Mitigate TH Tablet is primarily known as a pain killer. It is primarily used to treat pain caused due to muscle spasm. This medication is a combination of Aceclofenac and Thiocolchicoside.
These two drug belongs to the class of non-steroidal anti-inflammatory drugs and natural anti-inflammatory glycosides, respectively. The drug combination works together and helps in improving muscle movement and also relieves discomfort and pain associated with the spasm.
The side effects of this drug include nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, drowsiness, confusion, etc. You should not be taking this medicine if–
- You are allergic to this drug or other anti-inflammatory painkillers.
- You ever had a problem with stomach or duodenal bleeding.
- You have a heart condition or impaired kidney or liver function.
- You are pregnant or breastfeeding woman.
- You have high blood pressure or blood clotting problems.
This medication interacts with medicines like lithium, digoxin, corticosteroids, antihypertensives, etc and certain diseases like asthma, gastrointestinal toxicity. It can be taken with food or after food.
Drinking an adequate amount of water minimises chances of indigestion and stomach irritations. The duration and amount of medicine should be followed as per the doctor’s prescription.
This medication is used to treat:
How long is the duration of effect?This medicine is excreted in urine and the effect lasts for a duration of 12 to 16 hours.
What is the onset of action?The peak effect of this medicine can be observed in 1.5 to 3 hours after oral administration.
Are there any pregnancy warnings?This medicine is not recommended for pregnant women.
Is it habit forming?No habit forming tendencies were reported.
Are there any breast-feeding warnings?This medicine is not recommended for breastfeeding women.
Are there any missed dose instructions?Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.
Are there any overdose instructions?A doctor should be contacted immediately if an overdose of Mitigate TH Tablet is suspected.
This medication is a combination of Aceclofenac and Thiocolchicoside, thus it works via a dual mechanism of action. The former drug, Aceclofenac, belongs to the class of a non-steroidal anti-inflammatory drug that helps relieve pain. Prostaglandins are responsible for pain, inflammation, swelling and fever. It inhibits the action of cyclooxygenase in the brain which is involved in the production of prostaglandins.
The latter constituent, Thiocolchicoside, is a derivative of glucoside, colchicoside that is contained within the Colchicum autumnale plant. It is a type of synthetic sulphur derivative. This medication has a high affinity for g-aminobutyric acid receptors. It activates GABA pathways and acts on the muscular contractures.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
EthanolThis medicine should not be consumed with alcohol. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.
Interaction with Lab Test
LabInformation not available.
Interaction with Medicine
MedicineThis drug interacts with lithium, methotrexate, mifepristone, anti-coagulants, zidovudine, etc.
Interaction with Food
FoodInformation not available.
Ques: What is Mitigate TH Tablet?
Ques: How long do I need to use Mitigate TH Tablet before I see improvement in my condition?
Ques: At what frequency do I need to use Mitigate TH Tablet?
Ques: Should I use Mitigate TH Tablet empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Mitigate TH Tablet?
Aceclofenac- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/aceclofenac
Aceclofenac- DrugBank [Internet]. Drugbank.ca. 2010 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB06736
Thiocolchicoside- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/thiocolchicoside
Thiocolchicoside- DrugBank [Internet]. Drugbank.ca. 2016 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB11582
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