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Overview

Macova 2.5mg Tablet

Manufacturer :  Gynofem Heathcare Pvt. Ltd.
Medicine Composition :  Letrozole
Prescription vs OTC : Prescription by Doctor required

About Macova 2.5mg Tablet

Macova 2.5mg Tablet is primarily used to treat Breast Cancer in Post-Menopausal Women. Sometimes, excess Estrogen in the body can stimulate Cancerous Cells to grow in the Breast. It is commonly used to treat estrogen-dependent Tumors.

Macova 2.5mg Tablet belongs to a group of drugs called Aromatase Inhibitors that prevents the conversion of Androgen to Estrogen in women. In Menopausal Women, the Ovaries do not produce Estrogen. Instead, the Body Fat, using a Protein called Aromatase, produce it. Macova 2.5mg Tablet inhibits the production of Estrogen and thus prevents the growth of a Tumor.

It also increases the thickness of the Endometrium and improves Follicular development in the Ovaries. This medication can also induce Ovulation in females if they are unable to do so naturally. Sometimes, this drug can be also prescribed to men with Breast Cancer. It is only prescribed if the biopsy shows Oestrogen Receptors within the cells.

Macova 2.5mg Tablet helps to reduce chances of Cancer returning to the same breast or metastasize. It can be taken as a tablet, once a day for 5 days, with or without food.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the uses of Macova 2.5mg Tablet

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the contraindications of Macova 2.5mg Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the side effects of Macova 2.5mg Tablet ?

    • Hot Flashes

    • Bone Pain

    • Chronic Musculoskeletal Pain

    • Arthralgia

    • Flushing

    • Asthenia

    • Edema (Swelling)

    • Headache

    • Dizziness

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    Key highlights of Macova 2.5mg Tablet

    • How long is the duration of effect?

      Since, Letrozole is an endocrine therapy, it needs to be taken for 5 years after the surgery to maintain its effect on the cancer.

    • What is the onset of action?

      The drug therapy requires a minimum of 3-4 months to show any effect on the tumour.

    • Are there any pregnancy warnings?

      Letrozole is used in post-menopausal women only. It is contraindicated in pregnant women.

    • Is it habit forming?

      It is not habit-forming.

    • Are there any breast-feeding warnings?

      This drug is incompatible with breastfeeding women. There is an increased risk of foetal malformation.

    • Is It safe with alcohol?

      It is unsafe to drink alcohol while undergoing this hormone therapy for increases chances of headaches and nausea.

    • Is it safe to drive while on this medicine?

      Drive with caution if you are suffering from any of the side-effects.

    • Does this affect kidney function?

      There has been no kidney impairment reported due to this hormone therapy.

    • Does this affect liver function?

      It increases the enzyme level in the liver and interferes with the normal functioning of the liver.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      If you miss a dose, you do not need to take it the next day since the hormone level in your system will be high enough from the previous day.

    • Are there any overdose instructions?

      Contact emergency services immediately if you overdose. Overdosing will enhance the severity of the side-effects.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    Where is the Macova 2.5mg Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    How does this medication work?

    This medication falls under the class of non-steroidal aromatase inhibitors. It competitively binds to the haem of the cytochrome P450 subunit of the aromatase enzyme and inhibits the biosynthesis of estrogen in all the tissues. Thus inhibits the growth of breast cancer.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

      What are the interactions of Macova 2.5mg Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Medicine

        Macova 2.5mg Tablet interacts with other estrogen-containing drugs like hormone replacement therapy (HRT) and other drugs like ethinylestradiol, tamoxifen, cholera vaccine and eluxadoline.

      • Interaction with Food

        Information not available.
      • Interaction with Disease

        Macova 2.5mg Tablet is dangerous to be used in patients with existing liver disease. The drug increases the enzyme level in the liver.

      FAQs about Macova 2.5mg Tablet

      • Ques : Why have I been prescribed Macova 2.5mg Tablet?

        Ans : This drug is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women. Sometimes, it is also used to treat infertility caused due to an ovulation.

      • Ques : How does Macova 2.5mg Tablet work?

        Ans : This drug is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for the production of estrogen.

      • Ques : For how long should I take Macova 2.5mg Tablet?

        Ans : It is advised to consult the doctor and consume it as prescribed by your doctor.

      • Ques : If I am taking irbesartan to control my blood pressure, can I take Macova 2.5mg Tablet too?

        Ans : Yes, you can take irbesartan and Macova 2.5mg Tablet together.

      • Ques : Does Macova 2.5mg Tablet affect vision?

        Ans : Although it is very uncommon, this drug may cause cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.

      • Ques : What are the serious side effects of Macova 2.5mg Tablet?

        Ans : Side effects include stroke, angina, heart attack, blood clotting, cataract, osteoporosis and severe skin reactions.

      • Ques : Does Macova 2.5mg Tablet cause bone loss?

        Ans : It may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during, and after treatment.

      References

      • Letrozole-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/letrozole

      • Letrozole-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 7 June 2022].Available from:

        https://go.drugbank.com/drugs/DB01006

      • LETROZOLE tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=LETROZOLE

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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