  • Insomnia

  • Melasma

  • Breast Tenderness

  • Unexpected Weight Gain Or Loss

  • Is It safe with alcohol?

    Interaction with alcohol is unknown. Please consult your doctor.
  • Are there any pregnancy warnings?

    This drug is unsafe to use during pregnancy.
  • Are there any breast-feeding warnings?

    Unknown. Human and animal studies are not available. Please consult your doctor.
  • Is it safe to drive while on this medicine?

    There is no interaction between driving and consuming this drug. So dose alteration is not needed.
  • Does this affect kidney function?

    There is no data available. Please consult a doctor before consuming the drug.
  • Does this affect liver function?

    There is no data available. Please consult a doctor before consuming the drug.
  • How long is the duration of effect?

    The duration of effect of this medication is about 24 hours.
  • What is the onset of action?

    The onset of action of this medication is 1.5 hours to 2.3 hours.
  • Is it habit forming?

    No habit forming tendencies found.
  • Are there any overdose instructions?

    In case of overdose, consult your doctor.
  • Are there any missed dose instructions?

    The missed dose of this medicine should be taken as soon as you remember it. The missed dose, however, should be skipped if it is near the time of the next dose.

Below is the list of medicines, which contains Progesterone as ingredient

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This medication binds to the progesterone and estrogen receptors. The target cells are mammary gland, female reproductive tract, the pituitary and hypothalamus. When the binding takes place the release of GnRH is slowed and the luteinizing hormone rush.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Lab Test

    Inform your doctor if you are taking this medication before any pathological test. as this medicine may affect the result of tests like Thyroid function, metyrapone, liver function, coagulation tests, endocrine function tests.
  • Interaction with Medicine

    This medication interacts with-
    • CYP3A3/4 enzyme: substrate or inducer
    • Increase effect: Ketoconazole may increase the bioavailability of progesterone. Progesterone may increase concentrations of estrogenic compounds during concurrent therapy with conjugated estrogens.
    • Other medications: Immunosuppressants, Antisteroidal drugs, Anticoagulants, Diazepam, Tizanidine, and Terbinafine.
  • Interaction with Food

    No information available
  • Interaction with Disease

    This medication interacts with the following diseases which include Coronary artery disease (CAD) and Gall bladder disease. Use with caution in patients with impaired liver function, depression, diabetes, and epilepsy. Use of any progestin during the first 4 months of pregnancy is not recommended. Monitor closely for loss of vision, proptosis, diplopia, migraine, and signs or symptoms of embolic disorders. Not a progestin of choice in the elderly for hormonal cycling.

Ques: What is Progesterone?

Ans: Progesterone is a type of progesterone hormone which is extracted from plants, but its property matches with the human progesterone. This medicine undergoes a process called micronization where the size of the natural progesterone is reduced. The small size of the progesterone particles enhances its dissolution and absorption. This provides better availability of Progesterone in the body and decreases its side effects.

Ques: What are the instructions for storage and disposal Progesterone?

Ans: Progesterone should be kept in a cool dry place and its original packaging. Make sure this medication remains unreachable to children and pets.

Ques: How long do I need to use Progesterone before I see improvement in my condition?

Ans: This medication is to be taken till the time you see an improvement in your health conditions.

Ques: At what frequency do I need to use Progesterone?

Ans: This medication should be taken in the dosage as prescribed by the doctor.

Ques: Should I use Progesterone empty stomach, before food or after food?

Ans: This medication should be taken after food in a prescribed dosage.

Ques: What is Progesterone used to treat?

Ans: It is used to treat various disorders. It is given to women with secondary amenorrhea. It supports pregnancy, prevents premature labor, and treats bleeding disorders that may occur before menopause.

Ques: Can you take Progesterone every day?

Ans: Yes, it can be consumed every day. It is usually prescribed to be taken once daily in the evening or at bedtime. The usual duration of prescription may vary from 10-12 days a month to 25 days a month.

Ques: Does Progesterone cause weight gain?

Ans: Yes, Progesterone may cause weight gain. However, it is advised to contact your doctor in case your weight gain is worrying you.

Ques: Is Progesterone safe?

Ans: Yes, Progesterone is safer as compared to the normal synthetic progesterone. It is small in size which helps the body to absorb it easily. It is advised to take Progesterone as per the doctor’s prescription.

Ques: How is Progesterone beneficial for fertility and pregnancy?

Ans: It is a very crucial hormone in fertility. It prepares the uterus for pregnancy and also helps maintain it. Progesterone is also used to prevent premature labor.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Progesterone
What are the uses of Progesterone
What are the contraindications of Progesterone ?
What are the side effects of Progesterone ?
Key highlights of Progesterone
What are the dosage instructions?
Medicines containing Progesterone
How does this medication work?
What are the interactions of Progesterone ?
FAQs about Progesterone