Grenil Tablet

This medication a part of the dopamine antagonists and NSAID group of drugs used to treat migraine. This medicine prevents the signal of pain to reach the brain, thus reduces pain. Migraine pain causes nausea and vomiting stimulating the receptors in the brain responsible for it.

Its action helps to speed up the passing of the food that you intake - from your stomach to your intestine, reducing the feeling of nausea and sickness, also preventing vomiting. It can also block, or reduce stimulation in the ‘vomiting centre’ of your brain, which will eventually reduce the feeling of nausea and vomiting.

Grenil Tablet can be used for treating the slow passage of food in your gastrointestinal tract, generally associated with gastritis or diabetes. For people suffering from this condition, this medication can treat the symptoms of vomiting, nausea, bloating and feeling full. Apart from that, it can also prevent vomiting and nausea that is associated with Parkinson’s disease. This medication works by emptying your stomach quickly, reducing nausea.

The maximum dose that is recommended for adults is 4 tablets, in a severe migraine attack. The dose that would suit your body depends on your body weight, other medicines that you are currently taking and your health condition. Ensure that you take the medicine only in that amount as instructed by the doctor.

In case you miss a dose, you can take it later. However, do not take two doses together to make up for the previous one that has been missed. Overdose can cause disorientation, light-headedness, losing muscle or balance control or difficulty in talking.

You are advised not to take this medication if you have the following conditions:

• An allergy to the tablet or any other ingredient of this medicine
• Bleeding problems or blockage in your stomach or in the intestine
• Tumour in the pituitary gland
• Cardiac disease
• Incorrect levels of magnesium, potassium or calcium in the blood
• Severe/moderate liver impairment

The possible side effects of taking Grenil Tablet can be diarrhea, headache, migraine, dryness of the mouth or breast pain. These side effects are not very common and go away in a few days. If not, you can consult your doctor.

• Migraine

• Allergy

• Tumor Of Pituitary Gland

• Heart Diseases

• Difficulty In Breathing

• Skin Rash

• Convulsions

• Heart Rhythm Disorders

• Disrupted Menstrual Cycle

• Breast Pain

• Dry Mouth

• Loss Of Libido

• Breast Like Growth In Men

• How long is the duration of effect?

  The effect of this medicine lasts up to 6 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 30 to 60 minutes of administration.

• Are there any pregnancy warnings?

  This medicine should not be used by pregnant women unless suggested by the doctor. It is yet not established that what type of effect does this medicine would cause to the fetus. Hence, it should only be consumed after proper consultation with the doctor.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  Breastfeeding mothers should ignore this medicine as it may cause problems for the infant. Doctor consultation for proper evaluation of risks is highly recommended.

• Is It safe with alcohol?

  It is unsafe to consume alcohol with this medicine.

• Is it safe to drive while on this medicine?

  This medicine may affect the alertness of the patients. Thus it is advised to avoid driving while taking this medicine.

• Does this affect kidney function?

  Caution must be taken in patients with kidney disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

Below is the list of medicines, which have the same composition, strength and form as Grenil Tablet , and hence can be used as its substitute.

• Nograin 20Mg/500Mg Tablet

  Total Healthcare

• Diike 20 Mg/500 Mg Tablet

  Cadila Pharmaceuticals Ltd

• Domnext Tablet

  Concur Pharmaceuticals Pvt.Ltd

• Cetgrain 20 Mg/500 Mg Tablet

  Pegasus Farmaco India Pvt Ltd

• Are there any missed dose instructions?

  Skip the missed dose and resume with the next scheduled dose at the right time. The dose should not get doubled in an attempt to make up for the missed dose.

• Are there any overdose instructions?

  Contact your doctor if an overdose is suspected. Symptoms of overdose may include drowsiness, agitation, and convulsions and may be more prevalent in infants and children. Immediate medical attention including gastric lavage may be required in severe cases.

This medication attaches to the dopaminergic receptors without causing any release of the chemical dopamine. This in turn, facilitates gastric emptying and decreases small bowel transit time. And it selectively inhibits enzyme function in the brain which allows it to treat pain and fever. It activates certain receptors in the brain that inhibit pain signals.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  You should avoid consuming alcohol while taking this medicine. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.

• Interaction with Lab Test

  5-HIAA Urine Test

  You may get a false-positive result for this test if you take this medicine.

  The patients taking this medicine have been reported for false results, as it interacts with investigations of Neuroendocrine Tumors, Secretin Stimulation Test, Urine Tests for THC. Thus an alternative confirmatory test should be considered to verify the results.

• Interaction with Medicine

  One must take caution while taking this medicine. This medication may interact with other medication like Ketoconazole, Metformin, Anti-hypertensives if administered concomitantly. Also, Barbiturates, carbamazepine, hydantoins, sulfinpyrazone can increase the hepatotoxic potential of acetaminophen; chronic ethanol abuse increases the risk for acetaminophen toxicity; effect of warfarin may be enhanced.

• Interaction with Food

  May slightly delay absorption of extended-release preparations; rate of absorption may be decreased when given with food high in carbohydrates.

• Ques : What is Grenil tablet?

  Ans : This Tablet belongs to the dopamine antagonists class of drugs which are used to prevent the tendency of vomiting and nausea. It contains Domperidone and Paracetamol as active ingredients. Grenil works by increasing the pain threshold and increases the blood flow across the skin, heat loss and sweating and by blocking the dopamine receptors. It works by emptying the stomach rapidly and reducing nausea, also used in the treatment of Parkinson’s Disease.

• Ques : What is Grenil tablet used for?

  Ans : Grenil is used in the treatment, prevention of conditions and symptoms of diseases such as Headache, Cephalalgia, Cold, Fever, and Febrility. Apart from these, It is also used for the treatment for symptoms associated with idiopathic or diabetic gastroparesis, Joint pain, Ear pain, Treatment for intractable nausea and vomiting, Toothache, Periods pain, and Flu. The patient should consult a doctor before using it for any of the above condition about the dosage and side effects it may cause.

• Ques : What are the side effects of Grenil tablet?

  Ans : This is a list of possible side-effects that may occur because of the constituting ingredients of the Tablet. This is an exhaustive list. These side-effects have been observed but do not always occur. Some of the side-effects may be rare but serious. These include somnolence, feeling of sickness, swollen facial features, dry mouth, breast pain, skin reddening. Apart from these, it could also lead to conditions such as Cephalalgia, Allergic reactions and Shortness of breath. If any of these symptoms occur often or on daily basis, a doctor should be urgently consulted.

• Ques : Can I take a higher than the recommended dose of this medicine?

  Ans : It is not recommended to take a dose more than as prescribed by your doctor. Taking more doses will not improve your condition, and may even lead to a few side effects. The patient shall not give this medicine to other people even if it seems that they have a similar condition. This may lead to overdosage. Please consult a doctor or pharmacist or product package for more information.

• Ques : Can I get addicted to Grenil?

  Ans : No, tablet is not an addictive medication.

• Ques : What is the recommended storage condition for grenil?

  Ans : This Tablet should be stored between 15-20 degree celsius, away from heat and direct light. Keep it away from the reach of children and pets. It is important to dispose unused medications and expired medications properly to avoid adverse effects.

• Ques : Can the use of Grenil cause damage to liver?

  Ans : Yes, using this tablet can cause Liver damage. It may also lead to death due to liver failure.

• Ques : Should i use Grenil empty stomach, before food or after food?

  Ans : It is advised to take this Tablet 15-20 minutes before food. Patient can follow doctor's advise for dosage and consumption.

• Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/57808-66-9

• Domperidone 10mg Tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 23 April 2019]. Available from:

  https://www.medicines.org.uk/emc/product/556

• Acetaminophen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/paracetamol

• 7 Select Acetaminophen- acetaminophen tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2017 [Cited 23 April 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=168da31e-de62-4280-9c66-2b41d2d93c31