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Overview

Penicillamine

Prescription vs.OTC: Prescription by Doctor required

Penicillamine, is essentially an anti-rheumatic drug that is used to treat rheumatoid arthritis, by slowing its progression and improving daily functionality. It is also used to treat Wilson?s disease, which basically is the excessive accumulation of copper in the body. It is a metal binding agent that helps to remove this excess copper.

This medicine is not to be prescribed if you are allergic to any ingredient in it or penicillin. If you are pregnant or breastfeeding, have kidney problems, or are using anti-malarial or cytotoxic medicines, this should not be prescribed.

Penicillamine is to be taken on an empty stomach, either an hour before a meal or two hours after it. Take it two hours before or after medicines containing iron, magnesium and aluminum. The medicine takes about one to three months to take effect.

Some of the side effects of Penicillamine include diarrhea, nausea, vomiting, cramps, itching, rashes lip swelling, etc. It is important that patients taking this medicine get regular blood and urine tests done so as to monitor any side effects.

In addition to its intended effect, Penicillamine may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Protein in urine
Reduced blood platelets.
Is It safe with alcohol?
Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?
Cilamin 250mg capsule is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?
Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?
There is no data available. Please consult doctor before consuming the drug.
Does this affect kidney function?
Caution to be advised in patients with impaired renal function.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Are there any missed dose instructions?
If you miss a dose of Penicillamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Medicine
Troykcl 1.5Gm Injection
CERONA 0.5MG TABLET
LARIAGO DS 500MG TABLET
RESOCHIN 64.5MG INJECTION

Popular Questions & Answers

My wife is taking penicillamine tablet for Wilson disease? And she is taking thyroid tablet also. Can I have sex with her? Any problem come to me?

MD - Alternate Medicine, BHMS
Homeopath, Surat
My wife is taking penicillamine tablet for Wilson disease? And she is taking thyroid tablet also.
Can I have sex with...
No dear, as such no problems... You can have relation with your wife without any problems... Take care :)

What are d side effects of d penicillamine after taking fr 2 days I hve experiencing fear and some bleeding through nose and pain in right upper abdomen and upper right back.

C.S.C, D.C.H, M.B.B.S
General Physician,
What are d side effects of d penicillamine after taking fr 2 days I hve experiencing fear and some bleeding through n...
The possible side effects are itching or a rash; nausea, vomiting, diarrhea, or decreased appetite; ringing in the ears; decreased taste; sores in the mouth; poor wound healing; or. increased wrinkling of the skin. Please make sure that you mention the reason why you are taking the medicine,

Does chronic Mercury Poisoning patient can get normal with chelation therapy? If yes, which chelating agent is used and for how long?

C.S.C, D.C.H, M.B.B.S
General Physician,
Does chronic Mercury Poisoning patient can get normal with chelation therapy? If yes, which chelating agent is used a...
Chelation therapy for acute inorganic mercury poisoning can be done with DMSA, 2,3-dimercapto-1-propanesulfonic acid (DMPS), D-penicillamine (DPCN), or dimercaprol (BAL. All patients in unstable condition should be admitted to an intensive care unit (ICU). After the patient is admitted, supportive measures, decontamination, and careful monitoring should be continued. In cases of inorganic mercuric salt ingestion, carefully monitor the patient's renal function.

Can Chronic Mercury Poisoning Patient can seek treatment at which places and does his symptoms go out by how many sessions of chelation therapy and the price will be how much? If there any use of Hyper basic Oxygen Therapy for chronic mercury poisoning?

C.S.C, D.C.H, M.B.B.S
General Physician,
Can Chronic Mercury Poisoning Patient can seek treatment at which places and does his symptoms go out by how many ses...
Chelation therapy for acute inorganic mercury poisoning can be done with DMSA, 2,3-dimercapto-1-propanesulfonic acid (DMPS), D-penicillamine (DPCN), or dimercaprol (BAL).

I am 58 yrs old male. My taste of mouth has lost since last 2 yrs. I had sinus problem & I operate it but no gain in taste. What to do?

MBBS, DGO (cal)
General Physician,
Loss of taste is a common symptom of gastroesophageal reflux disease (gerd), salivary gland infection, sinusitis, poor dental hygiene, or even certain medicines. The medical term for a complete loss of taste is ageusia. A partial loss of taste is called dysgeusia. Loss of taste is caused by interruption of the transfer of taste sensations to the brain, or by a problem with the way the brain interprets these sensations. Although taste problems are common, complete loss of taste is rare. Loss of taste in mouth can be a sign of a serious condition. Seek prompt medical care if your loss of taste in mouth is persistent or causes you concern. A senior consultant in general medicine / internal medicine can help you.

Popular Health Tips

Few Things You Need To Know About Anetoderma!

MBBS, MD-SKIN
Dermatologist, Ahmedabad
Few Things You Need To Know About Anetoderma!

Healthy skin is one that stays taut and firm. Anetoderma is a rare benign condition where the dermis loses elastic tissue. This results in the formation of a depression in the skin or flaccid skin. This condition is also known as macular atrophy, anetoderma maculosa, and atrophia maculosa cutis. Anetoderma is not contagious.

Women are at a higher risk of suffering from this condition than men. It usually affects people in their late teens and early twenties. Premature babies born with a very low birth weight are also susceptible to this condition. In rare cases, it can run in the family and affect identical twins.

Depending on how it is triggered, there are two types of Anetoderma; primary and secondary. Both forms of this condition may be associated with systemic diseases that include infections like leprosy, HIV and lyme disease, inflammatory or autoimmune conditions and medications like penicillamine.

  • Primary Anetoderma: This is marked by the spontaneous eruptions of lesions on the skin without any other symptoms. The cause for primary anetoderma has not yet been determined. The suggested causes include antiphospholipid antibodies, immunological abnormalities and reduced production of elastin. It has also been associated with cataract, bone calcifications, myocardial infarction and blegvad-haxthausen syndrome
  • Secondary Anetoderma: In this case, atrophic lesions are preceded by inflammatory or autoimmune processes. This usually occurs at the site of skin conditions such as chicken pox, syphilis, tumours, acne, infantile haemangioma etc.

Both types of anetoderma can occur simultaneously. The main symptoms of primary and secondary anetoderma are:

Small, round or oval lesions on the upper arms, upper body and thighs. These lesions rarely occur on the neck, face, palms and soles. They may be isolated to grouped together to give a patchy appearance.

1. Atrophic papules

2. Loss of elastic tissue in the skin

3. Fine, diffused wrinkling

Till date, there is no known cure for this disease. If the number of lesions is limited the doctor may look at surgical excision as an option. Different forms of medication have been experimented with, but have not given consistent results. Some of the types of medication prescribed include aspirin, penicillin, vitamin E, niacin, topical epsilon-aminocaproic acid and oral colchicines.

Some cases have also shown improvement on being treated with carbon dioxide fractional lasers and pulsed dye lasers. In cases of secondary anetoderma, successfully identifying and curing the underlying condition can clear up the lesions as well.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2761 people found this helpful

Anetoderma - Facts You Should Know About it

M Derm, DNB (Dermatology & Venereology) , MBBS
Dermatologist, Gurgaon
Anetoderma - Facts You Should Know About it

Healthy skin is one that stays taut and firm. Anetoderma is a rare benign condition where the dermis loses elastic tissue. This results in the formation of a depression in the skin or flaccid skin. This condition is also known as macular atrophy, anetoderma maculosa, and atrophia maculosa cutis. Anetoderma is not contagious.

Women are at a higher risk of suffering from this condition than men. It usually affects people in their late teens and early twenties. Premature babies born with a very low birth weight are also susceptible to this condition. In rare cases, it can run in the family and affect identical twins.

Depending on how it is triggered, there are two types of Anetoderma; primary and secondary. Both forms of this condition may be associated with systemic diseases that include infections like leprosy, HIV and lyme disease, inflammatory or autoimmune conditions and medications like penicillamine.

Primary Anetoderma

This is marked by the spontaneous eruptions of lesions on the skin without any other symptoms. The cause for primary anetoderma has not yet been determined. The suggested causes include antiphospholipid antibodies, immunological abnormalities and reduced production of elastin. It has also been associated with cataract, bone calcifications, myocardial infarction and blegvad-haxthausen syndrome

Secondary Anetoderma

In this case, atrophic lesions are preceded by inflammatory or autoimmune processes. This usually occurs at the site of skin conditions such as chicken pox, syphilis, tumours, acne, infantile haemangioma etc.

Both types of anetoderma can occur simultaneously. The main symptoms of primary and secondary anetoderma are:

Small, round or oval lesions on the upper arms, upper body and thighs. These lesions rarely occur on the neck, face, palms and soles. They may be isolated to grouped together to give a patchy appearance.

1. Atrophic papules

2. Loss of elastic tissue in the skin

3. Fine, diffused wrinkling

Till date, there is no known cure for this disease. If the number of lesions is limited the doctor may look at surgical excision as an option. Different forms of medication have been experimented with, but have not given consistent results. Some of the types of medication prescribed include aspirin, penicillin, vitamin E, niacin, topical epsilon-aminocaproic acid and oral colchicines.

 

Some cases have also shown improvement on being treated with carbon dioxide fractional lasers and pulsed dye lasers. In cases of secondary anetoderma, successfully identifying and curing the underlying condition can clear up the lesions as well. If you wish to discuss about any specific problem, you can consult a dermatologist.

2706 people found this helpful

Vitamin and Trace Element Deficiencies

Homeopath,
Vitamin and Trace Element Deficiencies

Vitamin and trace element deficiencies 

Fat soluble vitamins 

Vitamin a (retinol)

• Found in dairy produce, eggs, fish oils, and liver.

• Deficiency causes night blindness, xerophthalmia, keratomalacia (corneal thickening) and follicular hyperkeratosis.


Vitamin d (cholecalciferol)

• Found in fish liver oils, dairy produce, and undergoes metabolism at the kidneys and the skin using uv light.

• Deficiency causes rickets (in children) and osteomalacia (in adults). Proximal muscle weakness may be evident. 


Vitamin e (alpha-tocopherol)

• Widely distributed, green vegetables, and vegetable oils.

• Deficiency causes hemolytic anemia (premature infants) and gross ataxia. 

Vitamin k (k 1 = phylloquinine k 2 = menaquinone)

• Widely distributed but particularly in green vegetables. Synthesized by intestinal bacteria.

• Deficiency causes coagulation defects seen as easy bruising and hemorrhage.


Water soluble vitamins 
Vitamin b 1 (thiamine)

• Found in cereals, peas, beans, yeast, and whole-wheat fl our. It is an essential factor in carbohydrate metabolism and transketolation reactions.

• Deficiency causes dry beri-beri (sensory and motor peripheral neuropathy), wet beri-beri (high output cardiac failure and edema), wernicke–korsakoff syndrome. 


Vitamin b 2 (ribofl avin)

• Found in whole-wheat flour, meat, fish, and dairy produce. It is a coenzyme in reversible electron carriage in oxidation–reduction reactions.

• Deficiency gives angular stomatitis (fissuring and inflammation at the corners of the mouth), inflamed oral mucous membranes, seborrhoeic dermatitis, and peripheral neuropatmhy. Drugs (e. G, isoniazid, hydralazine, penicillamine) and is also seen in alcoholism and pregnancy

Vitamin b 12 (cyanocobalamin)

• Causes of a deficiency are numerous and include partial or total gastrectomy, crohn’s disease, ileal resection, jejunal diverticulae, blind loop syndrome, and tapeworm.

• Deficiency causes megaloblastic anemia, peripheral neuropathy, subacute combined degeneration of the spinal cord depression, psychosis, and opticatrophy. 

Vitamin b 9 (folic acid)

• Deficiency can be caused by poor diet, malabsorption states, coeliac disease, crohn’s disease, gastrectomy, drugs (e. G, methotrexate, phenytoin), excessive utilization (E.G, leukemia, malignancy, inflammatory disease).

• Consequences of deficiency include megaloblastic anemia, and glossitis. 

Vitamin c (ascorbic acid) 

Deficiency causes scurvy (perifoillicular haemorrhage, bleeding swollen gums, spontaneous bruising, corkscrew hair, failure of wound healing), anemia, and osteoporosis. Trace elements Copper

• Deficiency results in hypochromic and microcytic anemia, wilson’s disease, impaired bone mineralization, menks’ kinky hair syndrome (growth failure, mental defi ciency, bone lesions, brittle hair, anemia).

• Usually caused by copper malabsorption. 

Zinc deficiency causes achondromatosis enterpathica (infants develop growth retardation, hair loss, severe diarrhea, candida and bacterial infections), impaired wound healing, skin ulcers, alopecia, night blindness, confusion, apathy, and depression. 

 Magnesium severe deficiency can cause cardiac arrhythmias, paraesthesia and tetany. Iodine severe deficiency can cause cretinism (children), hypothyroidism, and goiter. 

Vitamin b 3 (niacin)

• Found in fish, liver, nuts, and whole-wheat flour.

• Deficiency causes pellagra): dermatitis, diarrhea, dementia. 

Vitamin b 6 (pyridoxine)

• Widespread distribution, also synthesized from tryptophan.

• Deficiency causes peripheral neuropathy, convulsions, and sideroblastic anemia. Deficiency may be provoked by a number of commonly used.

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Health Benefits of Garlic

M.Sc. in Dietetics and Food Service Management , Post Graduate Diploma In Computer Application, P.G.Diploma in Clinical Nutrition & Dietetics , B.Sc.Clinical Nutrition & Dietetics
Dietitian/Nutritionist, Mumbai
Health Benefits of Garlic

Health benefits of garlic:

1. Garlic contains a compound called allicin, which has potent medicinal properties. Garlic is a plant in the allium (onion) family. It is closely related to onions, shallots, and leeks. It grows in many parts of the world and is a popular ingredient in cooking due to its strong smell and delicious taste.

However, throughout ancient history, the main use of garlic was for its health and medicinal properties. Its use was well documented by all the major civilizations including the Egyptians, Babylonians, greeks, Romans and the Chinese.

Garlic bulbs and cloves

The entire “head” is called a garlic bulb while each segment is called a clove. There are about 10-20 cloves in a single bulb, give or take.

We now know that most of the health effects are caused by one of the sulfur compounds formed when a garlic clove is chopped, crushed or chewed.

This compound is known as allicin and is also responsible for the distinct garlic smell. Allicin enters the body from the digestive tract and travels all over the body, where it exerts its potent biological effects (which we’ll get to in a bit).

Bottom line: garlic is a plant in the onion family, grown for its cooking properties and health effects. It is high in a sulfur compound called allicin, which is believed to bring most of the health benefits.

2. Garlic is highly nutritious but has very few calories. Calorie for calorie, garlic is incredibly nutritious.

A 1 ounce (28 grams) serving of garlic contains (3):

  • Manganese: 23% of the RDA.
  • Vitamin b6: 17% of the RDA.
  • Vitamin c: 15% of the RDA.
  • Selenium: 6% of the RDA.
  • Fiber: 1 gram.
  • Decent amounts of calcium, copper, potassium, phosphorus, iron and vitamin b1.
  • Garlic also contains trace amounts of various other nutrients. In fact, it contains a little bit of almost everything we need.

This is coming with 42 calories, with 1.8 grams of protein and 9 grams of carbs.

Bottom line: garlic is low in calories and very rich in vitamin c, vitamin b6 and manganese. It also contains trace amounts of various other nutrients.

3. Garlic can combat sickness, including the common cold. Garlic supplementation is known to boost the function of the immune system. According to a study, the average length of cold symptoms was also reduced by 70%, from 5 days in placebo to just 1.5 days in the garlic group.

Another study found that a high dose of garlic extract (2.56 grams per day) can reduce the number of days sick with cold or flu by 61%.

If you often get colds, then adding garlic to your diet could be incredibly helpful.

Bottom line: garlic supplementation helps to prevent and reduce the severity of common illnesses like the flu and common cold.

4. The active compounds in garlic can reduce blood pressure. Cardiovascular diseases like heart attacks and strokes are the world’s biggest killers. High blood pressure, or hypertension, is one of the most important drivers of these diseases. 

Human studies have found garlic supplementation to have a significant impact on reducing blood pressure in people with high blood pressure. In one study, aged garlic extract at doses of 600-1, 500 mg was just as effective as the drug atenolol at reducing blood pressure over a 24 week period.

Supplement doses must be fairly high to have these desired effects. The amount of allicin needed is equivalent to about four cloves of garlic per day.

Bottom line: high doses of garlic appear to improve blood pressure of those with known high blood pressure (hypertension). In some instances, supplementation can be as effective as regular medications.

5. Garlic improves cholesterol levels, which may lower the risk of heart disease. For those with high cholesterol, garlic supplementation appears to reduce total and/or LDL cholesterol by about 10-15%. Looking at LDL (the “bad”) and HDL (the “good”) cholesterol specifically, garlic appears to lower LDL but has no reliable effect on HDL. Garlic does not appear to lower triglyceride levels, another known risk factor for heart disease.

Bottom line: garlic supplementation seems to reduce total and ldl cholesterol, particularly in those who have high cholesterol. Hdl cholesterol and triglycerides do not seem to be affected.

6. Garlic contains antioxidants that may help prevent Alzheimer's disease and dementia. Garlic contains antioxidants that support the body’s protective mechanisms against oxidative damage. High doses of garlic supplementation have been shown to increase antioxidant enzymes in humans, as well as significantly reduce oxidative stress in those with high blood pressure

The combined effects on reducing cholesterol and blood pressure, as well as the antioxidant properties, may help prevent common brain diseases like Alzheimer's disease and dementia.

Bottom line: garlic contains antioxidants that protect against cell damage and aging. It may reduce the risk of Alzheimer's disease and dementia.

7. Garlic may help you live longer. Effects on longevity are basically impossible to prove in humans. But given the beneficial effects on important risk factors like blood pressure, it makes sense that garlic could help you live longer.

The fact that it can fight infectious disease is also an important factor because these are common causes of death, especially in the elderly or people with dysfunctional immune systems.

Bottom line: garlic has known beneficial effects on common causes of chronic disease, so it makes perfect sense that it could help you live longer.

8. Athletic performance can be improved with garlic supplementation. It was traditionally used in ancient cultures to reduce fatigue and enhance the work capacity of laborers.

Rodent studies have shown that garlic helps with exercise performance, but very few human studies have been done.

Subjects with heart disease that took garlic oil for 6 weeks had a reduction in peak heart rate of 12% and improved their exercise capacity. Other studies suggest that exercise-induced fatigue may be reduced with garlic.

Bottom line: garlic can improve physical performance in lab animals and people with heart disease. Benefits in healthy people are not yet conclusive.

9. Eating garlic can help detoxify heavy metals in the body. At high doses, the sulfur compounds in garlic have been shown to protect against organ damage from heavy metal toxicity.

A four-week study in employees of a car battery plant (excessive exposure to lead) found that garlic reduced lead levels in the blood by 19%. It also reduced many clinical signs of toxicity, including headaches and blood pressure.

Three doses of garlic each day even outperformed the drug d-penicillamine in symptom reduction.

Bottom line: garlic was shown to significantly reduce lead toxicity and related symptoms in one study.

10. Garlic may improve bone health. No human trials have measured the effects of garlic on bone loss.

Rodent studies have shown that it can minimize bone loss by increasing estrogen in females.

One study in menopausal women found that a daily dose of dry garlic extract (equal to 2 grams of raw garlic) significantly decreased a marker of estrogen deficiency. This suggests that this garlic may have beneficial effects on bone health in women.

Foods like garlic and onions have also been shown to have beneficial effects on osteoarthritis.

Bottom line: garlic appears to have some benefits for bone health by increasing estrogen levels in females, but more human studies are needed.

11. Garlic is easy to include in your diet and tastes absolutely delicious. The last one is not a health benefit, but still important. It is the fact that it is very easy (and delicious) to include garlic in your current diet. It complements most savory dishes, particularly soups and sauces. The strong taste of garlic can also add a punch to otherwise bland recipes.

Garlic comes in several forms, from whole cloves and smooth pastes to powders and supplements like garlic extract and garlic oil. The minimum effective dose for therapeutic effects is one clove eaten with meals, two or three times a day.

However, keep in mind that there are some downsides to garlic, such as bad breath. There are also some people who are allergic to it.

If you have a bleeding disorder or are taking blood-thinning medications, then talk to your doctor before increasing your garlic consumption.

The active compound allicin only forms when garlic is crushed or cleaved when it is raw. If you cook it before crushing it, then it won’t have the same health effects.

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