Letrozole is a drug sold under the trade name Femara for the treatment of breast cancer in post-menopausal women. Sometimes, excess estrogen in the body can stimulate cancerous cells to grow in the breasts. Letrozole is commonly used to treat estrogen-dependent tumours. It belongs to a group of drugs called aromatase inhibitors that prevents the conversion of androgen to estrogen in women. In menopausal women, the ovaries do not produce estrogen. Instead, the body fat, using a protein called aromatase, produce it. Letrozole inhibits the production of estrogen and thus prevents the growth of a tumour.
Letrozole also increases the thickness of the endometrium and improves follicular development in the ovaries. Letrozole can also induce ovulation in females if they are unable to do so naturally. Sometimes, this drug can be also prescribed to men with breast cancer. Letrozole is only prescribed if the biopsy shows oestrogen receptors within the cells.
Letrozole helps to reduce chances of the cancer returning to the same breast or metastasize. Letrozole is taken as a tablet, once a day for 5 days, with or without food.
It is prescribed to women with estrogen-induced breast cancer. It is usually given after chemotherapy and radiotherapy. Sometimes, it is prescribed to reduce the size of the tumour before surgery. It may also be prescribed to reduce the growth of the cancerous cells if surgery is not an option for you. It can also be used to treat recurring tumours.
How long is the duration of effect?
Since, Letrozole is an endocrine therapy, it needs to be taken for 5 years after the surgery to maintain its effect on the cancer.
What is the onset of action?
The drug therapy requires a minimum of 3-4 months to show any effect on the tumour.
Are there any pregnancy warnings?
Letrozole is used in post-menopausal women only. It is contraindicated in pregnant women.
Is it habit forming?
It is not habit-forming.
Are there any breast-feeding warnings?
This drug is incompatible with breastfeeding women. There is an increased risk of foetal malformation.
Is It safe with alcohol?
It is unsafe to drink alcohol while undergoing this hormone therapy for increases chances of headaches and nausea.
Is it safe to drive while on this medicine?
Drive with caution if you are suffering from any of the side-effects.
Does this affect kidney function?
There has been no kidney impairment reported due to this hormone therapy.
Does this affect liver function?
It increases the enzyme level in the liver and interferes with the normal functioning of the liver.
Below is the list of medicines, which have the same composition, strength and form as Letoval Tablet , and hence can be used as its substitute.
Are there any missed dose instructions?
If you miss a dose, you do not need to take it the next day since the hormone level in your system will be high enough from the previous day.
Are there any overdose instructions?
Contact emergency services immediately if you overdose. Overdosing will enhance the severity of the side-effects.
Letoval Tablet belongs to nonsteroidal aromatase inhibitors. It works by inhibiting the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Thus inhibits the growth of cancer of the breast.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Letrozole is dangerous to be used in patients with existing liver disease. The drug increases the enzyme level in the liver.
Interaction with Alcohol
AlcoholInteraction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Food
FoodInformation not available.
Interaction with Medicine
Letrozole interacts with other estrogen-containing drugs like hormone replacement therapy (HRT) and other drugs like ethinylestradiol, tamoxifen, cholera vaccine and eluxadoline.
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